DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Silica

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0000045	Autophagosome assembly	Increases phenotype	PMID:27613482
GO:0000380	Alternative mrna splicing, via spliceosome	Increases phenotype	PMID:32721576
GO:0000737	Dna catabolic process, endonucleolytic	Increases phenotype	PMID:39362619
GO:0001510	Rna methylation	Increases phenotype	PMID:37979906
GO:0001837	Epithelial to mesenchymal transition	Increases phenotype	PMID:33007385; PMID:36223831; PMID:37543170; PMID:39353502
GO:0002064	Epithelial cell development	Decreases phenotype	PMID:35288261
GO:0002232	Leukocyte chemotaxis involved in inflammatory response	Increases phenotype	PMID:26345256
GO:0002432	Granuloma formation	Increases phenotype	PMID:8454952
GO:0002523	Leukocyte migration involved in inflammatory response	Increases phenotype	PMID:25733726; PMID:30391304; PMID:31028789; PMID:38523403; PMID:26955063; PMID:26955063; PMID:30698894; PMID:31284023; PMID:36309172; PMID:39800143; PMID:30391304; PMID:31028789; PMID:30698894; PMID:31284023; PMID:36309172; PMID:39362619; PMID:39800143
GO:0002534	Cytokine production involved in inflammatory response	Increases phenotype	PMID:27428020
GO:0002693	Positive regulation of cellular extravasation	Increases phenotype	PMID:27714660; PMID:33749107
GO:0004457	Lactate dehydrogenase activity	Increases phenotype	PMID:27311643; PMID:32223187
GO:0004784	Superoxide dismutase activity	Decreases phenotype	PMID:31034866; PMID:32223187; PMID:39362619
GO:0005391	P-type sodium:potassium-exchanging transporter activity	Decreases phenotype	PMID:34170461
GO:0006260	Dna replication	Decreases phenotype	PMID:1323425
GO:0006264	Mitochondrial dna replication	Increases phenotype	PMID:34170461
GO:0006506	Gpi anchor biosynthetic process	Increases phenotype	PMID:38061438
GO:0006629	Lipid metabolic process	Affects phenotype	PMID:38061438
GO:0006665	Sphingolipid metabolic process	Increases phenotype	PMID:38061438
GO:0006749	Glutathione metabolic process	Increases phenotype	PMID:33428986; PMID:33749107; PMID:37075931
GO:0006750	Glutathione biosynthetic process	Decreases phenotype	PMID:24992398
GO:0006754	Atp biosynthetic process	Decreases phenotype	PMID:27917503; PMID:31034866
GO:0006874	Cellular calcium ion homeostasis	Affects phenotype	PMID:37075931
GO:0006883	Cellular sodium ion homeostasis	Affects phenotype	PMID:34170461
GO:0006914	Autophagy	Increases phenotype	PMID:28161448; PMID:33720480
GO:0006915	Apoptotic process	Increases phenotype	PMID:23650964; PMID:24831964; PMID:26263183; PMID:32223187; PMID:39362619
GO:0006954	Inflammatory response	Increases phenotype	PMID:30978436; PMID:33720480; PMID:8454952; PMID:31034866; PMID:33428986; PMID:33428986; PMID:33482250; PMID:34170461; PMID:34843873; PMID:35288145; PMID:33428986; PMID:34843873; PMID:34170461
GO:0006974	Cellular response to dna damage stimulus	Increases phenotype	PMID:30698894
GO:0006979	Response to oxidative stress	Increases phenotype	PMID:23973437
GO:0007005	Mitochondrion organization	Decreases phenotype	PMID:31034866; PMID:38523403
GO:0007033	Vacuole organization	Decreases phenotype	PMID:38523403
GO:0007204	Positive regulation of cytosolic calcium ion concentration	Increases phenotype	PMID:27939335
GO:0008219	Cell death	Increases phenotype	PMID:19783790; PMID:23806026; PMID:24737200; PMID:25895662; PMID:27917503; PMID:28161448; PMID:36860548
GO:0008283	Cell population proliferation	Decreases phenotype	PMID:24685903; PMID:24831964; PMID:24992398; PMID:27917503
