| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:12419695 | IVR | 1 % | 1 % | Decreased testosterone levels | Reproductive endocrine-mediated perturbations |
| IVR | 1 % | 1 % | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 0.01 % | - | No significant effects observed | - | |
| IVR | 0.1 % | 0.1 % | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| PMID:20132880 | IVR | 250 mg/kg | 250 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations |
| IVR | 62.5 mg/kg | - | No significant effects observed | - | |
| IVR | 1000 mg/kg | 1000 mg/kg | Alterations in endometrial morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg | 1000 mg/kg | Increased weights of adrenal gland | Metabolic endocrine-mediated perturbations | |
| PMID:22777679 | IVR | 62.5 mg/kg/day | 62.5 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Affects uterine contraction | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects uterine contraction | Reproductive endocrine-mediated perturbations | |
| PMID:31939680 | IVTH | 0.000001 - 1 M | 0.000001 - 1 M | Induce DNA damage in mammary gland cells | Reproductive endocrine-mediated perturbations |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.000001 - 1 mg/kg/day | 0.000001 - 1 mg/kg/day | Induce DNA damage in mammary gland cells | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00001 M | 0.00001 M | Alters estrogen-responsive genes | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Changes in mammary gland morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| PMID:33724348 | IVR | 0.02 - 1 mg/kg/day | 0.02 - 1 mg/kg/day | Alters estrogen-responsive genes | Reproductive endocrine-mediated perturbations |
| IVR | 0.02 - 1 mg/kg/day | 0.02 - 1 mg/kg/day | Changes in mammary gland morphology | Reproductive endocrine-mediated perturbations | |
| PMID:33957517 | IVR | 7.5 - 45 mg/kg/day | 7.5 - 45 mg/kg/day | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations |
| IVR | 45 mg/kg/day | 45 mg/kg/day | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 7.5 - 45 mg/kg/day | 7.5 - 45 mg/kg/day | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 7.5 - 45 mg/kg/day | 7.5 - 45 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 7.5 - 45 mg/kg/day | 7.5 - 45 mg/kg/day | Affects ovarian follicles population | Reproductive endocrine-mediated perturbations | |
| IVR | 7.5 - 45 mg/kg/day | 7.5 - 45 mg/kg/day | Induce apoptosis in ovary | Reproductive endocrine-mediated perturbations | |
| IVR | 7.5 - 45 mg/kg/day | 7.5 - 45 mg/kg/day | Changes in ovarian morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 7.5 - 45 mg/kg/day | 7.5 - 45 mg/kg/day | Causes inflammation | Immunological endocrine-mediated perturbations | |
| IVR | 7.5 - 45 mg/kg/day | 7.5 - 45 mg/kg/day | Affects intracellular signaling pathway | Metabolic endocrine-mediated perturbations | |
| IVR | 7.5 - 45 mg/kg/day | 7.5 - 45 mg/kg/day | Oxidative stress in ovaries | Reproductive endocrine-mediated perturbations | |
| IVR | 7.5 - 45 mg/kg/day | 7.5 - 45 mg/kg/day | Epigenomic alterations in ovary | Reproductive endocrine-mediated perturbations | |
| PMID:34101200 | IVR | 25 mg/kg | 25 mg/kg | Affects implantation | Reproductive endocrine-mediated perturbations |
| IVR | 25 mg/kg | 25 mg/kg | Affects fertility | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg | 25 mg/kg | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg | 25 mg/kg | Decreased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg | 25 mg/kg | Affects expression of progesterone receptor (PR) | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg | 25 mg/kg | Affects uterine morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg | 25 mg/kg | Affects expression of estrogen receptor (ER) | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg | 25 mg/kg | Alterations in endometrial morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg | 25 mg/kg | Increased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg | 25 mg/kg | Affects uterine function | Reproductive endocrine-mediated perturbations | |
| PMID:34365652 | IVR | 1 mg/kg | 1 mg/kg | Affects ovarian follicles population | Reproductive endocrine-mediated perturbations |
| IVR | 1 mg/kg | 1 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0000001 - 1 mg/kg | 0.0000001 - 1 mg/kg | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0000001 - 1 mg/kg | 0.0000001 - 1 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000001 - 1 M | 0.0000001 - 1 M | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000001 - 1 M | 0.0000001 - 1 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:35325608 | IVR | 7.5 mg/kg/day | 7.5 mg/kg/day | Affects survival of live fetus | Reproductive endocrine-mediated perturbations |
| IVR | 7.5 mg/kg/day | 7.5 mg/kg/day | Affects fertility | Reproductive endocrine-mediated perturbations | |
| IVR | 7.5 mg/kg/day | 7.5 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 7.5 mg/kg/day | 7.5 mg/kg/day | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 7.5 mg/kg/day | 7.5 mg/kg/day | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 7.5 mg/kg/day | 7.5 mg/kg/day | Affects intracellular signaling pathway | Metabolic endocrine-mediated perturbations | |
| IVR | 7.5 mg/kg/day | 7.5 mg/kg/day | Affects ovarian follicles population | Reproductive endocrine-mediated perturbations | |
| IVR | 7.5 mg/kg/day | 7.5 mg/kg/day | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| PMID:35810903 | IVTH | 0.00001 - 0.0001 M | 0.00001 - 0.0001 M | Cancer phenotype | Endocrine-mediated cancer |
| PMID:36702264 | IVTH | 0.000001 - 0.0001 M | 0.000001 - 0.0001 M | Cancer phenotype | Endocrine-mediated cancer |
| IVTH | 0.0001 M | 0.0001 M | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.000001 - 0.0001 M | 0.000001 - 0.0001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:37249771 | IVR | 1 mg/kg/day | 1 mg/kg/day | Affects sperm motility | Reproductive endocrine-mediated perturbations |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Oxidative stress in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Causes inflammation | Immunological endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Decreased Dihydroxytestosterone (DHT) levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| PMID:37409182 | IVTH | 0.000002 - 0.00002 M | 0.000002 - 0.00002 M | Alters estrogen-responsive genes | Reproductive endocrine-mediated perturbations |
| PMID:38316851 | IVTH | 0.00000000001 - 0.00000001 M | 0.0000000003986 M | Cancer phenotype | Endocrine-mediated cancer |
| IVTH | 0.00000000001 - 0.00000001 M | 0.00000000001 - 0.00000001 M | Cancer phenotype | Endocrine-mediated cancer | |
| IVTH | 0.000000001 M | 0.000000001 M | Alters estrogen-responsive genes | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.