Bis(4-hydroxyphenyl)sulfone

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Descriptors
• Chemical-gene interaction
• Chemical-phenotype interaction
• Chemical-disease association
• ToxCast endpoints
• Associated AOPs
• Presence in consumer products
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:17904329	IVR	1000 mg/kg/day	1000 mg/kg/day	Uterotrophic effect	Reproductive endocrine-mediated perturbations
PMID:24563381	IVTH	0.0000000001 - 0.0001 M	0.0000001 - 0.0000548 M	Decrease in corticosterone levels	Neurological endocrine-mediated perturbations
	IVTH	0.0000000001 - 0.0001 M	0.0000001 - 0.0000548 M	Decreased Dehydroepiandrosterone (DHEA) levels	Metabolic endocrine-mediated perturbations
	IVTH	0.0000000001 - 0.0001 M	0.0000001 - 0.0000548 M	Increased androstenedione levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0000000001 - 0.0001 M	0.0000001 - 0.0000548 M	Increased progestagens levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0000000001 - 0.0001 M	0.0000001 - 0.0000548 M	Decrease in cortisol levels	Neurological endocrine-mediated perturbations
	IVTH	0.0000000001 - 0.0001 M	0.0000001 - 0.0000548 M	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:25111128	IVTH	0.000000000001 M	0.000000000001 M	Increased triglycerides level	Metabolic endocrine-mediated perturbations
	IVTH	0.000000000001 M	0.000000000001 M	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVTH	0.000000000000001 M	0.000000000000001 M	Increased triglycerides level	Metabolic endocrine-mediated perturbations
	IVTH	0.000000000000001 M	0.000000000000001 M	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVTH	0.000000001 M	0.000000001 M	Increased triglycerides level	Metabolic endocrine-mediated perturbations
	IVTH	0.000000001 M	0.000000001 M	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Increased triglycerides level	Metabolic endocrine-mediated perturbations
PMID:26186136	IVR	0.01 mg/kg/day	0.01 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:26751127	IVTH	0.00001 - 0.0005 M	0.0000001 - 0.00007 M	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 - 0.0005 M	0.0000001 - 0.00007 M	Decreased aldosterone levels	Metabolic endocrine-mediated perturbations
	IVTH	0.00001 - 0.0005 M	0.0000001 - 0.00007 M	Decrease in cortisol levels	Neurological endocrine-mediated perturbations
	IVTH	0.00001 - 0.0005 M	0.0000001 - 0.00007 M	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:26994432	IVR	0.001 - 0.05 mg/kg/day	0.001 - 0.05 mg/kg/day	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	0.001 - 0.05 mg/kg/day	0.001 - 0.05 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.001 - 0.05 mg/kg/day	0.001 - 0.05 mg/kg/day	Affects the biochemical composition of liver	Hepatic endocrine-mediated perturbations
	IVR	0.001 - 0.05 mg/kg/day	0.001 - 0.05 mg/kg/day	Changes in testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	0.001 - 0.05 mg/kg/day	0.001 - 0.05 mg/kg/day	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
PMID:27003841	IVTH	0.000025 M	0.000025 M	Lead to obesity	Metabolic endocrine-mediated perturbations
PMID:28005399	IVR	0.002 mg/kg/day	0.002 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg/day	0.2 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:28628672	IVTH	0.00001 M	0.00001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.00000001 M	0.00000001 M	Cancer phenotype	Endocrine-mediated cancer
PMID:28676390	IVR	50000 mg/kg	50000 mg/kg	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	50000 mg/kg	50000 mg/kg	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	50000 mg/kg	50000 mg/kg	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Affects sertoli cells function	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Affects testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Increased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Affects sperm motility	Reproductive endocrine-mediated perturbations
PMID:28808208	IVTH	0.0000001 - 0.00001 M	0.0000001 - 0.00001 M	Induced migration capability of tumor cells	Endocrine-mediated cancer
	IVTH	0.0000001 - 0.00001 M	0.0000001 - 0.00001 M	Cancer phenotype	Endocrine-mediated cancer
PMID:29407803	IVR	50 mg/kg	50 mg/kg	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Delayed puberty	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Decreased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Decreased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Increased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Decreased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg	-	No significant effects observed	-
PMID:29526645	IVR	200000 mg/kg/day	200000 mg/kg/day	Affects expression of progesterone receptor (PR)	Reproductive endocrine-mediated perturbations
	IVR	200000 mg/kg/day	200000 mg/kg/day	Changes in mammary gland morphology	Reproductive endocrine-mediated perturbations
	IVR	200000 mg/kg/day	200000 mg/kg/day	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
	IVR	2000 mg/kg/day	2000 mg/kg/day	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
	IVR	2000 mg/kg/day	2000 mg/kg/day	Changes in mammary gland morphology	Reproductive endocrine-mediated perturbations
	IVR	2000 mg/kg/day	2000 mg/kg/day	Affects expression of progesterone receptor (PR)	Reproductive endocrine-mediated perturbations
