| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:11876496 | IVR | 5 mg/kg | 5 mg/kg | Affects sertoli cells function | Reproductive endocrine-mediated perturbations |
| IVR | 5 mg/kg | 5 mg/kg | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Decreased weights of adrenal gland | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Decreased weights of pituitary gland | Neurological endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg | 20 mg/kg | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg | 20 mg/kg | Affects sertoli cells function | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg | 20 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg | 20 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg | 20 mg/kg | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg | 20 mg/kg | Decreased weights of adrenal gland | Metabolic endocrine-mediated perturbations | |
| IVR | 20 mg/kg | 20 mg/kg | Decreased weights of pituitary gland | Neurological endocrine-mediated perturbations | |
| IVR | 80 mg/kg | 80 mg/kg | Affects morphology of hepatocytes | Hepatic endocrine-mediated perturbations | |
| IVR | 80 mg/kg | 80 mg/kg | Affects sertoli cells function | Reproductive endocrine-mediated perturbations | |
| IVR | 80 mg/kg | 80 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 80 mg/kg | 80 mg/kg | Affects survival of germ cells | Reproductive endocrine-mediated perturbations | |
| IVR | 80 mg/kg | 80 mg/kg | Atrophy in seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 80 mg/kg | 80 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 80 mg/kg | 80 mg/kg | Changes in epididymal morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 80 mg/kg | 80 mg/kg | Decreased weights of pituitary gland | Neurological endocrine-mediated perturbations | |
| IVR | 80 mg/kg | 80 mg/kg | Decreased liver weights | Hepatic endocrine-media | |
| IVR | 80 mg/kg | 80 mg/kg | Decreased weights of adrenal gland | ||
| IVR | 80 mg/kg | 80 mg/kg | Affects folliculogenesis | ||
| IVR | 80 mg/kg | 80 mg/kg | Affects uterine morphology | ||
| IVR | 80 mg/kg | 80 mg/kg | Atrophy of adrenal gland | ||
| IVR | 80 mg/kg | 80 mg/kg | Alteration in vaginal morphology | ||
| IVR | 80 mg/kg | 80 mg/kg | Decreased ovarian weights | ||
| IVR | 80 mg/kg | 80 mg/kg | Increased FSH levels | ||
| IVR | 80 mg/kg | 80 mg/kg | Induce apoptosis of endometrial cells | ||
| IVR | 80 mg/kg | 80 mg/kg | Reduced sperm counts | ||
| IVR | 80 mg/kg | 80 mg/kg | Decreased weights of epididymis | ||
| IVR | 80 mg/kg | 80 mg/kg | Decreased testis weights | ||
| PMID:14580781 | IVR | 100 mg/kg | 100 mg/kg | Uterine hyperplasia | Reproductive endocrine-mediated perturbations |
| IVR | 100 mg/kg | 100 mg/kg | Changes in mammary gland morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Decreased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Increase in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Affects locomotor activity | Neurological endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Hypertrophy in thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Changes in adrenal gland morphology | Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Increased Acid phosphatase (ACP) activity in the liver | Hepatic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Decreased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Increased Acid phosphatase (ACP) activity in the liver | Hepatic endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Affects locomotor activity | Neurological endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 600 mg/kg | 600 mg/kg | Decreased thymus gland weights | Immunological endocrine-mediated perturbations | |
