| Entrez gene ID | Gene symbol | Interaction type | Reference |
|---|---|---|---|
| 1026 | CDKN1A | Increases expression | PMID:30153467; PMID:36235125 |
| 120892 | LRRK2 | Decreases expression | PMID:34655599 |
| 1499 | CTNNB1 | Decreases expression | PMID:34655599 |
| 1509 | CTSD | Increases activity | PMID:24586459 |
| 1509 | CTSD | Increases expression | PMID:24586459 |
| 1543 | CYP1A1 | Decreases activity | PMID:11454723; PMID:21053930; PMID:27444380; PMID:27444380 |
| 1543 | CYP1A1 | Increases expression | PMID:20930378 |
| 1544 | CYP1A2 | Decreases activity | PMID:21053930; PMID:29753067 |
| 1545 | CYP1B1 | Decreases activity | PMID:21053930 |
| 1545 | CYP1B1 | Increases expression | PMID:31621310 |
| 1557 | CYP2C19 | Decreases activity | PMID:29753067 |
| 1559 | CYP2C9 | Decreases activity | PMID:29753067 |
| 1571 | CYP2E1 | Decreases activity | PMID:33007396 |
| 1576 | CYP3A4 | Decreases activity | PMID:21053930; PMID:29753067 |
| 1576 | CYP3A4 | Increases expression | PMID:19148864 |
| 1588 | CYP19A1 | Decreases activity | PMID:15319488; PMID:38403145; PMID:17895526; PMID:9435150 |
| 1645 | AKR1C1 | Decreases activity | PMID:16962702 |
| 1647 | GADD45A | Increases expression | PMID:36235125 |
| 1728 | NQO1 | Increases expression | PMID:24561720 |
| 1813 | DRD2 | Decreases expression | PMID:34655599 |
| 196 | AHR | Increases activity | PMID:17869316 |
| 207 | AKT1 | Decreases expression | PMID:36819991 |
| 2099 | ESR1 | Affects expression | PMID:24586459; PMID:30153467; PMID:36235125 |
| 2099 | ESR1 | Increases activity | PMID:10397250; PMID:9751507; PMID:10854714; PMID:16118406; PMID:12650720; PMID:24586459 |
| 2100 | ESR2 | Increases activity | PMID:16118406; PMID:17716812; PMID:9751507 |
| 2100 | ESR2 | Increases expression | PMID:30153467; PMID:30153467; PMID:36235125; PMID:36235125 |
| 2353 | FOS | Increases expression | PMID:28395574 |
| 23621 | BACE1 | Decreases activity | PMID:31194956 |
| 249 | ALPL | Increases activity | PMID:12650720 |
| 2539 | G6PD | Decreases activity | PMID:25130191; PMID:25228019 |
| 2729 | GCLC | Increases expression | PMID:31254498 |
| 2730 | GCLM | Increases expression | PMID:31254498 |
| 2765 | GML | Increases expression | PMID:36235125 |
| 2852 | GPER1 | Decreases expression | PMID:30153467; PMID:30153467; PMID:36235125; PMID:36235125 |
| 2876 | GPX1 | Decreases expression | PMID:28395574 |
| 2877 | GPX2 | Increases expression | PMID:24561720 |
| 2880 | GPX5 | Increases expression | PMID:24561720 |
| 2882 | GPX7 | Increases expression | PMID:24561720 |
| 2936 | GSR | Increases expression | PMID:24561720 |
| 2954 | GSTZ1 | Increases expression | PMID:24561720 |
| 3099 | HK2 | Increases expression | PMID:36235125 |
| 3162 | HMOX1 | Increases activity | PMID:22709785 |
| 3162 | HMOX1 | Increases expression | PMID:15316927; PMID:22709785; PMID:24561720 |
| 317 | APAF1 | Increases expression | PMID:27838343; PMID:36235125 |
| 332 | BIRC5 | Increases expression | PMID:36235125 |
| 355 | FAS | Increases expression | PMID:36235125 |
| 3551 | IKBKB | Increases expression | PMID:28395574 |
| 356 | FASLG | Increases expression | PMID:36235125 |
| 3569 | IL6 | Increases expression | PMID:36235125 |
| 3725 | JUN | Affects expression | PMID:28395574; PMID:36235125 |
| 3757 | KCNH2 | Decreases activity | PMID:18057881 |
| 396 | ARHGDIA | Increases expression | PMID:27838343 |
| 4025 | LPO | Increases expression | PMID:24561720 |
| 406933 | MIR141 | Decreases expression | PMID:36235125 |
| 4193 | MDM2 | Increases expression | PMID:36235125 |
| 4217 | MAP3K5 | Increases expression | PMID:27838343 |
| 4292 | MLH1 | Increases expression | PMID:36235125 |
| 4313 | MMP2 | Decreases activity | PMID:30431227 |
| 4313 | MMP2 | Decreases expression | PMID:30153467; PMID:30431227 |
| 4318 | MMP9 | Decreases activity | PMID:30431227 |
| 4318 | MMP9 | Decreases expression | PMID:30153467; PMID:30431227 |
| 4363 | ABCC1 | Increases activity | PMID:11306701 |
| 4654 | MYOD1 | Increases expression | PMID:36235125 |