PMID:29741722	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Increased estradiol levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Affects steroidogenesis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Affects germ cell development in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Reduced sperm counts in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Affects steroidogenesis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Affects steroidogenesis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Affects sperm motility in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Reduced sperm counts in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:29748175	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Decreased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Decreased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.000001 mg/kg/day	0.000001 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.000001 mg/kg/day	0.000001 mg/kg/day	Decreased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	0.01 mg/kg/day	0.01 mg/kg/day	Decreased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	0.01 mg/kg/day	0.01 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	0.01 mg/kg/day	0.01 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.01 mg/kg/day	0.01 mg/kg/day	Affects fertility	Reproductive endocrine-mediated perturbations
PMID:29909315	IVR	0.025 mg/kg/day	-	No significant effects observed	-
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Affects social behavior	Neurological endocrine-mediated perturbations
PMID:30102602	IVR	0.05 mg/kg	0.05 mg/kg	Changes in mammary gland morphology in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Changes in mammary gland morphology in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Alters mammary gland development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg	0.5 mg/kg	Changes in mammary gland morphology in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:30120946	IVR	0.005 mg/L	-	No significant effects observed	-
	IVR	0.05 mg/L	0.05 mg/L	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/L	0.05 mg/L	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/L	0.05 mg/L	Affects the biochemical composition of testis	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/L	0.05 mg/L	Decreased weights of epididymis	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/L	0.05 mg/L	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/L	0.05 mg/L	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/L	0.05 mg/L	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/L	0.05 mg/L	Affects testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/L	0.05 mg/L	Decreased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/L	0.05 mg/L	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/L	0.05 mg/L	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.025 mg/L	0.025 mg/L	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	0.025 mg/L	0.025 mg/L	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.025 mg/L	0.025 mg/L	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
	IVR	0.025 mg/L	0.025 mg/L	Affects the biochemical composition of testis	Reproductive endocrine-mediated perturbations
	IVR	0.025 mg/L	0.025 mg/L	Affects sperm motility	Reproductive endocrine-mediated perturbations
PMID:30523531	IVR	0.025 mg/kg/day	-	No significant effects observed	-
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Affects gluconeogenesis	Metabolic endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Affects gluconeogenesis	Metabolic endocrine-mediated perturbations
PMID:30613871	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Affects cell metabolism	Metabolic endocrine-mediated perturbations
PMID:30616060	IVTH	0.0000001 M	0.0000001 M	Induced migration capability of tumor cells	Endocrine-mediated cancer
	IVTH	0.00000001 M	0.00000001 M	Induce cancer metastasis	Endocrine-mediated cancer
	IVTH	0.00000001 M	0.00000001 M	Occurrence of mammary gland tumor	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
	IVTH	0.00000001 M	0.00000001 M	Induced migration capability of tumor cells	Endocrine-mediated cancer
	IVTH	0.000001 M	0.000001 M	Induced migration capability of tumor cells	Endocrine-mediated cancer
	IVTH	0.000001 M	0.000001 M	Occurrence of mammary gland tumor	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
	IVTH	0.0000001 M	0.0000001 M	Occurrence of mammary gland tumor	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Induce cancer metastasis	Endocrine-mediated cancer
	IVTH	0.0000001 M	0.0000001 M	Induce cancer metastasis	Endocrine-mediated cancer
PMID:30684532	IVTH	0.000000001 M	-	No significant effects observed	-
	IVTH	0.00000001 M	-	No significant effects observed	-
	IVTH	0.0000000001 M	-	No significant effects observed	-
	IVTH	0.0000001 M	-	No significant effects observed	-
	IVTH	0.0001 M	0.0001 M	Induce tumor progression	Endocrine-mediated cancer
	IVTH	0.0001 M	0.0001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.00001 M	0.00001 M	Induce tumor progression	Endocrine-mediated cancer
	IVTH	0.00001 M	0.00001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.000001 M	0.000001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.000001 M	0.000001 M	Induce tumor progression	Endocrine-mediated cancer
PMID:30817981	IVTH	0.00000001 M	0.00000001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.00000001 M	0.00000001 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
PMID:30822521	IVR	0.04 mg/kg	0.04 mg/kg	Prostate hyperplasia	Reproductive endocrine-mediated perturbations
	IVR	0.04 mg/kg	0.04 mg/kg	Alteration in prostate morphology	Reproductive endocrine-mediated perturbations
	IVR	0.04 mg/kg	0.04 mg/kg	Affects expression of androgen receptor (AR)	Reproductive endocrine-mediated perturbations
	IVR	0.04 mg/kg	0.04 mg/kg	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
PMID:30871434	IVR	50 mg/kg/day	50 mg/kg/day	Induce apoptosis of spermatogenic cells	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Alters sperm function	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg/day	-	No significant effects observed	-
	IVR	25 mg/kg/day	-	No significant effects observed	-
PMID:31132128	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	0.0005 - 0.05 mg/kg/day	0.0005 - 0.05 mg/kg/day	Alterations in vaginal opening	Reproductive endocrine-mediated perturbations
