| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:18602967 | IVR | 20 mg/kg/day | 20 mg/kg/day | Lead to obesity in offspring | Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| PMID:18648085 | IVR | 400 mg/kg/day | 400 mg/kg/day | Decrease in cortisol levels | Neurological endocrine-mediated perturbations |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Affects expression of estrogen receptor-beta (ER-beta) | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00003 M | 0.00003 M | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00003 M | 0.00003 M | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00003 M | 0.00003 M | Increased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Affects expression of estrogen receptor-beta (ER-beta) | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Decrease in cortisol levels | Neurological endocrine-mediated perturbations | |
| PMID:20132880 | IVR | 62.5 mg/kg | 62.5 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations |
| IVR | 62.5 mg/kg | 62.5 mg/kg | Changes in ovarian morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg | 1000 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 1000 mg/kg | 1000 mg/kg | Changes in ovarian morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 62.5 mg/kg | 62.5 mg/kg | Increased weights of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 1000 mg/kg | 1000 mg/kg | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 62.5 mg/kg | 62.5 mg/kg | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:22777679 | IVR | 250 mg/kg/day | 250 mg/kg/day | Affects folliculogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects uterine contraction | Reproductive endocrine-mediated perturbations | |
| IVR | 62.5 mg/kg/day | 62.5 mg/kg/day | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Affects uterine contraction | Reproductive endocrine-mediated perturbations | |
| PMID:24238989 | IVR | 1000 mg/kg | 1000 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 1000 mg/kg | 1000 mg/kg | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg | 1000 mg/kg | Induce apoptosis of spermatogenic cells | Reproductive endocrine-mediated perturbations | |
| PMID:24607685 | IVR | 400 mg/kg/day | 400 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Alterations in preputial separation | Reproductive endocrine-mediated perturbations | |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Alterations in preputial separation | Reproductive endocrine-mediated perturbations | |
| IVR | 64 mg/kg/day | - | No significant effects observed | - | |
| IVR | 160 mg/kg/day | - | No significant effects observed | - | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| PMID:26888303 | IVR | 400 mg/kg/day | 400 mg/kg/day | Altered germ cells morphology | Reproductive endocrine-mediated perturbations |
| IVR | 160 mg/kg/day | 160 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 64 mg/kg/day | - | No significant effects observed | - | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Altered germ cells morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:27120489 | IVR | 10 mg/kg | 10 mg/kg | Increased FSH levels | Reproductive endocrine-mediated perturbations |
| IVR | 100 mg/kg | 100 mg/kg | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| PMID:27122241 | IVR | 500 mg/kg/day | 200 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 500 mg/kg/day | 200 mg/kg/day | Affects anogenital distance in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 200 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects anogenital distance in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 200 mg/kg/day | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| PMID:27135907 | IVTH | 0.00000001 - 0.00001 M | 0.00000001 - 0.00001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| PMID:27535158 | IVR | 100 mg/kg/day | 100 mg/kg/day | Lead to obesity | Metabolic endocrine-mediated perturbations |
| PMID:29350491 | IVR | 50 mg/kg | 50 mg/kg | Alterations in number of leydig cells | Reproductive endocrine-mediated perturbations |
| IVR | 50 mg/kg | 50 mg/kg | Affects superoxide dismutase (SOD) levels | Hepatic endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Reduced sperm quality | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:29460325 | IVTH | 0.0001 M | 0.0001 M | Cancer phenotype | Endocrine-mediated cancer |
| IVTH | 0.0000001 M | 0.0000001 M | Cancer phenotype | Endocrine-mediated cancer | |
| IVTH | 0.00001 M | 0.00001 M | Cancer phenotype | Endocrine-mediated cancer | |
| PMID:29945225 | IVTH | 0.00001 M | 0.00001 M | Affects estrogen signaling | Reproductive endocrine-mediated perturbations |
