Nitrofen

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:15253041	IVTH	0.000001 - 0.001 M	0.0001 M	Cancer phenotype	Endocrine-mediated cancer
PMID:15585367	IVTH	0.00000625 M	0.00000625 M	Affects TR-mediated gene expression	Metabolic endocrine-mediated perturbations
	IVTH	0.0000125 M	0.0000125 M	Affects TR-mediated gene expression	Metabolic endocrine-mediated perturbations
	IVTH	0.00000312 M	0.00000312 M	Affects TR-mediated gene expression	Metabolic endocrine-mediated perturbations
	IVTH	0.000025 M	0.000025 M	Affects TR-mediated gene expression	Metabolic endocrine-mediated perturbations
PMID:6829046	IVR	500 mg/kg/day	500 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
PMID:6845349	IVR	150 mg/kg/day	150 mg/kg/day	Affects litter size	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increased testis weights	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Delayed puberty	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects developmental process	Developmental endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects litter size	Reproductive endocrine-mediated perturbations
	IVR	25 mg/kg/day	25 mg/kg/day	Affects developmental process	Developmental endocrine-mediated perturbations
	IVR	6.25 mg/kg/day	6.25 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Affects litter size	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Delayed puberty	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Affects developmental process	Developmental endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Affects survival of live fetus	Reproductive endocrine-mediated perturbations
	IVR	12.5 mg/kg/day	12.5 mg/kg/day	Increased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
	IVR	12.5 mg/kg/day	12.5 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.