Lead


Curated chemical-disease associations from CTD
Disease IDDisease nameReference
MESH:C562768 Hypothyroidism, Autoimmune PMID:24866691
MESH:D000013 Congenital Abnormalities PMID:25703175
MESH:D000067877 Autism Spectrum Disorder PMID:24284360
MESH:D000068079 Motor Disorders PMID:26859824
MESH:D000072660 Teratozoospermia PMID:29549816; PMID:34508822; PMID:36484981
MESH:D000077962 Body-Weight Trajectory PMID:30090589
MESH:D000090862 Neuroinflammatory Diseases PMID:37244597
MESH:D000098647 Generalized Anxiety Disorder PMID:36749608
MESH:D000419 Albuminuria PMID:19700501
MESH:D000690 Amyotrophic Lateral Sclerosis PMID:20406759; PMID:27377857; PMID:28122372
MESH:D000740 Anemia PMID:21482638; PMID:22573942
MESH:D000855 Anorexia PMID:30081045
MESH:D001008 Anxiety Disorders PMID:20019913; PMID:21458486; PMID:22538241; PMID:35760230
MESH:D001018 Aortic Diseases PMID:19167473
MESH:D001172 Arthritis, Rheumatoid PMID:34864016
MESH:D001254 Astrocytoma PMID:26505805
MESH:D001289 Attention Deficit Disorder with Hyperactivity PMID:20019913; PMID:22742795; PMID:26645203; PMID:31551411
MESH:D001321 Autistic Disorder PMID:25051312; PMID:28569757
MESH:D001523 Mental Disorders PMID:17823382; PMID:19672413; PMID:26586927
MESH:D001724 Birth Weight PMID:20562053; PMID:20659343; PMID:28123784
MESH:D001847 Bone Diseases PMID:23086611
MESH:D001848 Bone Diseases, Developmental PMID:17805416
MESH:D001930 Brain Injuries PMID:34816377; PMID:35398025
MESH:D002292 Carcinoma, Renal Cell PMID:21799727; PMID:39294077
MESH:D002318 Cardiovascular Diseases PMID:15569323; PMID:22142875; PMID:22184584
MESH:D002493 Central Nervous System Diseases PMID:21998611
MESH:D002653 Child Behavior Disorders PMID:30732589
MESH:D002658 Developmental Disabilities PMID:17905657; PMID:21592505
MESH:D002869 Chromosome Aberrations PMID:17176674
MESH:D003072 Cognition Disorders PMID:17311281; PMID:18571546; PMID:19440496; PMID:19672413; PMID:19723536; PMID:20466044; PMID:20959051; PMID:21803117; PMID:22101007; PMID:22796262; PMID:23732512; PMID:23958642; PMID:30905827
MESH:D003248 Constipation PMID:30081045
MESH:D003324 Coronary Artery Disease PMID:28431391
MESH:D003480 Cushing Syndrome PMID:18977374
MESH:D003643 Death PMID:19344498; PMID:20019902
MESH:D003704 Dementia PMID:16140633
MESH:D003866 Depressive Disorder PMID:22538241; PMID:30081045; PMID:36749608
MESH:D003876 Dermatitis, Atopic PMID:31921472
MESH:D003920 Diabetes Mellitus PMID:18276029; PMID:19802527
MESH:D003924 Diabetes Mellitus, Type 2 PMID:28347468; PMID:32747380
MESH:D004485 Eczema PMID:20337961
MESH:D004487 Edema PMID:35498220
MESH:D005128 Eye Diseases PMID:21473382
MESH:D005221 Fatigue PMID:30081045
MESH:D005234 Fatty Liver PMID:21126940
MESH:D005262 Feminization PMID:22300406
MESH:D005317 Fetal Growth Retardation PMID:12641193; PMID:19103280; PMID:19769572
MESH:D006130 Growth Disorders PMID:23247522; PMID:26715556
MESH:D006261 Headache PMID:30081045
MESH:D006402 Hematologic Diseases PMID:24631795; PMID:30090589; PMID:38653421
MESH:D006529 Hepatomegaly PMID:37676925
MESH:D006943 Hyperglycemia PMID:26689646
