Diisononyl phthalate


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0001541 Ovarian follicle development Decreases phenotype PMID:34597818; PMID:35762964
GO:0001547 Antral ovarian follicle growth Decreases phenotype PMID:28013214
GO:0001553 Luteinization Affects phenotype PMID:26161573
GO:0001568 Blood vessel development Increases phenotype PMID:37021957
GO:0001780 Neutrophil homeostasis Affects phenotype PMID:28240277
GO:0001890 Placenta development Affects phenotype PMID:37482143
GO:0002248 Connective tissue replacement involved in inflammatory response wound healing Increases phenotype PMID:29758289
GO:0002381 Immunoglobulin production involved in immunoglobulin-mediated immune response Increases phenotype PMID:29758289
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:27863430; PMID:28240277; PMID:29758289
GO:0003006 Developmental process involved in reproduction Affects phenotype PMID:37788136
GO:0003093 Regulation of glomerular filtration Affects phenotype PMID:32645486
GO:0004691 Camp-dependent protein kinase activity Increases phenotype PMID:33711355
GO:0006085 Acetyl-coa biosynthetic process Affects phenotype PMID:33391822
GO:0006171 Camp biosynthetic process Increases phenotype PMID:37552060
GO:0006473 Protein acetylation Increases phenotype PMID:31423773
GO:0006672 Ceramide metabolic process Affects phenotype PMID:33223173
GO:0006694 Steroid biosynthetic process Decreases phenotype PMID:35762964
GO:0007281 Germ cell development Decreases phenotype PMID:30802670; PMID:37788136
GO:0007283 Spermatogenesis Decreases phenotype PMID:30802670; PMID:37364641
GO:0007286 Spermatid development Decreases phenotype PMID:30802670
GO:0007565 Female pregnancy Decreases phenotype PMID:36929940
GO:0007618 Mating Decreases phenotype PMID:30649530
GO:0008210 Estrogen metabolic process Affects phenotype PMID:34597818
GO:0008219 Cell death Increases phenotype PMID:33711355
GO:0008283 Cell population proliferation Increases phenotype PMID:34428494
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:35739755
GO:0008584 Male gonad development Affects phenotype PMID:25445723; PMID:36921846; PMID:30802670
GO:0009566 Fertilization Decreases phenotype PMID:26545148; PMID:33711355
GO:0009790 Embryo development Decreases phenotype PMID:33711355
GO:0010460 Positive regulation of heart rate Increases phenotype PMID:30940551
GO:0010508 Positive regulation of autophagy Increases phenotype PMID:37976928
GO:0010511 Regulation of phosphatidylinositol biosynthetic process Affects phenotype PMID:31577137
GO:0010884 Positive regulation of lipid storage Increases phenotype PMID:29410257
GO:0010906 Regulation of glucose metabolic process Affects phenotype PMID:35739755; PMID:37364641
GO:0016525 Negative regulation of angiogenesis Increases phenotype PMID:37482143
GO:0018108 Peptidyl-tyrosine phosphorylation Increases phenotype PMID:33711355
GO:0019695 Choline metabolic process Affects phenotype PMID:32949613
GO:0030199 Collagen fibril organization Decreases phenotype PMID:29758289
GO:0030728 Ovulation Increases phenotype PMID:33316053
GO:0030850 Prostate gland development Decreases phenotype PMID:30802670; PMID:36921846
GO:0032308 Positive regulation of prostaglandin secretion Increases phenotype PMID:33316053
GO:0033685 Negative regulation of luteinizing hormone secretion Increases phenotype PMID:37812459
GO:0034199 Activation of protein kinase a activity Increases phenotype PMID:37552060
GO:0034255 Regulation of urea metabolic process Affects phenotype PMID:32949613
GO:0034614 Cellular response to reactive oxygen species Increases phenotype PMID:29758289
GO:0035936 Testosterone secretion Decreases phenotype PMID:28013214; PMID:30802670; PMID:31199487
GO:0035938 Estradiol secretion Decreases phenotype PMID:28013214
GO:0035941 Androstenedione secretion Decreases phenotype PMID:28013214
GO:0035943 Estrone secretion Decreases phenotype PMID:28013214
GO:0036211 Protein modification process Increases phenotype PMID:31423773
GO:0042221 Response to chemical Increases phenotype PMID:34428494
GO:0042448 Progesterone metabolic process Affects phenotype PMID:34597818
GO:0042629 Mast cell granule Increases phenotype PMID:27863430
GO:0042632 Cholesterol homeostasis Decreases phenotype PMID:35739755
GO:0042701 Progesterone secretion Affects phenotype PMID:33316053
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:33511402; PMID:35739755; PMID:37364641
GO:0043303 Mast cell degranulation Increases phenotype PMID:28240277; PMID:29758289
GO:0044237 Cellular metabolic process Affects phenotype PMID:31154059; PMID:34697989
GO:0044849 Estrous cycle Decreases phenotype PMID:30649530; PMID:36929940
GO:0045444 Fat cell differentiation Increases phenotype PMID:29991372
GO:0045600 Positive regulation of fat cell differentiation Increases phenotype PMID:31546122
GO:0045777 Positive regulation of blood pressure Increases phenotype PMID:30940551
