Benzophenone-2

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:15458793	IVR	250 mg/kg	250 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	250 mg/kg	250 mg/kg	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	250 mg/kg	250 mg/kg	Affects developmental process	Developmental endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Affects developmental process	Developmental endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
PMID:15458797	IVR	250 mg/kg	250 mg/kg	Affects the normal functioning of reproductive system	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Affects the normal functioning of reproductive system	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Affects expression of estrogen receptor-beta (ER-beta)	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
PMID:15721882	IVR	625 mg/kg/day	-	No significant effects observed	-
	IVR	250 mg/kg/day	-	No significant effects observed	-
	IVR	100 mg/kg/day	100 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
PMID:15951094	IVR	153 mg/kg	153 mg/kg	Increased triglycerides level	Metabolic endocrine-mediated perturbations
	IVR	153 mg/kg	153 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	677 mg/kg	677 mg/kg	Increased LH levels	Reproductive endocrine-mediated perturbations
PMID:17379648	IVR	0.01 mg/kg	-	No significant effects observed	-
	IVR	0.1 mg/kg	-	No significant effects observed	-
	IVR	0.033 mg/kg	-	No significant effects observed	-
	IVR	1 mg/kg	1 mg/kg	Increase in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	0.333 mg/kg	0.333 mg/kg	Increase in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	0.333 mg/kg	0.333 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
PMID:21726595	IVR	50 mg/kg	50 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Affects leydig cells function	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:28990245	IVTH	0.00001 M	-	No significant effects observed	-
	IVTH	0.0000001 M	0.0000001 M	Induced migration capability of tumor cells	Endocrine-mediated cancer
PMID:30817981	IVTH	0.000005 M	0.000005 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000005 M	0.000005 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations

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