| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:11099647 | IVR | 750 mg/kg/day | 750 mg/kg/day | Testicular atrophy | Reproductive endocrine-mediated perturbations |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Nipple retention | Reproductive endocrine-mediated perturbations | |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| PMID:14580783 | IVR | 4000 mg/L | - | No significant effects observed | - |
| IVR | 400 mg/L | - | No significant effects observed | - | |
| IVR | 20000 mg/L | 20000 mg/L | Decreased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 20000 mg/L | 20000 mg/L | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 20000 mg/L | 20000 mg/L | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 20000 mg/L | 20000 mg/L | Alterations in number of sertoli cells | Reproductive endocrine-mediated perturbations | |
| IVR | 20000 mg/L | 20000 mg/L | Changes in ovarian morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 20000 mg/L | 20000 mg/L | Decreased brain weights | Neurological endocrine-mediated perturbations | |
| IVR | 20000 mg/L | 20000 mg/L | Affects ovulation | Reproductive endocrine-mediated perturbations | |
| IVR | 20000 mg/L | 20000 mg/L | Increased weights of adrenal gland | Metabolic endocrine-mediated perturbations | |
| PMID:15013064 | IVR | 750 mg/kg/day | 750 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations |
| PMID:16493179 | IVR | 400 mg/L | 400 mg/L | Decreased testosterone levels | Reproductive endocrine-mediated perturbations |
| IVR | 400 mg/L | 400 mg/L | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 400 mg/L | 400 mg/L | Altered lordosis | Developmental endocrine-mediated perturbations | |
| IVR | 20000 mg/L | 20000 mg/L | Affects anogenital distance in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 20000 mg/L | 20000 mg/L | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 20000 mg/L | 20000 mg/L | Altered lordosis | Developmental endocrine-mediated perturbations | |
| IVR | 20000 mg/L | 20000 mg/L | Affects embryonic development | Developmental endocrine-mediated perturbations | |
| IVR | 40 mg/L | 40 mg/L | Altered lordosis | Developmental endocrine-mediated perturbations | |
| IVR | 4000 mg/L | 4000 mg/L | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 4000 mg/L | 4000 mg/L | Altered lordosis | Developmental endocrine-mediated perturbations | |
| IVR | 400 mg/L | 400 mg/L | Affects embryonic development | Developmental endocrine-mediated perturbations | |
| IVR | 40 mg/L | 40 mg/L | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 40 mg/L | 40 mg/L | Affects embryonic development | Developmental endocrine-mediated perturbations | |
| IVR | 40 mg/L | 40 mg/L | Affects social behavior | Neurological endocrine-mediated perturbations | |
| PMID:17654256 | IVR | 500 mg/kg | 500 mg/kg | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations |
| IVR | 100 mg/kg | 100 mg/kg | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg | 500 mg/kg | Decreased weights of bulbocavernosus muscles/LABC | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg | 20 mg/kg | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| PMID:20077217 | IVR | 500 mg/kg/day | 500 mg/kg/day | Increased liver weights | Hepatic endocrine-mediated perturbations |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| PMID:21075200 | IVR | 900 mg/kg/day | 900 mg/kg/day | Affects sperm motility | Reproductive endocrine-mediated perturbations |
| IVR | 600 mg/kg/day | 600 mg/kg/day | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg/day | - | No significant effects observed | - | |
| IVR | 900 mg/kg/day | 900 mg/kg/day | Causes masculinized behavior | Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 900 mg/kg/day | 900 mg/kg/day | Affects spatial learning | Neurological endocrine-mediated perturbations | |
| IVR | 900 mg/kg/day | 900 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 900 mg/kg/day | 900 mg/kg/day | Nipple retention | Reproductive endocrine-mediated perturbations | |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Nipple retention | Reproductive endocrine-mediated perturbations | |
| IVR | 900 mg/kg/day | 900 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| PMID:21633115 | IVR | 750 mg/kg/day | - | No significant effects observed | - |
| IVR | 500 mg/kg/day | - | No significant effects observed | - | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1500 mg/kg/day | 1500 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:22813627 | IVR | 50 mg/kg/day | - | No significant effects observed | - |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Abnormal proliferation of germ cells | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Abnormal proliferation of germ cells | Reproductive endocrine-mediated perturbations | |