	IVR	0.0005 - 0.05 mg/kg/day	0.0005 - 0.05 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:31201878	IVR	0.002 mg/kg/day	-	No significant effects observed	-
	IVR	0.2 mg/kg/day	0.2 mg/kg/day	Changes in mammary gland morphology	Reproductive endocrine-mediated perturbations
PMID:31231671	IVR	200000 mg/kg/day	200000 mg/kg/day	Affects placental development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	200000 mg/kg/day	200000 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
PMID:31245508	IVR	0.002 mg/kg/day	-	No significant effects observed	-
	IVR	2 mg/kg/day	-	No significant effects observed	-
	IVR	0.2 mg/kg/day	0.2 mg/kg/day	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
PMID:31292004	IVR	0.002 mg/kg	0.002 mg/kg	Changes in morphology of seminiferous tubules in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.002 mg/kg	0.002 mg/kg	Increased testis weights in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg	0.2 mg/kg	Increased testis weights in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg	0.2 mg/kg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg	0.2 mg/kg	Changes in morphology of seminiferous tubules in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:31388671	IVTH	0.000001 M	0.000001 M	Affects expression of progesterone receptor (PR)	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Cancer phenotype	Endocrine-mediated cancer
PMID:31424294	IVR	0.05 - 5 mg/kg	0.05 - 5 mg/kg	Decreased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Affects fertility	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Decreased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Changes in ovarian morphology	Reproductive endocrine-mediated perturbations
	IVR	0.05 - 5 mg/kg	0.05 - 5 mg/kg	Affects ovarian follicles population	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Decreased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Increased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.05 - 5 mg/kg	0.05 - 5 mg/kg	Oxidative stress in ovaries	Reproductive endocrine-mediated perturbations
PMID:31514588	IVR	0.05 mg/L	0.05 mg/L	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVR	0.05 mg/L	0.05 mg/L	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
	IVR	0.025 - 0.05 mg/L	0.025 - 0.05 mg/L	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	0.025 - 0.05 mg/L	0.025 - 0.05 mg/L	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	0.025 - 0.05 mg/L	0.025 - 0.05 mg/L	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/L	0.05 mg/L	Changes in testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/L	0.05 mg/L	Decreased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/L	0.05 mg/L	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.025 - 0.05 mg/L	0.025 - 0.05 mg/L	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/L	0.05 mg/L	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/L	0.05 mg/L	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/L	0.05 mg/L	Decreased LH levels	Reproductive endocrine-mediated perturbations
PMID:31532523	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.0005 - 0.05 mg/kg/day	0.0005 - 0.05 mg/kg/day	Epigenomic alterations in testis	Reproductive endocrine-mediated perturbations
	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Increased testis weights	Reproductive endocrine-mediated perturbations
	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	0.0005 - 0.05 mg/kg/day	0.0005 - 0.05 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.0005 - 0.05 mg/kg/day	0.0005 - 0.05 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	0.0005 - 0.05 mg/kg/day	0.0005 - 0.05 mg/kg/day	Decreased body weights	Metabolic endocrine-mediated perturbations
PMID:31601247	IVTH	0.00001 M	0.00001 M	Induced migration capability of tumor cells	Endocrine-mediated cancer
	IVTH	0.000000001 M	0.000000001 M	Induced migration capability of tumor cells	Endocrine-mediated cancer
PMID:31690802	IVTH	0.0000001 - 0.00001 M	0.0000001 - 0.00001 M	Cancer phenotype	Endocrine-mediated cancer
PMID:31875995	IVTH	0.000108 M	0.000108 M	Oxidative stress in prostate	Reproductive endocrine-mediated perturbations
	IVTH	0.000108 M	0.000108 M	Affects the biochemical composition of liver	Hepatic endocrine-mediated perturbations
PMID:31881267	IVR	0.01 mg/kg/day	-	No significant effects observed	-
	IVR	0.000001 mg/kg/day	-	No significant effects observed	-
	IVR	0.1 mg/kg/day	-	No significant effects observed	-
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Affects ovulation	Reproductive endocrine-mediated perturbations
PMID:31945527	IVTH	0.000000001 - 0.00001 M	0.000000001 - 0.00001 M	Cancer phenotype	Endocrine-mediated cancer
PMID:31995776	IVTH	0.00001 M	0.00001 M	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
PMID:32071231	IVR	0.2 mg/kg	0.2 mg/kg	Oxidative stress in placenta	Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg	0.2 mg/kg	Changes in placental morphology	Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg	0.2 mg/kg	Affects placental function	Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg	0.2 mg/kg	Decreased serotonin (5-HT) levels	Neurological endocrine-mediated perturbations
	IVR	0.2 mg/kg	0.2 mg/kg	Increased dopamine levels	Neurological endocrine-mediated perturbations
	IVR	0.2 mg/kg	0.2 mg/kg	Affects placental development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:32105160	IVTH	0.00000001 - 0.000001 M	0.00000001 - 0.000001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.00000001 - 0.000001 M	0.00000001 - 0.000001 M	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
PMID:32155818	IVTH	0.00001 - 0.00005 M	0.00001 - 0.00005 M	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 - 0.00005 M	0.00001 - 0.00005 M	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
