Cotinine


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0006306 Dna methylation Affects phenotype PMID:26339649
GO:0006805 Xenobiotic metabolic process Increases phenotype PMID:27818348
GO:0006915 Apoptotic process Increases phenotype PMID:8370474
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:25075717
GO:0007049 Cell cycle Decreases phenotype PMID:17984142
GO:0007610 Behavior Decreases phenotype PMID:36513211
GO:0007613 Memory Decreases phenotype PMID:36513211
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:22421054
GO:0008283 Cell population proliferation Affects phenotype PMID:17984142
GO:0010424 Dna methylation on cytosine within a cg sequence Affects phenotype PMID:22851337; PMID:24169490; PMID:34009014
GO:0010883 Regulation of lipid storage Affects phenotype PMID:29617909
GO:0031507 Heterochromatin formation Decreases phenotype PMID:26339649
GO:0035094 Response to nicotine Increases phenotype PMID:27589885
GO:0044030 Regulation of dna methylation Increases phenotype PMID:22851337; PMID:37914285
GO:0044237 Cellular metabolic process Affects phenotype PMID:31678612
GO:0045666 Positive regulation of neuron differentiation Increases phenotype PMID:37914285
GO:0045792 Negative regulation of cell size Increases phenotype PMID:29617909; PMID:37914285
GO:0050890 Cognition Decreases phenotype PMID:36513211
GO:1900017 Positive regulation of cytokine production involved in inflammatory response Increases phenotype PMID:29617909
GO:1902009 Positive regulation of toxin transport Decreases phenotype PMID:29501574

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.