MESH:D006948 Hyperkinesis PMID:19433104
MESH:D006949 Hyperlipidemias PMID:22001170
MESH:D006962 Hyperparathyroidism, Secondary PMID:21985997; PMID:22373954
MESH:D006965 Hyperplasia PMID:29549816
MESH:D006973 Hypertension PMID:10523326; PMID:11230275; PMID:12761246; PMID:14520025; PMID:15569323; PMID:17687441; PMID:18234738; PMID:19167473; PMID:19952788; PMID:20123609; PMID:21364929; PMID:26612503; PMID:28292314
MESH:D007154 Immune System Diseases PMID:21241821
MESH:D007172 Erectile Dysfunction PMID:26723573
MESH:D007248 Infertility, Male PMID:16780224; PMID:31647946
MESH:D007319 Sleep Initiation and Maintenance Disorders PMID:30081045
MESH:D007333 Insulin Resistance PMID:22354675; PMID:38180308
MESH:D007674 Kidney Diseases PMID:16601012; PMID:17715263; PMID:19700501; PMID:19921116; PMID:22066453; PMID:23792432; PMID:24276216; PMID:24631795; PMID:26612503; PMID:30090589; PMID:32246071; PMID:34350654; PMID:36840722
MESH:D007676 Kidney Failure, Chronic PMID:23343055
MESH:D007855 Lead Poisoning PMID:10928693; PMID:16700817; PMID:17366816; PMID:18501191; PMID:19921116; PMID:22186192; PMID:22240981; PMID:22437855; PMID:22466227; PMID:23792432; PMID:24280917; PMID:24631795; PMID:27339191; PMID:30081045; PMID:3507265
MESH:D007859 Learning Disabilities PMID:16384672; PMID:17384765; PMID:20639260; PMID:21803117; PMID:22342405; PMID:22387731; PMID:31539617; PMID:33223335; PMID:39947421
MESH:D007960 Leukocyte Disorders PMID:30090589
MESH:D008064 Lipidoses PMID:19056365
MESH:D008107 Liver Diseases PMID:24631795; PMID:38180308
MESH:D008175 Lung Neoplasms PMID:15496540
MESH:D008569 Memory Disorders PMID:16384672; PMID:17263510; PMID:21803117; PMID:22342405; PMID:22387731; PMID:28720388; PMID:30081045; PMID:31539617; PMID:33223335; PMID:35398025; PMID:39947421
MESH:D008579 Meningioma PMID:26091556
MESH:D008607 Intellectual Disability PMID:22300406
MESH:D009069 Movement Disorders PMID:21402136
MESH:D009203 Myocardial Infarction PMID:14515052
MESH:D009325 Nausea PMID:30081045
MESH:D009358 Congenital, Hereditary, and Neonatal Diseases and Abnormalities PMID:18501191
MESH:D009369 Neoplasms PMID:17916923
MESH:D009410 Nerve Degeneration PMID:19288233
MESH:D009422 Nervous System Diseases PMID:1227852; PMID:20929057; PMID:6592932
MESH:D009461 Neurologic Manifestations PMID:22184584
MESH:D009765 Obesity PMID:28321702
MESH:D009784 Occupational Diseases PMID:23084307
MESH:D009845 Oligospermia PMID:29549816; PMID:36484981
MESH:D010182 Pancreatic Diseases PMID:32246071; PMID:38180308
MESH:D010291 Paresis PMID:30081045
MESH:D010300 Parkinson Disease PMID:20807691
MESH:D010523 Peripheral Nervous System Diseases PMID:21998611; PMID:30081045
MESH:D011041 Poisoning PMID:19696718
MESH:D011115 Polyneuropathies PMID:16569935; PMID:8925321
MESH:D011164 Porphyrias PMID:3313115
MESH:D011225 Pre-Eclampsia PMID:37079392
MESH:D011297 Prenatal Exposure Delayed Effects PMID:12641193; PMID:16384672; PMID:18242880; PMID:18571546; PMID:19433104; PMID:20959051; PMID:21458486; PMID:21703292; PMID:21715242; PMID:26417717; PMID:27266277; PMID:28123784; PMID:30696509; PMID:31513824; PMID:573477