	IVTH	0.00005 M	0.00005 M	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
PMID:32170302	IVTH	0.0000001 - 0.000025 M	0.0000001 - 0.000025 M	Causes inflammation	Immunological endocrine-mediated perturbations
	IVTH	0.0000001 - 0.000025 M	0.0000001 - 0.000025 M	Altered adipocyte function	Metabolic endocrine-mediated perturbations
PMID:32289607	IVTH	0.0000001 - 0.0001 M	0.0000001 - 0.0001 M	Oxidative stress in granulosa cells	Reproductive endocrine-mediated perturbations
	IVTH	0.0001 M	0.0001 M	Decreased mitochondrial membrane potential in granulosa cells	Reproductive endocrine-mediated perturbations
	IVTH	0.0001 M	0.0001 M	Increased calcium levels	Metabolic endocrine-mediated perturbations
PMID:32466766	IVR	0.000001 mg/kg/day	0.000001 mg/kg/day	Epigenomic alterations in sperm	Reproductive endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Reduced sperm quality	Reproductive endocrine-mediated perturbations
	IVR	0.000001 - 0.1 mg/kg/day	0.000001 - 0.1 mg/kg/day	Affects testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	0.000001 - 0.001 mg/kg/day	0.000001 - 0.001 mg/kg/day	No significant effects observed	-
	IVR	0.000001 mg/kg/day	0.000001 mg/kg/day	Affects sperm motility	Reproductive endocrine-mediated perturbations
PMID:32742594	IVR	0.001 - 0.1 mg/kg	0.001 - 0.1 mg/kg	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	0.001 - 0.1 mg/kg	0.001 - 0.1 mg/kg	Decreased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	0.001 - 0.1 mg/kg	0.001 - 0.1 mg/kg	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	0.005 - 0.1 mg/kg	0.005 - 0.1 mg/kg	Induce apoptosis of ovarian follicles	Reproductive endocrine-mediated perturbations
PMID:32866863	IVR	0.002 - 0.01 mg/kg	0.002 - 0.01 mg/kg	Epigenomic alterations in ovary	Reproductive endocrine-mediated perturbations
	IVR	0.002 - 0.01 mg/kg	0.002 - 0.01 mg/kg	Affects embryonic development	Developmental endocrine-mediated perturbations
	IVR	0.002 - 0.01 mg/kg	0.002 - 0.01 mg/kg	Abnormal oocyte morphology	Reproductive endocrine-mediated perturbations
	IVR	0.002 - 0.01 mg/kg	0.002 - 0.01 mg/kg	Affects ovarian follicles population in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.002 - 0.01 mg/kg	0.002 - 0.01 mg/kg	Affects ovarian follicle development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.002 - 0.01 mg/kg	0.002 - 0.01 mg/kg	Affects ovarian follicles population	Reproductive endocrine-mediated perturbations
	IVR	0.002 - 0.01 mg/kg	0.002 - 0.01 mg/kg	Changes in ovarian morphology	Reproductive endocrine-mediated perturbations
PMID:32927158	IVTH	0.000000001 - 0.0001 M	0.000000001 - 0.0001 M	Increased oxidative stress in neurons	Neurological endocrine-mediated perturbations
	IVTH	0.000000001 - 0.0001 M	0.000000001 - 0.0001 M	Induce apoptosis in adipose tissue	Metabolic endocrine-mediated perturbations
	IVTH	0.0001 M	0.0001 M	Induce neuronal apoptosis	Neurological endocrine-mediated perturbations
PMID:32976960	IVTH	0.000000001 M	0.000000001 M	Altered adipogenesis	Metabolic endocrine-mediated perturbations
PMID:33017704	IVR	1 - 2 mg/kg/day	1 - 2 mg/kg/day	Changes in ovarian morphology	Reproductive endocrine-mediated perturbations
	IVR	1 - 2 mg/kg/day	1 - 2 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Affects ovarian follicles population	Reproductive endocrine-mediated perturbations
PMID:33181973	IVTH	0.00000001 M	0.00000001 M	Cancer phenotype	Endocrine-mediated cancer
PMID:33182144	IVR	1.5 mg/kg/day	1.5 mg/kg/day	Reduced insulin levels	Metabolic endocrine-mediated perturbations
	IVR	1.5 mg/kg/day	1.5 mg/kg/day	Reduced glucose levels	Metabolic endocrine-mediated perturbations
	IVR	1.5 mg/kg/day	1.5 mg/kg/day	Increased cholesterol levels	Metabolic endocrine-mediated perturbations
	IVR	1.5 mg/kg/day	1.5 mg/kg/day	Decreased triglycerides level	Metabolic endocrine-mediated perturbations
	IVR	1.5 mg/kg/day	1.5 mg/kg/day	Decreased cholesterol levels	Metabolic endocrine-mediated perturbations
PMID:33678156	IVR	0.05 mg/L	0.05 mg/L	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVR	0.05 mg/L	0.05 mg/L	Reduced insulin levels	Metabolic endocrine-mediated perturbations
	IVR	0.05 mg/L	0.05 mg/L	Decreased weights of epididymis	Reproductive endocrine-mediated perturbations
	IVR	0.005 - 0.05 mg/L	0.005 - 0.05 mg/L	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/L	0.05 mg/L	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/L	0.05 mg/L	Decreased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/L	0.05 mg/L	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	0.005 - 0.05 mg/L	0.005 - 0.05 mg/L	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/L	0.05 mg/L	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	0.005 - 0.05 mg/L	0.005 - 0.05 mg/L	Affects testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	0.005 - 0.05 mg/L	0.005 - 0.05 mg/L	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.005 - 0.05 mg/L	0.005 - 0.05 mg/L	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	0.005 - 0.05 mg/L	0.005 - 0.05 mg/L	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.005 - 0.05 mg/L	0.005 - 0.05 mg/L	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
PMID:33753083	IVTH	0.00000000156 - 0.000000025 M	0.00000000156 - 0.000000025 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.000000025 M	0.000000025 M	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00000000625 - 0.000000025 M	0.00000000625 - 0.000000025 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000000025 M	0.000000025 M	Increase in estradiol/testosterone ratio	Reproductive endocrine-mediated perturbations
PMID:33865937	IVTH	0.00000001 - 0.000025 M	0.00000001 - 0.000025 M	Altered adipogenesis	Metabolic endocrine-mediated perturbations
PMID:33885253	IVTH	0.00001 M	0.00001 M	Affects granulosa cells function	Reproductive endocrine-mediated perturbations
