2,2',4,4'-Tetrabromodiphenyl ether

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Descriptors
• Chemical-gene interaction
• Chemical-phenotype interaction
• Chemical-disease association
• ToxCast endpoints
• Associated AOPs
• Presence in consumer products
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:17361017	IVR	50 mg/kg/day	50 mg/kg/day	Affects neuronal signaling	Neurological endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Affects neuronal signaling	Neurological endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects neuronal signaling	Neurological endocrine-mediated perturbations
PMID:17964624	IVR	3 mg/kg/day	3 mg/kg/day	Cancer phenotype	Endocrine-mediated cancer
	IVR	10 mg/kg/day	10 mg/kg/day	Affects thyroid function	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects thyroid function	Metabolic endocrine-mediated perturbations
PMID:18335096	IVR	0.7 mg/kg	0.7 mg/kg	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	0.7 mg/kg	0.7 mg/kg	Increased weights of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	0.7 mg/kg	0.7 mg/kg	Decreased ovarian weights in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.7 mg/kg	0.7 mg/kg	Decreased liver weights	Hepatic endocrine-mediated perturbations
	IVR	0.7 mg/kg	0.7 mg/kg	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.14 mg/kg	0.14 mg/kg	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.14 mg/kg	0.14 mg/kg	Decreased ovarian weights in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.14 mg/kg	0.14 mg/kg	Decreased liver weights	Hepatic endocrine-mediated perturbations
	IVR	0.14 mg/kg	0.14 mg/kg	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
PMID:22233939	IVTH	0.00000000000001 - 0.0001 M	0.0000000001 - 0.00000001 M	Oxidative stress in liver	Hepatic endocrine-mediated perturbations
	IVTH	0.00000000000001 - 0.0001 M	0.0000000001 - 0.00000001 M	Cancer phenotype	Endocrine-mediated cancer
PMID:26217518	IVR	1 mg/kg/day	1 mg/kg/day	Affects glucose metabolism	Metabolic endocrine-mediated perturbations
PMID:27449334	IVR	10 mg/kg	10 mg/kg	Induce apoptosis of ovarian follicles	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Induce apoptosis of ovarian follicles	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Induce apoptosis of ovarian follicles	Reproductive endocrine-mediated perturbations
PMID:28712647	IVR	0.2 mg/kg	0.2 mg/kg	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg	0.2 mg/kg	Alterations in immune responses	Immunological endocrine-mediated perturbations
	IVR	0.2 mg/kg	0.2 mg/kg	Abnormal sperm morphology	Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg	0.2 mg/kg	Affects testicular function	Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg	0.2 mg/kg	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
PMID:29112739	IVR	1 mg/kg	1 mg/kg	Elevated glucose levels	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg	-	No significant effects observed	-
PMID:30849655	IVTH	0.0000001 M	0.0000001 M	Affects liver function	Hepatic endocrine-mediated perturbations
	IVTH	0.00000001 M	0.00000001 M	Affects liver function	Hepatic endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Affects liver function	Hepatic endocrine-mediated perturbations
PMID:33065364	IVR	0.1 - 1 mg/kg/day	0.1 - 1 mg/kg/day	Increased body weights	Metabolic endocrine-mediated perturbations
	IVR	0.1 - 1 mg/kg/day	0.1 - 1 mg/kg/day	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Increase in T3 levels	Metabolic endocrine-mediated perturbations
PMID:34370853	IVTH	0.00000001 - 0.00001 M	0.00000001 - 0.00001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.01 - 0.1 mg/kg	0.01 - 0.1 mg/kg	Increased weights of adrenal gland	Metabolic endocrine-mediated perturbations
	IVR	0.01 - 0.1 mg/kg	0.01 - 0.1 mg/kg	Increase in corticosterone levels	Neurological endocrine-mediated perturbations
PMID:35135005	IVTH	0.00001 - 0.00005 M	0.00001 - 0.00005 M	Cancer phenotype	Endocrine-mediated cancer
PMID:35238255	IVR	1 mg/kg/day	1 mg/kg/day	Increased testis weights	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Changes in testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
PMID:35875604	IVR	1 mg/kg/day	1 mg/kg/day	Changes in testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Induce testicular damage	Reproductive endocrine-mediated perturbations
PMID:39136868	IVTH	0.00001 M	0.00001 M	Increased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:39236844	IVR	2 mg/L	2 mg/L	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	2 mg/L	2 mg/L	Alters hypothalamic-pituitary-gonadal axis (HPG axis)	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	2 mg/L	2 mg/L	Alterations in immune responses	Immunological endocrine-mediated perturbations
	IVR	2 mg/L	2 mg/L	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
	IVR	2 mg/L	2 mg/L	Changes in morphology of pituitary gland	Neurological endocrine-mediated perturbations
	IVR	2 mg/L	2 mg/L	Alters hypothalamic-pituitary-liver axis	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations

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