Lead


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000080 Mitotic g1 phase Affects phenotype PMID:20020935; PMID:28035397; PMID:37467947
GO:0000084 Mitotic s phase Affects phenotype PMID:28035397; PMID:37467947
GO:0000085 Mitotic g2 phase Affects phenotype PMID:28035397
GO:0000266 Mitochondrial fission Increases phenotype PMID:31874198
GO:0000902 Cell morphogenesis Affects phenotype PMID:32142724
GO:0001510 Rna methylation Affects phenotype PMID:37269892
GO:0001649 Osteoblast differentiation Increases phenotype PMID:30731080
GO:0001774 Microglial cell activation Increases phenotype PMID:36308466
GO:0001776 Leukocyte homeostasis Decreases phenotype PMID:30081045
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:29115570; PMID:31874198
GO:0001951 Intestinal d-glucose absorption Increases phenotype PMID:22354675
GO:0001954 Positive regulation of cell-matrix adhesion Decreases phenotype PMID:28829631
GO:0002027 Regulation of heart rate Affects phenotype PMID:17107858
GO:0002118 Aggressive behavior Increases phenotype PMID:34728761
GO:0002301 Cd4-positive, alpha-beta intraepithelial t cell differentiation Decreases phenotype PMID:20109038
GO:0002377 Immunoglobulin production Affects phenotype PMID:15831097
GO:0002449 Lymphocyte mediated immunity Affects phenotype PMID:15831097
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:35498220; PMID:38180308
GO:0002534 Cytokine production involved in inflammatory response Increases phenotype PMID:34014775
GO:0002761 Regulation of myeloid leukocyte differentiation Affects phenotype PMID:28973681
GO:0002923 Regulation of humoral immune response mediated by circulating immunoglobulin Affects phenotype PMID:32276596
GO:0003006 Developmental process involved in reproduction Decreases phenotype PMID:32653800
GO:0003014 Renal system process Decreases phenotype PMID:33678412
GO:0003073 Regulation of systemic arterial blood pressure Affects phenotype PMID:28292314
GO:0003084 Positive regulation of systemic arterial blood pressure Increases phenotype PMID:19921116; PMID:23484121
GO:0003093 Regulation of glomerular filtration Affects phenotype PMID:25424620
GO:0003094 Glomerular filtration Affects phenotype PMID:19700501; PMID:33678412; PMID:26852280
GO:0003104 Positive regulation of glomerular filtration Increases phenotype PMID:31326826
GO:0003872 6-phosphofructokinase activity Decreases phenotype PMID:34508822
GO:0003954 Nadh dehydrogenase activity Decreases phenotype PMID:32407874
GO:0003993 Acid phosphatase activity Increases phenotype PMID:35307918
GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity Increases phenotype PMID:30081045
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:16092086; PMID:35307918
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:30081045
GO:0004111 Creatine kinase activity Decreases phenotype PMID:21725498
GO:0004129 Cytochrome-c oxidase activity Decreases phenotype PMID:33038468; PMID:39547369
GO:0004357 Glutamate-cysteine ligase activity Decreases phenotype PMID:29630945
GO:0004364 Glutathione transferase activity Decreases phenotype PMID:30359721; PMID:31610155; PMID:39270966
GO:0004457 Lactate dehydrogenase activity Decreases phenotype PMID:34508822
GO:0004575 Sucrose alpha-glucosidase activity Decreases phenotype PMID:16092086
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:23424868; PMID:30738203; PMID:32407874; PMID:37415728
GO:0004697 Protein kinase c activity Decreases phenotype PMID:31843630
GO:0004743 Pyruvate kinase activity Decreases phenotype PMID:31647946
GO:0004784 Superoxide dismutase activity Increases phenotype PMID:23424868; PMID:29630945; PMID:30738203; PMID:31874198; PMID:35398025; PMID:35752206; PMID:37415728; PMID:40010429
GO:0005243 Gap junction channel activity Decreases phenotype PMID:33242459
GO:0005391 P-type sodium:potassium-exchanging transporter activity Decreases phenotype PMID:31874198
GO:0005515 Protein binding Increases phenotype PMID:29170096
