| GO ID | GO name | Interaction type | Reference |
|---|---|---|---|
| GO:0000084 | Mitotic s phase | Affects phenotype | PMID:22981619; PMID:23940045; PMID:33771647; PMID:33932074; PMID:37245849 |
| GO:0000086 | G2/m transition of mitotic cell cycle | Affects phenotype | PMID:22981619; PMID:23940045; PMID:37245849 |
| GO:0000278 | Mitotic cell cycle | Affects phenotype | PMID:37245849 |
| GO:0000725 | Recombinational repair | Increases phenotype | PMID:39029599 |
| GO:0001836 | Release of cytochrome c from mitochondria | Increases phenotype | PMID:23288922; PMID:24053669 |
| GO:0004197 | Cysteine-type endopeptidase activity | Increases phenotype | PMID:22960397; PMID:26335980; PMID:28983606 |
| GO:0004407 | Histone deacetylase activity | Decreases phenotype | PMID:27220438 |
| GO:0004457 | Lactate dehydrogenase activity | Increases phenotype | PMID:36646296 |
| GO:0005262 | Calcium channel activity | Increases phenotype | PMID:28790335 |
| GO:0005757 | Mitochondrial permeability transition pore complex | Affects phenotype | PMID:24026541 |
| GO:0006306 | Dna methylation | Decreases phenotype | PMID:21953684 |
| GO:0006497 | Protein lipidation | Increases phenotype | PMID:35561756 |
| GO:0006582 | Melanin metabolic process | Affects phenotype | PMID:23738040 |
| GO:0006606 | Protein import into nucleus | Affects phenotype | PMID:36646296 |
| GO:0006749 | Glutathione metabolic process | Increases phenotype | PMID:30547568 |
| GO:0006914 | Autophagy | Increases phenotype | PMID:37148176 |
| GO:0006915 | Apoptotic process | Increases phenotype | PMID:22687461; PMID:22960397; PMID:22981619; PMID:23202692; PMID:23288922; PMID:27307158; PMID:23776099; PMID:23940708; PMID:24053669; PMID:24053669; PMID:29124153; PMID:32141582; PMID:26335980; PMID:28843007; PMID:28983606; PMID:26335980; PMID:28983606; PMID:27515134; PMID:27606422; PMID:28444915; PMID:28843007; PMID:29421518; PMID:32141582; PMID:32818234; PMID:35123993; PMID:35561756; PMID:36941454; PMID:37148176 |
| GO:0006974 | Cellular response to dna damage stimulus | Increases phenotype | PMID:22687461; PMID:22981619; PMID:23940045; PMID:26335980; PMID:26335980; PMID:26822515; PMID:29421518 |
| GO:0008219 | Cell death | Increases phenotype | PMID:24053669; PMID:24053669; PMID:28961056; PMID:24451020; PMID:25240866; PMID:27979589; PMID:28961056 |
| GO:0008234 | Cysteine-type peptidase activity | Increases phenotype | PMID:36941454 |
| GO:0008283 | Cell population proliferation | Affects phenotype | PMID:23776099; PMID:23940708; PMID:25821186; PMID:27515134; PMID:29421518; PMID:30090394; PMID:33771647; PMID:33932074; PMID:37245849 |
| GO:0008284 | Positive regulation of cell population proliferation | Increases phenotype | PMID:30506647; PMID:37951342; PMID:39179171 |
| GO:0008285 | Negative regulation of cell population proliferation | Affects phenotype | PMID:28836394; PMID:28886972; PMID:29555536; PMID:30547568 |
| GO:0010424 | Dna methylation on cytosine within a cg sequence | Affects phenotype | PMID:23973255 |
| GO:0010508 | Positive regulation of autophagy | Increases phenotype | PMID:28263894; PMID:35302183 |
| GO:0010729 | Positive regulation of hydrogen peroxide biosynthetic process | Increases phenotype | PMID:28263894 |
| GO:0010942 | Positive regulation of cell death | Increases phenotype | PMID:26867644 |
| GO:0010971 | Positive regulation of g2/m transition of mitotic cell cycle | Increases phenotype | PMID:30506647 |
| GO:0015267 | Channel activity | Affects phenotype | PMID:24026541 |
| GO:0016042 | Lipid catabolic process | Increases phenotype | PMID:24026541; PMID:30567741 |
| GO:0016049 | Cell growth | Decreases phenotype | PMID:30567741 |
| GO:0016209 | Antioxidant activity | Decreases phenotype | PMID:26056850 |
| GO:0016477 | Cell migration | Increases phenotype | PMID:26807887 |
| GO:0019233 | Sensory perception of pain | Increases phenotype | PMID:28790335 |
| GO:0030099 | Myeloid cell differentiation | Increases phenotype | PMID:30090394 |
| GO:0030154 | Cell differentiation | Affects phenotype | PMID:30090394 |
| GO:0030218 | Erythrocyte differentiation | Affects phenotype | PMID:23973255; PMID:23973255; PMID:24709103; PMID:28733890; PMID:32198055; PMID:37329354; PMID:24709103; PMID:28733890; PMID:30090394; PMID:32198055 |
| GO:0031532 | Actin cytoskeleton reorganization | Increases phenotype | PMID:32818234 |
| GO:0031987 | Locomotion involved in locomotory behavior | Decreases phenotype | PMID:27606422 |
| GO:0032125 | Micronucleus organization | Increases phenotype | PMID:19778234 |
| GO:0032148 | Activation of protein kinase b activity | Decreases phenotype | PMID:28886972 |
| GO:0032776 | Dna methylation on cytosine | Affects phenotype | PMID:23940045 |
| GO:0034116 | Positive regulation of heterotypic cell-cell adhesion | Increases phenotype | PMID:34718823 |
