2,2',4,4'-Tetrabromodiphenyl ether


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:27060917
GO:0002281 Macrophage activation involved in immune response Increases phenotype PMID:38407484
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:37357614
GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity Increases phenotype PMID:38040069
GO:0004035 Alkaline phosphatase activity Decreases phenotype PMID:34547414
GO:0006094 Gluconeogenesis Increases phenotype PMID:29523931
GO:0006304 Dna modification Increases phenotype PMID:39922519
GO:0006306 Dna methylation Decreases phenotype PMID:20064773
GO:0006542 Glutamine biosynthetic process Increases phenotype PMID:29523931
GO:0006545 Glycine biosynthetic process Increases phenotype PMID:29523931
GO:0006592 Ornithine biosynthetic process Increases phenotype PMID:29523931
GO:0006650 Glycerophospholipid metabolic process Affects phenotype PMID:38040069
GO:0006699 Bile acid biosynthetic process Increases phenotype PMID:29523931
GO:0006750 Glutathione biosynthetic process Affects phenotype PMID:25305463; PMID:25462306; PMID:25639565
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:24599297; PMID:26640238
GO:0006909 Phagocytosis Decreases phenotype PMID:25462306
GO:0006915 Apoptotic process Increases phenotype PMID:25462306; PMID:25639565; PMID:25697951; PMID:25797475; PMID:27060917; PMID:34547414
GO:0006919 Activation of cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:36269211
GO:0006935 Chemotaxis Decreases phenotype PMID:32142752
GO:0006974 Cellular response to dna damage stimulus Affects phenotype PMID:26808241; PMID:27060917; PMID:27589474
GO:0006997 Nucleus organization Decreases phenotype PMID:38101597
GO:0007040 Lysosome organization Decreases phenotype PMID:35135005
GO:0007283 Spermatogenesis Decreases phenotype PMID:28300557
GO:0007610 Behavior Affects phenotype PMID:31326823
GO:0007612 Learning Decreases phenotype PMID:32521479
GO:0008206 Bile acid metabolic process Affects phenotype PMID:32679240
GO:0008219 Cell death Increases phenotype PMID:26640238; PMID:26808241; PMID:28851516
GO:0008283 Cell population proliferation Increases phenotype PMID:24451063; PMID:25063376; PMID:26808241; PMID:25697951; PMID:25797475; PMID:26988655; PMID:27060917; PMID:27589474; PMID:31173147; PMID:33581290
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:30796839
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:37116683
GO:0008361 Regulation of cell size Affects phenotype PMID:32679240
GO:0008584 Male gonad development Decreases phenotype PMID:28712647
GO:0009062 Fatty acid catabolic process Decreases phenotype PMID:38040069
GO:0009086 Methionine biosynthetic process Decreases phenotype PMID:29523931
GO:0009097 Isoleucine biosynthetic process Increases phenotype PMID:29523931
GO:0009410 Response to xenobiotic stimulus Increases phenotype PMID:28300557
GO:0010001 Glial cell differentiation Decreases phenotype PMID:28851516
GO:0010424 Dna methylation on cytosine within a cg sequence Increases phenotype PMID:30202865; PMID:31173147
GO:0010508 Positive regulation of autophagy Increases phenotype PMID:38995820
GO:0010742 Macrophage derived foam cell differentiation Increases phenotype PMID:35575305
GO:0010823 Negative regulation of mitochondrion organization Increases phenotype PMID:30714368
GO:0010867 Positive regulation of triglyceride biosynthetic process Increases phenotype PMID:38040069
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:24296301
GO:0010918 Positive regulation of mitochondrial membrane potential Decreases phenotype PMID:25659769
GO:0010942 Positive regulation of cell death Increases phenotype PMID:25449125; PMID:25659769; PMID:30202865
GO:0014047 Glutamate secretion Increases phenotype PMID:26640238
GO:0016042 Lipid catabolic process Increases phenotype PMID:25639565; PMID:25639565; PMID:25797475; PMID:25797475; PMID:26640238
GO:0016477 Cell migration Decreases phenotype PMID:33969458