GO:0008284	Positive regulation of cell population proliferation	Affects phenotype	PMID:26163174; PMID:27939335; PMID:28757444
GO:0008285	Negative regulation of cell population proliferation	Increases phenotype	PMID:21766316; PMID:29203145; PMID:29894800; PMID:31082419; PMID:31927068; PMID:32097614; PMID:32097614; PMID:35689653; PMID:33012733
GO:0009409	Response to cold	Increases phenotype	PMID:27714660
GO:0010507	Negative regulation of autophagy	Increases phenotype	PMID:33010382
GO:0010718	Positive regulation of epithelial to mesenchymal transition	Increases phenotype	PMID:29113749; PMID:32097614; PMID:34969174; PMID:38491797
GO:0010759	Positive regulation of macrophage chemotaxis	Increases phenotype	PMID:30453980
GO:0010763	Positive regulation of fibroblast migration	Increases phenotype	PMID:26163174; PMID:26865670; PMID:27616297
GO:0010942	Positive regulation of cell death	Increases phenotype	PMID:25448807; PMID:25735930; PMID:29673857
GO:0016042	Lipid catabolic process	Increases phenotype	PMID:28512001; PMID:31034866; PMID:33428986
GO:0016049	Cell growth	Affects phenotype	PMID:29484482
GO:0016887	Atp hydrolysis activity	Decreases phenotype	PMID:31034866
GO:0030036	Actin cytoskeleton organization	Decreases phenotype	PMID:29658397
GO:0030199	Collagen fibril organization	Increases phenotype	PMID:25733726; PMID:25733726; PMID:30978436; PMID:31034866; PMID:31181250; PMID:33720480; PMID:34779285; PMID:29216763; PMID:29216763; PMID:33482250; PMID:34481903; PMID:34843873; PMID:35271943; PMID:36309172; PMID:39800143; PMID:30391304; PMID:31028789; PMID:31181250; PMID:33482250; PMID:36309172; PMID:39800143
GO:0030201	Heparan sulfate proteoglycan metabolic process	Decreases phenotype	PMID:29673857
GO:0030262	Apoptotic nuclear changes	Increases phenotype	PMID:31082419
GO:0030335	Positive regulation of cell migration	Increases phenotype	PMID:36223831; PMID:38491797
GO:0030397	Membrane disassembly	Increases phenotype	PMID:28161448
GO:0030399	Autophagosome membrane disassembly	Decreases phenotype	PMID:33232774
GO:0030512	Negative regulation of transforming growth factor beta receptor signaling pathway	Increases phenotype	PMID:29113749
GO:0031324	Negative regulation of cellular metabolic process	Increases phenotype	PMID:34973136
GO:0032148	Activation of protein kinase b activity	Increases phenotype	PMID:26163174; PMID:27616297; PMID:29894800
GO:0032609	Type ii interferon production	Increases phenotype	PMID:23640035
GO:0032612	Interleukin-1 production	Increases phenotype	PMID:8454952
GO:0032731	Positive regulation of interleukin-1 beta production	Affects phenotype	PMID:23640035
GO:0032753	Positive regulation of interleukin-4 production	Affects phenotype	PMID:23640035
GO:0032755	Positive regulation of interleukin-6 production	Affects phenotype	PMID:24211531
GO:0032757	Positive regulation of interleukin-8 production	Affects phenotype	PMID:24211531
GO:0032760	Positive regulation of tumor necrosis factor production	Affects phenotype	PMID:23640035
GO:0032963	Collagen metabolic process	Affects phenotype	PMID:36309172
GO:0032964	Collagen biosynthetic process	Increases phenotype	PMID:30391304; PMID:30391304; PMID:31181250; PMID:31181250; PMID:33428986; PMID:33428986; PMID:39800143; PMID:39353502; PMID:39800143
GO:0032967	Positive regulation of collagen biosynthetic process	Increases phenotype	PMID:23640035; PMID:26163174; PMID:26345256; PMID:30453980; PMID:30658076; PMID:29673857; PMID:30658076; PMID:32097614; PMID:32097614; PMID:32721576; PMID:32721576
