DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

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ToxCast endpoints for intended target type: RNA

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
CLD_ABCG2_48hr	Liver	Human	9429	ABCG2	Gain	0.2 μM
LTEA_HepaRG_ABCB1	Liver	Human	5243	ABCB1	Inhibitory	18.0 μM
LTEA_HepaRG_ABCC2	Liver	Human	1244	ABCC2	Activatory	15.17 μM
LTEA_HepaRG_ACOX1	Liver	Human	51	ACOX1	Activatory	11.7 μM
LTEA_HepaRG_ALPP	Liver	Human	250	ALPP	Activatory	0.38 μM
LTEA_HepaRG_CCND1	Liver	Human	595	CCND1	Inhibitory	22.81 μM
LTEA_HepaRG_CYP2B6	Liver	Human	1555	CYP2B6	Activatory	0.5 μM
LTEA_HepaRG_CYP2E1	Liver	Human	1571	CYP2E1	Inhibitory	0.59 μM
LTEA_HepaRG_CYP3A7	Liver	Human	1551	CYP3A7	Activatory	93.25 μM
LTEA_HepaRG_EGF	Liver	Human	1950	EGF	Activatory	50.0 μM
LTEA_HepaRG_EGR1	Liver	Human	1958	EGR1	Activatory	15.67 μM
LTEA_HepaRG_FAS	Liver	Human	355	FAS	Activatory	17.67 μM
LTEA_HepaRG_FASN	Liver	Human	2194	FASN	Activatory	13.38 μM
LTEA_HepaRG_FOXO1	Liver	Human	2308	FOXO1	Inhibitory	11.7 μM
LTEA_HepaRG_GADD45B	Liver	Human	4616	GADD45B	Activatory	16.52 μM
LTEA_HepaRG_GSTM3	Liver	Human	2947	GSTM3	Activatory	23.88 μM
LTEA_HepaRG_HGF	Liver	Human	3082	HGF	Activatory	24.09 μM
LTEA_HepaRG_HIF1A	Liver	Human	3091	HIF1A	Activatory	24.75 μM
LTEA_HepaRG_HSPA1A	Liver	Human	3303	HSPA1A	Activatory	28.85 μM
LTEA_HepaRG_JUN	Liver	Human	3725	JUN	Inhibitory	17.84 μM
LTEA_HepaRG_KCNK1	Liver	Human	3775	KCNK1	Inhibitory	16.36 μM
LTEA_HepaRG_MMP10	Liver	Human	4319	MMP10	Activatory	21.23 μM
LTEA_HepaRG_MMP3	Liver	Human	4314	MMP3	Activatory	19.66 μM
LTEA_HepaRG_NFE2L2	Liver	Human	4780	NFE2L2	Activatory	7.62 μM
LTEA_HepaRG_PDK4	Liver	Human	5166	PDK4	Inhibitory	18.47 μM
LTEA_HepaRG_PEG10	Liver	Human	23089	PEG10	Inhibitory	0.17 μM
LTEA_HepaRG_PPP2R4	Liver	Human	5524	PTPA	Inhibitory	50.0 μM
LTEA_HepaRG_SDHB	Liver	Human	6390	SDHB	Activatory	0.36 μM
LTEA_HepaRG_SLCO1B1	Liver	Human	10599	SLCO1B1	Activatory	11.79 μM
LTEA_HepaRG_SULT2A1	Liver	Human	6822	SULT2A1	Activatory	18.51 μM
LTEA_HepaRG_TGFA	Liver	Human	7039	TGFA	Inhibitory	7.78 μM
LTEA_HepaRG_TIMP1	Liver	Human	7076	TIMP1	Activatory	10.13 μM
LTEA_HepaRG_TNFRSF1A	Liver	Human	7132	TNFRSF1A	Inhibitory	50.0 μM
LTEA_HepaRG_UGT1A1	Liver	Human	54658	UGT1A1	Inhibitory	24.75 μM
LTEA_HepaRG_UGT1A6	Liver	Human	54578	UGT1A6	Inhibitory	24.48 μM

