| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:2363183 | IVR | 20 - 80 mg/kg | 30 mg/kg | Affects androgen production | Reproductive endocrine-mediated perturbations |
| IVR | 20 - 80 mg/kg | 40 mg/kg | Decreased Dihydroxytestosterone (DHT) levels | Reproductive endocrine-mediated perturbations | |
| IVR | 20 - 80 mg/kg | 40 mg/kg | Alteration in prostate morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 20 - 80 mg/kg | 40 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 20 - 80 mg/kg | 80 mg/kg | Decreased Dihydroxytestosterone (DHT) levels | Reproductive endocrine-mediated perturbations | |
| IVR | 20 - 80 mg/kg | 80 mg/kg | Alteration in prostate morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 20 - 80 mg/kg | 80 mg/kg | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 20 - 80 mg/kg | 80 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 20 - 80 mg/kg | 80 mg/kg | Decreased weights of accessory sex organs | Reproductive endocrine-mediated perturbations | |
| PMID:27152447 | IVTH | 0.0000008 - 0.00005 M | 0.000025 - 0.00005 M | Decreased estradiol levels | Reproductive endocrine-mediated perturbations |
| PMID:3564018 | IVR | 20 mg/kg | 20 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations |
| IVR | 40 mg/kg | 40 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 80 mg/kg | 80 mg/kg | Decreased weights of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 80 mg/kg | 80 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 80 mg/kg | 80 mg/kg | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| PMID:3593420 | IVR | 20 mg/kg | 20 mg/kg | Affects glucose metabolism | Metabolic endocrine-mediated perturbations |
| IVR | 20 mg/kg | 20 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 40 mg/kg | 40 mg/kg | Affects glucose metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 40 mg/kg | 40 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 80 mg/kg | 80 mg/kg | Affects liver function | Hepatic endocrine-mediated perturbations | |
| IVR | 80 mg/kg | 80 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| PMID:4032495 | IVR | 75 mg/kg | 75 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations |
| IVR | 75 mg/kg | 75 mg/kg | Decrease in T3 levels | Metabolic endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.