| 4780 | NFE2L2 | Increases activity | PMID:31254498 |
| 4780 | NFE2L2 | Increases expression | PMID:24561720 |
| 4795 | NFKBIL1 | Increases expression | PMID:27838343 |
| 4830 | NME1 | Increases expression | PMID:27838343 |
| 5052 | PRDX1 | Decreases expression | PMID:27838343 |
| 5226 | PGD | Decreases activity | PMID:25130191 |
| 5241 | PGR | Increases activity | PMID:24586459 |
| 5241 | PGR | Increases expression | PMID:10397250; PMID:24586459 |
| 5243 | ABCB1 | Increases expression | PMID:19148864 |
| 54205 | CYCS | Increases expression | PMID:27838343 |
| 5444 | PON1 | Increases expression | PMID:15169886 |
| 54658 | UGT1A1 | Increases expression | PMID:31621310 |
| 5594 | MAPK1 | Decreases activity | PMID:30431227 |
| 5594 | MAPK1 | Decreases expression | PMID:36819991 |
| 5595 | MAPK3 | Decreases activity | PMID:30431227 |
| 56475 | RPRM | Increases expression | PMID:36235125 |
| 5664 | PSEN2 | Increases activity | PMID:24586459 |
| 5664 | PSEN2 | Increases expression | PMID:24586459 |
| 5728 | PTEN | Increases expression | PMID:36235125 |
| 5742 | PTGS1 | Increases expression | PMID:24561720 |
| 575 | ADGRB1 | Increases expression | PMID:36235125 |
| 57521 | RPTOR | Increases expression | PMID:27838343 |
| 578 | BAK1 | Increases expression | PMID:27838343 |
| 581 | BAX | Decreases expression | PMID:30153467 |
| 595 | CCND1 | Decreases expression | PMID:30153467 |
| 596 | BCL2 | Decreases expression | PMID:30153467; PMID:36235125 |
| 597 | BCL2A1 | Increases expression | PMID:36235125 |
| 598 | BCL2L1 | Decreases expression | PMID:27838343 |
| 627 | BDNF | Increases expression | PMID:34655599 |
| 63970 | TP53AIP1 | Increases expression | PMID:36235125 |
| 6476 | SI | Decreases activity | PMID:24412302 |
| 6513 | SLC2A1 | Decreases activity | PMID:14642735 |
| 6531 | SLC6A3 | Decreases expression | PMID:34655599 |
| 6591 | SNAI2 | Decreases expression | PMID:30431227 |
| 6615 | SNAI1 | Decreases expression | PMID:30431227 |
| 6622 | SNCA | Increases expression | PMID:34655599 |
| 6647 | SOD1 | Decreases expression | PMID:28395574 |
| 6657 | SOX2 | Decreases expression | PMID:27468969 |
| 675 | BRCA2 | Increases expression | PMID:36235125 |
| 7054 | TH | Decreases expression | PMID:34655599 |
| 7124 | TNF | Decreases activity | PMID:22709785 |
| 7124 | TNF | Increases expression | PMID:36235125 |
| 7157 | TP53 | Increases expression | PMID:27838343; PMID:30153467 |
| 7161 | TP73 | Increases expression | PMID:36235125 |
| 7173 | TPO | Decreases activity | PMID:26884060 |
| 7490 | WT1 | Increases expression | PMID:36235125 |
| 7832 | BTG2 | Decreases expression | PMID:36235125 |
| 79758 | DHRS12 | Decreases expression | PMID:27838343 |
| 79923 | NANOG | Decreases expression | PMID:27468969 |
| 80313 | LRRC27 | Increases expression | PMID:27838343 |
| 835 | CASP2 | Increases expression | PMID:36235125 |
| 836 | CASP3 | Increases activity | PMID:19124070; PMID:22692793 |
| 836 | CASP3 | Increases expression | PMID:27838343; PMID:34655599 |
| 840 | CASP7 | Increases expression | PMID:27838343 |
| 842 | CASP9 | Increases activity | PMID:19124070 |
| 842 | CASP9 | Increases expression | PMID:27838343; PMID:36235125 |
| 847 | CAT | Decreases expression | PMID:28395574 |
| 847 | CAT | Increases activity | PMID:27417253; PMID:34655599 |
| 8626 | TP63 | Increases expression | PMID:36235125 |
| 8644 | AKR1C3 | Decreases activity | PMID:19007764 |
| 8738 | CRADD | Increases expression | PMID:36235125 |
| 8793 | TNFRSF10D | Increases expression | PMID:36235125 |
| 8842 | PROM1 | Decreases expression | PMID:27468969 |
| 8850 | KAT2B | Increases expression | PMID:36235125 |
| 8856 | NR1I2 | Increases activity | PMID:25455453 |
| 898 | CCNE1 | Decreases expression | PMID:30153467 |
| 9021 | SOCS3 | Increases expression | PMID:23782265 |
| 9232 | PTTG1 | Increases expression | PMID:36235125 |
| 993 | CDC25A | Increases expression | PMID:36235125 |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.