GO:0034440	Lipid oxidation	Increases phenotype	PMID:33749107; PMID:37075931
GO:0035650	Ap-1 adaptor complex binding	Increases phenotype	PMID:19778233
GO:0035752	Lysosomal lumen ph elevation	Increases phenotype	PMID:29203145
GO:0042307	Positive regulation of protein import into nucleus	Increases phenotype	PMID:33012733
GO:0042554	Superoxide anion generation	Increases phenotype	PMID:19783790; PMID:28512001
GO:0043032	Positive regulation of macrophage activation	Increases phenotype	PMID:26865670; PMID:30453980
GO:0043065	Positive regulation of apoptotic process	Increases phenotype	PMID:28757444; PMID:33749107; PMID:39742911
GO:0043507	Positive regulation of jun kinase activity	Increases phenotype	PMID:35689653
GO:0044237	Cellular metabolic process	Affects phenotype	PMID:30698894; PMID:32223187; PMID:34979141; PMID:35288261; PMID:37543170; PMID:39362619
GO:0044319	Wound healing, spreading of cells	Increases phenotype	PMID:34481903; PMID:37543170; PMID:34979141; PMID:37543170
GO:0045026	Plasma membrane fusion	Increases phenotype	PMID:25625797
GO:0045454	Cell redox homeostasis	Increases phenotype	PMID:23973437
GO:0045542	Positive regulation of cholesterol biosynthetic process	Increases phenotype	PMID:38061438
GO:0045840	Positive regulation of mitotic nuclear division	Increases phenotype	PMID:25625797
GO:0045919	Positive regulation of cytolysis	Increases phenotype	PMID:33012733; PMID:34766707
GO:0045930	Negative regulation of mitotic cell cycle	Increases phenotype	PMID:31927068; PMID:33749107
GO:0046034	Atp metabolic process	Affects phenotype	PMID:34170461; PMID:38523403
GO:0046485	Ether lipid metabolic process	Increases phenotype	PMID:38061438
GO:0048146	Positive regulation of fibroblast proliferation	Increases phenotype	PMID:39855310
GO:0050665	Hydrogen peroxide biosynthetic process	Increases phenotype	PMID:19783790
GO:0050729	Positive regulation of inflammatory response	Increases phenotype	PMID:23640035; PMID:27714660; PMID:33012733; PMID:34969174
GO:0050766	Positive regulation of phagocytosis	Increases phenotype	PMID:29203145
GO:0050900	Leukocyte migration	Increases phenotype	PMID:33428986
GO:0051091	Positive regulation of dna-binding transcription factor activity	Increases phenotype	PMID:26368635
GO:0051457	Maintenance of protein location in nucleus	Decreases phenotype	PMID:31082419
GO:0051881	Regulation of mitochondrial membrane potential	Increases phenotype	PMID:26263183; PMID:32223187; PMID:34170461
GO:0061517	Macrophage proliferation	Increases phenotype	PMID:31034866
GO:0061909	Autophagosome-lysosome fusion	Decreases phenotype	PMID:33232774
GO:0070265	Necrotic cell death	Increases phenotype	PMID:34170461; PMID:39362619
GO:0070994	Detection of oxidative stress	Increases phenotype	PMID:33428986; PMID:39362619
GO:0072537	Fibroblast activation	Increases phenotype	PMID:26163174; PMID:26865670; PMID:27616297
GO:0072593	Reactive oxygen species metabolic process	Increases phenotype	PMID:24685903; PMID:24831964; PMID:24992398; PMID:34170461; PMID:35689653; PMID:37075931; PMID:38523403; PMID:39362619
GO:0072676	Lymphocyte migration	Increases phenotype	PMID:33428986; PMID:36309172
GO:0072683	T cell extravasation	Increases phenotype	PMID:27428020
GO:0085029	Extracellular matrix assembly	Increases phenotype	PMID:33007385; PMID:33007385; PMID:33428986; PMID:33428986
GO:0090200	Positive regulation of release of cytochrome c from mitochondria	Increases phenotype	PMID:21766316; PMID:31082419
