4-tert-Octylphenol

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Descriptors
• Chemical-gene interaction
• Chemical-phenotype interaction
• Chemical-disease association
• ToxCast endpoints
• Associated AOPs
• Presence in consumer products
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:10746942	IVR	400 mg/kg	400 mg/kg	Decreased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg	200 mg/kg	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Alterations in vaginal opening	Reproductive endocrine-mediated perturbations
PMID:10825674	IVR	400 mg/kg	400 mg/kg	Affects implantation	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	-	No significant effects observed	-
	IVR	300 mg/kg	-	No significant effects observed	-
	IVR	200 mg/kg	-	No significant effects observed	-
PMID:10860870	IVR	12.5 mg/kg/day	-	No significant effects observed	-
	IVR	50 mg/kg/day	-	No significant effects observed	-
	IVR	100 mg/kg/day	100 mg/kg/day	Uterine hyperplasia	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Alterations in vaginal opening	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Alters hypothalamic-pituitary-ovarian axis	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Endometrial hyperplasia	Reproductive endocrine-mediated perturbations
	IVR	25 mg/kg/day	-	No significant effects observed	-
PMID:10906426	IVR	12.5 mg/kg/day	12.5 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	12.5 mg/kg/day	12.5 mg/kg/day	Increased spleen weights	Immunological endocrine-mediated perturbations
	IVR	25 mg/kg/day	25 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	25 mg/kg/day	25 mg/kg/day	Increased spleen weights	Immunological endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
PMID:11259270	IVR	100 mg/kg	100 mg/kg	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Cognitive impairment	Neurological endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Decreased LH levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Alterations in vaginal opening	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Altered lordosis	Developmental endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Decreased prolactin levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Decreased FSH levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:11275424	IVR	62.5 mg/kg	62.5 mg/kg	Affects implantation	Reproductive endocrine-mediated perturbations
	IVR	125 mg/kg	125 mg/kg	Affects implantation	Reproductive endocrine-mediated perturbations
	IVR	125 mg/kg	125 mg/kg	Affects survival of live fetus	Reproductive endocrine-mediated perturbations
	IVR	31.3 mg/kg	31.3 mg/kg	Affects survival of live fetus	Reproductive endocrine-mediated perturbations
	IVR	15.6 mg/kg	-	No significant effects observed	-
	IVR	31.3 mg/kg	31.3 mg/kg	Affects implantation	Reproductive endocrine-mediated perturbations
PMID:11936222	IVTH	0.00000001 - 0.001 M	0.000001 - 0.00001 M	Cancer phenotype	Endocrine-mediated cancer
	IVR	200 mg/kg/day	200 mg/kg/day	Affects neuronal differentiation	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Affects neuronal differentiation	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Affects neuronal differentiation	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	10 mg/kg/day	-	No significant effects observed	-
PMID:12051553	IVR	100 mg/kg	100 mg/kg	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Affects developmental process	Developmental endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Cancer phenotype	Endocrine-mediated cancer
	IVR	100 mg/kg	100 mg/kg	Affects differentiation process	Developmental endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Alterations in endometrial morphology	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Affects uterine morphology	Reproductive endocrine-mediated perturbations
PMID:12127004	IVR	25 - 3000 mg/kg	125 mg/kg	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	25 - 3000 mg/kg	750 - 3000 mg/kg	Alteration in vaginal morphology	Reproductive endocrine-mediated perturbations
	IVR	25 - 3000 mg/kg	3000 mg/kg	Decreased liver weights	Hepatic endocrine-mediated perturbations
	IVR	25 - 3000 mg/kg	3000 mg/kg	Affects uterine morphology	Reproductive endocrine-mediated perturbations
	IVR	25 - 3000 mg/kg	500 - 700 mg/kg	Decreased spleen weights	Immunological endocrine-mediated perturbations