| IVR | 600 mg/kg | 600 mg/kg | Changes in adrenal gland morphology | Metabolic endocrine-mediated perturbations | |
| IVR | 600 mg/kg | 600 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 600 mg/kg | 600 mg/kg | Increase in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 600 mg/kg | 600 mg/kg | Affects locomotor activity | Neurological endocrine-mediated perturbations | |
| IVR | 600 mg/kg | 600 mg/kg | Decrease in T3 levels | Metabolic endocrin | |
| IVR | 600 mg/kg | 600 mg/kg | Increased weights of adrenal gland | ||
| IVR | 600 mg/kg | 600 mg/kg | Hypertrophy in thyroid gland | ||
| IVR | 600 mg/kg | 600 mg/kg | Decreased ovarian weights | ||
| IVR | 600 mg/kg | 600 mg/kg | Decreased cholesterol levels | ||
| IVR | 600 mg/kg | 600 mg/kg | Uterine hyperplasia | ||
| IVR | 600 mg/kg | 600 mg/kg | Increase in TSH levels | ||
| IVR | 600 mg/kg | 600 mg/kg | Changes in mammary gland morphology | ||
| IVR | 600 mg/kg | 600 mg/kg | Increased uterine weights | ||
| IVR | 600 mg/kg | 600 mg/kg | Abnormal estrous cycles | ||
| IVR | 40 mg/kg | 40 mg/kg | Oligospermic | ||
| IVR | 40 mg/kg | 40 mg/kg | Reduced sperm counts | ||
| IVR | 40 mg/kg | 40 mg/kg | Decreased weights of epididymis | ||
| IVR | 40 mg/kg | 40 mg/kg | Decreased LH levels | ||
| IVR | 40 mg/kg | 40 mg/kg | |||
| IVR | 40 mg/kg | 40 mg/kg | |||
| IVR | 40 mg/kg | 40 mg/kg | |||
| IVR | 40 mg/kg | 40 mg/kg | |||
| IVR | 40 mg/kg | 40 mg/kg | |||
| IVR | 40 mg/kg | 40 mg/kg | |||
| IVR | 40 mg/kg | 40 mg/kg | |||
| IVR | 40 mg/kg | 40 mg/kg | |||
| IVR | 40 mg/kg | 40 mg/kg | |||
| IVR | 200 mg/kg | 200 mg/kg | |||
| IVR | 200 mg/kg | 200 mg/kg | |||
| IVR | 200 mg/kg | 200 mg/kg | |||
| IVR | 200 mg/kg | 200 mg/kg | |||
| IVR | 200 mg/kg | 200 mg/kg | |||
| IVR | 200 mg/kg | 200 mg/kg | |||
| IVR | 200 mg/kg | 200 mg/kg | |||
| IVR | 200 mg/kg | 200 mg/kg | |||
| IVR | 200 mg/kg | 200 mg/kg | |||
| IVR | 200 mg/kg | 200 mg/kg | |||
| IVR | 200 mg/kg | 200 mg/kg | |||
| IVR | 200 mg/kg | 200 mg/kg | |||
| IVR | 200 mg/kg | 200 mg/kg | |||
| IVR | 200 mg/kg | 200 mg/kg | |||
| IVR | 200 mg/kg | 200 mg/kg | |||
| IVR | 200 mg/kg | 200 mg/kg | |||
| IVR | 200 mg/kg | 200 mg/kg | |||
| IVR | 200 mg/kg | 200 mg/kg | |||
| PMID:15013065 | IVR | 2 mg/kg/day | 2 mg/kg/day | Decreased weights of adrenal gland | Metabolic endocrine-mediated perturbations |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Increased weights of bulbocavernosus muscles/LABC | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Increased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 40 mg/kg/day | 40 mg/kg/day | Increased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 40 mg/kg/day | 40 mg/kg/day | Increased weights of bulbocavernosus muscles/LABC | Reproductive endocrine-mediated perturbations | |
| IVR | 40 mg/kg/day | 40 mg/kg/day | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 40 mg/kg/day | 40 mg/kg/day | Increased cowper's gland weights | Reproductive endocrine-mediated perturbations | |
| IVR | 40 mg/kg/day | 40 mg/kg/day | Increased weights of penis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.5 mg/kg/day | - | No significant effects observed | - | |
| PMID:15337578 | IVR | 40 mg/kg | 40 mg/kg | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations |
| IVR | 40 mg/kg | 40 mg/kg | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 40 mg/kg | 40 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 40 mg/kg | 40 mg/kg | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 40 mg/kg | 40 mg/kg | Decreased thymus gland weights | Immunological endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.