| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:10641015 | IVR | 500 mg/kg | 500 mg/kg | Decreased testis weights | Reproductive endocrine-mediated perturbations |
| IVR | 500 mg/kg | 500 mg/kg | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg | 500 mg/kg | Alterations in preputial separation | Reproductive endocrine-mediated perturbations | |
| PMID:15518916 | IVR | 0.087 M | 0.087 M | Affects spatial memory | Neurological endocrine-mediated perturbations |
| IVR | 0.087 M | 0.087 M | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| IVR | 0.087 M | 0.087 M | Affects locomotor activity | Neurological endocrine-mediated perturbations | |
| PMID:15620428 | IVR | 0.087 M | 0.087 M | Affects social behavior | Neurological endocrine-mediated perturbations |
| IVR | 0.087 M | 0.087 M | Affects dopaminergic pathways | Neurological endocrine-mediated perturbations | |
| IVR | 0.087 M | 0.087 M | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| PMID:15883486 | IVTH | 0.000000001 - 0.001 M | 0.000001 - 0.0001 M | Cancer phenotype | Endocrine-mediated cancer |
| PMID:16493179 | IVR | 200 mg/L | 200 mg/L | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 200 mg/L | 200 mg/L | Altered lordosis | Developmental endocrine-mediated perturbations | |
| IVR | 10000 mg/L | 10000 mg/L | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 2000 mg/L | 2000 mg/L | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 2000 mg/L | 2000 mg/L | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 10000 mg/L | 10000 mg/L | Affects embryonic development | Developmental endocrine-mediated perturbations | |
| IVR | 2000 mg/L | 2000 mg/L | Altered lordosis | Developmental endocrine-mediated perturbations | |
| IVR | 2000 mg/L | 2000 mg/L | Affects embryonic development | Developmental endocrine-mediated perturbations | |
| IVR | 10000 mg/L | 10000 mg/L | Altered lordosis | Developmental endocrine-mediated perturbations | |
| IVR | 20 mg/L | 20 mg/L | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/L | 20 mg/L | Altered lordosis | Developmental endocrine-mediated perturbations | |
| IVR | 10000 mg/L | 10000 mg/L | Affects anogenital distance in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| PMID:17379376 | IVR | 250 mg/kg/day | - | No significant effects observed | - |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Increased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects expression of estrogen receptor-beta (ER-beta) | Reproductive endocrine-mediated perturbations | |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Lead to obesity | Metabolic endocrine-mediated perturbations | |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Affects expression of thyroid receptor (TR) | Metabolic endocrine-mediated perturbations | |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Affects expression of estrogen receptor-beta (ER-beta) | Reproductive endocrine-mediated perturbations | |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Affects expression of androgen receptor (AR) | Reproductive endocrine-mediated perturbations | |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Affects testis development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Affects cholesterol transport | Metabolic endocrine-mediated perturbations | |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects expression of androgen receptor (AR) | Reproductive endocrine-mediated perturbations | |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Alterations in immune responses | Immunological endocrine-mediated perturbations | |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Affects fatty acid metabolism | Metabolic endocrine-mediated perturbations | |
| PMID:17654256 | IVR | 100 mg/kg | 100 mg/kg | Increased prostate weights | Reproductive endocrine-mediated perturbations |
| IVR | 500 mg/kg | 500 mg/kg | Increased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg | 20 mg/kg | Increased prostate weights | Reproductive endocrine-mediated perturbations | |
| PMID:17725530 | IVTH | 0 | - | Affects fertility | Reproductive endocrine-mediated perturbations |
| PMID:19533667 | IVR | 1 % | 1 % | Affects spatial learning | Neurological endocrine-mediated perturbations |
| IVR | 1 % | 1 % | Affects spatial memory | Neurological endocrine-mediated perturbations | |
| IVR | 1 % | 1 % | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 1 % | 1 % | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1 % | 1 % | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 0.111 % | - | No significant effects observed | - | |
| IVR | 0.037 % | 0.037 % | Affects spatial memory | Neurological endocrine-mediated perturbations | |
| IVR | 0.037 % | 0.037 % | Affects spatial learning | Neurological endocrine-mediated perturbations | |
| IVR | 0.333 % | 0.333 % | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| PMID:19903717 | IVR | 250 mg/kg/day | 250 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Induce apoptosis of spermatogenic cells | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:21657945 | IVR | 750 mg/kg/day | 750 mg/kg/day | Affects Wnt signaling pathway | Developmental endocrine-mediated perturbations |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Abnormal development of gonads in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| PMID:21841806 | IVR | 10 mg/kg/day | 10 mg/kg/day | Increased FSH levels | Reproductive endocrine-mediated perturbations |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Alterations in number of sertoli cells | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Alterations in number of sertoli cells | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Cancer phenotype | Endocrine-mediated cancer | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| PMID:22179484 | IVTH | 0.00000001 - 0.00001 M | 0.0000001 - 0.00001 M | Induced migration capability of tumor cells | Endocrine-mediated cancer |