GO:0005757 Mitochondrial permeability transition pore complex Affects phenotype PMID:31874198; PMID:35300571
GO:0005776 Autophagosome Affects phenotype PMID:36840722
GO:0006006 Glucose metabolic process Affects phenotype PMID:25874871; PMID:34508822
GO:0006020 Inositol metabolic process Affects phenotype PMID:17450218
GO:0006089 Lactate metabolic process Affects phenotype PMID:33038468; PMID:34508822
GO:0006090 Pyruvate metabolic process Affects phenotype PMID:29529432; PMID:34508822
GO:0006096 Glycolytic process Decreases phenotype PMID:36096218
GO:0006119 Oxidative phosphorylation Decreases phenotype PMID:36096218; PMID:39547369
GO:0006264 Mitochondrial dna replication Decreases phenotype PMID:31874198
GO:0006281 Dna repair Affects phenotype PMID:22466227; PMID:31769258
GO:0006304 Dna modification Increases phenotype PMID:38700421
GO:0006306 Dna methylation Decreases phenotype PMID:24519525; PMID:28858830; PMID:38833407
GO:0006325 Chromatin organization Decreases phenotype PMID:30905827
GO:0006497 Protein lipidation Increases phenotype PMID:33242459
GO:0006600 Creatine metabolic process Affects phenotype PMID:19590687
GO:0006606 Protein import into nucleus Increases phenotype PMID:33080273
GO:0006629 Lipid metabolic process Affects phenotype PMID:30081045; PMID:38180308
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:39461408
GO:0006749 Glutathione metabolic process Affects phenotype PMID:24881885; PMID:32407874; PMID:34165617; PMID:34508822; PMID:35307918; PMID:35752206; PMID:36642386; PMID:37676925; PMID:39032614; PMID:39276841; PMID:40010429
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:26989453; PMID:29630945; PMID:30359721; PMID:30476502; PMID:30738203; PMID:31874198
GO:0006754 Atp biosynthetic process Decreases phenotype PMID:31647946; PMID:31874198; PMID:32407874
GO:0006813 Potassium ion transport Affects phenotype PMID:33038468
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:31843630; PMID:39153536
GO:0006878 Cellular copper ion homeostasis Affects phenotype PMID:40010429
GO:0006879 Cellular iron ion homeostasis Affects phenotype PMID:39276841
GO:0006915 Apoptotic process Increases phenotype PMID:15336320; PMID:28035397; PMID:29115570; PMID:29630945; PMID:30905827; PMID:30950269; PMID:31874198; PMID:32004626; PMID:32179164; PMID:33242459; PMID:37467947; PMID:40010429
GO:0006919 Activation of cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:31874198
GO:0006954 Inflammatory response Increases phenotype PMID:29630945
GO:0006959 Humoral immune response Affects phenotype PMID:15831097
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:32142724; PMID:34508822
GO:0006979 Response to oxidative stress Increases phenotype PMID:15336320; PMID:20025841; PMID:23578882; PMID:30081045
GO:0006997 Nucleus organization Decreases phenotype PMID:30905827
GO:0007005 Mitochondrion organization Decreases phenotype PMID:30905827; PMID:31874198; PMID:36642386; PMID:39276841; PMID:39547369
GO:0007006 Mitochondrial membrane organization Decreases phenotype PMID:33038468; PMID:37142061
GO:0007009 Plasma membrane organization Decreases phenotype PMID:30738203
GO:0007029 Endoplasmic reticulum organization Decreases phenotype PMID:30905827
GO:0007033 Vacuole organization Increases phenotype PMID:38157908; PMID:38180308
GO:0007268 Chemical synaptic transmission Affects phenotype PMID:31785328
GO:0007283 Spermatogenesis Decreases phenotype PMID:29549816; PMID:31647946; PMID:32142724; PMID:32976933; PMID:34508822; PMID:36484981
GO:0007409 Axonogenesis Decreases phenotype PMID:36096218
GO:0007420 Brain development Decreases phenotype PMID:16717205; PMID:20829427
GO:0007601 Visual perception Decreases phenotype PMID:27266277; PMID:31666078
GO:0007605 Sensory perception of sound Decreases phenotype PMID:23022869; PMID:27266277
GO:0007610 Behavior Affects phenotype PMID:20019913; PMID:31513824; PMID:21510976; PMID:30732589; PMID:31454729; PMID:34728761