ToxCast endpoints for intended target type: Protein

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
CCTE_Deisenroth_5AR_NBTE_ratio	Kidney	Human	6716	SRD5A2	Activatory	30.58 μM
NVS_ADME_hCYP2C19		Human	1557	CYP2C19	Loss	0.43 μM
NVS_NR_hGR		Human	2908	NR3C1	Loss	0.32 μM
ATG_AP_1_CIS	Liver	Human	2353\|3725	FOS\|JUN	Activatory	0.0 μM
ATG_BRE_CIS	Liver	Human	4086	SMAD1	Activatory	0.01 μM
ATG_C_EBP_CIS	Liver	Human	1051	CEBPB	Activatory	0.02 μM
ATG_CRE_CIS	Liver	Human	10488	CREB3	Activatory	0.03 μM
ATG_DR5_RAR_CIS	Liver	Human	5914\|5915\|5916	RARA\|RARB\|RARG	Inhibitory	0.02 μM
ATG_MRE_CIS	Liver	Human	4520	MTF1	Inhibitory	0.09 μM
ATG_NF_kB_CIS	Liver	Human	4790	NFKB1	Activatory	0.06 μM
ATG_NRF2_ARE_CIS	Liver	Human	4780	NFE2L2	Inhibitory	0.01 μM
ATG_Oct_MLP_CIS	Liver	Human	5451	POU2F1	Activatory	0.03 μM
ATG_p53_CIS	Liver	Human	7157	TP53	Activatory	0.02 μM
ATG_PBREM_CIS	Liver	Human	9970	NR1I3	Inhibitory	0.05 μM
ATG_PPRE_CIS	Liver	Human	5465\|5467\|5468	PPARA\|PPARD\|PPARG	Inhibitory	0.03 μM
ATG_Sp1_CIS	Liver	Human	6667	SP1	Inhibitory	0.04 μM
ATG_SREBP_CIS	Liver	Human	6720	SREBF1	Inhibitory	0.0 μM
ATG_VDRE_CIS	Liver	Human	7421	VDR	Activatory	0.03 μM
ATG_Xbp1_CIS	Liver	Human	7494	XBP1	Inhibitory	0.02 μM
ATG_THRa1_TRANS	Liver	Human	7067	THRA	Gain	0.24 μM
BSK_3C_Eselectin	Vascular	Human	6401	SELE	Inhibitory	20.0 μM
BSK_3C_IL8	Vascular	Human	3576	CXCL8	Inhibitory	20.0 μM
BSK_3C_MCP1	Vascular	Human	6347	CCL2	Inhibitory	34.81 μM
BSK_3C_TissueFactor	Vascular	Human	2152	F3	Inhibitory	8.69 μM
BSK_3C_uPAR	Vascular	Human	5329	PLAUR	Inhibitory	7.25 μM
BSK_3C_VCAM1	Vascular	Human	7412	VCAM1	Inhibitory	20.0 μM
BSK_4H_Eotaxin3	Vascular	Human	10344	CCL26	Inhibitory	20.0 μM
BSK_4H_MCP1	Vascular	Human	6347	CCL2	Inhibitory	29.29 μM
BSK_4H_Pselectin	Vascular	Human	6403	SELP	Inhibitory	10.26 μM
BSK_4H_VCAM1	Vascular	Human	7412	VCAM1	Inhibitory	8.68 μM
BSK_BE3C_HLADR	Lung	Human	3122	HLA-DRA	Inhibitory	8.14 μM
BSK_BE3C_IP10	Lung	Human	3627	CXCL10	Inhibitory	20.0 μM
BSK_BE3C_MIG	Lung	Human	4283	CXCL9	Inhibitory	20.0 μM
BSK_BE3C_uPA	Lung	Human	5328	PLAU	Inhibitory	0.14 μM
BSK_CASM3C_Thrombomodulin	Vascular	Human	7056	THBD	Inhibitory	0.16 μM
BSK_CASM3C_VCAM1	Vascular	Human	7412	VCAM1	Inhibitory	29.55 μM