PMID:14654251	IVR	200 mg/kg/day	200 mg/kg/day	Affects neuronal differentiation	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	600 mg/kg/day	600 mg/kg/day	Affects neuronal differentiation	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Affects neuronal differentiation	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Affects embryonic development	Developmental endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Affects uterine contraction	Reproductive endocrine-mediated perturbations
	IVR	600 mg/kg/day	600 mg/kg/day	Affects embryonic development	Developmental endocrine-mediated perturbations
PMID:14689164	IVR	200 mg/kg	200 mg/kg	Affects uterine function	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg	200 mg/kg	Alteration in vaginal morphology	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg	200 mg/kg	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg	200 mg/kg	Affects uterine morphology	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg	-	No significant effects observed	-
	IVR	50 mg/kg	-	No significant effects observed	-
PMID:14763995	IVR	40 mg/kg	40 mg/kg	Affects expression of progesterone receptor (PR)	Reproductive endocrine-mediated perturbations
PMID:15219628	IVR	200 mg/kg/day	200 mg/kg/day	Affects neuronal signaling	Neurological endocrine-mediated perturbations
	IVR	600 mg/kg/day	600 mg/kg/day	Affects neuronal signaling	Neurological endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Affects neuronal signaling	Neurological endocrine-mediated perturbations
PMID:15509668	IVR	250 mg/kg	250 mg/kg	Affects uterine contraction	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Affects uterine contraction	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	-	No significant effects observed	-
PMID:17011747	IVR	600 mg/kg/day	600 mg/kg/day	Affects differentiation process	Developmental endocrine-mediated perturbations
	IVR	600 mg/kg/day	600 mg/kg/day	Affects neuronal differentiation	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	600 mg/kg/day	600 mg/kg/day	Affects innate immunity	Immunological endocrine-mediated perturbations
	IVR	600 mg/kg/day	600 mg/kg/day	Induce tumor progression	Endocrine-mediated cancer
	IVR	600 mg/kg/day	600 mg/kg/day	Affects uterine function	Reproductive endocrine-mediated perturbations
	IVR	600 mg/kg/day	600 mg/kg/day	Affects developmental process	Developmental endocrine-mediated perturbations
	IVR	600 mg/kg/day	600 mg/kg/day	Alters estrogen-responsive genes	Reproductive endocrine-mediated perturbations
	IVR	600 mg/kg/day	600 mg/kg/day	Uterotrophic effect	Reproductive endocrine-mediated perturbations
PMID:17033158	IVR	10 mg	10 mg	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	10 mg	10 mg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:17365578	IVR	200 mg/kg	200 mg/kg	Affects neuronal signaling	Neurological endocrine-mediated perturbations
	IVR	600 mg/kg	600 mg/kg	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg	400 mg/kg	Affects neuronal signaling	Neurological endocrine-mediated perturbations
	IVR	600 mg/kg	600 mg/kg	Affects neuronal signaling	Neurological endocrine-mediated perturbations
PMID:17696135	IVR	2 mg/kg	2 mg/kg	Alterations in number of leydig cells	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Changes in testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Decreased body weights	Metabolic endocrine-mediated perturbations
PMID:19145065	IVR	100 mg/kg	-	No significant effects observed	-
	IVR	10 mg/kg	-	No significant effects observed	-
	IVR	600 mg/kg	600 mg/kg	Increase in Growth Hormone (GH) levels	Metabolic endocrine-mediated perturbations
	IVR	600 mg/kg	600 mg/kg	Increased prolactin levels	Reproductive endocrine-mediated perturbations
PMID:20197112	IVTH	0.00000000001 - 0.0000001 M	0.000000001 - 0.0000001 M	Induced migration capability of tumor cells	Endocrine-mediated cancer
PMID:23219593	IVTH	0.000001 M	0.000001 M	Cancer phenotype	Endocrine-mediated cancer
PMID:23664861	IVR	100 mg/kg/day	100 mg/kg/day	Affects neuronal differentiation	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects uterine contraction	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects uterine contraction	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects neuronal differentiation	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects uterine contraction	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