GO:0007611 Learning or memory Decreases phenotype PMID:27936013; PMID:27936013; PMID:29476096; PMID:32058320
GO:0007612 Learning Decreases phenotype PMID:31539617; PMID:31539617; PMID:34742682; PMID:33223335; PMID:37244597; PMID:33978298; PMID:34742682; PMID:36308466; PMID:37244597; PMID:38160928; PMID:39947421
GO:0007613 Memory Decreases phenotype PMID:25141213; PMID:29301062; PMID:30090589; PMID:31539617; PMID:31539617; PMID:34742682; PMID:33223335; PMID:37244597; PMID:33978298; PMID:33978298; PMID:35367965; PMID:34742682; PMID:36652739; PMID:37244597; PMID:37415728; PMID:38160928; PMID:39947421
GO:0007625 Grooming behavior Increases phenotype PMID:35760230
GO:0007631 Feeding behavior Affects phenotype PMID:37676925
GO:0008121 Ubiquinol-cytochrome-c reductase activity Decreases phenotype PMID:33038468
GO:0008137 Nadh dehydrogenase (ubiquinone) activity Decreases phenotype PMID:31647946; PMID:33038468; PMID:39547369
GO:0008152 Metabolic process Affects phenotype PMID:29966840; PMID:31551411
GO:0008177 Succinate dehydrogenase (ubiquinone) activity Decreases phenotype PMID:31647946; PMID:33038468
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:39461408
GO:0008206 Bile acid metabolic process Affects phenotype PMID:30090589
GO:0008217 Regulation of blood pressure Affects phenotype PMID:18087585; PMID:33407552; PMID:20123609; PMID:20478760; PMID:25582168; PMID:39461408
GO:0008219 Cell death Increases phenotype PMID:23578882; PMID:23719929; PMID:31708536
GO:0008283 Cell population proliferation Affects phenotype PMID:24953315; PMID:29549816; PMID:32004626; PMID:34816377; PMID:37386098; PMID:38563870
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:37142061; PMID:37436718
GO:0008542 Visual learning Decreases phenotype PMID:30836164
GO:0008584 Male gonad development Affects phenotype PMID:31647946
GO:0009060 Aerobic respiration Decreases phenotype PMID:31756223
GO:0009308 Amine metabolic process Affects phenotype PMID:19590687
GO:0010288 Response to lead ion Affects phenotype PMID:19938001; PMID:23855546
GO:0010424 Dna methylation on cytosine within a cg sequence Affects phenotype PMID:26115033; PMID:29481626; PMID:31119761; PMID:31636367; PMID:32734142
GO:0010468 Regulation of gene expression Affects phenotype PMID:32458983
GO:0010508 Positive regulation of autophagy Increases phenotype PMID:36652739
GO:0010918 Positive regulation of mitochondrial membrane potential Decreases phenotype PMID:25981801
GO:0010942 Positive regulation of cell death Increases phenotype PMID:22610977; PMID:22610977; PMID:24881885; PMID:25981801
GO:0010996 Response to auditory stimulus Decreases phenotype PMID:27266277
GO:0014002 Astrocyte development Decreases phenotype PMID:20829427
GO:0015692 Lead ion transport Increases phenotype PMID:23238610; PMID:30025905; PMID:34051273; PMID:34508822
GO:0016042 Lipid catabolic process Increases phenotype PMID:29630945; PMID:30738203; PMID:31610155; PMID:31874198; PMID:32407874; PMID:34508822; PMID:35307918; PMID:35398025; PMID:35752206
GO:0016049 Cell growth Decreases phenotype PMID:30950269
GO:0016079 Synaptic vesicle exocytosis Decreases phenotype PMID:29029315
GO:0016174 Nad(p)h oxidase h2o2-forming activity Increases phenotype PMID:25596430
GO:0016358 Dendrite development Decreases phenotype PMID:31708536
GO:0016477 Cell migration Decreases phenotype PMID:38157908
GO:0016573 Histone acetylation Increases phenotype PMID:24291742
GO:0017121 Plasma membrane phospholipid scrambling Increases phenotype PMID:21482638
GO:0018158 Protein oxidation Increases phenotype PMID:30081045; PMID:32407874; PMID:36484981; PMID:38700421
GO:0018394 Peptidyl-lysine acetylation Decreases phenotype PMID:31647946
GO:0019695 Choline metabolic process Affects phenotype PMID:19590687
GO:0021778 Oligodendrocyte cell fate specification Increases phenotype PMID:32458983
GO:0022008 Neurogenesis Decreases phenotype PMID:33978298
GO:0022010 Central nervous system myelination Decreases phenotype PMID:39150886
