Propyl thiouracil


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0001580 Detection of chemical stimulus involved in sensory perception of bitter taste Increases phenotype PMID:22384968
GO:0002118 Aggressive behavior Increases phenotype PMID:31068541
GO:0004303 Estradiol 17-beta-dehydrogenase activity Decreases phenotype PMID:29578053
GO:0004364 Glutathione transferase activity Affects phenotype PMID:36038036
GO:0004602 Glutathione peroxidase activity Affects phenotype PMID:23921912; PMID:25882089; PMID:34047416
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:29896988; PMID:34047416
GO:0006534 Cysteine metabolic process Increases phenotype PMID:39441382
GO:0006541 Glutamine metabolic process Increases phenotype PMID:39441382
GO:0006590 Thyroid hormone generation Decreases phenotype PMID:27216871; PMID:27233481; PMID:27902923
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:34047416
GO:0006749 Glutathione metabolic process Affects phenotype PMID:25371773; PMID:34047416
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:25882089
GO:0006915 Apoptotic process Increases phenotype PMID:10718548
GO:0006954 Inflammatory response Increases phenotype PMID:34047416
GO:0006979 Response to oxidative stress Increases phenotype PMID:19059302; PMID:35871495
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:21629661; PMID:29347925
GO:0007268 Chemical synaptic transmission Increases phenotype PMID:12933695
GO:0007420 Brain development Decreases phenotype PMID:27216871
GO:0007611 Learning or memory Decreases phenotype PMID:27233481; PMID:35869475
GO:0007612 Learning Decreases phenotype PMID:27216871
GO:0007613 Memory Affects phenotype PMID:29796989
GO:0007631 Feeding behavior Affects phenotype PMID:31068541
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:23517243; PMID:34047416
GO:0008283 Cell population proliferation Affects phenotype PMID:29578053; PMID:39441382; PMID:7531505; PMID:7531505; PMID:7819453
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:32949729; PMID:36506574
GO:0008542 Visual learning Decreases phenotype PMID:26606422; PMID:29796989
GO:0008584 Male gonad development Affects phenotype PMID:29578053
GO:0010459 Negative regulation of heart rate Increases phenotype PMID:30769017
GO:0010918 Positive regulation of mitochondrial membrane potential Decreases phenotype PMID:25371773
GO:0010942 Positive regulation of cell death Increases phenotype PMID:25371773
GO:0016042 Lipid catabolic process Increases phenotype PMID:25882089; PMID:25882089; PMID:26459835; PMID:34047416
GO:0019530 Taurine metabolic process Increases phenotype PMID:39441382
GO:0021542 Dentate gyrus development Affects phenotype PMID:33150595
GO:0021884 Forebrain neuron development Decreases phenotype PMID:22987596
GO:0021954 Central nervous system neuron development Decreases phenotype PMID:28973696
GO:0030899 Calcium-dependent atpase activity Decreases phenotype PMID:29896988
GO:0031987 Locomotion involved in locomotory behavior Increases phenotype PMID:31068541
GO:0034276 Kynurenic acid biosynthetic process Increases phenotype PMID:32663543
GO:0035936 Testosterone secretion Decreases phenotype PMID:29578053
GO:0036093 Germ cell proliferation Decreases phenotype PMID:29578053
GO:0036211 Protein modification process Affects phenotype PMID:23921912
GO:0042048 Olfactory behavior Affects phenotype PMID:36706583
GO:0042403 Thyroid hormone metabolic process Affects phenotype PMID:25060363; PMID:25060363; PMID:29896988; PMID:34047416; PMID:37295576; PMID:39441382; PMID:29896988; PMID:34047416; PMID:37295576; PMID:39441382; PMID:34047416; PMID:34047416; PMID:37295576; PMID:37295576
GO:0042593 Glucose homeostasis Affects phenotype PMID:34234489
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:33462684; PMID:36506574
GO:0043066 Negative regulation of apoptotic process Increases phenotype PMID:25298361
GO:0043525 Positive regulation of neuron apoptotic process Increases phenotype PMID:33603838; PMID:34609722
GO:0045429 Positive regulation of nitric oxide biosynthetic process Increases phenotype PMID:34234489
GO:0045907 Positive regulation of vasoconstriction Increases phenotype PMID:36942326
GO:0046034 Atp metabolic process Affects phenotype PMID:32949729
GO:0046466 Membrane lipid catabolic process Affects phenotype PMID:15473886; PMID:19174171; PMID:1991336
GO:0050667 Homocysteine metabolic process Increases phenotype PMID:39441382
GO:0060112 Generation of ovulation cycle rhythm Affects phenotype PMID:27902923
GO:0061370 Testosterone biosynthetic process Decreases phenotype PMID:29578053
GO:0070265 Necrotic cell death Increases phenotype PMID:34047416
GO:0102727 3beta-hydroxysteroid dehydrogenase activity Decreases phenotype PMID:29578053
GO:0110090 Positive regulation of hippocampal neuron apoptotic process Increases phenotype PMID:31885695
GO:1900272 Negative regulation of long-term synaptic potentiation Increases phenotype PMID:26606422
GO:1900409 Positive regulation of cellular response to oxidative stress Increases phenotype PMID:31414343
GO:1901142 Insulin metabolic process Affects phenotype PMID:34234489
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:34234489; PMID:36038036
GO:1902552 Negative regulation of catalase activity Increases phenotype PMID:36038036
GO:1902553 Positive regulation of catalase activity Increases phenotype PMID:34234489
GO:1902722 Positive regulation of prolactin secretion Increases phenotype PMID:27902923
GO:1902884 Positive regulation of response to oxidative stress Increases phenotype PMID:36038036; PMID:36506574
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:36038036
GO:1904662 Positive regulation of sensory perception of bitter taste Increases phenotype PMID:29347925
GO:2000469 Negative regulation of peroxidase activity Increases phenotype PMID:25371773
GO:2000609 Regulation of thyroid hormone generation Affects phenotype PMID:30085217
GO:2000610 Negative regulation of thyroid hormone generation Increases phenotype PMID:27216871; PMID:31414343; PMID:27216871; PMID:34234489; PMID:35101570; PMID:27216871; PMID:38070162; PMID:28973696; PMID:31697382; PMID:34234489; PMID:35101570; PMID:39069214
GO:2000612 Regulation of thyroid-stimulating hormone secretion Decreases phenotype PMID:40023229
GO:2000614 Positive regulation of thyroid-stimulating hormone secretion Increases phenotype PMID:25060363; PMID:27902923; PMID:34234489; PMID:35101570; PMID:34234489; PMID:35101570; PMID:40023229
GO:2000822 Regulation of behavioral fear response Affects phenotype PMID:27216871
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:36506574
GO:2000845 Positive regulation of testosterone secretion Increases phenotype PMID:35871495
GO:2001171 Positive regulation of atp biosynthetic process Increases phenotype PMID:39069214
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.