Bisphenol E

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Descriptors
• Chemical-gene interaction
• Chemical-phenotype interaction
• Chemical-disease association
• ToxCast endpoints
• Associated AOPs
• Presence in consumer products
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:24563381	IVTH	0.0000000001 - 0.0001 M	0.0000001 - 0.0000548 M	Decreased Dehydroepiandrosterone (DHEA) levels	Metabolic endocrine-mediated perturbations
	IVTH	0.0000000001 - 0.0001 M	0.0000001 - 0.0000548 M	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0000000001 - 0.0001 M	0.0000001 - 0.0000548 M	Increase in corticosterone levels	Neurological endocrine-mediated perturbations
	IVTH	0.0000000001 - 0.0001 M	0.0000001 - 0.0000548 M	Decrease in cortisol levels	Neurological endocrine-mediated perturbations
	IVTH	0.0000000001 - 0.0001 M	0.0000001 - 0.0000548 M	Increased progestagens levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0000000001 - 0.0001 M	0.0000001 - 0.0000548 M	Increased androstenedione levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0000000001 - 0.0001 M	0.0000001 - 0.0000548 M	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
PMID:28676390	IVR	50000 mg/kg	50000 mg/kg	Increased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	50000 mg/kg	50000 mg/kg	Affects testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	50000 mg/kg	50000 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	50000 mg/kg	50000 mg/kg	Changes in testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	50000 mg/kg	50000 mg/kg	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	50000 mg/kg	50000 mg/kg	Alterations in vaginal opening	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	50000 mg/kg	50000 mg/kg	Affects sertoli cells function	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Increased estradiol levels	Reproductive endocrine-mediated perturbations
PMID:29741722	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Reduced sperm counts in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Affects germ cell development in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Affects steroidogenesis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Reduced sperm counts in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Affects sperm motility in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Affects steroidogenesis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Reduced sperm counts in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:31132128	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	0.0005 - 0.05 mg/kg/day	0.0005 - 0.05 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Alterations in vaginal opening	Reproductive endocrine-mediated perturbations
PMID:31388671	IVTH	0.000001 M	0.000001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.000001 M	0.000001 M	Affects expression of progesterone receptor (PR)	Reproductive endocrine-mediated perturbations
PMID:31532523	IVR	0.0005 - 0.05 mg/kg/day	0.0005 - 0.05 mg/kg/day	Epigenomic alterations in testis	Reproductive endocrine-mediated perturbations
	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	0.0005 - 0.05 mg/kg/day	0.0005 - 0.05 mg/kg/day	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	0.0005 - 0.05 mg/kg/day	0.0005 - 0.05 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
PMID:37164221	IVR	1 mg/kg/day	1 mg/kg/day	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Affects penis development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.05 - 1 mg/kg/day	0.05 - 1 mg/kg/day	Affects testicular development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Affects developmental process	Developmental endocrine-mediated perturbations
PMID:9449681	IVTH	0.0000000001 - 0.00000001 M	0.0000000001 - 0.00000001 M	Occurrence of mammary gland tumor	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
	IVTH	0.0000000001 - 0.00000001 M	0.0000000001 - 0.00000001 M	Affects expression of progesterone receptor (PR)	Reproductive endocrine-mediated perturbations

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DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.