| PMID:28300662 | IVR | 50 mg/kg | 50 mg/kg | Alterations in immune responses | Immunological endocrine-mediated perturbations |
| PMID:28893586 | IVR | 200 mg/kg | 200 mg/kg | Decreased uterine weights | Reproductive endocrine-mediated perturbations |
| IVR | 2 mg/kg | 2 mg/kg | Decreased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg | 20 mg/kg | Decreased uterine weights | Reproductive endocrine-mediated perturbations | |
| PMID:30649530 | IVR | 200 mg/kg/day | - | No significant effects observed | - |
| IVR | 20 mg/kg/day | - | No significant effects observed | - | |
| IVR | 0.02 mg/kg/day | 0.02 mg/kg/day | Affects fertility | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Alters sex ratio | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| PMID:31904422 | IVR | 0.02 mg/kg/day | - | No significant effects observed | - |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Affects ovarian follicles population | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Pregnancy complications | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Affects ovarian follicles population | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Increased inhibin-B levels | Reproductive endocrine-mediated perturbations | |
| PMID:32165126 | IVR | 2 mg/kg | 2 mg/kg | Increased progesterone levels | Reproductive endocrine-mediated perturbations |
| IVR | 0.1 - 2 mg/kg | 0.1 - 2 mg/kg | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 - 2 mg/kg | 0.1 - 2 mg/kg | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.02 - 0.1 mg/kg | 0.02 - 0.1 mg/kg | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.02 - 2 mg/kg | 0.02 - 2 mg/kg | Affects ovarian follicles population | Reproductive endocrine-mediated perturbations | |
| IVR | 0.02 - 2 mg/kg | 0.02 - 2 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.02 - 2 mg/kg | 0.02 - 2 mg/kg | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| PMID:33223173 | IVR | 4.8 mg/kg | 4.8 mg/kg | Altered lipid profile | Metabolic endocrine-mediated perturbations |
| IVR | 4.8 mg/kg | 4.8 mg/kg | Increased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 4.8 mg/kg | 4.8 mg/kg | Oxidative stress in liver | Hepatic endocrine-mediated perturbations | |
| PMID:33391822 | IVR | 75 mg/kg | 75 mg/kg | Affects fatty acid metabolism | Metabolic endocrine-mediated perturbations |
| PMID:33983380 | IVR | 15 mg/kg/day | 15 mg/kg/day | Affects cholesterol metabolism | Metabolic endocrine-mediated perturbations |
| IVR | 1 - 75 mg/kg/day | 1 - 75 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 75 mg/kg/day | 1 - 75 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:36929940 | IVR | 15 ppm | 15 ppm | Pregnancy complications | Reproductive endocrine-mediated perturbations |
| IVR | 15 ppm | 15 ppm | Affects fertility | Reproductive endocrine-mediated perturbations | |
| PMID:37482143 | IVR | 0.02 mg/kg/day | 0.02 mg/kg/day | Decreased placental weights | Reproductive endocrine-mediated perturbations |
| IVR | 0.02 mg/kg/day | 0.02 mg/kg/day | Affects fertility | Reproductive endocrine-mediated perturbations | |
| IVR | 0.02 mg/kg/day | 0.02 mg/kg/day | Decreased body weights in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
| IVR | 0.02 mg/kg/day | 0.02 mg/kg/day | Changes in placental morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 0.02 mg/kg/day | 0.02 mg/kg/day | Affects endometrial angiogenesis | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.02 mg/kg/day | 0.02 mg/kg/day | Affects placental function | Reproductive endocrine-mediated perturbations | |
| IVR | 0.02 mg/kg/day | 0.02 mg/kg/day | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 0.02 mg/kg/day | 0.02 mg/kg/day | Affects uterine morphology | Reproductive endocrine-mediated perturbations | |
| PMID:38926453 | IVR | 5 mg/kg | 5 mg/kg | Neuronal degeneration | Neurological endocrine-mediated perturbations |
| IVR | 5 mg/kg | 5 mg/kg | Oxidative stress in neurons | Neurological endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Causes inflammation | Immunological endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Abnormal neuronal distribution | Neurological endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Affects neuronal function | Neurological endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Affects neuronal density | Neurological endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Induce neuronal apoptosis | Neurological endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.