Finasteride

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:10641015	IVR	25 mg/kg	25 mg/kg	Decreased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	25 mg/kg	25 mg/kg	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
PMID:11248141	IVR	20 mg/kg/day	20 mg/kg/day	Alterations in preputial separation	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Decreased Dihydroxytestosterone (DHT) levels	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Decreased weights of epididymis	Reproductive endocrine-mediated perturbations
	IVR	80 mg/kg/day	80 mg/kg/day	Decreased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	80 mg/kg/day	80 mg/kg/day	Alterations in preputial separation	Reproductive endocrine-mediated perturbations
	IVR	80 mg/kg/day	80 mg/kg/day	Decreased Dihydroxytestosterone (DHT) levels	Reproductive endocrine-mediated perturbations
	IVR	80 mg/kg/day	80 mg/kg/day	Decreased weights of epididymis	Reproductive endocrine-mediated perturbations
	IVR	80 mg/kg/day	80 mg/kg/day	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
PMID:15013065	IVR	5 mg/kg/day	5 mg/kg/day	Increased cowper's gland weights	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Increased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Increased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Increased cowper's gland weights	Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg/day	-	No significant effects observed	-
	IVR	25 mg/kg/day	25 mg/kg/day	Increased weights of penis	Reproductive endocrine-mediated perturbations
	IVR	25 mg/kg/day	25 mg/kg/day	Increased cowper's gland weights	Reproductive endocrine-mediated perturbations
	IVR	25 mg/kg/day	25 mg/kg/day	Increased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	25 mg/kg/day	25 mg/kg/day	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
PMID:30768126	IVR	10 mg/kg/day	10 mg/kg/day	Affects fatty acid metabolism	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects developmental process	Developmental endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects calcium signaling	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects gluconeogenesis	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects glucose metabolism	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Exhibit sexual dimorphism	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.