| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:10188188 | IVR | 0.02 mg/kg | 0.02 mg/kg | Increased prostate weights | Reproductive endocrine-mediated perturbations |
| IVR | 2 mg/kg | 2 mg/kg | Decreased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Increased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.02 mg/kg | 0.02 mg/kg | Decreased liver weights | Hepatic endocrine-mediated perturbations | |
| PMID:10188190 | IVR | 200 mg/kg/day | 200 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Delayed puberty | Reproductive endocrine-mediated perturbations | |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Decreased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Pregnancy complications | Reproductive endocrine-mediated perturbations | |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg/day | 300 mg/kg/day | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg/day | 300 mg/kg/day | Decreased weights of pituitary gland | Neurological endocrine-mediated perturbations | |
| IVR | 300 mg/kg/day | 300 mg/kg/day | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg/day | 300 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Decreased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Affects litter size | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Decreased weights of pituitary gland | Neurological endocrine-mediated perturbations | |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Affects sperm motility | Reproductive endocrine | |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Decreased weights of pituitary gland | ||
| IVR | 300 mg/kg/day | 300 mg/kg/day | Decreased testis weights | ||
| IVR | 300 mg/kg/day | 300 mg/kg/day | Decreased liver weights | ||
| IVR | 300 mg/kg/day | 300 mg/kg/day | Decreased weights of seminal vesicles | ||
| IVR | 300 mg/kg/day | 300 mg/kg/day | Reduced sperm counts | ||
| PMID:10746942 | IVR | 100 mg/kg | 100 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations |
| IVR | 50 mg/kg | 50 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Alteration in vaginal morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg | 25 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg | 25 mg/kg | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| PMID:10825674 | IVR | 200 mg/kg | 200 mg/kg | Affects implantation | Reproductive endocrine-mediated perturbations |
| IVR | 50 mg/kg | 50 mg/kg | Affects implantation | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg | - | No significant effects observed | - | |
| IVR | 6.25 mg/kg | - | No significant effects observed | - | |
| IVR | 12.5 mg/kg | - | No significant effects observed | - | |
| IVR | 300 mg/kg | 300 mg/kg | Affects implantation | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Affects implantation | Reproductive endocrine-mediated perturbations | |
| PMID:11534990 | IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Affects anogenital distance in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Affects social behavior | Neurological endocrine-mediated perturbations | |
| IVR | 0.02 mg/kg/day | 0.02 mg/kg/day | Affects social behavior | Neurological endocrine-mediated perturbations | |
| IVR | 2 mg/kg/day | 2 mg/kg/day | Affects anogenital distance in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| PMID:11760811 | IVR | 100 mg/kg | 100 mg/kg | Changes in morphology of pituitary gland | Neurological endocrine-mediated perturbations |
| IVR | 100 mg/kg | 100 mg/kg | Changes in adrenal gland morphology | Metabolic endocrine-mediated perturbations | |
| IVR | 500 mg/kg | 500 mg/kg | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Changes in mammary gland morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Increased weights of pituitary gland | Neurological endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Atrophy of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Affects morphology of hepatocytes | Hepatic endocrine-mediated perturbations | |
| IVR | 20 mg/kg | 20 mg/kg | Atrophy of mammary gland | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg | 500 mg/kg | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg | 500 mg/kg | Thymus atrophy | Immunological endocrine-mediated perturbations | |
| IVR | 500 mg/kg | 500 mg/kg | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 500 mg/kg | 500 mg/kg | Increased prolactin levels | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg | 500 mg/kg | Changes in mammary gland morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg | 500 mg/kg | Ovarian atrophy | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Alteration in prostate morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg | 500 mg/kg | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg | 500 mg/kg | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg | 500 mg/kg | Changes in morphology of cervix | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg | 500 mg/kg | Decreased thymus gland weights | Immunological endocrine-mediated perturbations | |
| IVR | 500 mg/kg | 500 mg/kg | Increased weights of adrenal gland | Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Alterations in endometrial morphology | Reproductive endocrine-m | |