GO:0030001 Metal ion transport Affects phenotype PMID:28721440
GO:0030097 Hemopoiesis Decreases phenotype PMID:39461408
GO:0030154 Cell differentiation Affects phenotype PMID:37467947
GO:0030182 Neuron differentiation Decreases phenotype PMID:24519525; PMID:36096218; PMID:37467947
GO:0030199 Collagen fibril organization Increases phenotype PMID:33223335
GO:0030220 Platelet formation Decreases phenotype PMID:34083740
GO:0030222 Eosinophil differentiation Increases phenotype PMID:39461408
GO:0030263 Apoptotic chromosome condensation Affects phenotype PMID:30905827; PMID:31708536; PMID:38180308
GO:0030282 Bone mineralization Increases phenotype PMID:30731080
GO:0030308 Negative regulation of cell growth Increases phenotype PMID:37142061
GO:0031175 Neuron projection development Affects phenotype PMID:29301062; PMID:33080273; PMID:39947421
GO:0031324 Negative regulation of cellular metabolic process Increases phenotype PMID:34189835
GO:0031394 Positive regulation of prostaglandin biosynthetic process Increases phenotype PMID:25268557
GO:0031966 Mitochondrial membrane Affects phenotype PMID:33038468
GO:0031987 Locomotion involved in locomotory behavior Decreases phenotype PMID:35398025
GO:0032042 Mitochondrial dna metabolic process Affects phenotype PMID:30753999
GO:0032469 Endoplasmic reticulum calcium ion homeostasis Affects phenotype PMID:36308466
GO:0032471 Negative regulation of endoplasmic reticulum calcium ion concentration Increases phenotype PMID:25921245
GO:0032616 Interleukin-13 production Increases phenotype PMID:31921472
GO:0032680 Regulation of tumor necrosis factor production Affects phenotype PMID:31652851
GO:0032729 Positive regulation of type ii interferon production Increases phenotype PMID:33483752
GO:0032760 Positive regulation of tumor necrosis factor production Increases phenotype PMID:29028684; PMID:31652851
GO:0032776 Dna methylation on cytosine Affects phenotype PMID:33445541
GO:0032790 Ribosome disassembly Increases phenotype PMID:30905827
GO:0032962 Positive regulation of inositol trisphosphate biosynthetic process Increases phenotype PMID:25921245
GO:0033555 Multicellular organismal response to stress Affects phenotype PMID:22112310
GO:0034101 Erythrocyte homeostasis Decreases phenotype PMID:30081045
GO:0034108 Positive regulation of erythrocyte clearance Increases phenotype PMID:21482638
GO:0034199 Activation of protein kinase a activity Decreases phenotype PMID:22610977
GO:0034440 Lipid oxidation Increases phenotype PMID:30081045; PMID:32678766; PMID:36484981; PMID:36642386; PMID:37676925; PMID:39276841; PMID:40010429
GO:0034599 Cellular response to oxidative stress Increases phenotype PMID:32058320
GO:0034650 Cortisol metabolic process Affects phenotype PMID:24916609
GO:0035176 Social behavior Decreases phenotype PMID:26586927; PMID:28569757; PMID:30836164; PMID:35760230
GO:0035633 Maintenance of blood-brain barrier Decreases phenotype PMID:24431214
GO:0035640 Exploration behavior Decreases phenotype PMID:35760230
GO:0036035 Osteoclast development Affects phenotype PMID:26518054
GO:0036050 Peptidyl-lysine succinylation Decreases phenotype PMID:31647946
GO:0036123 Histone h3-k9 dimethylation Increases phenotype PMID:28712943
GO:0036344 Platelet morphogenesis Decreases phenotype PMID:39461408
GO:0036444 Calcium import into the mitochondrion Decreases phenotype PMID:24881885
GO:0038061 Nik/nf-kappab signaling Increases phenotype PMID:26518054
GO:0040014 Regulation of multicellular organism growth Decreases phenotype PMID:26715556
GO:0040018 Positive regulation of multicellular organism growth Decreases phenotype PMID:25224708
GO:0042403 Thyroid hormone metabolic process Affects phenotype PMID:30090589; PMID:33223335; PMID:38797200
GO:0042541 Hemoglobin biosynthetic process Decreases phenotype PMID:22573942; PMID:23022869
GO:0042554 Superoxide anion generation Increases phenotype PMID:25596430; PMID:35398025
GO:0042593 Glucose homeostasis Decreases phenotype PMID:22354675