BSK_hDFCGF_CollagenIII	Skin	Human	1281	COL3A1	Inhibitory	20.0 μM
BSK_hDFCGF_VCAM1	Skin	Human	7412	VCAM1	Inhibitory	7.39 μM
BSK_KF3CT_IP10	Skin	Human	3627	CXCL10	Inhibitory	31.78 μM
BSK_KF3CT_MMP9	Skin	Human	4318	MMP9	Inhibitory	15.64 μM
BSK_LPS_Eselectin	Vascular	Human	6401	SELE	Inhibitory	20.0 μM
BSK_LPS_IL1a	Vascular	Human	3552	IL1A	Inhibitory	15.03 μM
BSK_LPS_IL8	Vascular	Human	3576	CXCL8	Inhibitory	36.98 μM
BSK_LPS_MCP1	Vascular	Human	6347	CCL2	Inhibitory	26.81 μM
BSK_LPS_MCSF	Vascular	Human	1435	CSF1	Inhibitory	13.44 μM
BSK_LPS_TissueFactor	Vascular	Human	2152	F3	Inhibitory	8.75 μM
BSK_LPS_TNFa	Vascular	Human	7124	TNF	Inhibitory	20.0 μM
BSK_SAg_CD40	Vascular	Human	958	CD40	Inhibitory	7.75 μM
BSK_SAg_MCP1	Vascular	Human	6347	CCL2	Inhibitory	16.7 μM
BSK_SAg_MIG	Vascular	Human	4283	CXCL9	Inhibitory	27.21 μM
CCTE_Simmons_AUR_rTPO	Thyroid gland	Rat	54314	Tpo	Loss	26.48 μM
CPHEA_Stoker_NIS_Inhibition_RAIU	Kidney	Human	6528	SLC5A5	Loss	0.06 μM
TOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881	Breast	Human	367	AR	Loss	0.2 μM
TOX21_Aromatase_LUC_Antagonist	Breast	Human	1588	CYP19A1	Loss	14.67 μM
TOX21_ERa_BLA_Antagonist_ratio	Kidney	Human	2099	ESR1	Loss	19.46 μM
TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2	Breast	Human	2099	ESR1	Loss	0.15 μM
TOX21_TR_LUC_GH3_Antagonist	Pituitary gland	Rat	7067\|7068	THRA\|THRB	Loss	0.21 μM
TOX21_RORg_LUC_CHO_Antagonist	Ovary	Chinese hamster	6097	RORC	Loss	0.07 μM
TOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881	Breast	Human	367	AR	Loss	0.05 μM
TOX21_TSHR_HTRF_Agonist_ratio	Kidney	Human	7253	TSHR	Gain	27.19 μM
TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2	Breast	Human	2099	ESR1	Loss	0.04 μM
TOX21_ERR_LUC_Antagonist	Kidney	Human	2101	ESRRA	Loss	0.01 μM
TOX21_ERb_BLA_Antagonist_ratio	Kidney	Human	2100	ESR2	Loss	10.32 μM
TOX21_PR_BLA_Antagonist_ratio	Kidney	Human	5241	PGR	Loss	9.74 μM
TOX21_p450_CYP3A4_Antagonist		Human	1576	CYP3A4	Loss	9.98 μM
TOX21_p450_CYP2D6_Antagonist		Human	1565	CYP2D6	Loss	35.35 μM
TOX21_p450_CYP2C9_Antagonist		Human	1559	CYP2C9	Loss	7.37 μM
TOX21_AR_BLA_Antagonist_ratio	Kidney	Human	367	AR	Loss	0.2 μM
TOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881	Breast	Human	367	AR	Loss	0.04 μM