MESH:D011470 Prostatic Hyperplasia PMID:23479318
MESH:D011507 Proteinuria PMID:17497640; PMID:33670331
MESH:D011596 Psychomotor Disorders PMID:21592505
MESH:D012640 Seizures PMID:15149801; PMID:30081045
MESH:D013158 Splenic Diseases PMID:30090589; PMID:32246071
MESH:D013733 Testicular Diseases PMID:31647946; PMID:34508822; PMID:36484981
MESH:D013959 Thyroid Diseases PMID:33223335; PMID:38797200
MESH:D014202 Tremor PMID:21145352; PMID:30081045
MESH:D015352 Dry Eye Syndromes PMID:30746909
MESH:D015430 Weight Gain PMID:28123784; PMID:33083328; PMID:35307918
MESH:D015431 Weight Loss PMID:33978298; PMID:34816377; PMID:35752206; PMID:36484981; PMID:37244597; PMID:37415728
MESH:D015746 Abdominal Pain PMID:30081045
MESH:D016388 Tooth Loss PMID:20019902
MESH:D016472 Motor Neuron Disease PMID:26703636
MESH:D017202 Myocardial Ischemia PMID:26629599
MESH:D018149 Glucose Intolerance PMID:25874871
MESH:D018242 Neuroectodermal Tumors, Primitive PMID:26505805
MESH:D018476 Hypokinesia PMID:25703175
MESH:D018771 Arthralgia PMID:30081045
MESH:D019189 Iron Metabolism Disorders PMID:21458486
MESH:D019465 Craniofacial Abnormalities PMID:19769572
MESH:D019636 Neurodegenerative Diseases PMID:16717205; PMID:22056337
MESH:D019954 Neurobehavioral Manifestations PMID:21124968; PMID:8925321
MESH:D019955 Conduct Disorder PMID:18629321
MESH:D019957 Motor Skills Disorders PMID:25451970
MESH:D019958 Attention Deficit and Disruptive Behavior Disorders PMID:17384765; PMID:25451971
MESH:D020022 Genetic Predisposition to Disease PMID:20123609
MESH:D020078 Neurogenic Inflammation PMID:25288670
MESH:D020263 Lead Poisoning, Nervous System PMID:17823382; PMID:20947467; PMID:20959051; PMID:21439310
MESH:D020264 Lead Poisoning, Nervous System, Childhood PMID:20019902; PMID:20019903; PMID:21510976; PMID:22056337; PMID:22345308
MESH:D020329 Essential Tremor PMID:14594619; PMID:18007985
MESH:D020423 Median Neuropathy PMID:21439310
MESH:D020424 Ulnar Neuropathies PMID:21439310
MESH:D020427 Peroneal Neuropathies PMID:21439310
MESH:D024821 Metabolic Syndrome PMID:23302150; PMID:24065312
MESH:D034381 Hearing Loss PMID:34273409
MESH:D042822 Genomic Instability PMID:32567310
MESH:D046110 Hypertension, Pregnancy-Induced PMID:20019901
MESH:D047928 Premature Birth PMID:25342170
MESH:D048629 Micronuclei, Chromosome-Defective PMID:19938001
MESH:D049188 Prenatal Injuries PMID:18501191; PMID:6592932
MESH:D050171 Dyslipidemias PMID:21911985; PMID:22354675
MESH:D050197 Atherosclerosis PMID:31808705
MESH:D051436 Renal Insufficiency, Chronic PMID:21248295; PMID:33670331
MESH:D051437 Renal Insufficiency PMID:20014231
MESH:D053609 Lethargy PMID:30081045
MESH:D056486 Chemical and Drug Induced Liver Injury PMID:15803060; PMID:16044092; PMID:20014231; PMID:22001170; PMID:32246071; PMID:35752206; PMID:37676925; PMID:38180308; PMID:39988223
MESH:D060825 Cognitive Dysfunction PMID:28270159
MESH:D063806 Myalgia PMID:30081045
MESH:D064806 Dysbiosis PMID:29529432
MESH:D065886 Neurodevelopmental Disorders PMID:25446717; PMID:26968381
MESH:D066126 Cardiotoxicity PMID:32246071

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.