PMID:33916708	IVTH	0.000025 - 0.00005 M	0.000025 - 0.00005 M	Induce apoptosis of placental cells	Reproductive endocrine-mediated perturbations
PMID:34002388	IVR	2 mg/kg	2 mg/kg	Abnormal sperm morphology	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Changes in testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Induce apoptosis in testis	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Affects sperm motility	Reproductive endocrine-mediated perturbations
PMID:34038751	IVR	0.005 mg/L	0.005 mg/L	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.005 mg/L	0.005 mg/L	Increased estradiol levels	Reproductive endocrine-mediated perturbations
PMID:34174261	IVTH	0.00001 M	0.00001 M	Causes inflammation	Immunological endocrine-mediated perturbations
PMID:34186270	IVTH	0.000001 M	0.000001 M	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
	IVTH	0.00000001 - 0.00005 M	0.00000001 - 0.00005 M	Affects lipid metabolism	Metabolic endocrine-mediated perturbations
	IVTH	0.00000001 M	0.00000001 M	Increased leptin levels	Metabolic endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Decreased adiponectin levels	Metabolic endocrine-mediated perturbations
PMID:34270681	IVTH	0.00000000001 - 0.0000001 M	0.00000000001 - 0.0000001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.00000000001 M	0.00000000001 M	Causes inflammation	Immunological endocrine-mediated perturbations
	IVTH	0.0000001 - 0.00001 M	0.0000001 - 0.00001 M	Induce cancer metastasis	Endocrine-mediated cancer
	IVTH	0.000000001 - 0.0000001 M	0.000000001 - 0.0000001 M	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
PMID:34474391	IVR	0.1 - 1 mg/kg/day	0.1 - 1 mg/kg/day	Induce behavioral changes	Neurological endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Affects neuronal signaling	Neurological endocrine-mediated perturbations
PMID:34831106	IVTH	0.0001 M	0.0001 M	Induce cancer metastasis	Endocrine-mediated cancer
	IVTH	0.000001 - 0.0001 M	0.000001 - 0.0001 M	Affects expression of progesterone receptor (PR)	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 - 0.0001 M	0.000001 - 0.0001 M	Affects expression of estrogen receptor (ER)	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 - 0.0001 M	0.00001 - 0.0001 M	Affects expression of estrogen receptor-beta (ER-beta)	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 - 0.0001 M	0.00001 - 0.0001 M	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
	IVTH	0.0001 M	0.0001 M	Cancer phenotype	Endocrine-mediated cancer
PMID:34912683	IVR	5 mg/kg/day	5 mg/kg/day	Decreased body weights	Metabolic endocrine-mediated perturbations
PMID:35283775	IVR	0.0000002 - 0.00002 mg/day	0.0000002 - 0.00002 mg/day	Affects fertility	Reproductive endocrine-mediated perturbations
	IVR	0.00002 mg/day	0.00002 mg/day	Epigenomic alterations in epididymis	Reproductive endocrine-mediated perturbations
	IVR	0.0000002 mg/day	0.0000002 mg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
PMID:35457000	IVTH	0.000000001 - 0.000001 M	0.000000001 - 0.000001 M	Reduced insulin levels	Metabolic endocrine-mediated perturbations
	IVTH	0.000000001 - 0.0000001 M	0.000000001 - 0.0000001 M	Affects function of pancreatic cells	Metabolic endocrine-mediated perturbations
PMID:35561261	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Increased calcium levels	Metabolic endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Increased body weights	Metabolic endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Induce behavioral changes	Neurological endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Oxidative stress in liver	Hepatic endocrine-mediated perturbations
PMID:35842007	IVR	0.0004 - 0.004 mg/kg/day	0.0004 - 0.004 mg/kg/day	Epigenomic alterations in sperm	Reproductive endocrine-mediated perturbations
	IVR	0.0004 - 0.004 mg/kg/day	0.0004 - 0.004 mg/kg/day	Induce apoptosis in testis	Reproductive endocrine-mediated perturbations
	IVR	0.0004 - 0.004 mg/kg/day	0.0004 - 0.004 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.0004 - 0.004 mg/kg/day	0.0004 - 0.004 mg/kg/day	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	0.0004 - 0.004 mg/kg/day	0.0004 - 0.004 mg/kg/day	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	0.0004 - 0.004 mg/kg/day	0.0004 - 0.004 mg/kg/day	Causes inflammation	Immunological endocrine-mediated perturbations
	IVR	0.0004 - 0.004 mg/kg/day	0.0004 - 0.004 mg/kg/day	Affects expression of estrogen receptor (ER)	Reproductive endocrine-mediated perturbations
	IVR	0.0004 - 0.004 mg/kg/day	0.0004 - 0.004 mg/kg/day	Affects expression of androgen receptor (AR)	Reproductive endocrine-mediated perturbations
	IVR	0.0004 mg/kg/day	0.0004 mg/kg/day	Increased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.0004 - 0.04 mg/kg/day	0.0004 - 0.04 mg/kg/day	Increased testis weights	Reproductive endocrine-mediated perturbations
	IVR	0.0004 - 0.04 mg/kg/day	0.0004 - 0.04 mg/kg/day	Increased body weights in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	0.04 mg/kg/day	0.04 mg/kg/day	Alters sex ratio	Reproductive endocrine-mediated perturbations
	IVR	0.0004 - 0.004 mg/kg/day	0.0004 - 0.004 mg/kg/day	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.0004 - 0.004 mg/kg/day	0.0004 - 0.004 mg/kg/day	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
	IVR	0.004 mg/kg/day	0.004 mg/kg/day	Reduced sperm quality	Reproductive endocrine-mediated perturbations
PMID:35850097	IVR	0.004 mg/kg/day	0.004 mg/kg/day	Affects survival of live fetus	Reproductive endocrine-mediated perturbations
	IVR	0.004 mg/kg/day	0.004 mg/kg/day	Induce behavioral changes	Neurological endocrine-mediated perturbations
PMID:35940389	IVTH	0.00001 M	0.00001 M	Induce apoptosis of endometrial cells	Reproductive endocrine-mediated perturbations
