| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:17785682 | IVR | 50 mg/kg/day | 50 mg/kg/day | Increased liver weights | Hepatic endocrine-mediated perturbations |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Pregnancy complications | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 15 mg/kg/day | 15 mg/kg/day | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 15 mg/kg/day | 15 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 15 mg/kg/day | 15 mg/kg/day | Affects anogenital distance in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 15 mg/kg/day | 15 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| PMID:18067565 | IVR | 50 mg/kg/day | 50 mg/kg/day | Decreased estradiol levels | Reproductive endocrine-mediated perturbations |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:20708073 | IVTH | 0.000000001 - 0.0001 M | 0.00000625 - 0.000075 M | Cancer phenotype | Endocrine-mediated cancer |
| IVTH | 0.0000001 - 0.00003 M | 0.000003 - 0.00003 M | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000001 - 0.00003 M | 0.0000003 - 0.00003 M | Increased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000001 - 0.00003 M | 0.0000001 - 0.00003 M | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| PMID:22140080 | IVR | 100 mg/kg | - | No significant effects observed | - |
| IVR | 50 mg/kg | - | No significant effects observed | - | |
| IVR | 150 mg/kg | 150 mg/kg | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| IVR | 150 mg/kg | 150 mg/kg | Undescended testes (or cryptorchidism) | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.