Naringenin
| Predicted ADME Properties | |||||
|---|---|---|---|---|---|
| Type | Property | Tool | Interpretation | Probability/Value | |
| Absorption | Caco-2 permeability | admetSAR | High | 62.72 % | |
| pkCSM | High | 1.029 cm/s | |||
| Human Intestinal Absorption | admetSAR | High | 94.34 % | ||
| pkCSM | High | 91.31 % | |||
| SwissADME | High | - | |||
| Human Oral Bioavailability | admetSAR | Low Bioavailability | 15.88 % | ||
| Log Kp (Skin permeation) | pkCSM | High | -2.742 logkp (cm/h) | ||
| SwissADME | - | -6.17 logkp (cm/s) | |||
| Distribution | P-glycoprotein substrate | admetSAR | Low | 9.97 % | |
| pkCSM | Yes | - | |||
| SwissADME | Yes | - | |||
| vNN | No | - | |||
| P-glycoprotein inhibitor | admetSAR | Low | 34.44 % | ||
| vNN | No | - | |||
| P-glycoprotein inhibitor I | pkCSM | No | - | ||
| P-glycoprotein inhibitor II | pkCSM | No | - | ||
| Blood Brain Barrier | admetSAR | High | 50.59 % | ||
| pkCSM | Moderate | -0.578 logBB | |||
| SwissADME | No | - | |||
| vNN | No | - | |||
| CNS permeability | pkCSM | Moderate | -2.215 logPS | ||
| Fraction unbound in human | pkCSM | - | 0.064 | ||
| Plasma protein binding | admetSAR | 97.16 % | High | ||
| Steady state volume of distribution (VDss) | pkCSM | Moderate | -0.015 log(L/kg) | ||
| Metabolism | CYP1A2 inhibitor | admetSAR | High | 97.59 % | |
| pkCSM | Yes | - | |||
| SwissADME | Yes | - | |||
| vNN | Yes | - | |||
| CYP2C19 inhibitor | admetSAR | High | 69.58 % | ||
| pkCSM | No | - | |||
| SwissADME | No | - | |||
| vNN | Yes | - | |||
| CYP2C9 inhibitor | admetSAR | High | 59.74 % | ||
| pkCSM | No | - | |||
| SwissADME | No | - | |||
| vNN | No | - | |||
| CYP2C9 substrate | admetSAR | Low | 8.04 % | ||
| CYP2D6 inhibitor | admetSAR | High | 58.39 % | ||
| pkCSM | No | - | |||
| SwissADME | No | - | |||
| vNN | No | - | |||
| CYP2D6 substrate | admetSAR | Low | 5.26 % | ||
| pkCSM | No | - | |||
| CYP3A4 inhibitor | admetSAR | Low | 34.86 % | ||
| pkCSM | No | - | |||
| SwissADME | Yes | - | |||
| vNN | No | - | |||
| CYP3A4 substrate | admetSAR | Low | 8.27 % | ||
| pkCSM | No | - | |||
| Human Liver Microsomal (HLM) stability assay | vNN | No Prediction | - | ||
| OATP2B1 inhibitor | admetSAR | Low | 32.79 % | ||
| OATP1B1 inhibitor | admetSAR | High | 84.63 % | ||
| OATP1B3 inhibitor | admetSAR | High | 86.53 % | ||
| MATE1 inhibitor | admetSAR | Low | 33.21 % | ||
| BSEP inhibitor | admetSAR | High | 54.04 % | ||
| UGT catalysis | admetSAR | High | 95.76 % | ||
| Excretion | Renal OCT2 inhibitor | admetSAR | Low | 28.18 % | |
| Renal OCT2 substrate | pkCSM | No | - | ||
| Total clearance | pkCSM | - | 0.06 ml/min/kg | ||
| Predicted Toxicity properties | ||||
|---|---|---|---|---|
| Property | Tool | Interpretation | Probability/Value | |
| Acute oral toxicity | admetSAR | - | -3.18114757537842 log(mg/kg) | |
| ProTox | - | 2000 mg/kg | ||
| Acute oral toxicity class | admetSAR | Low | 27.87 % | |
| ProTox | 4 | - | ||
| Biodegradation | admetSAR | Low | 30.85 % | |
| Toxtree | Class 2 (persistent chemical) | - | ||
| Carcinogens | admetSAR | High | 80.02 % | |
| Toxtree | No | - | ||
| Cramer's rule | Toxtree | High (Class III) | - | |
| Cytotoxicity | vNN | NoPrediction | - | |
| Genotoxic carcinogenity | Toxtree | No | - | |
| Hepatotoxicity | admetSAR | Low | 49.96 % | |
| pkCSM | No | - | ||
| vNN | NoPrediction | - | ||
| Human Ether-a-go-go-Related Gene Inhibitor | admetSAR | Low | 20.42 % | |
| vNN | No | - | ||
| Human Ether-a-go-go-Related Gene Inhibitor I | pkCSM | No | - | |
| Human Ether-a-go-go-Related Gene Inhibitor II | pkCSM | No | - | |
| Mitochondrial Membrane Potential (MMP) | vNN | NoPrediction | - | |
| Maximum Recommended Tolerated Dose (MRTD) | pkCSM | Low | -0.176 log(mg/kg/day) | |
| vNN | - | 1530 mg/day | ||
| Non-Genotoxic carcinogenicity | Toxtree | No | - | |
| Oral rat acute toxicity | pkCSM | - | 1.791 log(mg/kg_bw/day) (LD50) | |
| pkCSM | - | 1.944 log(mg/kg_bw/day) (LOAEL) | ||
| Micronucleus | admetSAR | High | 67.21 % | |
| Skin sensitisation | pkCSM | No | - | |
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