GO:0016567 Protein ubiquitination Increases phenotype PMID:25639565
GO:0018158 Protein oxidation Increases phenotype PMID:25797475
GO:0019216 Regulation of lipid metabolic process Affects phenotype PMID:30294300
GO:0019249 Lactate biosynthetic process Increases phenotype PMID:29523931
GO:0019567 Arabinose biosynthetic process Increases phenotype PMID:29523931
GO:0019646 Aerobic electron transport chain Decreases phenotype PMID:25659769
GO:0022008 Neurogenesis Decreases phenotype PMID:31173147
GO:0030103 Vasopressin secretion Affects phenotype PMID:17434953
GO:0030182 Neuron differentiation Affects phenotype PMID:28851516
GO:0030431 Sleep Affects phenotype PMID:31326823
GO:0030497 Fatty acid elongation Affects phenotype PMID:38040069
GO:0030517 Negative regulation of axon extension Increases phenotype PMID:28003438
GO:0031999 Negative regulation of fatty acid beta-oxidation Increases phenotype PMID:38040069
GO:0032060 Bleb assembly Increases phenotype PMID:37357614
GO:0032148 Activation of protein kinase b activity Increases phenotype PMID:29264491
GO:0032469 Endoplasmic reticulum calcium ion homeostasis Affects phenotype PMID:24599297
GO:0032930 Positive regulation of superoxide anion generation Increases phenotype PMID:24296301
GO:0033148 Positive regulation of intracellular estrogen receptor signaling pathway Increases phenotype PMID:30796839
GO:0033993 Response to lipid Increases phenotype PMID:28300557
GO:0034440 Lipid oxidation Increases phenotype PMID:39922519
GO:0035115 Embryonic forelimb morphogenesis Decreases phenotype PMID:30561715
GO:0035358 Regulation of peroxisome proliferator activated receptor signaling pathway Affects phenotype PMID:38040069
GO:0035935 Androgen secretion Increases phenotype PMID:33581290
GO:0035936 Testosterone secretion Affects phenotype PMID:33581290
GO:0036164 Cell-abiotic substrate adhesion Decreases phenotype PMID:26808241
GO:0042403 Thyroid hormone metabolic process Decreases phenotype PMID:26372669; PMID:31826744; PMID:32679240; PMID:37116683
GO:0042412 Taurine biosynthetic process Increases phenotype PMID:29523931
GO:0042425 Choline biosynthetic process Increases phenotype PMID:29523931
GO:0042445 Hormone metabolic process Affects phenotype PMID:23333513; PMID:27094376
GO:0042593 Glucose homeostasis Decreases phenotype PMID:24559133; PMID:27291303; PMID:28300557; PMID:29523931
GO:0042632 Cholesterol homeostasis Affects phenotype PMID:34425642
GO:0042733 Embryonic digit morphogenesis Decreases phenotype PMID:30561715
GO:0042775 Mitochondrial atp synthesis coupled electron transport Decreases phenotype PMID:36269211
GO:0042866 Pyruvate biosynthetic process Increases phenotype PMID:29523931
GO:0042908 Xenobiotic transport Increases phenotype PMID:28300557
GO:0043030 Regulation of macrophage activation Affects phenotype PMID:38407484
GO:0043045 Dna methylation involved in embryo development Affects phenotype PMID:32653021
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:38407484
GO:0043525 Positive regulation of neuron apoptotic process Increases phenotype PMID:36269211
GO:0044029 Hypomethylation of cpg island Increases phenotype PMID:26406892
GO:0044030 Regulation of dna methylation Affects phenotype PMID:29107676; PMID:31272017
GO:0044237 Cellular metabolic process Decreases phenotype PMID:33078273; PMID:33969458; PMID:34547414; PMID:37357614; PMID:38101597
GO:0044319 Wound healing, spreading of cells Increases phenotype PMID:25784559; PMID:32142752; PMID:39922519
GO:0045542 Positive regulation of cholesterol biosynthetic process Increases phenotype PMID:38040069
GO:0045600 Positive regulation of fat cell differentiation Increases phenotype PMID:24559133
GO:0045795 Positive regulation of cell volume Increases phenotype PMID:37357614
GO:0045851 Ph reduction Increases phenotype PMID:31622892
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:26808241
GO:0046369 Galactose biosynthetic process Increases phenotype PMID:29523931