GO:0042670 Retinal cone cell differentiation Decreases phenotype PMID:28050121
GO:0042696 Menarche Affects phenotype PMID:36729392
GO:0042697 Menopause Affects phenotype PMID:32832842
GO:0042756 Drinking behavior Increases phenotype PMID:31550440; PMID:37676925
GO:0042775 Mitochondrial atp synthesis coupled electron transport Decreases phenotype PMID:31756223
GO:0043005 Neuron projection Decreases phenotype PMID:33080273; PMID:38160928
GO:0043046 Dna methylation involved in gamete generation Affects phenotype PMID:26417717
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:20829427; PMID:25921245
GO:0043197 Dendritic spine Affects phenotype PMID:39947421
GO:0043374 Cd8-positive, alpha-beta t cell differentiation Decreases phenotype PMID:21241821
GO:0043970 Histone h3-k9 acetylation Increases phenotype PMID:27239543; PMID:28712943
GO:0044030 Regulation of dna methylation Affects phenotype PMID:26115033; PMID:33445541
GO:0044062 Regulation of excretion Increases phenotype PMID:23806787
GO:0044237 Cellular metabolic process Affects phenotype PMID:20020935; PMID:28035397; PMID:29115570; PMID:29957541; PMID:30476502; PMID:31610155; PMID:31843630; PMID:31874198; PMID:31874198; PMID:35300571; PMID:39032614; PMID:39547369; PMID:32004626; PMID:32142724; PMID:34508822; PMID:32344020; PMID:32344020; PMID:39947421; PMID:34165617; PMID:34508822; PMID:35300571; PMID:36484981; PMID:36642386; PMID:36925031; PMID:38157908; PMID:38700421; PMID:39032614; PMID:39276841; PMID:39547369; PMID:40010429
GO:0044648 Histone h3-k4 dimethylation Increases phenotype PMID:27239543
GO:0044728 Dna methylation or demethylation Affects phenotype PMID:33445541
GO:0044838 Cell quiescence Increases phenotype PMID:33483752; PMID:37436718
GO:0045216 Cell-cell junction organization Decreases phenotype PMID:36642386
GO:0045333 Cellular respiration Decreases phenotype PMID:33038468
GO:0045780 Positive regulation of bone resorption Increases phenotype PMID:23247522
GO:0045919 Positive regulation of cytolysis Increases phenotype PMID:34189835
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:30738203
GO:0046034 Atp metabolic process Affects phenotype PMID:33038468; PMID:34508822; PMID:36484981; PMID:39547369
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:35752206; PMID:37676925
GO:0046323 Glucose import Decreases phenotype PMID:31874198
GO:0046415 Urate metabolic process Decreases phenotype PMID:30081045
GO:0046449 Creatinine metabolic process Decreases phenotype PMID:30081045
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:10928693; PMID:10928693; PMID:20025841; PMID:20025841; PMID:30031113; PMID:32976933
GO:0046501 Protoporphyrinogen ix metabolic process Affects phenotype PMID:19938001
GO:0046622 Positive regulation of organ growth Increases phenotype PMID:25268557
GO:0046697 Decidualization Increases phenotype PMID:32004626
GO:0046850 Regulation of bone remodeling Affects phenotype PMID:21839992
GO:0046933 Proton-transporting atp synthase activity, rotational mechanism Decreases phenotype PMID:39547369
GO:0048143 Astrocyte activation Increases phenotype PMID:34742682
GO:0048714 Positive regulation of oligodendrocyte differentiation Increases phenotype PMID:32458983
GO:0048821 Erythrocyte development Increases phenotype PMID:39461408
GO:0048874 Host-mediated regulation of intestinal microbiota composition Affects phenotype PMID:35037767
GO:0050665 Hydrogen peroxide biosynthetic process Increases phenotype PMID:30738203
GO:0050667 Homocysteine metabolic process Affects phenotype PMID:28789684
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:25288670
GO:0050766 Positive regulation of phagocytosis Increases phenotype PMID:21482638
GO:0050801 Monoatomic ion homeostasis Affects phenotype PMID:30090589
GO:0050890 Cognition Decreases phenotype PMID:15583371; PMID:16002379; PMID:17687454; PMID:17905657; PMID:19643133; PMID:20019913; PMID:21205584; PMID:22999658; PMID:27562236; PMID:28270159; PMID:31327061; PMID:31666078; PMID:21450073; PMID:26968381; PMID:25288670; PMID:35750750
