| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:37852555 | IVTH | 0.00001 - 0.0005 M | 0.00001 - 0.0005 M | Decreased estradiol levels | Reproductive endocrine-mediated perturbations |
| IVTH | 0.00001 - 0.0005 M | 0.00001 - 0.0005 M | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00001 - 0.0005 M | 0.00001 - 0.0005 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:38499550 | IVR | 1 ppm | 1 ppm | Decrease in T4 levels | Metabolic endocrine-mediated perturbations |
| IVR | 1 ppm | 1 ppm | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1 ppm | 1 ppm | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 1 ppm | 1 ppm | Hypertrophy in thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 1 ppm | 1 ppm | Hyperplasia in thyroid gland | Metabolic endocrine-mediated perturbations | |
| PMID:39365753 | IVTH | 0.00003 M | 0.00003 M | Decreased androgen levels | Reproductive endocrine-mediated perturbations |
| IVTH | 0.00003 M | 0.00003 M | Decreased estrogen levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00003 M | 0.00003 M | Increased progesterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:7749267 | IVR | 50 mg/kg | 50 mg/kg | Affects survival of live fetus | Reproductive endocrine-mediated perturbations |
| IVR | 50 mg/kg | 50 mg/kg | Affects skeletal development in fetus | Developmental endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Affects embryonic development | Developmental endocrine-mediated perturbations | |
| IVR | 75 mg/kg | 75 mg/kg | Affects skeletal development in fetus | Developmental endocrine-mediated perturbations | |
| IVR | 20 mg/kg | 20 mg/kg | Affects uterine morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 75 mg/kg | 75 mg/kg | Affects survival of live fetus | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg | 20 mg/kg | Affects developmental process | Developmental endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.