DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

N-Nitrosodiethylamine

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0000050	Urea cycle	Increases phenotype	PMID:30920066
GO:0000080	Mitotic g1 phase	Increases phenotype	PMID:30826251
GO:0000084	Mitotic s phase	Increases phenotype	PMID:30826251; PMID:35882637
GO:0000086	G2/m transition of mitotic cell cycle	Affects phenotype	PMID:35882637
GO:0000087	Mitotic m phase	Increases phenotype	PMID:30826251
GO:0000278	Mitotic cell cycle	Affects phenotype	PMID:36608567
GO:0000737	Dna catabolic process, endonucleolytic	Increases phenotype	PMID:35882637; PMID:36442531
GO:0001525	Angiogenesis	Increases phenotype	PMID:24060683; PMID:28693887
GO:0002232	Leukocyte chemotaxis involved in inflammatory response	Increases phenotype	PMID:30098279
GO:0002260	Lymphocyte homeostasis	Decreases phenotype	PMID:38369053
GO:0002523	Leukocyte migration involved in inflammatory response	Increases phenotype	PMID:27151938
GO:0004035	Alkaline phosphatase activity	Increases phenotype	PMID:27836789; PMID:27836789; PMID:36037915; PMID:28414157; PMID:29923357; PMID:30779474; PMID:30779474; PMID:30920066; PMID:38367245; PMID:30920066; PMID:36037915; PMID:38367245
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	Affects phenotype	PMID:27836789; PMID:27836789; PMID:36037915; PMID:28414157; PMID:28693887; PMID:28693887; PMID:29923357; PMID:28804948; PMID:28804948; PMID:30779474; PMID:30920066; PMID:38367245; PMID:29923357; PMID:30920066; PMID:36037915; PMID:38367245
GO:0004364	Glutathione transferase activity	Decreases phenotype	PMID:27048571; PMID:28414157; PMID:27836789; PMID:28414157; PMID:28804948; PMID:28935427; PMID:29923357; PMID:30423403; PMID:30920066
GO:0004457	Lactate dehydrogenase activity	Increases phenotype	PMID:27836789; PMID:30920066
GO:0004602	Glutathione peroxidase activity	Decreases phenotype	PMID:27048571; PMID:27048571; PMID:28414157; PMID:27836789; PMID:28414157; PMID:28634113; PMID:28804948; PMID:28804948; PMID:30920066; PMID:35437842; PMID:28935427; PMID:29923357; PMID:30423403; PMID:30779474; PMID:30920066; PMID:35437842
GO:0004784	Superoxide dismutase activity	Decreases phenotype	PMID:27048571; PMID:27048571; PMID:28414157; PMID:27836789; PMID:28414157; PMID:28804948; PMID:28804948; PMID:30920066; PMID:35437842; PMID:28935427; PMID:29923357; PMID:30423403; PMID:30920066; PMID:35437842
GO:0005243	Gap junction channel activity	Decreases phenotype	PMID:36037915
GO:0006119	Oxidative phosphorylation	Decreases phenotype	PMID:28903497
GO:0006304	Dna modification	Increases phenotype	PMID:25683344; PMID:36731809; PMID:36731809
GO:0006308	Dna catabolic process	Increases phenotype	PMID:36037915
GO:0006601	Creatine biosynthetic process	Increases phenotype	PMID:30920066
GO:0006606	Protein import into nucleus	Affects phenotype	PMID:35523338; PMID:35882637
GO:0006646	Phosphatidylethanolamine biosynthetic process	Increases phenotype	PMID:38369053
GO:0006686	Sphingomyelin biosynthetic process	Increases phenotype	PMID:38369053
GO:0006695	Cholesterol biosynthetic process	Increases phenotype	PMID:28804948; PMID:28804948; PMID:31129132; PMID:31129132
GO:0006749	Glutathione metabolic process	Increases phenotype	PMID:22393308; PMID:22393308; PMID:35437842; PMID:27553677; PMID:30098279; PMID:32302048; PMID:35437842; PMID:38798245
GO:0006750	Glutathione biosynthetic process	Affects phenotype	PMID:27048571; PMID:27048571; PMID:28414157; PMID:28414157; PMID:28634113; PMID:28693887; PMID:28693887; PMID:29923357; PMID:28804948; PMID:28804948; PMID:30920066; PMID:28935427; PMID:29923357; PMID:30423403; PMID:30920066; PMID:31129132
GO:0006809	Nitric oxide biosynthetic process	Increases phenotype	PMID:28414157; PMID:30779474; PMID:30920066
GO:0006869	Lipid transport	Decreases phenotype	PMID:38369053
GO:0006915	Apoptotic process	Affects phenotype	PMID:16434500; PMID:24060683; PMID:24954034; PMID:27058323; PMID:27151938; PMID:28634113; PMID:31067004