PMID:36096261	IVR	0.0375 mg/L	0.0375 mg/L	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	0.000375 - 0.0375 mg/L	0.000375 - 0.0375 mg/L	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	0.0375 mg/L	0.0375 mg/L	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.0375 mg/L	0.0375 mg/L	Changes in testicular morphology	Reproductive endocrine-mediated perturbations
PMID:36098747	IVR	0.05 - 5 mg/kg/day	0.05 - 5 mg/kg/day	Affects testicular development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.15 mg/L	0.15 mg/L	Decreased testis weights	Reproductive endocrine-mediated perturbations
PMID:36310694	IVR	0.00000025 M	0.00000025 M	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	0.00000025 M	0.00000025 M	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
	IVR	0.00000025 M	0.00000025 M	Affects expression of estrogen receptor-beta (ER-beta)	Reproductive endocrine-mediated perturbations
	IVR	0.00000025 M	0.00000025 M	Elevated glucose levels	Metabolic endocrine-mediated perturbations
PMID:36541330	IVR	2 mg/kg	2 mg/kg	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:36584861	IVTH	0.00000001 - 0.0000001 M	0.00000001 - 0.0000001 M	Induce cancer metastasis	Endocrine-mediated cancer
	IVTH	0.00000001 - 0.0000001 M	0.00000001 - 0.0000001 M	Elevated glucose levels	Metabolic endocrine-mediated perturbations
	IVTH	0.00000001 M	0.00000001 M	Affects glucose metabolism	Metabolic endocrine-mediated perturbations
	IVTH	0.00000001 M	0.00000001 M	Affects cell metabolism	Metabolic endocrine-mediated perturbations
PMID:36592828	IVR	0.004 - 0.04 mg/kg/day	0.004 - 0.04 mg/kg/day	Decreased cholesterol levels	Metabolic endocrine-mediated perturbations
	IVR	0.004 - 0.04 mg/kg/day	0.004 - 0.04 mg/kg/day	Decreased HDL levels	Metabolic endocrine-mediated perturbations
	IVR	0.004 mg/kg/day	0.004 mg/kg/day	Causes insulin resistance in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	0.004 mg/kg/day	0.004 mg/kg/day	Elevated insulin levels in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	0.004 mg/kg/day	0.004 mg/kg/day	Impaired glucose tolerance in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	0.04 mg/kg/day	0.04 mg/kg/day	Reduced insulin levels in offsrping	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	0.004 - 0.04 mg/kg/day	0.004 - 0.04 mg/kg/day	Elevated glucose levels in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	0.004 mg/kg/day	0.004 mg/kg/day	Elevated insulin levels	Metabolic endocrine-mediated perturbations
	IVR	0.004 - 0.04 mg/kg/day	0.004 - 0.04 mg/kg/day	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVR	0.004 mg/kg/day	0.004 mg/kg/day	Causes insulin resistance	Metabolic endocrine-mediated perturbations
	IVR	0.004 - 0.04 mg/kg/day	0.004 - 0.04 mg/kg/day	Increase in cholesterol/HDL ratio	Metabolic endocrine-mediated perturbations
	IVR	0.004 mg/kg/day	0.004 mg/kg/day	Lead to obesity in offspring	Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:36609592	IVR	5 mg/kg	5 mg/kg	Neuronal degeneration	Neurological endocrine-mediated perturbations
PMID:36690098	IVR	0.3 mg/kg/day	0.3 mg/kg/day	Affects uterine development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.3 mg/kg/day	0.3 mg/kg/day	Alterations in endometrial morphology	Reproductive endocrine-mediated perturbations
	IVR	0.3 mg/kg/day	0.3 mg/kg/day	Affects ovarian follicles population	Reproductive endocrine-mediated perturbations
	IVR	0.3 mg/kg/day	0.3 mg/kg/day	Changes in ovarian morphology	Reproductive endocrine-mediated perturbations
	IVR	0.3 mg/kg/day	0.3 mg/kg/day	Affects uterine morphology	Reproductive endocrine-mediated perturbations
PMID:36750500	IVR	0.004 mg/kg/day	0.004 mg/kg/day	Induce behavioral changes	Neurological endocrine-mediated perturbations
	IVR	0.004 mg/kg/day	0.004 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
PMID:37164221	IVR	1 mg/kg/day	1 mg/kg/day	Affects developmental process	Developmental endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Affects testicular development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:37234927	IVTH	0.0000001 M	0.0000001 M	Affects expression of estrogen receptor-beta (ER-beta)	Reproductive endocrine-mediated perturbations
	IVTH	0.000000001 M	0.000000001 M	Induce cancer metastasis	Endocrine-mediated cancer
	IVR	3 mg/kg/day	3 mg/kg/day	Uterine hypertrophy	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Uterine hyperplasia	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Alterations in endometrial morphology	Reproductive endocrine-mediated perturbations
PMID:37298413	IVTH	0.000000005 M	0.000000005 M	Cancer phenotype	Endocrine-mediated cancer
PMID:37315367	IVTH	0.0000001 - 0.000001 M	0.0000001 - 0.000001 M	Cancer phenotype	Endocrine-mediated cancer
PMID:37419196	IVTH	0.0000001 M	0.0000001 M	Affects embryonic development	Developmental endocrine-mediated perturbations
PMID:37487893	IVR	2 mg/kg/day	2 mg/kg/day	Increase in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	0.02 - 2 mg/kg/day	0.02 - 2 mg/kg/day	Affects thyroid hormone synthesis	Metabolic endocrine-mediated perturbations
	IVR	2 mg/kg/day	2 mg/kg/day	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
PMID:37505069	IVTH	0.000000001 - 0.00001 M	0.000000001 - 0.00001 M	Affects human umbilical arteries	Reproductive endocrine-mediated perturbations
PMID:37660821	IVR	0.0004 mg/kg	0.0004 mg/kg	Increase in corticosterone levels	Neurological endocrine-mediated perturbations
	IVR	0.0004 mg/kg	0.0004 mg/kg	Increased adiposity	Metabolic endocrine-mediated perturbations
	IVR	0.0004 - 0.004 mg/kg	0.0004 - 0.004 mg/kg	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVR	0.0004 - 0.004 mg/kg	0.0004 - 0.004 mg/kg	Altered adipocyte morphology	Metabolic endocrine-mediated perturbations
	IVR	0.0004 - 0.004 mg/kg	0.0004 - 0.004 mg/kg	Affects lipid metabolism	Metabolic endocrine-mediated perturbations