| IVTH | 0.00000001 - 0.00001 M | 0.0000001 - 0.00001 M | Cancer phenotype | Endocrine-mediated cancer | |
| PMID:22238399 | IVR | 500 mg/kg | 500 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 500 mg/kg | 500 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:23314658 | IVR | 250 mg/kg/day | 250 mg/kg/day | Abnormal development of gonads in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| PMID:23536518 | IVR | 5 mg/kg/day | 5 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| PMID:23766129 | IVR | 250 mg/kg/day | 250 mg/kg/day | Affects spermatogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Increased inhibin-B cells | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | - | No significant effects observed | - | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increased inhibin-B cells | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Alterations in number of sertoli cells | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Increased inhibin-B cells | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Increased inhibin-B cells | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Increased inhibin-B cells | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:25016925 | IVTH | 0.000000001 - 0.000001 M | 0.000000001 - 0.000001 M | Cancer phenotype | Endocrine-mediated cancer |
| IVTH | 0.000000001 - 0.000001 M | 0.000000001 - 0.000001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:25614580 | IVR | 2 - 6 mg/kg/day | 2 - 6 mg/kg/day | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations |
| IVR | 2 - 6 mg/kg/day | 2 - 6 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 2 - 6 mg/kg/day | 2 - 6 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 2 - 6 mg/kg/day | 2 - 6 mg/kg/day | Decreased Lactate dehydrogenase (LDH) levels | Metabolic endocrine-mediated perturbations | |
| IVR | 2 - 6 mg/kg/day | 2 - 6 mg/kg/day | Oxidative stress in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 2 - 6 mg/kg/day | 2 - 6 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 2 - 6 mg/kg/day | 2 - 6 mg/kg/day | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 2 - 6 mg/kg/day | 2 - 6 mg/kg/day | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| PMID:25697569 | IVR | 5 mg/kg/day | 5 mg/kg/day | Lead to obesity | Metabolic endocrine-mediated perturbations |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Alteration in prostate morphology | Reproductive endocrine-mediated perturbations | |
| PMID:25765776 | IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Increased FSH levels | Reproductive endocrine-mediated perturbations |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Induce apoptosis of ovarian follicles | Reproductive endocrine-mediated perturbations | |
| IVR | 0.01 mg/kg/day | 0.01 mg/kg/day | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.01 mg/kg/day | 0.01 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Induce apoptosis of ovarian follicles | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| PMID:26948521 | IVR | 750 mg/kg/day | 750 mg/kg/day | Abnormal development of gonads in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:27943041 | IVR | 500 mg/kg/day | 500 mg/kg/day | Affects neural development | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects survival of live fetus | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects litter size | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects skeletal development | Developmental endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects implantation | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Decreased placental weights | Reproductive endocrine-mediated perturbations | |
| PMID:28104404 | IVTH | 0.01 - 100 mg/L | 10 - 100 mg/L | Decreased estradiol levels | Reproductive endocrine-mediated perturbations |
| IVTH | 0.01 - 100 mg/L | 10 - 100 mg/L | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.01 - 100 mg/L | 10 - 100 mg/L | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:28641505 | IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Alterations in number of sertoli cells | Reproductive endocrine-mediated perturbations | |
| PMID:28823096 | IVR | 50 mg/kg | 50 mg/kg | Affects the biochemical composition of liver | Hepatic endocrine-mediated perturbations |
| IVR | 50 mg/kg | 50 mg/kg | Elevated glucose levels | Metabolic endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Affects the biochemical composition of liver | Hepatic endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Decreased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Increased Lactate dehydrogenase (LDH) levels | Metabolic endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Elevated glucose levels | Metabolic endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Decreased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| PMID:28898977 | IVR | 500 mg/kg | 500 mg/kg | Affects the biochemical composition of testis | Reproductive endocrine-mediated perturbations |