GO:0046034 Atp metabolic process Affects phenotype PMID:33711355
GO:0046322 Negative regulation of fatty acid oxidation Increases phenotype PMID:33391822
GO:0046339 Diacylglycerol metabolic process Affects phenotype PMID:33223173
GO:0046546 Development of primary male sexual characteristics Affects phenotype PMID:36921846
GO:0046697 Decidualization Decreases phenotype PMID:37482143
GO:0046880 Regulation of follicle-stimulating hormone secretion Affects phenotype PMID:37812459
GO:0046881 Positive regulation of follicle-stimulating hormone secretion Increases phenotype PMID:37364641
GO:0048240 Sperm capacitation Increases phenotype PMID:33711355
GO:0048246 Macrophage chemotaxis Increases phenotype PMID:40323316
GO:0048599 Oocyte development Decreases phenotype PMID:28013214
GO:0048856 Anatomical structure development Decreases phenotype PMID:25353625
GO:0050679 Positive regulation of epithelial cell proliferation Increases phenotype PMID:40323316
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:31199487
GO:0060135 Maternal process involved in female pregnancy Decreases phenotype PMID:30649530
GO:0060305 Regulation of cell diameter Affects phenotype PMID:37021957
GO:0060376 Positive regulation of mast cell differentiation Increases phenotype PMID:37021957
GO:0060467 Negative regulation of fertilization Increases phenotype PMID:30649530
GO:0060512 Prostate gland morphogenesis Decreases phenotype PMID:31199487
GO:0060618 Nipple development Affects phenotype PMID:37788136
GO:0060658 Nipple morphogenesis Increases phenotype PMID:36921846
GO:0061107 Seminal vesicle development Decreases phenotype PMID:30802670; PMID:36921846
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:33983380; PMID:34597818; PMID:36921846
GO:0061458 Reproductive system development Decreases phenotype PMID:37788136
GO:0070328 Triglyceride homeostasis Decreases phenotype PMID:35739755
GO:0070662 Mast cell proliferation Increases phenotype PMID:27863430
GO:0070994 Detection of oxidative stress Increases phenotype PMID:27863430
GO:0071736 Igg immunoglobulin complex, circulating Increases phenotype PMID:28240277
GO:0071743 Ige immunoglobulin complex, circulating Increases phenotype PMID:27863430
GO:0072520 Seminiferous tubule development Decreases phenotype PMID:30802670; PMID:37364641
GO:0090181 Regulation of cholesterol metabolic process Affects phenotype PMID:31577137; PMID:33223173
GO:0097722 Sperm motility Decreases phenotype PMID:30802670; PMID:33711355
GO:0140042 Lipid droplet formation Increases phenotype PMID:31546122
GO:0140354 Lipid import into cell Increases phenotype PMID:35739755; PMID:37927243
GO:0140747 Regulation of ncrna transcription Affects phenotype PMID:37003585
GO:0150175 Regulation of phosphatidylethanolamine metabolic process Affects phenotype PMID:31577137; PMID:33223173
GO:0150178 Regulation of phosphatidylserine metabolic process Affects phenotype PMID:31577137
GO:1900015 Regulation of cytokine production involved in inflammatory response Affects phenotype PMID:38954831
GO:1900017 Positive regulation of cytokine production involved in inflammatory response Increases phenotype PMID:40323316
GO:1901318 Negative regulation of flagellated sperm motility Increases phenotype PMID:24140385
GO:1902884 Positive regulation of response to oxidative stress Increases phenotype PMID:35739755
GO:1902894 Negative regulation of mirna transcription Increases phenotype PMID:37003585
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:29758289; PMID:31423773
GO:1903725 Regulation of phospholipid metabolic process Affects phenotype PMID:33223173
GO:1903786 Regulation of glutathione biosynthetic process Affects phenotype PMID:32949613
GO:1904177 Regulation of adipose tissue development Affects phenotype PMID:37021957
GO:1904598 Positive regulation of connective tissue replacement involved in inflammatory response wound healing Increases phenotype PMID:35739755
GO:1905867 Epididymis development Affects phenotype PMID:30802670; PMID:36921846
GO:2000184 Positive regulation of progesterone biosynthetic process Increases phenotype PMID:37552060
GO:2000225 Negative regulation of testosterone biosynthetic process Increases phenotype PMID:37788136
GO:2000318 Positive regulation of t-helper 17 type immune response Increases phenotype PMID:29758289
GO:2000553 Positive regulation of t-helper 2 cell cytokine production Increases phenotype PMID:29758289
GO:2000786 Positive regulation of autophagosome assembly Increases phenotype PMID:37976928
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:37839492; PMID:39947446
GO:2000845 Positive regulation of testosterone secretion Increases phenotype PMID:37364641
GO:2000865 Negative regulation of estradiol secretion Increases phenotype PMID:37839492
GO:2000866 Positive regulation of estradiol secretion Increases phenotype PMID:34453847; PMID:37364641
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.