GO:0006954	Inflammatory response	Increases phenotype	PMID:33290806; PMID:35437842
GO:0006974	Cellular response to dna damage stimulus	Increases phenotype	PMID:27048571; PMID:29777724
GO:0006979	Response to oxidative stress	Affects phenotype	PMID:22393308
GO:0007631	Feeding behavior	Affects phenotype	PMID:36037915
GO:0008283	Cell population proliferation	Affects phenotype	PMID:16434500; PMID:2573356; PMID:27058323; PMID:27058323; PMID:27151938; PMID:35523338; PMID:27151938; PMID:28414157; PMID:28634113; PMID:30826251; PMID:35523338; PMID:36608567; PMID:38367245
GO:0008284	Positive regulation of cell population proliferation	Increases phenotype	PMID:20435455; PMID:23665045; PMID:24012840; PMID:24511000; PMID:28100771; PMID:28943392
GO:0009101	Glycoprotein biosynthetic process	Affects phenotype	PMID:30423403
GO:0010243	Response to organonitrogen compound	Decreases phenotype	PMID:29458170
GO:0010512	Negative regulation of phosphatidylinositol biosynthetic process	Increases phenotype	PMID:38369053
GO:0010867	Positive regulation of triglyceride biosynthetic process	Increases phenotype	PMID:38369053
GO:0010915	Regulation of very-low-density lipoprotein particle clearance	Affects phenotype	PMID:38369053
GO:0010940	Positive regulation of necrotic cell death	Increases phenotype	PMID:36113623
GO:0016042	Lipid catabolic process	Increases phenotype	PMID:27048571; PMID:27048571; PMID:28414157; PMID:28414157; PMID:28634113; PMID:28693887; PMID:28693887; PMID:29923357; PMID:28804948; PMID:28804948; PMID:30920066; PMID:28935427; PMID:29923357; PMID:30423403; PMID:30779474; PMID:30920066; PMID:31067004; PMID:32302048; PMID:35113675; PMID:35437842
GO:0016049	Cell growth	Increases phenotype	PMID:38367245
GO:0016712	Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Decreases phenotype	PMID:32805337
GO:0016887	Atp hydrolysis activity	Decreases phenotype	PMID:30423403
GO:0018158	Protein oxidation	Increases phenotype	PMID:27048571; PMID:30423403; PMID:32302048
GO:0019319	Hexose biosynthetic process	Affects phenotype	PMID:30423403
GO:0019432	Triglyceride biosynthetic process	Increases phenotype	PMID:28804948; PMID:28804948; PMID:31129132; PMID:31129132
GO:0019627	Urea metabolic process	Affects phenotype	PMID:35113675
GO:0019852	L-ascorbic acid metabolic process	Affects phenotype	PMID:32302048
GO:0030010	Establishment of cell polarity	Decreases phenotype	PMID:36608567
GO:0030199	Collagen fibril organization	Increases phenotype	PMID:33290806; PMID:36731809
GO:0032125	Micronucleus organization	Increases phenotype	PMID:35882637
GO:0032148	Activation of protein kinase b activity	Increases phenotype	PMID:34726822
GO:0032308	Positive regulation of prostaglandin secretion	Increases phenotype	PMID:30098279
GO:0032967	Positive regulation of collagen biosynthetic process	Increases phenotype	PMID:28943392
GO:0034440	Lipid oxidation	Increases phenotype	PMID:18404532; PMID:27553677; PMID:28943392; PMID:30098279; PMID:33840231; PMID:38798245
GO:0035703	Monocyte migration into blood stream	Increases phenotype	PMID:38369053
GO:0036053	Glomerular endothelium fenestra	Affects phenotype	PMID:36731809
GO:0040018	Positive regulation of multicellular organism growth	Affects phenotype	PMID:28943392; PMID:30298849
GO:0042168	Heme metabolic process	Affects phenotype	PMID:35113675
GO:0042353	Fucose biosynthetic process	Affects phenotype	PMID:30423403
GO:0042427	Serotonin biosynthetic process	Increases phenotype	PMID:27565560; PMID:29698782
GO:0042593	Glucose homeostasis	Decreases phenotype	PMID:30298849
GO:0042755	Eating behavior	Decreases phenotype	PMID:30298849
GO:0042756	Drinking behavior	Decreases phenotype	PMID:30298849
GO:0043065	Positive regulation of apoptotic process	Increases phenotype	PMID:20435455; PMID:27553677; PMID:27553677; PMID:28100771; PMID:28100771