GO:0050974 Detection of mechanical stimulus involved in sensory perception Affects phenotype PMID:32340109
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:37142061
GO:0051170 Import into nucleus Increases phenotype PMID:31539617
GO:0051281 Positive regulation of release of sequestered calcium ion into cytosol Increases phenotype PMID:25921245
GO:0051402 Neuron apoptotic process Increases phenotype PMID:33978298; PMID:37467947
GO:0051462 Regulation of cortisol secretion Affects phenotype PMID:26926653
GO:0051480 Regulation of cytosolic calcium ion concentration Increases phenotype PMID:29170096
GO:0051560 Mitochondrial calcium ion homeostasis Affects phenotype PMID:36308466
GO:0051561 Positive regulation of mitochondrial calcium ion concentration Increases phenotype PMID:25921245
GO:0051775 Response to redox state Decreases phenotype PMID:30081045
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:30738203; PMID:31874198; PMID:32407874; PMID:33038468; PMID:35300571
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:29115570; PMID:36484981; PMID:37142061
GO:0051913 Regulation of synaptic plasticity by chemical substance Affects phenotype PMID:29939358
GO:0051964 Negative regulation of synapse assembly Increases phenotype PMID:28050121
GO:0055065 Metal ion homeostasis Increases phenotype PMID:11450370; PMID:12173534; PMID:19847775; PMID:21241821; PMID:22647239; PMID:24315962; PMID:29452138; PMID:30081045; PMID:32208856
GO:0055069 Zinc ion homeostasis Affects phenotype PMID:35398025
GO:0055074 Calcium ion homeostasis Affects phenotype PMID:30905827
GO:0060047 Heart contraction Affects phenotype PMID:18091001
GO:0060221 Retinal rod cell differentiation Decreases phenotype PMID:28050121
GO:0060314 Regulation of ryanodine-sensitive calcium-release channel activity Affects phenotype PMID:29170096
GO:0060322 Head development Decreases phenotype PMID:12641193
GO:0060348 Bone development Decreases phenotype PMID:26518054; PMID:30696509
GO:0060996 Dendritic spine development Decreases phenotype PMID:27936013; PMID:39947421
GO:0061000 Negative regulation of dendritic spine development Increases phenotype PMID:29476096
GO:0061092 Positive regulation of phospholipid translocation Decreases phenotype PMID:21482638
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:32232643; PMID:36484981
GO:0070265 Necrotic cell death Increases phenotype PMID:34165617; PMID:38180308
GO:0070444 Oligodendrocyte progenitor proliferation Decreases phenotype PMID:39150886
GO:0070994 Detection of oxidative stress Increases phenotype PMID:16507456; PMID:26612503; PMID:32678766; PMID:34816377; PMID:35398025; PMID:36484981; PMID:37415728; PMID:38180308; PMID:39547369
GO:0070997 Neuron death Increases phenotype PMID:36308466
GO:0071277 Cellular response to calcium ion Increases phenotype PMID:29170096
GO:0071284 Cellular response to lead ion Increases phenotype PMID:32458983
GO:0071461 Cellular response to redox state Increases phenotype PMID:31756223
GO:0071480 Cellular response to gamma radiation Affects phenotype PMID:31769258
GO:0071763 Nuclear membrane organization Decreases phenotype PMID:30905827
GO:0071971 Extracellular exosome assembly Increases phenotype PMID:36840722
GO:0072346 Cadpr-sensitive calcium-release channel activity Increases phenotype PMID:29170096
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:28035397; PMID:32407874; PMID:35300571; PMID:36642386; PMID:38700421; PMID:39032614; PMID:39276841; PMID:40010429
GO:0080182 Histone h3-k4 trimethylation Increases phenotype PMID:28712943
GO:0090090 Negative regulation of canonical wnt signaling pathway Increases phenotype PMID:37436718
GO:0090648 Response to environmental enrichment Decreases phenotype PMID:35398025
GO:0097062 Dendritic spine maintenance Decreases phenotype PMID:30738087; PMID:38160928