GO:0046449 Creatinine metabolic process Affects phenotype PMID:37357614
GO:0048709 Oligodendrocyte differentiation Affects phenotype PMID:33969458
GO:0048874 Host-mediated regulation of intestinal microbiota composition Affects phenotype PMID:29523931; PMID:33078840
GO:0051216 Cartilage development Decreases phenotype PMID:30561715
GO:0051348 Negative regulation of transferase activity Affects phenotype PMID:29331935
GO:0051402 Neuron apoptotic process Increases phenotype PMID:38995820
GO:0051480 Regulation of cytosolic calcium ion concentration Affects phenotype PMID:24599297
GO:0051881 Regulation of mitochondrial membrane potential Increases phenotype PMID:26808241; PMID:27060917; PMID:38101597
GO:0051901 Positive regulation of mitochondrial depolarization Increases phenotype PMID:30714368
GO:0051923 Sulfation Decreases phenotype PMID:29331935
GO:0055074 Calcium ion homeostasis Affects phenotype PMID:30056177
GO:0055088 Lipid homeostasis Decreases phenotype PMID:38040069
GO:0060322 Head development Decreases phenotype PMID:32653021
GO:0060326 Cell chemotaxis Increases phenotype PMID:25784559; PMID:39922519
GO:0061370 Testosterone biosynthetic process Increases phenotype PMID:19079713; PMID:28300557; PMID:33581290
GO:0061739 Protein lipidation involved in autophagosome assembly Decreases phenotype PMID:30029115
GO:0070266 Necroptotic process Increases phenotype PMID:37357614
GO:0070328 Triglyceride homeostasis Decreases phenotype PMID:28300557; PMID:29264491
GO:0070633 Transepithelial transport Increases phenotype PMID:31622892
GO:0070994 Detection of oxidative stress Increases phenotype PMID:37357614
GO:0071897 Dna biosynthetic process Increases phenotype PMID:39668266
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:25639565; PMID:26026498
GO:0098703 Calcium ion import across plasma membrane Increases phenotype PMID:24599297
GO:0140042 Lipid droplet formation Increases phenotype PMID:30294300; PMID:35575305
GO:0140354 Lipid import into cell Increases phenotype PMID:35575305
GO:1901164 Negative regulation of trophoblast cell migration Increases phenotype PMID:30202865
GO:1901537 Positive regulation of dna demethylation Increases phenotype PMID:30714368
GO:1902512 Positive regulation of apoptotic dna fragmentation Increases phenotype PMID:30029115
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:25462306; PMID:25697951; PMID:25797475; PMID:26640238; PMID:26808241; PMID:27060917
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:25659769; PMID:35135005
GO:1904214 Positive regulation of iodide transmembrane transport Decreases phenotype PMID:26827900
GO:1904251 Regulation of bile acid metabolic process Affects phenotype PMID:33078840
GO:1904263 Positive regulation of torc1 signaling Increases phenotype PMID:29264491
GO:1904358 Positive regulation of telomere maintenance via telomere lengthening Increases phenotype PMID:34193151
GO:1904515 Positive regulation of torc2 signaling Increases phenotype PMID:29264491
GO:1904596 Regulation of connective tissue replacement involved in inflammatory response wound healing Increases phenotype PMID:38407484
GO:2000111 Positive regulation of macrophage apoptotic process Increases phenotype PMID:38407484
GO:2000183 Negative regulation of progesterone biosynthetic process Increases phenotype PMID:30714368
GO:2000193 Positive regulation of fatty acid transport Increases phenotype PMID:38040069
GO:2000609 Regulation of thyroid hormone generation Affects phenotype PMID:25965908; PMID:39626304
GO:2000610 Negative regulation of thyroid hormone generation Increases phenotype PMID:37116683
GO:2000611 Positive regulation of thyroid hormone generation Increases phenotype PMID:30029115
GO:2000786 Positive regulation of autophagosome assembly Increases phenotype PMID:38995820
GO:2001170 Negative regulation of atp biosynthetic process Increases phenotype PMID:30714368
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.