GO:0043507	Positive regulation of jun kinase activity	Affects phenotype	PMID:29458170
GO:0045023	G0 to g1 transition	Increases phenotype	PMID:31067004
GO:0045723	Positive regulation of fatty acid biosynthetic process	Increases phenotype	PMID:38369053
GO:0045833	Negative regulation of lipid metabolic process	Increases phenotype	PMID:38369053
GO:0045930	Negative regulation of mitotic cell cycle	Increases phenotype	PMID:31067004
GO:0046186	Acetaldehyde biosynthetic process	Increases phenotype	PMID:35523338
GO:0046415	Urate metabolic process	Decreases phenotype	PMID:30098279
GO:0046449	Creatinine metabolic process	Increases phenotype	PMID:29923357; PMID:30098279; PMID:30920066; PMID:35113675
GO:0046466	Membrane lipid catabolic process	Increases phenotype	PMID:16061884
GO:0046621	Negative regulation of organ growth	Increases phenotype	PMID:30298849
GO:0050729	Positive regulation of inflammatory response	Increases phenotype	PMID:38369053
GO:0051092	Positive regulation of nf-kappab transcription factor activity	Increases phenotype	PMID:18404532
GO:0061621	Canonical glycolysis	Decreases phenotype	PMID:28903497
GO:0070265	Necrotic cell death	Increases phenotype	PMID:27151938; PMID:29777724; PMID:29923357; PMID:36731809; PMID:38367245
GO:0070994	Detection of oxidative stress	Increases phenotype	PMID:28804948; PMID:28804948; PMID:38367245; PMID:38367245
GO:0072593	Reactive oxygen species metabolic process	Increases phenotype	PMID:23665939; PMID:24144777; PMID:36037915
GO:0090023	Positive regulation of neutrophil chemotaxis	Increases phenotype	PMID:27553677
GO:0090026	Positive regulation of monocyte chemotaxis	Increases phenotype	PMID:27553677
GO:0090181	Regulation of cholesterol metabolic process	Affects phenotype	PMID:20435455
GO:0090398	Cellular senescence	Increases phenotype	PMID:26589970
GO:0097198	Histone h3-k36 trimethylation	Decreases phenotype	PMID:38367245
GO:0097676	Histone h3-k36 dimethylation	Decreases phenotype	PMID:38367245
GO:0098532	Histone h3-k27 trimethylation	Increases phenotype	PMID:38367245
GO:0140409	Positive regulation of mrna alternative polyadenylation	Increases phenotype	PMID:37021545
GO:1900469	Negative regulation of phosphatidylserine biosynthetic process	Increases phenotype	PMID:38369053
GO:1901224	Positive regulation of nik/nf-kappab signaling	Increases phenotype	PMID:18404532
GO:1901668	Regulation of superoxide dismutase activity	Affects phenotype	PMID:22393308
GO:1901670	Negative regulation of superoxide dismutase activity	Increases phenotype	PMID:30098279; PMID:34726822
GO:1901687	Glutathione derivative biosynthetic process	Decreases phenotype	PMID:28943392
GO:1902551	Regulation of catalase activity	Affects phenotype	PMID:22393308
GO:1903047	Mitotic cell cycle process	Affects phenotype	PMID:35882637
GO:1903283	Negative regulation of glutathione peroxidase activity	Increases phenotype	PMID:30098279; PMID:34726822
GO:1903284	Positive regulation of glutathione peroxidase activity	Decreases phenotype	PMID:28943392
GO:1903409	Reactive oxygen species biosynthetic process	Increases phenotype	PMID:30423403; PMID:32749121
GO:1903721	Positive regulation of i-kappab phosphorylation	Increases phenotype	PMID:18404532
GO:1904179	Positive regulation of adipose tissue development	Increases phenotype	PMID:30298849
GO:1904647	Response to rotenone	Affects phenotype	PMID:29458170
GO:1905220	Negative regulation of platelet formation	Increases phenotype	PMID:38369053
GO:1905477	Positive regulation of protein localization to membrane	Increases phenotype	PMID:20435455
GO:2000083	Negative regulation of l-ascorbic acid biosynthetic process	Increases phenotype	PMID:32805337
GO:2001246	Negative regulation of phosphatidylcholine biosynthetic process	Increases phenotype	PMID:38369053
GO:2001280	Positive regulation of unsaturated fatty acid biosynthetic process	Increases phenotype	PMID:38369053

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.