PMID:24278580	IVTH	0.000000001 - 0.00001 M	0.000000001 - 0.00001 M	Induced migration capability of tumor cells	Endocrine-mediated cancer
PMID:24698786	IVR	0.00000001 - 0.0001 M	0.00000001 - 0.0001 M	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	0.00000001 - 0.0001 M	0.00000001 - 0.0001 M	Abnormal sperm morphology	Reproductive endocrine-mediated perturbations
	IVR	0.00000001 - 0.0001 M	0.00000001 - 0.0001 M	Alteration in the levels of cAMP	Metabolic endocrine-mediated perturbations
PMID:25324873	IVR	10 mg/kg/day	-	No significant effects observed	-
	IVR	100 mg/kg/day	100 mg/kg/day	Affects uterine contraction	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects uterine contraction	Reproductive endocrine-mediated perturbations
PMID:27145024	IVTH	0.000001 M	0.000001 M	Induce cancer metastasis	Endocrine-mediated cancer
PMID:29561242	IVR	40 mg/kg	40 mg/kg	Affects the biochemical composition of liver	Hepatic endocrine-mediated perturbations
	IVR	40 mg/kg	40 mg/kg	Oxidative stress in liver	Hepatic endocrine-mediated perturbations
	IVR	40 mg/kg	40 mg/kg	Affects cytokine signaling	Immunological endocrine-mediated perturbations
	IVR	40 mg/kg	40 mg/kg	Affects liver function	Hepatic endocrine-mediated perturbations
	IVR	40 mg/kg	40 mg/kg	Changes in liver morphology	Hepatic endocrine-mediated perturbations
PMID:30061528	IVR	100 mg/kg/day	100 mg/kg/day	Affects implantation	Reproductive endocrine-mediated perturbations
PMID:31201952	IVTH	0.00001 M	0.00001 M	Alterations in endometrial morphology	Reproductive endocrine-mediated perturbations
	IVTH	0.000005 M	0.000005 M	Pregnancy complications	Reproductive endocrine-mediated perturbations
PMID:31911191	IVR	360 mg/kg	360 mg/kg	Increased serotonin (5-HT) levels	Neurological endocrine-mediated perturbations
	IVR	360 mg/kg	360 mg/kg	Affects tryptophan metabolism	Metabolic endocrine-mediated perturbations
	IVR	360 mg/kg	360 mg/kg	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	360 mg/kg	360 mg/kg	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	120 mg/kg	120 mg/kg	Affects tryptophan metabolism	Metabolic endocrine-mediated perturbations
	IVR	120 mg/kg	120 mg/kg	Increased serotonin (5-HT) levels	Neurological endocrine-mediated perturbations
	IVR	120 mg/kg	120 mg/kg	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	120 mg/kg	120 mg/kg	Affects neuronal signaling	Neurological endocrine-mediated perturbations
	IVR	40 mg/kg	40 mg/kg	Increased serotonin (5-HT) levels	Neurological endocrine-mediated perturbations
	IVR	360 mg/kg	360 mg/kg	Affects neuronal signaling	Neurological endocrine-mediated perturbations
PMID:33294128	IVR	1 - 5 mg/kg/day	1 - 5 mg/kg/day	Induce behavioral changes	Neurological endocrine-mediated perturbations
	IVR	1 - 5 mg/kg/day	1 - 5 mg/kg/day	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	1 - 5 mg/kg/day	1 - 5 mg/kg/day	Abnormal proliferation of neuronal cells	Neurological endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Altered cell cycle in neurons	Neurological endocrine-mediated perturbations
	IVR	1 - 5 mg/kg/day	1 - 5 mg/kg/day	Affects spatial memory	Neurological endocrine-mediated perturbations
	IVR	1 - 5 mg/kg/day	1 - 5 mg/kg/day	Decreased brain weights	Neurological endocrine-mediated perturbations
	IVR	1 - 5 mg/kg/day	1 - 5 mg/kg/day	Induce neuronal apoptosis	Neurological endocrine-mediated perturbations
	IVR	1 - 5 mg/kg/day	1 - 5 mg/kg/day	Cognitive impairment	Neurological endocrine-mediated perturbations
PMID:38997027	IVTH	0.000001 - 0.00005 M	0.000001 - 0.00005 M	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
	IVTH	0.000001 - 0.00005 M	0.000001 - 0.00005 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:39471617	IVR	5 mg/kg/day	5 mg/kg/day	Changes in brain morphology	Neurological endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Affects neuronal density	Neurological endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Causes inflammation	Immunological endocrine-mediated perturbations
PMID:9241039	IVR	20 mg	20 mg	Decreased weights of accessory sex organs	Reproductive endocrine-mediated perturbations
	IVR	80 mg	80 mg	Decreased weights of accessory sex organs	Reproductive endocrine-mediated perturbations

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DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.