Methimazole


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0002027 Regulation of heart rate Decreases phenotype PMID:1387618
GO:0002218 Activation of innate immune response Increases phenotype PMID:26177832
GO:0002720 Positive regulation of cytokine production involved in immune response Affects phenotype PMID:22407903
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:34788025
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:34788025
GO:0006094 Gluconeogenesis Decreases phenotype PMID:29990518
GO:0006695 Cholesterol biosynthetic process Decreases phenotype PMID:29990518
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:26177832; PMID:27421576
GO:0006915 Apoptotic process Increases phenotype PMID:10718548; PMID:11834455; PMID:17171702
GO:0006979 Response to oxidative stress Increases phenotype PMID:21314467
GO:0007049 Cell cycle Decreases phenotype PMID:8404692
GO:0008217 Regulation of blood pressure Increases phenotype PMID:8921835
GO:0008219 Cell death Increases phenotype PMID:14500569
GO:0008283 Cell population proliferation Affects phenotype PMID:20036711; PMID:8404692
GO:0019432 Triglyceride biosynthetic process Decreases phenotype PMID:29990518
GO:0019884 Antigen processing and presentation of exogenous antigen Increases phenotype PMID:25531135
GO:0031987 Locomotion involved in locomotory behavior Affects phenotype PMID:26177832; PMID:34757178
GO:0032689 Negative regulation of type ii interferon production Affects phenotype PMID:22407903
GO:0032753 Positive regulation of interleukin-4 production Affects phenotype PMID:22407903
GO:0032754 Positive regulation of interleukin-5 production Affects phenotype PMID:22407903
GO:0042104 Positive regulation of activated t cell proliferation Increases phenotype PMID:25531135
GO:0042403 Thyroid hormone metabolic process Affects phenotype PMID:20036711; PMID:20036711; PMID:34757178; PMID:34757178
GO:0046058 Camp metabolic process Affects phenotype PMID:20036711
GO:0046620 Regulation of organ growth Decreases phenotype PMID:1387618
GO:0061024 Membrane organization Decreases phenotype PMID:26808022
GO:0070265 Necrotic cell death Increases phenotype PMID:26177832
GO:0071639 Positive regulation of monocyte chemotactic protein-1 production Affects phenotype PMID:22407903
GO:0071954 Chemokine (c-c motif) ligand 11 production Increases phenotype PMID:22407903
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:29964313
GO:2000343 Positive regulation of chemokine (c-x-c motif) ligand 2 production Affects phenotype PMID:22407903
GO:2000553 Positive regulation of t-helper 2 cell cytokine production Affects phenotype PMID:22407903
GO:2000555 Negative regulation of t-helper 1 cell cytokine production Affects phenotype PMID:22407903
GO:2000610 Negative regulation of thyroid hormone generation Increases phenotype PMID:31697382
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.