TOX21_Aromatase_LUC_Antagonist	Breast	Human	1588	CYP19A1	Loss	19.0 μM
TOX21_ERa_BLA_Antagonist_ratio	Kidney	Human	2099	ESR1	Loss	40.94 μM
TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2	Breast	Human	2099	ESR1	Loss	0.04 μM
TOX21_TR_LUC_GH3_Antagonist	Pituitary gland	Rat	7067\|7068	THRA\|THRB	Loss	0.03 μM
TOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881	Breast	Human	367	AR	Loss	0.02 μM
TOX21_TSHR_HTRF_Agonist_ratio	Kidney	Human	7253	TSHR	Gain	20.35 μM
TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2	Breast	Human	2099	ESR1	Loss	0.02 μM
TOX21_ERR_LUC_Antagonist	Kidney	Human	2101	ESRRA	Loss	0.02 μM
TOX21_PGC_ERR_LUC_Antagonist	Kidney	Human	2101	ESRRA	Loss	0.01 μM
TOX21_ERb_BLA_Antagonist_ratio	Kidney	Human	2100	ESR2	Loss	20.61 μM
TOX21_PXR_LUC_Agonist	Liver	Human	8856	NR1I2	Gain	0.02 μM
TOX21_p450_CYP3A4_Antagonist		Human	1576	CYP3A4	Loss	8.94 μM
TOX21_p450_CYP1A2_Antagonist		Human	1544	CYP1A2	Loss	36.63 μM
TOX21_hERG_U2OS_Antagonist	Bone	Human	3757	KCNH2	Loss	34.23 μM
TOX21_ARE_KS_LUC_Agonist	Skin	Human	4780	NFE2L2	Gain	22.37 μM
TOX21_AR_BLA_Antagonist_ratio	Kidney	Human	367	AR	Loss	0.18 μM
TOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881	Breast	Human	367	AR	Loss	0.02 μM
TOX21_Aromatase_LUC_Antagonist	Breast	Human	1588	CYP19A1	Loss	25.92 μM
TOX21_ERa_BLA_Antagonist_ratio	Kidney	Human	2099	ESR1	Loss	40.67 μM
TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2	Breast	Human	2099	ESR1	Loss	0.02 μM
TOX21_TR_LUC_GH3_Antagonist	Pituitary gland	Rat	7067\|7068	THRA\|THRB	Loss	0.08 μM
TOX21_RORg_LUC_CHO_Antagonist	Ovary	Chinese hamster	6097	RORC	Loss	0.4 μM
TOX21_TSHR_HTRF_Agonist_ratio	Kidney	Human	7253	TSHR	Gain	28.12 μM
TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2	Breast	Human	2099	ESR1	Loss	0.01 μM
TOX21_PGC_ERR_LUC_Antagonist	Kidney	Human	2101	ESRRA	Loss	0.0 μM
TOX21_ERb_BLA_Antagonist_ratio	Kidney	Human	2100	ESR2	Loss	19.08 μM
TOX21_p450_CYP3A4_Antagonist		Human	1576	CYP3A4	Loss	11.59 μM
TOX21_p450_CYP2D6_Antagonist		Human	1565	CYP2D6	Loss	47.99 μM
TOX21_p450_CYP1A2_Antagonist		Human	1544	CYP1A2	Loss	31.38 μM
TOX21_hERG_U2OS_Antagonist	Bone	Human	3757	KCNH2	Loss	22.46 μM
TOX21_ARE_KS_LUC_Agonist	Skin	Human	4780	NFE2L2	Gain	46.08 μM

