Mestranol

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Descriptors
• Chemical-gene interaction
• Chemical-phenotype interaction
• Chemical-disease association
• ToxCast endpoints
• Associated AOPs
• Presence in consumer products
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:36098747	IVR	0.05 - 0.15 mg/kg/day	0.05 - 0.15 mg/kg/day	Decreased body weights	Metabolic endocrine-mediated perturbations
	IVR	0.05 - 0.15 mg/L	0.05 - 0.15 mg/L	Decreased liver weights	Hepatic endocrine-mediated perturbations
	IVR	0.15 mg/L	0.15 mg/L	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	0.15 mg/L	0.15 mg/L	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	0.05 - 0.15 mg/kg/day	0.05 - 0.15 mg/kg/day	Decreased liver weights	Hepatic endocrine-mediated perturbations
	IVR	0.05 - 5 mg/kg/day	0.05 - 5 mg/kg/day	Affects leydig cells function	Reproductive endocrine-mediated perturbations
	IVR	0.15 mg/L	0.15 mg/L	Abnormal proliferation of germ cells	Reproductive endocrine-mediated perturbations
	IVR	0.05 - 5 mg/kg/day	0.05 - 5 mg/kg/day	Affects testicular development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.05 - 0.15 mg/L	0.05 - 0.15 mg/L	Alterations in number of leydig cells	Reproductive endocrine-mediated perturbations
	IVR	0.05 - 0.15 mg/L	0.05 - 0.15 mg/L	Decreased body weights	Metabolic endocrine-mediated perturbations
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Affects estrogen signaling	Reproductive endocrine-mediated perturbations
	IVR	0.05 - 0.15 mg/L	0.05 - 0.15 mg/L	Changes in testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.05 - 0.15 mg/kg/day	0.05 - 0.15 mg/kg/day	Alterations in number of leydig cells	Reproductive endocrine-mediated perturbations
	IVR	0.05 - 0.15 mg/kg/day	0.05 - 0.15 mg/kg/day	Changes in testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	0.05 - 5 mg/L	0.05 - 5 mg/L	Affects testicular development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.15 mg/L	0.15 mg/L	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	0.05 - 0.15 mg/L	0.05 - 0.15 mg/L	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	0.15 mg/L	0.15 mg/L	Decreased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	0.15 mg/L	0.15 mg/L	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Decreased gonadotropin-releasing hormone (GnRH) levels	Reproductive endocrine-med
	IVR	0.05 - 0.15 mg/kg/day	0.05 - 0.15 mg/kg/day	Affects anogenital distance

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.