Tributylchlorostannane

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Descriptors
• Chemical-gene interaction
• Chemical-phenotype interaction
• Chemical-disease association
• ToxCast endpoints
• Associated AOPs
• Presence in consumer products
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:12083789	IVR	0.000004 M	0.000004 M	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	0.000004 M	0.000004 M	Affects steroid metabolism	Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:12773765	IVR	20 mg/kg	20 mg/kg	Affects skeletal development in fetus	Developmental endocrine-mediated perturbations
	IVR	20 mg/kg	20 mg/kg	Increased placental weights	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg	20 mg/kg	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	20 mg/kg	20 mg/kg	Affects implantation	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg	20 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	2.5 mg/kg	2.5 mg/kg	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	2.5 mg/kg	2.5 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	0.25 mg/kg	0.25 mg/kg	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Increased placental weights	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Affects skeletal development in fetus	Developmental endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	20 mg/kg	20 mg/kg	Affects litter size	Reproductive endocrine-mediated perturbations
PMID:14667468	IVR	0.025 mg/kg	0.025 mg/kg	Decreased liver weights	Hepatic endocrine-mediated perturbations
	IVR	2.5 mg/kg	2.5 mg/kg	Increased spleen weights	Immunological endocrine-mediated perturbations
	IVR	2.5 mg/kg	2.5 mg/kg	Decreased liver weights	Hepatic endocrine-mediated perturbations
	IVR	2.5 mg/kg	2.5 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	2.5 mg/kg	2.5 mg/kg	Increased weights of adrenal gland	Metabolic endocrine-mediated perturbations
	IVR	2.5 mg/kg	2.5 mg/kg	Decreased thymus gland weights	Immunological endocrine-mediated perturbations
	IVR	2.5 mg/kg	2.5 mg/kg	Increase in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	2.5 mg/kg	2.5 mg/kg	Increased triglycerides level	Metabolic endocrine-mediated perturbations
	IVR	0.25 mg/kg	0.25 mg/kg	Decreased thymus gland weights	Immunological endocrine-mediated perturbations
PMID:16513093	IVTH	0.000000001 - 0.00001 M	0.0000001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:16613991	IVR	0.05 mg/kg	0.05 mg/kg	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVR	0.05 mg/kg	0.05 mg/kg	Alteration in gonadal morphology	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/kg	0.05 mg/kg	Changes in liver morphology	Hepatic endocrine-mediated perturbations
	IVR	0.3 mg/kg	0.3 mg/kg	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVR	0.3 mg/kg	0.3 mg/kg	Affects thyroid hormone metabolism	Metabolic endocrine-mediated perturbations
	IVR	0.5 mg/kg	0.5 mg/kg	Changes in liver morphology	Hepatic endocrine-mediated perturbations
	IVR	0.5 mg/kg	0.5 mg/kg	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVR	0.5 mg/kg	0.5 mg/kg	Alteration in gonadal morphology	Reproductive endocrine-mediated perturbations
PMID:18246498	IVR	0.25 mg/kg/day	-	No significant effects observed	-
	IVR	2.5 mg/kg/day	-	No significant effects observed	-
	IVR	10 mg/kg/day	10 mg/kg/day	Decreased liver weights	Hepatic endocrine-mediated perturbations
PMID:20052771	IVR	0.017 mg/kg/day	0.017 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	0.17 mg/kg/day	0.17 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.17 mg/kg/day	0.17 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	0.17 mg/kg/day	0.17 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	0.017 mg/kg/day	0.017 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
PMID:22362710	IVR	0.01 mg/kg/day	0.01 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	0.001 mg/kg/day	0.001 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	0.001 mg/kg/day	0.001 mg/kg/day	Alterations in vaginal opening	Reproductive endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Alterations in vaginal opening	Reproductive endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	0.01 mg/kg/day	0.01 mg/kg/day	Alterations in vaginal opening	Reproductive endocrine-mediated perturbations
PMID:22972585	IVR	0.001 mg/kg	-	No significant effects observed	-
	IVR	0.1 mg/kg	0.1 mg/kg	Undescended testes (or cryptorchidism)	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.1 mg/kg	0.1 mg/kg	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	0.01 mg/kg	0.01 mg/kg	Affects social behavior	Neurological endocrine-mediated perturbations
PMID:23523586	IVTH	0.0000001 M	0.0000001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.0000001 M	0.0000001 M	Affects cytokine signaling	Immunological endocrine-mediated perturbations
	IVTH	0.000000025 M	0.000000025 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.00000005 M	0.00000005 M	Affects cytokine signaling	Immunological endocrine-mediated perturbations
	IVTH	0.00000005 M	0.00000005 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:23913619	IVR	0.001 mg/kg/day	0.001 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	0.001 mg/kg/day	0.001 mg/kg/day	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Induce apoptosis in seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	0.01 mg/kg/day	0.01 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	0.01 mg/kg/day	0.01 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	0.01 mg/kg/day	0.01 mg/kg/day	Affects sperm motility	Reproductive endocrine-mediated perturbations
PMID:2466803	IVR	5 - 60 mg/kg	35 mg/kg	Decreased spleen weights	Immunological endocrine-mediated perturbations
	IVR	5 - 60 mg/kg	60 mg/kg	Decreased spleen weights	Immunological endocrine-mediated perturbations
	IVR	5 - 60 mg/kg	10 mg/kg	Decreased thymus gland weights	Immunological endocrine-mediated perturbations
	IVR	5 - 60 mg/kg	10 mg/kg	Lymph nodes inflammation	Immunological endocrine-mediated perturbations
PMID:24895210	IVR	30 mg/kg	30 mg/kg	Affects blood-brain barrier (BBB)	Neurological endocrine-mediated perturbations
	IVR	30 mg/kg	30 mg/kg	Oxidative stress in nervous system	Neurological endocrine-mediated perturbations
	IVR	20 mg/kg	20 mg/kg	Affects blood-brain barrier (BBB)	Neurological endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Oxidative stress in nervous system	Neurological endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Affects blood-brain barrier (BBB)	Neurological endocrine-mediated perturbations
	IVR	20 mg/kg	20 mg/kg	Oxidative stress in nervous system	Neurological endocrine-mediated perturbations
PMID:25101840	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Alters thyroglobulin levels	Metabolic endocrine-mediated perturbations
