Butyl p-hydroxybenzoate


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0001541 Ovarian follicle development Decreases phenotype PMID:22777679; PMID:28208728; PMID:34383603
GO:0001547 Antral ovarian follicle growth Affects phenotype PMID:34383603
GO:0001552 Ovarian follicle atresia Affects phenotype PMID:34383603
GO:0004879 Nuclear receptor activity Increases phenotype PMID:29945225
GO:0006703 Estrogen biosynthetic process Increases phenotype PMID:26888303
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:28893613
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:29319206
GO:0007281 Germ cell development Affects phenotype PMID:34383603
GO:0007283 Spermatogenesis Decreases phenotype PMID:27122241; PMID:27444704; PMID:29350491
GO:0008283 Cell population proliferation Increases phenotype PMID:23744433; PMID:23744433; PMID:24481588; PMID:24481588; PMID:26502914; PMID:27444704
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:29074358; PMID:29945225
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:29319206
GO:0008584 Male gonad development Affects phenotype PMID:26888303
GO:0008585 Female gonad development Affects phenotype PMID:27122241
GO:0010470 Regulation of gastrulation Affects phenotype PMID:28184906
GO:0016049 Cell growth Affects phenotype PMID:17121429; PMID:36277366
GO:0030521 Androgen receptor signaling pathway Increases phenotype PMID:26812027
GO:0030850 Prostate gland development Decreases phenotype PMID:27122241
GO:0030879 Mammary gland development Increases phenotype PMID:27122241
GO:0032148 Activation of protein kinase b activity Decreases phenotype PMID:26253279; PMID:29319206
GO:0032332 Positive regulation of chondrocyte differentiation Increases phenotype PMID:28527915
GO:0033148 Positive regulation of intracellular estrogen receptor signaling pathway Increases phenotype PMID:23567241; PMID:25449125; PMID:29945225
GO:0034440 Lipid oxidation Increases phenotype PMID:29350491
GO:0035064 Methylated histone binding Affects phenotype PMID:34383603
GO:0035938 Estradiol secretion Increases phenotype PMID:30817981
GO:0038002 Endocrine signaling Decreases phenotype PMID:27122241
GO:0042403 Thyroid hormone metabolic process Affects phenotype PMID:32798586
GO:0042711 Maternal behavior Affects phenotype PMID:34383603
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:29319206
GO:0043970 Histone h3-k9 acetylation Affects phenotype PMID:34383603
GO:0044237 Cellular metabolic process Decreases phenotype PMID:36277366; PMID:37690743
GO:0044849 Estrous cycle Affects phenotype PMID:34383603
GO:0045333 Cellular respiration Affects phenotype PMID:33140513
GO:0045444 Fat cell differentiation Increases phenotype PMID:24155963
GO:0045600 Positive regulation of fat cell differentiation Increases phenotype PMID:27659731; PMID:28527915
GO:0045669 Positive regulation of osteoblast differentiation Increases phenotype PMID:28527915
GO:0046884 Follicle-stimulating hormone secretion Increases phenotype PMID:28208728
GO:0048135 Female germ-line cyst formation Affects phenotype PMID:34383603
GO:0048160 Primary follicle stage Affects phenotype PMID:22777679
GO:0050810 Regulation of steroid biosynthetic process Affects phenotype PMID:27122241
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:33140513
GO:0051901 Positive regulation of mitochondrial depolarization Increases phenotype PMID:29319206
GO:0060207 Diestrus Increases phenotype PMID:28208728; PMID:34383603
GO:0060208 Proestrus Affects phenotype PMID:34383603
GO:0060209 Estrus Affects phenotype PMID:34383603
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:26888303; PMID:27444704
GO:0061628 H3k27me3 modified histone binding Affects phenotype PMID:34383603
GO:0070374 Positive regulation of erk1 and erk2 cascade Increases phenotype PMID:26253279
GO:0070577 Lysine-acetylated histone binding Affects phenotype PMID:34383603
GO:0072520 Seminiferous tubule development Affects phenotype PMID:27444704
GO:0080182 Histone h3-k4 trimethylation Affects phenotype PMID:34383603
GO:0097722 Sperm motility Affects phenotype PMID:27444704
GO:0098532 Histone h3-k27 trimethylation Affects phenotype PMID:34383603
GO:0140042 Lipid droplet formation Increases phenotype PMID:28527915; PMID:31016361; PMID:39778647
GO:1901164 Negative regulation of trophoblast cell migration Increases phenotype PMID:29319206
GO:1901318 Negative regulation of flagellated sperm motility Increases phenotype PMID:29350491
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:29350491
GO:1901671 Positive regulation of superoxide dismutase activity Increases phenotype PMID:29350491
GO:1905898 Positive regulation of response to endoplasmic reticulum stress Increases phenotype PMID:29319206
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:29350491
GO:2000866 Positive regulation of estradiol secretion Increases phenotype PMID:29350491
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.