GO:0097119 Postsynaptic density protein 95 clustering Decreases phenotype PMID:26660114
GO:0097205 Renal filtration Increases phenotype PMID:16581550
GO:0097707 Ferroptosis Increases phenotype PMID:36642386
GO:0097722 Sperm motility Decreases phenotype PMID:29549816; PMID:36484981
GO:0098532 Histone h3-k27 trimethylation Increases phenotype PMID:27239543; PMID:28712943; PMID:29301062
GO:0098727 Maintenance of cell number Affects phenotype PMID:30836164; PMID:30950269
GO:0098771 Inorganic ion homeostasis Affects phenotype PMID:22923205
GO:0098801 Regulation of renal system process Decreases phenotype PMID:19921116
GO:0140657 Atp-dependent activity Decreases phenotype PMID:35307918
GO:0150104 Transport across blood-brain barrier Affects phenotype PMID:36641952
GO:0150195 Transport across blood-cerebrospinal fluid barrier Affects phenotype PMID:36642386
GO:1900017 Positive regulation of cytokine production involved in inflammatory response Increases phenotype PMID:39579145
GO:1900272 Negative regulation of long-term synaptic potentiation Increases phenotype PMID:29476096
GO:1901216 Positive regulation of neuron death Increases phenotype PMID:18353414
GO:1901318 Negative regulation of flagellated sperm motility Affects phenotype PMID:32976933
GO:1901612 Cardiolipin binding Decreases phenotype PMID:35300571
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:30031113; PMID:30081045; PMID:31756223
GO:1901671 Positive regulation of superoxide dismutase activity Increases phenotype PMID:32976933
GO:1902003 Regulation of amyloid-beta formation Affects phenotype PMID:22313790
GO:1902034 Negative regulation of hematopoietic stem cell proliferation Increases phenotype PMID:33483752
GO:1902237 Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Increases phenotype PMID:24791885
GO:1902552 Negative regulation of catalase activity Increases phenotype PMID:31756223
GO:1902600 Proton transmembrane transport Affects phenotype PMID:33038468
GO:1902882 Regulation of response to oxidative stress Affects phenotype PMID:23479318
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:20020935; PMID:28035397; PMID:37467947
GO:1903409 Reactive oxygen species biosynthetic process Affects phenotype PMID:30476502; PMID:30738203; PMID:30905827; PMID:31610155; PMID:31647946; PMID:31874198
GO:1903427 Negative regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:34189835
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:24881885; PMID:36308466; PMID:37142061
GO:1903561 Extracellular vesicle Increases phenotype PMID:34044057
GO:1903703 Enterocyte differentiation Affects phenotype PMID:38563870
GO:1905037 Autophagosome organization Affects phenotype PMID:36840722
GO:1905456 Regulation of lymphoid progenitor cell differentiation Affects phenotype PMID:32428222
GO:1905457 Negative regulation of lymphoid progenitor cell differentiation Increases phenotype PMID:32428222
GO:1905603 Regulation of blood-brain barrier permeability Decreases phenotype PMID:20829427
GO:1990051 Activation of protein kinase c activity Decreases phenotype PMID:22610977
GO:1990079 Cartilage homeostasis Affects phenotype PMID:21839992
GO:1990182 Exosomal secretion Increases phenotype PMID:36840722
GO:2000379 Positive regulation of reactive oxygen species metabolic process Increases phenotype PMID:36308466
GO:2000403 Positive regulation of lymphocyte migration Increases phenotype PMID:36220500
GO:2000617 Positive regulation of histone h3-k9 acetylation Increases phenotype PMID:29301062
GO:2000653 Regulation of genetic imprinting Affects phenotype PMID:26115033
GO:2000774 Positive regulation of cellular senescence Increases phenotype PMID:39579145
GO:2000808 Negative regulation of synaptic vesicle clustering Increases phenotype PMID:35367965
GO:2000872 Positive regulation of progesterone secretion Decreases phenotype PMID:25981801
GO:2001057 Reactive nitrogen species metabolic process Affects phenotype PMID:32407874
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.