GO:0097212	Lysosomal membrane organization	Decreases phenotype	PMID:34170461
GO:0097531	Mast cell migration	Increases phenotype	PMID:33428986
GO:0097707	Ferroptosis	Increases phenotype	PMID:37075931
GO:0098609	Cell-cell adhesion	Decreases phenotype	PMID:25733726
GO:0140639	Positive regulation of pyroptosis	Increases phenotype	PMID:34766707
GO:1900017	Positive regulation of cytokine production involved in inflammatory response	Increases phenotype	PMID:27714660
GO:1900087	Positive regulation of g1/s transition of mitotic cell cycle	Decreases phenotype	PMID:28757444
GO:1900227	Positive regulation of nlrp3 inflammasome complex assembly	Increases phenotype	PMID:34766707
GO:1900745	Positive regulation of p38mapk cascade	Increases phenotype	PMID:26163174; PMID:27616297; PMID:31082419; PMID:34653535
GO:1901203	Positive regulation of extracellular matrix assembly	Increases phenotype	PMID:30658076
GO:1901666	Positive regulation of nad+ adp-ribosyltransferase activity	Increases phenotype	PMID:28757444
GO:1901670	Negative regulation of superoxide dismutase activity	Increases phenotype	PMID:33749107
GO:1901687	Glutathione derivative biosynthetic process	Decreases phenotype	PMID:33749107
GO:1902255	Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator	Increases phenotype	PMID:21766316
GO:1902413	Negative regulation of mitotic cytokinesis	Increases phenotype	PMID:25625797
GO:1903283	Negative regulation of glutathione peroxidase activity	Increases phenotype	PMID:33749107
GO:1903409	Reactive oxygen species biosynthetic process	Increases phenotype	PMID:11896666; PMID:27311643; PMID:30698894; PMID:32223187
GO:1903428	Positive regulation of reactive oxygen species biosynthetic process	Increases phenotype	PMID:21766316; PMID:25448807; PMID:29203145; PMID:29894800; PMID:32097614; PMID:32097614; PMID:35689653
GO:1903543	Positive regulation of exosomal secretion	Increases phenotype	PMID:36075289
GO:1903626	Positive regulation of dna catabolic process	Increases phenotype	PMID:33749107
GO:1903955	Positive regulation of protein targeting to mitochondrion	Increases phenotype	PMID:31082419
GO:1904951	Positive regulation of establishment of protein localization	Increases phenotype	PMID:31082419
GO:1905166	Negative regulation of lysosomal protein catabolic process	Increases phenotype	PMID:29203145
GO:1905517	Macrophage migration	Increases phenotype	PMID:31034866; PMID:31284023; PMID:31284023; PMID:34843873; PMID:33428986; PMID:33428986; PMID:34843873; PMID:34843873; PMID:36309172
GO:1990266	Neutrophil migration	Increases phenotype	PMID:33428986; PMID:34170461; PMID:36309172
GO:2000111	Positive regulation of macrophage apoptotic process	Increases phenotype	PMID:26865670; PMID:27616297
GO:2000341	Regulation of chemokine (c-x-c motif) ligand 2 production	Increases phenotype	PMID:23640035
GO:2000379	Positive regulation of reactive oxygen species metabolic process	Affects phenotype	PMID:23973437
GO:2000391	Positive regulation of neutrophil extravasation	Increases phenotype	PMID:30453980
GO:2000551	Regulation of t-helper 2 cell cytokine production	Affects phenotype	PMID:23640035
GO:2000554	Regulation of t-helper 1 cell cytokine production	Affects phenotype	PMID:23640035
GO:2000786	Positive regulation of autophagosome assembly	Increases phenotype	PMID:29658397; PMID:33232774
GO:2001171	Positive regulation of atp biosynthetic process	Increases phenotype	PMID:29203145

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.