No ToxCast endpoints for intended target type: Molecular messenger

ToxCast endpoints for intended target type: Pathway

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
UPITT_HCI_U2OS_AR_TIF2_Nucleoli_Antagonist	Bone	Human	367	AR	Loss	50.0 μM
APR_HepG2_p53Act_24hr	Liver	Human	7157	TP53	Activatory	20.58 μM
OT_NURR1_NURR1RXRa_0480	Kidney	Human	4929\|6256	NR4A2\|RXRA	Gain	17.56 μM
ACEA_ER_80hr	Breast	Human	2099	ESR1	Gain	0.0 μM
OT_AR_ARSRC1_0960	Kidney	Human	367\|6714	AR\|SRC	Gain	0.04 μM
OT_FXR_FXRSRC1_0480	Kidney	Human	6714\|9971	SRC\|NR1H4	Gain	18.23 μM
OT_FXR_FXRSRC1_1440	Kidney	Human	6714\|9971	SRC\|NR1H4	Gain	9.92 μM
OT_NURR1_NURR1RXRa_0480	Kidney	Human	4929\|6256	NR4A2\|RXRA	Gain	15.7 μM
OT_NURR1_NURR1RXRa_1440	Kidney	Human	4929\|6256	NR4A2\|RXRA	Gain	21.99 μM
TOX21_p53_BLA_p1_ratio	Intestinal	Human	7157	TP53	Gain	0.27 μM
TOX21_p53_BLA_p2_ratio	Intestinal	Human	7157	TP53	Gain	0.41 μM
TOX21_p53_BLA_p3_ratio	Intestinal	Human	7157	TP53	Gain	0.23 μM
TOX21_PPARg_BLA_Antagonist_ratio	Kidney	Human	5468	PPARG	Loss	8.14 μM
TOX21_SHH_3T3_GLI3_LUC_Antagonist	Embryo	Mouse	6469	SHH	Loss	0.0 μM
TOX21_ARE_BLA_Agonist_ratio	Liver	Human	4780	NFE2L2	Gain	0.02 μM
TOX21_p53_BLA_p1_ratio	Intestinal	Human	7157	TP53	Gain	0.11 μM
TOX21_FXR_BLA_Antagonist_ratio	Kidney	Human	9971	NR1H4	Loss	0.25 μM
TOX21_PPARg_BLA_Antagonist_ratio	Kidney	Human	5468	PPARG	Loss	11.17 μM
TOX21_p53_BLA_p2_ratio	Intestinal	Human	7157	TP53	Gain	0.08 μM
TOX21_p53_BLA_p3_ratio	Intestinal	Human	7157	TP53	Gain	0.06 μM
TOX21_p53_BLA_p4_ratio	Intestinal	Human	7157	TP53	Gain	0.17 μM
TOX21_p53_BLA_p5_ratio	Intestinal	Human	7157	TP53	Gain	0.11 μM
TOX21_SHH_3T3_GLI3_LUC_Antagonist	Embryo	Mouse	6469	SHH	Loss	0.01 μM
TOX21_p53_BLA_p7_ratio	Intestinal	Human	7157	TP53	Gain	0.16 μM
TOX21_ARE_BLA_Agonist_ratio	Liver	Human	4780	NFE2L2	Gain	0.01 μM
TOX21_p53_BLA_p1_ratio	Intestinal	Human	7157	TP53	Gain	0.22 μM
TOX21_PPARd_BLA_Antagonist_ratio	Kidney	Human	5467	PPARD	Loss	29.95 μM
TOX21_p53_BLA_p2_ratio	Intestinal	Human	7157	TP53	Gain	0.07 μM
TOX21_p53_BLA_p3_ratio	Intestinal	Human	7157	TP53	Gain	0.08 μM
TOX21_p53_BLA_p4_ratio	Intestinal	Human	7157	TP53	Gain	0.1 μM
TOX21_SHH_3T3_GLI3_LUC_Antagonist	Embryo	Mouse	6469	SHH	Loss	0.02 μM

No ToxCast endpoints for intended target type: Cellular

No ToxCast endpoints for intended target type: Hormone

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.