	IVR	0.0004 - 0.004 mg/kg	0.0004 - 0.004 mg/kg	Affects steroid metabolism	Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.0004 - 0.004 mg/kg	0.0004 - 0.004 mg/kg	Causes inflammation	Immunological endocrine-mediated perturbations
	IVR	0.0004 - 0.004 mg/kg	0.0004 - 0.004 mg/kg	Induce apoptosis in adipose tissue	Metabolic endocrine-mediated perturbations
PMID:37834465	IVTH	0.0000001 M	0.0000001 M	Affects embryonic development	Developmental endocrine-mediated perturbations
PMID:37842186	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Induce behavioral changes	Neurological endocrine-mediated perturbations
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Affects social behavior	Neurological endocrine-mediated perturbations
PMID:37944787	IVTH	0.00005 M	0.00005 M	Oxidative stress in placenta	Reproductive endocrine-mediated perturbations
	IVTH	0.000025 - 0.0001 M	0.000025 - 0.0001 M	Decreased estrogen levels	Reproductive endocrine-mediated perturbations
PMID:38042429	IVR	0.004 mg/kg	0.004 mg/kg	Induce behavioral changes	Neurological endocrine-mediated perturbations
	IVR	0.004 mg/kg	0.004 mg/kg	Changes in brain morphology	Neurological endocrine-mediated perturbations
PMID:38275408	IVTH	5 mg/L	5 mg/L	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:38276253	IVTH	0.00000005 - 0.00001 M	0.00000005 - 0.00001 M	Decreased cholesterol levels	Metabolic endocrine-mediated perturbations
	IVTH	0.00005 - 0.0001 M	0.00005 - 0.0001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.00000005 - 0.0001 M	0.00000005 - 0.0001 M	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 - 0.0001 M	0.00001 - 0.0001 M	Decrease in cortisol levels	Neurological endocrine-mediated perturbations
	IVTH	0.00001 M	0.00001 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00000005 - 0.0001 M	0.00000005 - 0.0001 M	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000025 - 0.0001 M	0.000025 - 0.0001 M	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00000005 - 0.00001 M	0.00000005 - 0.00001 M	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000025 - 0.0001 M	0.000025 - 0.0001 M	Increased cholesterol levels	Metabolic endocrine-mediated perturbations
PMID:38334486	IVTH	0.15 mg/L	0.15 mg/L	Oxidative stress in placenta	Reproductive endocrine-mediated perturbations
	IVTH	0.15 mg/L	0.15 mg/L	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.15 mg/L	0.15 mg/L	Induce apoptosis of placental cells	Reproductive endocrine-mediated perturbations
	IVTH	0.15 mg/L	0.15 mg/L	Causes inflammation	Immunological endocrine-mediated perturbations
	IVTH	0.15 mg/L	0.15 mg/L	Affects placental function	Reproductive endocrine-mediated perturbations
PMID:38588857	IVR	0.0015 mg/day	0.0015 mg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	0.0015 mg/day	0.0015 mg/day	Increased cholesterol levels	Metabolic endocrine-mediated perturbations
	IVR	0.0015 mg/day	0.0015 mg/day	Increased triglycerides level	Metabolic endocrine-mediated perturbations
	IVR	0.0015 mg/day	0.0015 mg/day	Elevated glucose levels	Metabolic endocrine-mediated perturbations
	IVR	0.0015 mg/day	0.0015 mg/day	Increased Alanine aminotransferase (ALT) levels	Hepatic endocrine-mediated perturbations
	IVR	0.0015 mg/day	0.0015 mg/day	Increased Aspartate aminotransferase (AST) level	Hepatic endocrine-mediated perturbations
	IVR	0.0015 mg/day	0.0015 mg/day	Increased body weights	Metabolic endocrine-mediated perturbations
PMID:38593938	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Induce apoptosis in ovary	Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Affects ovarian follicles population	Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Decreased Anti-Müllerian hormone (AMH) levels	Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Alterations in vaginal opening	Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Affects developmental process	Developmental endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Induce autophagy in ovary	Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Changes in ovarian morphology	Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Oxidative stress in ovaries	Reproductive endocrine-mediated perturbations
PMID:38614345	IVR	0.05 - 2 mg/kg	0.05 - 2 mg/kg	Changes in hypothalamus morphology	Neurological endocrine-mediated perturbations
	IVR	0.05 - 2 mg/kg	0.05 - 2 mg/kg	Increased progesterone levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.05 - 2 mg/kg	0.05 - 2 mg/kg	Increased estradiol levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.05 - 2 mg/kg	0.05 - 2 mg/kg	Increased LH levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.05 - 2 mg/kg	0.05 - 2 mg/kg	Decreased Anti-Müllerian hormone (AMH) levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.05 - 2 mg/kg	0.05 - 2 mg/kg	Decreased gonadotropin-releasing hormone (GnRH) levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.05 - 2 mg/kg	0.05 - 2 mg/kg	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.05 - 2 mg/kg	0.05 - 2 mg/kg	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	0.05 - 2 mg/kg	0.05 - 2 mg/kg	Increased LH levels	Reproductive endocrine-mediated perturbations
	IVR	0.05 - 2 mg/kg	0.05 - 2 mg/kg	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	0.05 - 2 mg/kg	0.05 - 2 mg/kg	Decreased Anti-Müllerian hormone (AMH) levels	Reproductive endocrine-mediated perturbations
	IVR	0.05 - 2 mg/kg	0.05 - 2 mg/kg	Decreased gonadotropin-releasing hormone (GnRH) levels	Reproductive endocrine-mediated perturbations
	IVR	0.05 - 2 mg/kg	0.05 - 2 mg/kg	Changes in ovarian morphology	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Affects survival of live fetus in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.05 - 2 mg/kg	0.05 - 2 mg/kg	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	0.05 - 2 mg/kg	0.05 - 2 mg/kg	Alters hypothalamic-pituitary-ovarian axis	Neurological endocrine-mediated perturbations;Reprod
