Silica


Curated chemical-disease associations from CTD
Disease IDDisease nameReference
MESH:C563515 Neutrophil Chemotactic Response, Abnormal PMID:24466574
MESH:D001327 Autoimmune Diseases PMID:22087542
MESH:D002429 Cecal Diseases PMID:31654707
MESH:D002471 Cell Transformation, Neoplastic PMID:20123007
MESH:D002526 Cerebellar Diseases PMID:39362619
MESH:D003643 Death PMID:31369748
MESH:D004195 Disease Models, Animal PMID:20421647; PMID:29341224; PMID:31181250; PMID:32721576; PMID:33428986; PMID:33482250; PMID:34843873; PMID:35288145; PMID:36309172
MESH:D005355 Fibrosis PMID:20421647; PMID:22273745; PMID:25280005; PMID:25388157
MESH:D006965 Hyperplasia PMID:22861000
MESH:D006976 Hypertension, Pulmonary PMID:30453980
MESH:D007246 Infertility PMID:31369748
MESH:D007249 Inflammation PMID:17301066; PMID:20421647; PMID:21602193; PMID:22273745; PMID:22861000; PMID:23640035; PMID:27616297; PMID:27714660; PMID:33749107
MESH:D007964 Leukocytosis PMID:19875681
MESH:D008171 Lung Diseases PMID:19580863; PMID:19875681; PMID:21602193; PMID:22087542; PMID:34779285
MESH:D008175 Lung Neoplasms PMID:22411970
MESH:D008180 Lupus Erythematosus, Systemic PMID:16373255
MESH:D009336 Necrosis PMID:24992398
MESH:D009410 Nerve Degeneration PMID:39362619
MESH:D010490 Pericardial Effusion PMID:26943738
MESH:D011014 Pneumonia PMID:21414392; PMID:29341224; PMID:31284023; PMID:32017981; PMID:8063194
MESH:D011041 Poisoning PMID:22245848
MESH:D011123 Polyploidy PMID:25625797
MESH:D011654 Pulmonary Edema PMID:30978436; PMID:34843873
MESH:D011658 Pulmonary Fibrosis PMID:12193738; PMID:14975940; PMID:17365031; PMID:18403674; PMID:20490462; PMID:21414392; PMID:21868503; PMID:22861000; PMID:23640035; PMID:23973437; PMID:25733726; PMID:26163174; PMID:26345256; PMID:26368622; PMID:27616297; PMID:29113749; PMID:29216763; PMID:29341224; PMID:30658076; PMID:30978436; PMID:31028789; PMID:31181250; PMID:31284023; PMID:32017981; PMID:32097614; PMID:32721576; PMID:33007385; PMID:33428986; PMID:33482250; PMID:33720480; PMID:34481903; PMID:34843873; PMID:35271943; PMID:36223831; PMID:36403901; PMID:38523403; PMID:39353502; PMID:8063194
MESH:D012141 Respiratory Tract Infections PMID:17650330
MESH:D012594 Scleroderma, Localized PMID:1724723
MESH:D012595 Scleroderma, Systemic PMID:1724723
MESH:D012829 Silicosis PMID:18604214; PMID:18666137; PMID:18685790; PMID:19151164; PMID:20421647; PMID:22087542; PMID:22273745; PMID:23640035; PMID:24986923; PMID:25027041; PMID:25733726; PMID:26163174; PMID:26865670; PMID:27616297; PMID:29341224; PMID:30391304; PMID:30453980; PMID:31028789; PMID:31034866; PMID:31181250; PMID:32017981; PMID:32097614; PMID:32721576; PMID:33010382; PMID:33482250; PMID:34779285; PMID:34843873; PMID:34979141; PMID:35288145; PMID:35288261; PMID:36223831; PMID:36309172; PMID:38403151; PMID:38523403; PMID:38811393; PMID:39245427; PMID:39353502
MESH:D013927 Thrombosis PMID:29658397
MESH:D014890 Granulomatosis with Polyangiitis PMID:26596772
MESH:D015431 Weight Loss PMID:30453980; PMID:30978436; PMID:33007385; PMID:33428986
MESH:D019457 Chromosome Breakage PMID:28757444; PMID:32600046
MESH:D029481 Bronchitis, Chronic PMID:25027041
MESH:D048629 Micronuclei, Chromosome-Defective PMID:25448807
MESH:D055370 Lung Injury PMID:17301066; PMID:25280005; PMID:30698894; PMID:33007385; PMID:33428986; PMID:33482250; PMID:34843873
MESH:D056486 Chemical and Drug Induced Liver Injury PMID:33749107
MESH:D059366 Asthma, Occupational PMID:25027041
MESH:D064420 Drug-Related Side Effects and Adverse Reactions PMID:20654680
MESH:D066253 Vascular Remodeling PMID:30453980

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.