| PMID:30218874 | IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects folliculogenesis in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects ovarian follicles population in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Alterations in vaginal opening of offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Increased weights of adrenal gland in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects uterine morphology in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects fertility in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects folliculogenesis in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Affects folliculogenesis in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Affects fertility in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Abnormal estrous cycles in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Increased weights of pituitary gland in offspring | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Increased hypothalamus weights in offspring | Deve | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Decreased weights of pituitary gland in offspring | ||
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased uterine weights in offspring | ||
| IVR | 100 mg/kg/day | 100 mg/kg/day | Alterations in vaginal opening of offspring | ||
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects implantation in offspring | ||
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Abnormal estrous cycles in offspring | ||
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects fertility in offspring | ||
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects implantation in offspring | ||
| PMID:30817981 | IVTH | 0.00000001 M | 0.00000001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| IVTH | 0.00000001 M | 0.00000001 M | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| PMID:31195070 | IVR | 600 mg/kg/day | 150 mg/kg/day | Oxidative stress in testis | Reproductive endocrine-mediated perturbations |
| IVR | 150 mg/kg/day | 150 mg/kg/day | Oxidative stress in liver | Hepatic endocrine-mediated perturbations | |
| IVR | 600 mg/kg/day | 150 mg/kg/day | Oxidative stress in liver | Hepatic endocrine-mediated perturbations | |
| IVR | 600 mg/kg/day | 600 mg/kg/day | Oxidative stress in liver | Hepatic endocrine-mediated perturbations | |
| IVR | 600 mg/kg/day | 600 mg/kg/day | Affects the biochemical composition of liver | Hepatic endocrine-mediated perturbations | |
| IVR | 600 mg/kg/day | 300 mg/kg/day | Oxidative stress in liver | Hepatic endocrine-mediated perturbations | |
| IVR | 600 mg/kg/day | 300 mg/kg/day | Oxidative stress in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg/day | 300 mg/kg/day | Oxidative stress in liver | Hepatic endocrine-mediated perturbations | |
| PMID:31672375 | IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects testicular function in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects spermatogenesis in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects steroidogenesis in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects implantation in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects sperm motility in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Reduced sperm counts in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased testosterone levels in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects steroidogenesis in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects implantation in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Changes in morphology of seminiferous tubules in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Affects expression of androgen receptor (AR) in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) in offspring | D | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Atrophy in seminiferous tubules in offspring | ||
| IVR | 10 mg/kg/day | 10 mg/kg/day | Decreased estradiol levels in offspring | ||
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increased weights of pituitary gland in offspring | ||
| IVR | 100 mg/kg/day | 100 mg/kg/day | Atrophy in seminiferous tubules in offspring | ||
| IVR | 100 mg/kg/day | 100 mg/kg/day | Changes in morphology of seminiferous tubules in offspring | ||
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Atrophy in seminiferous tubules in offspring | ||
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Changes in morphology of seminiferous tubules in offspring | ||
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Decreased testosterone levels in offspring | ||
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects expression of estrogen receptor-beta (ER-beta) in offspring | ||
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Increased LH levels in offspring | ||
| PMID:32623865 | IVR | 2 - 8 mg/kg/day | 2 - 8 mg/kg/day | Induce behavioral changes | Neurological endocrine-mediated perturbations |
| IVR | 2 mg/kg/day | 2 mg/kg/day | Decreased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 4 - 8 mg/kg/day | 4 - 8 mg/kg/day | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 4 mg/kg/day | 4 mg/kg/day | Decreased Alanine aminotransferase (ALT) levels | Hepatic endocrine-mediated perturbations | |
| IVR | 4 - 8 mg/kg/day | 4 - 8 mg/kg/day | Decreased Aspartate aminotransferase (AST) levels | Hepatic endocrine-mediated perturbations | |
| IVR | 2 - 8 mg/kg/day | 2 - 8 mg/kg/day | Oxidative stress in neurons | Neurological endocrine-mediated perturbations | |
| IVR | 2 - 8 mg/kg/day | 2 - 8 mg/kg/day | Oxidative stress in liver | Hepatic endocrine-mediated perturbations | |
