Naringenin


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000280 Nuclear division Decreases phenotype PMID:38308452
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:25855085
GO:0001516 Prostaglandin biosynthetic process Increases phenotype PMID:21341175
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:31254498
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:38308452
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:23283742
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Affects phenotype PMID:29223569; PMID:38308452
GO:0004364 Glutathione transferase activity Affects phenotype PMID:23283742; PMID:27206700; PMID:38308452
GO:0004457 Lactate dehydrogenase activity Affects phenotype PMID:25855085; PMID:27206700; PMID:38308452
GO:0004602 Glutathione peroxidase activity Affects phenotype PMID:23192364; PMID:23283742; PMID:38308452
GO:0004697 Protein kinase c activity Increases phenotype PMID:25855085
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:23192364; PMID:23283742; PMID:25855085; PMID:27417253; PMID:34655599; PMID:38308452
GO:0004855 Xanthine oxidase activity Increases phenotype PMID:27206700
GO:0005978 Glycogen biosynthetic process Decreases phenotype PMID:29223569
GO:0006171 Camp biosynthetic process Increases phenotype PMID:31301536
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:23192364
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:37076581
GO:0006695 Cholesterol biosynthetic process Increases phenotype PMID:29223569
GO:0006749 Glutathione metabolic process Increases phenotype PMID:25855085; PMID:27206700; PMID:34655599; PMID:36235125; PMID:38308452
GO:0006750 Glutathione biosynthetic process Affects phenotype PMID:23283742; PMID:29223569; PMID:31254498
GO:0006754 Atp biosynthetic process Decreases phenotype PMID:31254498
GO:0006809 Nitric oxide biosynthetic process Increases phenotype PMID:15316927; PMID:31254498
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:25855085
GO:0006915 Apoptotic process Increases phenotype PMID:25855085; PMID:30153467
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:30153467; PMID:31254498
GO:0007283 Spermatogenesis Decreases phenotype PMID:36807407
GO:0008137 Nadh dehydrogenase (ubiquinone) activity Decreases phenotype PMID:31254498
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:37076581
GO:0008219 Cell death Increases phenotype PMID:24561720
GO:0008283 Cell population proliferation Affects phenotype PMID:23192364; PMID:24586459; PMID:28855101; PMID:34655599
GO:0008284 Positive regulation of cell population proliferation Decreases phenotype PMID:27838343
GO:0009306 Protein secretion Increases phenotype PMID:31301536
GO:0016042 Lipid catabolic process Affects phenotype PMID:19489629; PMID:23283742; PMID:27417253; PMID:29223569; PMID:31254498
GO:0016049 Cell growth Decreases phenotype PMID:30153467
GO:0016477 Cell migration Affects phenotype PMID:25866363; PMID:30431227
GO:0016887 Atp hydrolysis activity Decreases phenotype PMID:31254498
GO:0018158 Protein oxidation Increases phenotype PMID:29223569; PMID:31254498
GO:0019432 Triglyceride biosynthetic process Increases phenotype PMID:29223569
GO:0019627 Urea metabolic process Affects phenotype PMID:38308452
GO:0030263 Apoptotic chromosome condensation Increases phenotype PMID:34655599
GO:0030335 Positive regulation of cell migration Decreases phenotype PMID:27468969
GO:0031324 Negative regulation of cellular metabolic process Increases phenotype PMID:36235125
GO:0031987 Locomotion involved in locomotory behavior Affects phenotype PMID:34655599
GO:0034374 Low-density lipoprotein particle remodeling Increases phenotype PMID:19489629
GO:0034440 Lipid oxidation Increases phenotype PMID:30372826; PMID:34655599; PMID:38308452
GO:0042310 Vasoconstriction Increases phenotype PMID:34411564
GO:0042360 Vitamin e metabolic process Increases phenotype PMID:19489629
GO:0042554 Superoxide anion generation Increases phenotype PMID:31254498
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:27838343; PMID:28395574; PMID:36235125
GO:0043408 Regulation of mapk cascade Increases phenotype PMID:24586459
GO:0044237 Cellular metabolic process Decreases phenotype PMID:31063766; PMID:31194956; PMID:34655599; PMID:37217155
GO:0044319 Wound healing, spreading of cells Decreases phenotype PMID:30153467
GO:0045786 Negative regulation of cell cycle Increases phenotype PMID:25855085
GO:0045919 Positive regulation of cytolysis Increases phenotype PMID:36235125
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:30153467
GO:0046034 Atp metabolic process Affects phenotype PMID:34655599
GO:0046449 Creatinine metabolic process Affects phenotype PMID:38308452
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:27206700
GO:0048143 Astrocyte activation Increases phenotype PMID:34655599
GO:0048870 Cell motility Decreases phenotype PMID:24347325
GO:0050665 Hydrogen peroxide biosynthetic process Increases phenotype PMID:31254498
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:23192364; PMID:25855085; PMID:31254498
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:34655599
GO:0051899 Membrane depolarization Increases phenotype PMID:25855085
GO:0060623 Regulation of chromosome condensation Affects phenotype PMID:23192364
GO:0061113 Pancreas morphogenesis Affects phenotype PMID:29223569
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:36807407
GO:0070265 Necrotic cell death Increases phenotype PMID:38308452
GO:0070989 Oxidative demethylation Decreases phenotype PMID:33007396
GO:0070994 Detection of oxidative stress Increases phenotype PMID:36807407
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:23192364; PMID:25855085; PMID:34655599
GO:0097722 Sperm motility Decreases phenotype PMID:28395574; PMID:36807407
GO:0098737 Protein insertion into plasma membrane Decreases phenotype PMID:31301536
GO:1900745 Positive regulation of p38mapk cascade Increases phenotype PMID:27838343
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:27206700; PMID:30372826
GO:1901671 Positive regulation of superoxide dismutase activity Increases phenotype PMID:36235125
GO:1902459 Positive regulation of stem cell population maintenance Decreases phenotype PMID:27468969
GO:1902552 Negative regulation of catalase activity Increases phenotype PMID:27206700
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:27206700
GO:1903409 Reactive oxygen species biosynthetic process Affects phenotype PMID:19958256; PMID:24561720; PMID:30153467; PMID:31254498
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:27838343; PMID:28395574
GO:2000018 Regulation of male gonad development Affects phenotype PMID:28395574
GO:2000648 Positive regulation of stem cell proliferation Decreases phenotype PMID:27468969
GO:2001057 Reactive nitrogen species metabolic process Affects phenotype PMID:25855085
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.