	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Increase in Thyrotropin-releasing hormone (TRH) levels	Metabolic endocrine-mediated perturbations
	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Increase in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Increase in Thyrotropin-releasing hormone (TRH) levels	Metabolic endocrine-mediated perturbations
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Increase in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Alters thyroglobulin levels	Metabolic endocrine-mediated perturbations
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	0.005 mg/kg/day	0.005 mg/kg/day	Alters thyroglobulin levels	Metabolic endocrine-mediated perturbations
	IVR	0.005 mg/kg/day	0.005 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	0.005 mg/kg/day	0.005 mg/kg/day	Increase in Thyrotropin-releasing hormone (TRH) levels	Metabolic endocrine-mediated perturbations
	IVR	0.005 mg/kg/day	0.005 mg/kg/day	Increase in TSH levels	Metabolic endocrine-mediated perturbations
PMID:25819109	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Lead to obesity	Metabolic endocrine-mediated perturbations
PMID:25898838	IVR	4 mg/kg	4 mg/kg	Affects implantation	Reproductive endocrine-mediated perturbations
	IVR	4 mg/kg	4 mg/kg	Affects embryonic development	Developmental endocrine-mediated perturbations
	IVR	8 mg/kg	8 mg/kg	Affects implantation	Reproductive endocrine-mediated perturbations
	IVR	8 mg/kg	8 mg/kg	Affects embryonic development	Developmental endocrine-mediated perturbations
PMID:27267847	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Increased levels of Corticotropin-releasing hormone (CRH)	Neurological endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Alters hypothalamic-pituitary-adrenal (HPA) axis	Metabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Increase in corticosterone levels	Neurological endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Lead to obesity	Metabolic endocrine-mediated perturbations
PMID:27521499	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
PMID:28161095	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Increased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Alters hypothalamic-pituitary-gonadal axis (HPG axis)	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Affects fertility	Reproductive endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
PMID:28781899	IVR	5 mg/kg	5 mg/kg	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Reduced glutathione levels	Metabolic endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Increase in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
PMID:30831249	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Increased mammary gland weights	Reproductive endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Alters mammary gland development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Decreased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Oxidative stress in mammary gland	Reproductive endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Affects embryonic development	Developmental endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Oxidative stress in liver	Hepatic endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Affects lipid metabolism	Metabolic endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Decreased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Increased triglycerides level	Metabolic endocrine-mediated perturbations
PMID:31821856	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
PMID:31927052	IVTH	0.00000000625 - 0.0000001 M	0.00000000625 - 0.0000001 M	Increased cortisone levels	Neurological endocrine-mediated perturbations
PMID:32783468	IVR	5 mg/kg/day	5 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Abnormal sperm morphology	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Increase in the number of abnormal sperms	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Reduced sperm quality	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Decreased FSH levels	Reproductive endocrine-mediated perturbations
PMID:36858099	IVR	25 mg/kg	25 mg/kg	Affects locomotor activity	Neurological endocrine-mediated perturbations
	IVR	25 mg/kg	25 mg/kg	Induce behavioral changes	Neurological endocrine-mediated perturbations
PMID:37406193	IVR	0.0001 mg/kg	0.0001 mg/kg	Changes in brain morphology	Neurological endocrine-mediated perturbations
	IVR	0.0001 mg/kg	0.0001 mg/kg	Increased brain weights	Neurological endocrine-mediated perturbations
	IVR	0.0001 mg/kg	0.0001 mg/kg	Increased dopamine levels	Neurological endocrine-mediated perturbations
	IVR	0.0001 mg/kg	0.0001 mg/kg	Increased serotonin (5-HT) levels	Neurological endocrine-mediated perturbations
	IVR	0.0001 mg/kg	0.0001 mg/kg	Induce behavioral changes	Neurological endocrine-mediated perturbations
PMID:38621455	IVR	0.0001 - 0.001 mg/kg/day	0.0001 - 0.001 mg/kg/day	Decreased leptin levels	Metabolic endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Reduced insulin levels	Metabolic endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Increase in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	0.0001 - 0.001 mg/kg/day	0.0001 - 0.001 mg/kg/day	Affects developmental process	Developmental endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Decreased body weights	Metabolic endocrine-mediated perturbations
	IVR	0.0001 - 0.001 mg/kg/day	0.0001 - 0.001 mg/kg/day	Increase in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Increased triglycerides level	Metabolic endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Affects breast milk quality	Reproductive endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	0.0001 - 0.001 mg/kg/day	0.0001 - 0.001 mg/kg/day	Increased adiposity	Metabolic endocrine-mediated perturbations
	IVR	0.0001 - 0.001 mg/kg/day	0.0001 - 0.001 mg/kg/day	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Decrease in corticosterone levels	Neurological endocrine-mediated perturbations
PMID:7900160	IVR	25 mg/kg	25 mg/kg	Affects implantation	Reproductive endocrine-mediated perturbations
	IVR	25 mg/kg	25 mg/kg	Affects embryonic development	Developmental endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Affects embryonic development	Developmental endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Affects implantation	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Affects embryonic development	Developmental endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Affects implantation	Reproductive endocrine-mediated perturbations

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DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.