| GO:0035640 | Exploration behavior | Decreases phenotype | PMID:27606422 |
| GO:0042308 | Negative regulation of protein import into nucleus | Increases phenotype | PMID:28836394; PMID:28886972 |
| GO:0042310 | Vasoconstriction | Increases phenotype | PMID:22414385 |
| GO:0042428 | Serotonin metabolic process | Affects phenotype | PMID:27606422 |
| GO:0042438 | Melanin biosynthetic process | Decreases phenotype | PMID:31256213 |
| GO:0042541 | Hemoglobin biosynthetic process | Increases phenotype | PMID:23973255; PMID:23973255; PMID:24709103; PMID:24709103; PMID:28733890 |
| GO:0042554 | Superoxide anion generation | Affects phenotype | PMID:22687461 |
| GO:0043065 | Positive regulation of apoptotic process | Increases phenotype | PMID:28263894; PMID:28836394; PMID:28886972; PMID:35302183; PMID:39029599 |
| GO:0043303 | Mast cell degranulation | Increases phenotype | PMID:22414385 |
| GO:0043966 | Histone h3 acetylation | Increases phenotype | PMID:30448557 |
| GO:0043970 | Histone h3-k9 acetylation | Decreases phenotype | PMID:27515134 |
| GO:0043971 | Histone h3-k18 acetylation | Decreases phenotype | PMID:27515134 |
| GO:0044237 | Cellular metabolic process | Increases phenotype | PMID:22960397; PMID:22981619; PMID:23202692; PMID:23288922; PMID:23288922; PMID:31900833; PMID:23791922; PMID:23940045; PMID:23940708; PMID:24451020; PMID:25240866; PMID:26335980; PMID:27515134; PMID:28961056; PMID:28961056; PMID:29124153; PMID:32141582; PMID:30976846; PMID:32141582; PMID:32334435; PMID:32334435; PMID:32818234; PMID:32818234; PMID:33932074; PMID:34200499; PMID:35123993; PMID:36646296; PMID:35561756; PMID:36646296; PMID:37148176 |
| GO:0044546 | Nlrp3 inflammasome complex assembly | Increases phenotype | PMID:36646296 |
| GO:0044754 | Autolysosome | Increases phenotype | PMID:37148176 |
| GO:0045023 | G0 to g1 transition | Affects phenotype | PMID:23940045; PMID:33932074; PMID:37245849 |
| GO:0045333 | Cellular respiration | Decreases phenotype | PMID:32334435 |
| GO:0045930 | Negative regulation of mitotic cell cycle | Increases phenotype | PMID:28444915; PMID:28886972 |
| GO:0046034 | Atp metabolic process | Decreases phenotype | PMID:28983606; PMID:32334435 |
| GO:0051276 | Chromosome organization | Affects phenotype | PMID:19778234 |
| GO:0051881 | Regulation of mitochondrial membrane potential | Affects phenotype | PMID:23288922; PMID:23776099; PMID:28843007; PMID:28961056; PMID:32818234; PMID:35561756 |
| GO:0051882 | Mitochondrial depolarization | Decreases phenotype | PMID:35123993 |
| GO:0051899 | Membrane depolarization | Increases phenotype | PMID:36941454 |
| GO:0051901 | Positive regulation of mitochondrial depolarization | Increases phenotype | PMID:35302183 |
| GO:0060326 | Cell chemotaxis | Increases phenotype | PMID:33771647; PMID:33932074 |
| GO:0061739 | Protein lipidation involved in autophagosome assembly | Increases phenotype | PMID:28263894 |
| GO:0070212 | Protein poly-adp-ribosylation | Affects phenotype | PMID:26822515 |
| GO:0070265 | Necrotic cell death | Increases phenotype | PMID:32818234 |
| GO:0070269 | Pyroptosis | Increases phenotype | PMID:36646296 |
| GO:0070994 | Detection of oxidative stress | Increases phenotype | PMID:36646296; PMID:36941454 |
| GO:0072593 | Reactive oxygen species metabolic process | Increases phenotype | PMID:23776099; PMID:23940045; PMID:24709103; PMID:26335980; PMID:28983606; PMID:28843007; PMID:28961056; PMID:28961056; PMID:32141582; PMID:32141582; PMID:32818234; PMID:34200499; PMID:35123993; PMID:35561756; PMID:37148176 |
| GO:0140042 | Lipid droplet formation | Increases phenotype | PMID:24484068 |
| GO:0140454 | Protein aggregate center assembly | Increases phenotype | PMID:36941454 |
| GO:1901989 | Positive regulation of cell cycle phase transition | Increases phenotype | PMID:37951342 |
| GO:1901990 | Regulation of mitotic cell cycle phase transition | Affects phenotype | PMID:26047893 |
| GO:1903047 | Mitotic cell cycle process | Affects phenotype | PMID:22981619; PMID:23940045; PMID:33771647; PMID:33932074 |
| GO:1903409 | Reactive oxygen species biosynthetic process | Affects phenotype | PMID:29935983; PMID:30448557; PMID:30976846 |
| GO:1903427 | Negative regulation of reactive oxygen species biosynthetic process | Increases phenotype | PMID:30506647 |
| GO:1903428 | Positive regulation of reactive oxygen species biosynthetic process | Increases phenotype | PMID:28836394; PMID:35302183 |
| GO:1905517 | Macrophage migration | Increases phenotype | PMID:22465845 |
| GO:1905603 | Regulation of blood-brain barrier permeability | Affects phenotype | PMID:27587462 |
| GO:2000786 | Positive regulation of autophagosome assembly | Increases phenotype | PMID:28263894 |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.