| IVR | 500 mg/kg | 500 mg/kg | Testicular atrophy | ||
| IVR | 500 mg/kg | 500 mg/kg | Atrophy in seminiferous tubules | ||
| IVR | 500 mg/kg | 500 mg/kg | Decreased weights of seminal vesicles | ||
| IVR | 500 mg/kg | 500 mg/kg | Changes in morphology of pituitary gland | ||
| IVR | 500 mg/kg | 500 mg/kg | Alteration in prostate morphology | ||
| IVR | 500 mg/kg | 500 mg/kg | Alterations in endometrial morphology | ||
| IVR | 500 mg/kg | 500 mg/kg | Changes in adrenal gland morphology | ||
| IVR | 500 mg/kg | 500 mg/kg | Reduced sperm counts | ||
| IVR | 100 mg/kg | 100 mg/kg | Decrease in T3 levels | ||
| IVR | 100 mg/kg | 100 mg/kg | Changes in morphology of cervix | ||
| IVR | 500 mg/kg | 500 mg/kg | Affects uterine morphology | ||
| IVR | 500 mg/kg | 500 mg/kg | Decrease in T3 levels | ||
| IVR | 500 mg/kg | 500 mg/kg | |||
| IVR | 100 mg/kg | 100 mg/kg | |||
| IVR | 500 mg/kg | 500 mg/kg | |||
| IVR | 500 mg/kg | 500 mg/kg | |||
| IVR | 500 mg/kg | 500 mg/kg | |||
| IVR | 100 mg/kg | 100 mg/kg | |||
| IVR | 500 mg/kg | 500 mg/kg | |||
| IVR | 500 mg/kg | 500 mg/kg | |||
| IVR | 100 mg/kg | 100 mg/kg | |||
| IVR | 100 mg/kg | 100 mg/kg | |||
| IVR | 500 mg/kg | 500 mg/kg | |||
| IVR | 100 mg/kg | 100 mg/kg | |||
| IVR | 100 mg/kg | 100 mg/kg | |||
| IVR | 100 mg/kg | 100 mg/kg | |||
| IVR | 500 mg/kg | 500 mg/kg | |||
| IVR | 500 mg/kg | 500 mg/kg | |||
| IVR | 500 mg/kg | 500 mg/kg | |||
| PMID:11836072 | IVR | 0.2 mg/kg | 0.2 mg/kg | Affects locomotor activity | Neurological endocrine-mediated perturbations |
| IVR | 0.02 mg/kg | 0.02 mg/kg | Affects lactation | Reproductive endocrine-mediated perturbations | |
| IVR | 0.02 mg/kg | 0.02 mg/kg | Affects locomotor activity | Neurological endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Affects locomotor activity | Neurological endocrine-mediated perturbations | |
| PMID:11969380 | IVR | 150 mg/kg | 150 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations |
| IVR | 5 mg/kg | 5 mg/kg | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 150 mg/kg | 150 mg/kg | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Alterations in number of sertoli cells | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 150 mg/kg | 150 mg/kg | Alterations in number of sertoli cells | Reproductive endocrine-mediated perturbations | |
| IVR | 150 mg/kg | 150 mg/kg | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Alterations in number of sertoli cells | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| PMID:12052007 | IVR | 125 mg/kg/day | 125 mg/kg/day | Increased uterine weights | Reproductive endocrine-mediated perturbations |
| IVR | 125 mg/kg/day | 125 mg/kg/day | Decreased liver weights | Hepatic endocrine-mediated perturbations | |
| PMID:12858341 | IVTH | 0.000001 M | 0.000001 M | Cancer phenotype | Endocrine-mediated cancer |
| IVTH | 0.000001 M | 0.000001 M | Affects placental differentiation | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| PMID:12919727 | IVR | 150 mg/kg | 150 mg/kg | Affects liver function | Hepatic endocrine-mediated perturbations |
| IVR | 150 mg/kg | 150 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Affects liver function | Hepatic endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 150 mg/kg | 150 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Affects liver function | Hepatic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Affects liver function | Hepatic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| PMID:12954667 | IVR | 150 mg/kg | 150 mg/kg | Affects survival of germ cells | Reproductive endocrine-mediated perturbations |
| IVR | 150 mg/kg | 150 mg/kg | Abnormal proliferation of germ cells | Reproductive endocrine-mediated perturbations | |
| IVR | 150 mg/kg | 150 mg/kg | Affects testis development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Affects survival of germ cells | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Affects testis development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Abnormal proliferation of germ cells | Reproductive endocrine-mediated perturbations | |
| PMID:14580783 | IVR | 1200 mg/L | 1200 mg/L | Decreased testis weights | Reproductive endocrine-mediated perturbations |
| IVR | 1200 mg/L | 1200 mg/L | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| IVR | 1200 mg/L | 1200 mg/L | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 1200 mg/L | 1200 mg/L | Alterations in preputial separation | Reproductive endocrine-mediated perturbations | |
| IVR | 240 mg/L | - | No significant effects observed | - | |
| IVR | 24 mg/L | - | No significant effects observed | - | |
| PMID:14598022 | IVR | 1200 mg/L | 1200 mg/L | Decreased prolactin levels | Reproductive endocrine-mediated perturbations |
| IVR | 1200 mg/L | 1200 mg/L | Increased weights of pituitary gland | Neurological endocrine-mediated perturbations | |
| IVR | 1200 mg/L | 1200 mg/L | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1200 mg/L | 1200 mg/L | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 240 mg/L | 240 mg/L | Increased prolactin levels | Reproductive endocrine-mediated perturbations | |
| IVR | 24 mg/L | - | No significant effects observed | - | |