| IVR | 500 mg/kg | 500 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| PMID:28918339 | IVTH | 0.0000000000001 - 0.00001 M | 0.00000001 M | Affects estrogen metabolism | Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVTH | 0.0000000000001 - 0.00001 M | 0.00000001 M | Affects prostate development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| PMID:29064414 | IVR | 250 mg/kg/day | 250 mg/kg/day | Affects testicular morphology | Reproductive endocrine-mediated perturbations |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Affects anogenital distance in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Induce apoptosis in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Affects testis development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Induce apoptosis in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Affects anogenital distance in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Induce apoptosis in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Induce apoptosis of sertoli cells | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects anogenital distance in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects testis development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Cancer phenotype | Endocrine-mediated cancer | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Induce apoptosis of sertoli cells | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Cancer phenotype | Endocrine-mediated cancer | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Induce apoptosis of sertoli cells | Reproductive endocrine-mediated perturbations | |
| PMID:29137315 | IVR | 500 mg/kg/day | 500 mg/kg/day | Affects anogenital distance in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Alterations in immune responses | Immunological endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Increased testis weights in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| PMID:29969652 | IVR | 250 mg/kg/day | 250 mg/kg/day | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Affects ovarian follicles population | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| PMID:30031264 | IVR | 250 mg/kg/day | 250 mg/kg/day | Decreased testosterone levels in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Decreased testosterone levels in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 125 mg/kg/day | - | No significant effects observed | - | |
| PMID:30391722 | IVTH | 0.000000002 M | - | No significant effects observed | - |
| IVTH | 0.000002 M | - | No significant effects observed | - | |
| IVTH | 0.00000002 M | - | No significant effects observed | - | |
| IVTH | 0.0000002 M | - | No significant effects observed | - | |
| IVTH | 0.000006 M | 0.000006 M | Alters sperm function | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.000006 M | 0.000006 M | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| PMID:30940548 | IVR | 5 mg/kg/day | 5 mg/kg/day | Increased cholesterol levels in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations |
| IVR | 50 mg/kg/day | - | No significant effects observed | - | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Increased triglycerides level in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Alterations in vaginal opening of offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Elevated glucose levels in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
| PMID:31158667 | IVR | 1 mg/kg | - | No significant effects observed | - |
| IVR | 10 mg/kg | 10 mg/kg | Affects ovulation | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Affects ovulation | Reproductive endocrine-mediated perturbations | |
| PMID:31318015 | IVR | 1 mg/kg/day | 1 mg/kg/day | Affects folliculogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Affects ovarian function | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Cancer phenotype | Endocrine-mediated cancer | |
| IVR | 0.01 mg/kg/day | 0.01 mg/kg/day | Cancer phenotype | Endocrine-mediated cancer | |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Affects ovarian function | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Cancer phenotype | Endocrine-mediated cancer | |
| PMID:31387634 | IVR | 500 mg/kg/day | 500 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations |
| IVR | 50 mg/kg/day | - | No significant effects observed | - | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects intracellular signaling pathway | Metabolic endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects intracellular signaling pathway | Metabolic endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| PMID:31979393 | IVR | 5 mg/kg/day | 5 mg/kg/day | Induce behavioral changes | Neurological endocrine-mediated perturbations |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Elevated glucose levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Decreased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increased LDL levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increased triglycerides level | Metabolic endocrine-mediated perturbations | |
| PMID:32292708 | IVR | 5 mg/kg/day | 5 mg/kg/day | Decrease in T3 levels | Metabolic endocrine-mediated perturbations |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Affects neuronal function | Neurological endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Decrease in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Changes in brain morphology | Neurological endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Neuronal degeneration | Neurological endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Decreased body weights | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Reduced acetylcholinesterase activity | Neurological endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Induce behavioral changes | Neurological endocrine-mediated perturbations | |
| PMID:32334352 | IVTH | 0.0001 - 0.001 M | 0.0001 - 0.001 M | Cancer phenotype | Endocrine-mediated cancer |
| IVTH | 0.0000025 - 0.0025 M | 0.0000025 - 0.0025 M | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00000025 - 0.0025 M | 0.00000025 - 0.0025 M | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:32388187 | IVR | 5 - 25 mg/kg/day | 5 - 25 mg/kg/day | Increased gonadotropin-releasing hormone (GnRH) levels | Reproductive endocrine-mediated perturbations |