| IVR | 2 - 8 mg/kg/day | 2 - 8 mg/kg/day | Oxidative stress in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 2 - 8 mg/kg/day | 2 - 8 mg/kg/day | Changes in brain morphology | Neurological endocrine-mediated perturbations | |
| IVR | 2 - 8 mg/kg/day | 2 - 8 mg/kg/day | Changes in liver morphology | Hepatic endocrine-mediated perturbations | |
| IVR | 2 - 8 mg/kg/day | 2 - 8 mg/kg/day | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| PMID:32702374 | IVR | 4 - 15 ppm | 4 - 15 ppm | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations |
| IVR | 4 - 15 ppm | 4 - 15 ppm | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 4 - 15 ppm | 4 - 15 ppm | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 4 ppm | 4 ppm | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 4 - 15 ppm | 4 - 15 ppm | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 4 ppm | 4 ppm | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 4 - 15 ppm | 4 - 15 ppm | Changes in adrenal gland morphology | Metabolic endocrine-mediated perturbations | |
| IVR | 4 - 15 ppm | 4 - 15 ppm | Decreased body weights | Metabolic endocrine-mediated perturbations | |
| IVR | 4 - 15 ppm | 4 - 15 ppm | Decreased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 15 ppm | 15 ppm | Hyperplasia in liver | Hepatic endocrine-mediated perturbations | |
| IVR | 4 - 15 ppm | 4 - 15 ppm | Changes in liver morphology | Hepatic endocrine-mediated perturbations | |
| PMID:32798586 | IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Affects thyroid function | Metabolic endocrine-mediated perturbations |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Increase in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| PMID:33844042 | IVR | 1 mg/kg/day | 1 mg/kg/day | Decreased weights of pituitary gland | Neurological endocrine-mediated perturbations |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Decreased thymus gland weights | Immunological endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Increased Alanine aminotransferase (ALT) levels | Hepatic endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Increased Aspartate aminotransferase (AST) levels | Hepatic endocrine-mediated perturbations | |
| IVR | 2 mg/kg/day | 2 mg/kg/day | Changes in white blood cell (WBC) populations | Immunological endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Changes in haemocrit values | Immunological endocrine-mediated perturbations | |
| PMID:35810903 | IVTH | 0.000005 - 0.0001 M | 0.000005 - 0.0001 M | Cancer phenotype | Endocrine-mediated cancer |
| PMID:35962557 | IVR | 1 mg/kg/day | 1 mg/kg/day | Alterations in number of leydig cells | Reproductive endocrine-mediated perturbations |
| PMID:36702264 | IVTH | 0.000001 M | 0.000001 M | Increased testosterone levels | Reproductive endocrine-mediated perturbations |
| IVTH | 0.00001 - 0.0001 M | 0.00001 - 0.0001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000005 - 0.00005 M | 0.0000005 - 0.00005 M | Cancer phenotype | Endocrine-mediated cancer | |
| IVTH | 0.00001 M | 0.00001 M | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0001 M | 0.0001 M | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:37409182 | IVTH | 0.000000002 - 0.00002 M | 0.000000002 - 0.00002 M | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations |
| IVTH | 0.000002 - 0.00002 M | 0.000002 - 0.00002 M | Alters estrogen-responsive genes | Reproductive endocrine-mediated perturbations | |
| PMID:37837697 | IVR | 5 mg/kg | 5 mg/kg | Affects intracellular signaling pathway | Metabolic endocrine-mediated perturbations |
| IVR | 5 mg/kg | 5 mg/kg | Induce apoptosis of ovarian follicles | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Affects mitochondrial function in the ovaries | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Oxidative stress in ovaries | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Induce behavioral changes | Neurological endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Affects ovarian follicles population | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Increased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Affects fertility | Reproductive endocrine-mediated perturbations | |
| IVR | 5 - 15 mg/kg | 5 - 15 mg/kg | Abnormal oocyte morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Decreased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Decreased hypothalamus weights | Neurological endocrine-mediated perturbations | |
| PMID:38402305 | IVR | 5 mg/kg/day | 5 mg/kg/day | Decrease in T4 levels | Metabolic endocrine-mediated perturbations |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increased weights of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Affects thyroid function | Metabolic endocrine-mediated perturbations | |
| IVTH | 1 - 8 mg/L | 1 - 8 mg/L | Affects thyroid hormone synthesis | Metabolic endocrine-mediated perturbations | |
| IVTH | 1 - 8 mg/L | 1 - 8 mg/L | Induce apoptosis of thyroid tissue | Metabolic endocrine-mediated perturbations | |
| IVTH | 1 - 8 mg/L | 1 - 8 mg/L | Abnormal proliferation of thyroid cells | Metabolic endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.