| PMID:14613717 | IVR | 100 mg/kg/day | 100 mg/kg/day | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| PMID:15253041 | IVTH | 0.000001 - 0.0001 M | 0.00001 M | Cancer phenotype | Endocrine-mediated cancer |
| PMID:15596257 | IVR | 100 mg/L | 100 mg/L | Decreased thymus gland weights | Immunological endocrine-mediated perturbations |
| IVR | 100 mg/L | 100 mg/L | Alterations in splenocytes population | Immunological endocrine-mediated perturbations | |
| IVR | 100 mg/L | 100 mg/L | Changes in white blood cell (WBC) populations | Immunological endocrine-mediated perturbations | |
| IVR | 1000 mg/L | 1000 mg/L | Changes in T-cell populations | Immunological endocrine-mediated perturbations | |
| IVR | 1000 mg/L | 1000 mg/L | Alterations in splenocytes population | Immunological endocrine-mediated perturbations | |
| IVR | 1000 mg/L | 1000 mg/L | Changes in white blood cell (WBC) populations | Immunological endocrine-mediated perturbations | |
| IVR | 1000 mg/L | 1000 mg/L | Decreased thymus gland weights | Immunological endocrine-mediated perturbations | |
| IVR | 1000 mg/L | 1000 mg/L | Decreased spleen weights | Immunological endocrine-mediated perturbations | |
| IVR | 10 mg/L | 10 mg/L | Changes in white blood cell (WBC) populations | Immunological endocrine-mediated perturbations | |
| IVR | 10 mg/L | 10 mg/L | Alterations in splenocytes population | Immunological endocrine-mediated perturbations | |
| PMID:15890768 | IVTH | 0.000001 - 0.00005 M | 0.000001 M | Affects developmental process | Developmental endocrine-mediated perturbations |
| IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 2 mg/kg/day | 2 mg/kg/day | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Affects developmental process | Developmental endocrine-mediated perturbations | |
| PMID:15933200 | IVR | 100 - 200 mg/kg | 100 - 200 mg/kg | Affects spermatogenesis in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 100 - 200 mg/kg | 100 - 200 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 100 - 200 mg/kg | 100 - 200 mg/kg | Affects fertility | Reproductive endocrine-mediated perturbations | |
| IVR | 100 - 200 mg/kg | 100 - 200 mg/kg | Induce apoptosis of spermatogenic cells | Reproductive endocrine-mediated perturbations | |
| IVR | 100 - 200 mg/kg | 100 - 200 mg/kg | Reduced sperm counts in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| PMID:16243481 | IVTH | 0.0000002 - 0.00002 M | 0.0000002 - 0.00002 M | Affects neuronal differentiation | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations |
| PMID:16443925 | IVR | 800 mg/L | 800 mg/L | Exhibit sexual dimorphism | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 800 mg/L | 800 mg/L | Changes in mammary gland morphology | Reproductive endocrine-mediated perturbations | |
| PMID:16996190 | IVTH | 0.000001 - 0.00001 M | 0.000003 - 0.00001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| PMID:17170213 | IVR | 100 mg/kg/day | 100 mg/kg/day | Alterations in immune responses | Immunological endocrine-mediated perturbations |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Alterations in number of granulosa cells | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Alterations in number of granulosa cells | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Alterations in immune responses | Immunological endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Alterations in immune responses | Immunological endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects ovarian follicles population | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | - | No significant effects observed | - | |
| IVR | 10 mg/kg/day | - | No significant effects observed | - | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Alterations in number of granulosa cells | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects ovarian follicles population | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| PMID:17568585 | IVR | 0.02 mg/kg | 0.02 mg/kg | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| PMID:18854640 | IVTH | 0.000000001 - 0.00001 M | 0.000001 - 0.00001 M | Cancer phenotype | Endocrine-mediated cancer |
| PMID:19589859 | IVR | 0.02 mg/kg/day | 0.02 mg/kg/day | Affects ovarian function | Reproductive endocrine-mediated perturbations |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects ovarian function | Reproductive endocrine-mediated perturbations | |
| PMID:20077207 | IVR | 50 mg/kg/day | 50 mg/kg/day | Increased uterine weights | Reproductive endocrine-mediated perturbations |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| PMID:21062904 | IVR | 10 mg/kg/day | 10 mg/kg/day | Affects embryonic development | Developmental endocrine-mediated perturbations |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Alters sperm function | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| PMID:21726579 | IVR | 2 mg | 2 mg | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 2 mg | 2 mg | Alteration in vaginal morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg | 2 mg | Compromised endometrial receptivity | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg | - | No significant effects observed | - | |
| PMID:22016562 | IVR | 0.1 mg/kg | 0.1 mg/kg | Affects social behavior | Neurological endocrine-mediated perturbations |