| PMID:32497820 | IVR | 25 mg/kg/day | 25 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Affects testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:32810643 | IVR | 75 mg/kg | 75 mg/kg | Elevated glucose levels | Metabolic endocrine-mediated perturbations |
| IVR | 75 mg/kg | 75 mg/kg | Affects pancreas development | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
| PMID:33004990 | IVR | 5 mg/kg/day | 5 mg/kg/day | Increased adiposity | Metabolic endocrine-mediated perturbations |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Affects lipid metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Lead to obesity | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increased triglycerides level | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increased leptin levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Elevated insulin levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increased adipose tissue weights | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Changes in morphology of adipose tissue | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Elevated glucose levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increased body weights | Metabolic endocrine-mediated perturbations | |
| PMID:33086118 | IVR | 75 mg/kg/day | 75 mg/kg/day | Decreased weights of penis | Reproductive endocrine-mediated perturbations |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Affects penis development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Undescended testes (or cryptorchidism) | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Affects testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Hypospadias | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| PMID:33920546 | IVR | 5 mg/kg | 5 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 5 mg/kg | 5 mg/kg | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Decreased body weights | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| PMID:33983380 | IVR | 1 - 75 mg/kg/day | 1 - 75 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations |
| IVR | 1 - 75 mg/kg/day | 1 - 75 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 75 mg/kg/day | 1 - 75 mg/kg/day | Affects cholesterol metabolism | Metabolic endocrine-mediated perturbations | |
| PMID:34015706 | IVR | 1 - 12.5 mg/kg/day | 1 - 12.5 mg/kg/day | Decreased weights of penis | Reproductive endocrine-mediated perturbations |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Increased body weights | Metabolic endocrine-mediated perturbations | |
| IVR | 1 - 8 mg/kg/day | 1 - 8 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 8 mg/kg/day | 1 - 8 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 12.5 mg/kg/day | 1 - 12.5 mg/kg/day | Affects testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 12.5 mg/kg/day | 1 - 12.5 mg/kg/day | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 12.5 mg/kg/day | 1 - 12.5 mg/kg/day | Induce apoptosis in testis | Reproductive endocrine-mediated perturbations | |
| PMID:34088158 | IVTH | 0.00001 M | 0.00001 M | Induce cancer metastasis | Endocrine-mediated cancer |
| IVTH | 0.000000001 - 0.00005 M | 0.000000001 - 0.00005 M | Cancer phenotype | Endocrine-mediated cancer | |
| PMID:34097988 | IVR | 5 mg/kg/day | 5 mg/kg/day | Oxidative stress in pancreas | Metabolic endocrine-mediated perturbations |
| PMID:34280466 | IVR | 5 - 25 mg/kg/day | 5 - 25 mg/kg/day | Affects blood-testis barrier (BTB) | Reproductive endocrine-mediated perturbations |
| IVR | 5 - 25 mg/kg/day | 5 - 25 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 5 - 25 mg/kg/day | 5 - 25 mg/kg/day | Lead to obesity | Metabolic endocrine-mediated perturbations | |
| IVR | 5 - 25 mg/kg/day | 5 - 25 mg/kg/day | Alterations in preputial separation | Reproductive endocrine-mediated perturbations | |
| IVR | 5 - 25 mg/kg/day | 5 - 25 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 5 - 25 mg/kg/day | 5 - 25 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 5 - 25 mg/kg/day | 5 - 25 mg/kg/day | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 5 - 25 mg/kg/day | 5 - 25 mg/kg/day | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 5 - 25 mg/kg/day | 5 - 25 mg/kg/day | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 - 25 mg/kg/day | 5 - 25 mg/kg/day | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 - 25 mg/kg/day | 5 - 25 mg/kg/day | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 - 25 mg/kg/day | 5 - 25 mg/kg/day | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Increased gonadotropin-releasing hormone (GnRH) levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 - 25 mg/kg/day | 5 - 25 mg/kg/day | Decreased gonadotropin-releasing hormone (GnRH) levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 - 25 mg/kg/day | 5 - 25 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:34395617 | IVR | 1 mg/kg | 1 mg/kg | Increased body weights | Metabolic endocrine-mediated perturbations |
| IVR | 1 mg/kg | 1 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Oxidative stress in liver | Hepatic endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Increased Non esterified Fatty acid (NEFA) levels | Metabolic endocrine-mediated perturbations | |
| PMID:34474386 | IVR | 5 mg/kg | 5 mg/kg | Induce apoptosis in testis | Reproductive endocrine-mediated perturbations |
| IVR | 5 mg/kg | 5 mg/kg | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| PMID:34488563 | IVR | 5 mg/kg | 5 mg/kg | Induce behavioral changes | Neurological endocrine-mediated perturbations |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Changes in brain morphology | Neurological endocrine-mediated perturbations | |
| PMID:34793900 | IVR | 5 mg/kg/day | 5 mg/kg/day | Oxidative stress in thymus | Immunological endocrine-mediated perturbations |
