| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:38677070 | IVR | 0.125 - 6.25 mg/L | 0.125 - 6.25 mg/L | Changes in mammary gland morphology | Reproductive endocrine-mediated perturbations |
| IVR | 0.125 - 6.25 mg/L | 0.125 - 6.25 mg/L | Oxidative stress in uterus | Reproductive endocrine-mediated perturbations | |
| IVR | 6.25 mg/L | 6.25 mg/L | Decrease in Growth Hormone (GH) levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.125 - 6.25 mg/L | 0.125 - 6.25 mg/L | Affects uterine morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 0.125 - 6.25 mg/L | 0.125 - 6.25 mg/L | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 0.125 - 6.25 mg/L | 0.125 - 6.25 mg/L | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.125 - 6.25 mg/L | 0.125 - 6.25 mg/L | Increased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 6.25 mg/L | 6.25 mg/L | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.125 - 6.25 mg/L | 0.125 - 6.25 mg/L | Induce apoptosis in uterus | Reproductive endocrine-mediated perturbations | |
| IVR | 0.125 - 6.25 mg/L | 0.125 - 6.25 mg/L | Decreased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.125 - 6.25 mg/L | 0.125 - 6.25 mg/L | Affects uterine development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.