Iprodione

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Descriptors
• Chemical-gene interaction
• Chemical-phenotype interaction
• Chemical-disease association
• ToxCast endpoints
• Associated AOPs
• Presence in consumer products
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:17931804	IVR	50 mg/kg/day	50 mg/kg/day	Decreased aldosterone levels	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Alterations in preputial separation	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Delayed puberty	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Delayed puberty	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Decreased weights of epididymis	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Alterations in preputial separation	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Increased weights of adrenal gland	Metabolic endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Decreased aldosterone levels	Metabolic endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
PMID:34060014	IVR	2 mg/kg	2 mg/kg	Alteration in prostate morphology	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Induce apoptosis in testis	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Changes in testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Affects testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Abnormal sperm morphology	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Abnormal development of gonads in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Decreased body weights	Metabolic endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Changes in epididymal morphology	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:37959855	IVTH	0.00000001 - 0.000005 M	0.00000001 - 0.000005 M	Cancer phenotype	Endocrine-mediated cancer

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DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.