| PMID:34864161 | IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Decreased weights of adrenal gland | Metabolic endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Causes inflammation | Immunological endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Decrease in corticosterone levels | Neurological endocrine-mediated perturbations | |
| PMID:35567983 | IVTH | 0.0001 - 0.0004 M | 0.0001 - 0.0004 M | Altered adipocyte function | Metabolic endocrine-mediated perturbations |
| PMID:35605887 | IVTH | 0.0001 - 75 M | 0.0001 - 75 M | Induce apoptosis in testis | Reproductive endocrine-mediated perturbations |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 - 75 mg/kg/day | 0.0001 - 75 mg/kg/day | Induce apoptosis in testis | Reproductive endocrine-mediated perturbations | |
| PMID:35919841 | IVR | 5 mg/kg/day | 5 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Delayed puberty | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Increase in the number of abnormal sperms | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Decreased body weights | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Alters sex ratio | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Affects implantation | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Affects fertility | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Decreased body weights in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
| PMID:35955852 | IVR | 1 mg/kg/day | 1 mg/kg/day | Affects expression of luteinizing hormone receptor (LHR) | Reproductive endocrine-mediated perturbations |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Oxidative stress in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:36215882 | IVR | 2 mg/kg | 2 mg/kg | Affects sperm motility | Reproductive endocrine-mediated perturbations |
| IVR | 2 mg/kg | 2 mg/kg | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Induce apoptosis in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Alters sperm function | Reproductive endocrine-mediated perturbations | |
| PMID:36230992 | IVTH | 0.0005 M | 0.0005 M | Decreased androstenedione levels | Reproductive endocrine-mediated perturbations |
| IVTH | 0.00001 - 0.0001 M | 0.00001 - 0.0001 M | Increase in cortisol levels | Neurological endocrine-mediated perturbations | |
| IVTH | 0.0005 M | 0.0005 M | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:36308879 | IVR | 75 mg/kg/day | 75 mg/kg/day | Affects expression of estrogen receptor (ER) | Reproductive endocrine-mediated perturbations |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Hypospadias | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Undescended testes (or cryptorchidism) | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Affects testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Affects expression of androgen receptor (AR) | Reproductive endocrine-mediated perturbations | |
| PMID:37167869 | IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Increased body weights | Metabolic endocrine-mediated perturbations |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Affects ovarian follicles population | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Induce behavioral changes | Neurological endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| PMID:37237912 | IVR | 5 mg/kg/day | 5 mg/kg/day | Oxidative stress in testis | Reproductive endocrine-mediated perturbations |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Reduced sperm quality | Reproductive endocrine-mediated perturbations | |
| PMID:37277016 | IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Affects folliculogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Affects ovarian follicles population | Reproductive endocrine-mediated perturbations | |
| PMID:37762641 | IVTH | 0.000000001 M | 0.000000001 M | Induce cancer metastasis | Endocrine-mediated cancer |
| IVTH | 0.000000001 M | 0.000000001 M | Oxidative stress in prostate | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.000000001 M | 0.000000001 M | Affects expression of androgen receptor (AR) | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.000000001 M | 0.000000001 M | Affects expression of estrogen receptor (ER) | Reproductive endocrine-mediated perturbations | |
| PMID:37977363 | IVR | 5 mg/kg | 5 mg/kg | Elevated glucose levels | Metabolic endocrine-mediated perturbations |
| IVR | 5 mg/kg | 5 mg/kg | Reduced insulin levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Oxidative stress in pancreas | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Induce apoptosis in pancreas | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Affects glucose metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Changes in morphology of pancreas | Metabolic endocrine-mediated perturbations | |
| PMID:38246300 | IVR | 5 mg/kg | 5 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations |
| IVR | 5 mg/kg | 5 mg/kg | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Induce ferroptosis in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Oxidative stress in testis | Reproductive endocrine-mediated perturbations | |
| PMID:39262327 | IVR | 5 mg/kg/day | 5 mg/kg/day | Decrease in T3 levels | Metabolic endocrine-mediated perturbations |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increase in cortisol levels | Neurological endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increased dopamine levels | Neurological endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Decreased serotonin (5-HT) levels | Neurological endocrine-mediated perturbations | |
| PMID:39560046 | IVR | 5 mg/kg | 5 mg/kg | Oxidative stress in testis | Reproductive endocrine-mediated perturbations |
| IVR | 5 mg/kg | 5 mg/kg | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Decreased testis weights | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.