	IVR	2 mg/kg	2 mg/kg	Affects steroid metabolism
	IVR	0.05 mg/kg	0.05 mg/kg	Lead to obesity in offspring
	IVR	2 mg/kg	2 mg/kg	Affects ovarian development
	IVR	0.05 mg/kg	0.05 mg/kg	Decreased body weights
PMID:38635025	IVR	0.04 mg/kg/day	0.04 mg/kg/day	Induce behavioral changes	Neurological endocrine-mediated perturbations
PMID:38702036	IVTH	0.0001 M	0.0001 M	Induce apoptosis of granulosa cells	Reproductive endocrine-mediated perturbations
	IVTH	0.0001 M	0.0001 M	Oxidative stress in granulosa cells	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 - 0.0001 M	0.00001 - 0.0001 M	Induce mitochondrial dysfunction in granulosa cells	Reproductive endocrine-mediated perturbations
PMID:38821392	IVR	0.0004 mg/kg	0.0004 mg/kg	Increased body weights	Metabolic endocrine-mediated perturbations
PMID:38966215	IVTH	0.00001 - 0.0001 M	0.00001 - 0.0001 M	Increased 17-OH-progesterone to androstenedione ratio	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 - 0.001 M	0.000001 - 0.001 M	Decreased 11-deoxycortisol level	Neurological endocrine-mediated perturbations
	IVTH	0.0001 - 0.001 M	0.0001 - 0.001 M	Decreased androstenedione levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 - 0.0001 M	0.00001 - 0.0001 M	Decreased 17-OH-progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000025 - 0.0001 M	0.000025 - 0.0001 M	Decreased Dehydroepiandrosterone (DHEA) levels	Metabolic endocrine-mediated perturbations
	IVTH	0.000001 - 0.001 M	0.000001 - 0.001 M	Decrease in cortisol levels	Neurological endocrine-mediated perturbations
	IVTH	0.000025 - 0.001 M	0.000025 - 0.001 M	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0001 - 0.001 M	0.0001 - 0.001 M	Decreased Dihydroxytestosterone (DHT) levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 - 0.00005 M	0.00001 - 0.00005 M	Increased 17-OH-progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 - 0.0001 M	0.00001 - 0.0001 M	Decrease in testosterone/estradiol ratio	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 - 0.0001 M	0.00001 - 0.0001 M	Increased 11-deoxycortisol levels	Neurological endocrine-mediated perturbations
	IVTH	0.00005 - 0.0001 M	0.00005 - 0.0001 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 - 0.00025 M	0.000001 - 0.00025 M	Decreased 11-Deoxy-corsticosterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 - 0.001 M	0.00001 - 0.001 M	Decreased 21-deoxycortisol level	Neurological endocrine-mediated perturbations
	IVTH	0.0001 M	0.0001 M	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 - 0.0001 M	0.00001 - 0.0001 M	Decreased aldosterone levels	Metabolic endocrine-mediated perturbations
	IVTH	0.00001 - 0.00005 M	0.00001 - 0.00005 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:39002480	IVR	0.2 - 1 mg/kg/day	0.2 - 1 mg/kg/day	Causes inflammation	Immunological endocrine-mediated perturbations
	IVR	0.2 - 1 mg/kg/day	0.2 - 1 mg/kg/day	Oxidative stress in neurons	Neurological endocrine-mediated perturbations
	IVR	0.2 - 1 mg/kg/day	0.2 - 1 mg/kg/day	Induce behavioral changes	Neurological endocrine-mediated perturbations
	IVR	0.02 - 1 mg/kg/day	0.02 - 1 mg/kg/day	Affects neuronal signaling	Neurological endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Increase in corticosterone levels	Neurological endocrine-mediated perturbations
	IVR	0.02 - 1 mg/kg/day	0.02 - 1 mg/kg/day	Decreased 5-HIAA levels	Neurological endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decreased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	0.02 - 1 mg/kg/day	0.02 - 1 mg/kg/day	Decreased serotonin (5-HT) levels	Neurological endocrine-mediated perturbations
PMID:39032682	IVTH	0.0000001 - 0.0001 M	0.0000001 - 0.0001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.0000001 M	0.0000001 M	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
	IVTH	0.0000001 - 0.00001 M	0.0000001 - 0.00001 M	Induce cancer metastasis	Endocrine-mediated cancer
PMID:39138139	IVR	1 - 5 mg/kg/day	1 - 5 mg/kg/day	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	1 - 5 mg/kg/day	1 - 5 mg/kg/day	Oxidative stress in thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	1 - 5 mg/kg/day	1 - 5 mg/kg/day	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
PMID:39236844	IVR	2 mg/L	2 mg/L	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
	IVR	2 mg/L	2 mg/L	Alterations in immune responses	Immunological endocrine-mediated perturbations
	IVR	2 mg/L	2 mg/L	Changes in morphology of pituitary gland	Neurological endocrine-mediated perturbations
	IVR	2 mg/L	2 mg/L	Alters hypothalamic-pituitary-liver axis	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	2 mg/L	2 mg/L	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:39520287	IVTH	0.00001 - 0.00005 M	0.00001 - 0.00005 M	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000005 - 0.00002 M	0.000005 - 0.00002 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.000005 - 0.00005 M	0.000005 - 0.00005 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
PMID:39736419	IVTH	5 - 125 mg/L	5 - 125 mg/L	Cancer phenotype	Endocrine-mediated cancer
PMID:39828186	IVR	0.004 mg/kg/day	0.004 mg/kg/day	Changes in brain morphology in offspring	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	0.004 mg/kg/day	0.004 mg/kg/day	Affects sexual behavior in offspring	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.004 mg/kg/day	0.004 mg/kg/day	Cognitive impairment in offspring	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	0.004 mg/kg/day	0.004 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	0.004 mg/kg/day	0.004 mg/kg/day	Accelerated onset of puberty in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations

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DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.