| IVR | 0.1 mg/kg | 0.1 mg/kg | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg | 0.1 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 0.02 mg/kg | 0.02 mg/kg | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| PMID:22285353 | IVR | 200 mg/kg | 200 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations |
| IVR | 200 mg/kg | 200 mg/kg | Decreased androstenedione levels | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Prostate atrophy | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Increase in the number of abnormal sperms | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Increased weights of adrenal gland | Metabolic endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decreased liver weights | Hepatic endocrine-mediated perturbations | |
| PMID:22307313 | IVTH | 0.000001 M | 0.000001 M | Cancer phenotype | Endocrine-mediated cancer |
| PMID:22348781 | IVR | 1500 mg/L | 1500 mg/L | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations |
| IVR | 1500 mg/L | 1500 mg/L | Alterations in preputial separation | Reproductive endocrine-mediated perturbations | |
| IVR | 1500 mg/L | 1500 mg/L | Affects fertility | Reproductive endocrine-mediated perturbations | |
| IVR | 1500 mg/L | 1500 mg/L | Affects implantation | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/L | 500 mg/L | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 1500 mg/L | 1500 mg/L | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1500 mg/L | 1500 mg/L | Changes in ovarian morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1500 mg/L | 1500 mg/L | Decreased weights of accessory sex organs | Reproductive endocrine-mediated perturbations | |
| IVR | 1500 mg/L | 1500 mg/L | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1500 mg/L | 1500 mg/L | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/L | - | No significant effects observed | - | |
| IVR | 500 mg/L | 500 mg/L | Decreased weights of accessory sex organs | Reproductive endocrine-mediated perturbations | |
| PMID:23303685 | IVR | 0.02 mg/kg/day | 0.02 mg/kg/day | Affects ovulation | Reproductive endocrine-mediated perturbations |
| IVR | 0.02 mg/kg/day | 0.02 mg/kg/day | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.02 mg/kg/day | 0.02 mg/kg/day | Affects estrogen metabolism | Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects estrogen metabolism | Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects ovulation | Reproductive endocrine-mediated perturbations | |
| PMID:24835555 | IVTH | 0.000000001 - 0.000001 M | 0.000000001 - 0.0001 M | Cancer phenotype | Endocrine-mediated cancer |
| IVTH | 0.000000001 - 0.000001 M | 0.000000001 - 0.0001 M | Ovarian carcinoma | Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations | |
| PMID:25034310 | IVR | 200 mg/kg | 200 mg/kg | Affects folliculogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 200 mg/kg | 200 mg/kg | Oxidative stress in liver | Hepatic endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Changes in ovarian morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| PMID:27103539 | IVR | 75 mg/kg/day | 75 mg/kg/day | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| PMID:30817981 | IVTH | 0.000001 M | 0.000001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| IVTH | 0.000001 M | 0.000001 M | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| PMID:33013709 | IVR | 0.02 mg/kg/day | 0.02 mg/kg/day | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations |
| IVR | 0.02 mg/kg/day | 0.02 mg/kg/day | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 0.02 mg/kg/day | 0.02 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.02 mg/kg/day | 0.02 mg/kg/day | Changes in brain morphology | Neurological endocrine-mediated perturbations | |
| IVR | 0.02 mg/kg/day | 0.02 mg/kg/day | Alterations in preputial separation | Reproductive endocrine-mediated perturbations | |
| IVR | 0.02 mg/kg/day | 0.02 mg/kg/day | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| IVR | 0.02 mg/kg/day | 0.02 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 0.02 mg/kg/day | 0.02 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| PMID:6458924 | IVR | 5 % | 5 % | Increase in the number of abnormal sperms | Reproductive endocrine-mediated perturbations |
| PMID:8593856 | IVTH | 0.00001 M | 0.00001 M | Occurrence of mammary gland tumor | Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations |
| PMID:9398496 | IVR | 150 mg/kg/day | 150 mg/kg/day | Decreased FSH levels | Reproductive endocrine-mediated perturbations |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| IVR | 150 mg/kg/day | 150 mg/kg/day | Alters mammary gland development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 150 mg/kg/day | 150 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Alters mammary gland development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 150 mg/kg/day | 150 mg/kg/day | Affects uterine morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 150 mg/kg/day | 150 mg/kg/day | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 150 mg/kg/day | 150 mg/kg/day | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Affects uterine morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.