Perfluorooctanoic acid


Curated chemical-disease associations from CTD
Disease IDDisease nameReference
MESH:C535682 Right ventricle hypoplasia PMID:29800642
MESH:D000015 Abnormalities, Multiple PMID:31494276
MESH:D000022 Abortion, Spontaneous PMID:23978332; PMID:32319790
MESH:D000067877 Autism Spectrum Disorder PMID:29298162
MESH:D000077962 Body-Weight Trajectory PMID:33208860
MESH:D001008 Anxiety Disorders PMID:36105436
MESH:D001284 Atrophy PMID:19464571
MESH:D001289 Attention Deficit Disorder with Hyperactivity PMID:20551004
MESH:D001523 Mental Disorders PMID:18063051
MESH:D001724 Birth Weight PMID:36920051
MESH:D001835 Body Weight PMID:34464680
MESH:D001927 Brain Diseases PMID:18063051
MESH:D001941 Breast Diseases PMID:22414604
MESH:D001943 Breast Neoplasms PMID:28610584
MESH:D002318 Cardiovascular Diseases PMID:22652006; PMID:22945282; PMID:38758093
MESH:D002471 Cell Transformation, Neoplastic PMID:29502166
MESH:D003093 Colitis, Ulcerative PMID:23735465
MESH:D003643 Death PMID:20686339
MESH:D003924 Diabetes Mellitus, Type 2 PMID:29498927; PMID:33993001
MESH:D004485 Eczema PMID:32717646
MESH:D004802 Eosinophilia PMID:17369199
MESH:D005128 Eye Diseases PMID:32059142
MESH:D005234 Fatty Liver PMID:32822737; PMID:37806615
MESH:D005313 Fetal Death PMID:17098816
MESH:D005317 Fetal Growth Retardation PMID:23978332; PMID:27656770
MESH:D005327 Fetal Resorption PMID:20637823
MESH:D006058 Gonadal Disorders PMID:17488742
MESH:D006130 Growth Disorders PMID:17098816; PMID:17488742
MESH:D006331 Heart Diseases PMID:22273728; PMID:23941634
MESH:D006505 Hepatitis PMID:23458897
MESH:D006528 Carcinoma, Hepatocellular PMID:21984479
MESH:D006529 Hepatomegaly PMID:11879971; PMID:17369199; PMID:19440492; PMID:19540903; PMID:20614104; PMID:20637823; PMID:22531602; PMID:23143925; PMID:23458897; PMID:25543169; PMID:25949234; PMID:27153767; PMID:28049043; PMID:32074459; PMID:32320774; PMID:32822737; PMID:34464680; PMID:34958885; PMID:3609246; PMID:38182912
MESH:D006937 Hypercholesterolemia PMID:25260175
MESH:D006943 Hyperglycemia PMID:28947262
MESH:D006965 Hyperplasia PMID:20614104
MESH:D006969 Hypersensitivity, Immediate PMID:22322153
MESH:D006973 Hypertension PMID:22652006; PMID:32958007
MESH:D006984 Hypertrophy PMID:20614104; PMID:20686339
MESH:D007019 Hypoproteinemia PMID:20686339
MESH:D007035 Hypothermia PMID:27682001
MESH:D007153 Immunologic Deficiency Syndromes PMID:19240040
MESH:D007247 Infertility, Female PMID:28143724
MESH:D007248 Infertility, Male PMID:25743374
MESH:D007249 Inflammation PMID:30711707
MESH:D007984 Leydig Cell Tumor PMID:22531602; PMID:8812269
MESH:D008113 Liver Neoplasms PMID:14757943; PMID:18709148; PMID:20143881
MESH:D008114 Liver Neoplasms, Experimental PMID:2040027; PMID:21984479
MESH:D008231 Lymphopenia PMID:19540903
MESH:D008607 Intellectual Disability PMID:29298162
MESH:D009336 Necrosis PMID:21499893; PMID:23948355; PMID:26054880
MESH:D009361 Neoplasm Invasiveness PMID:24960061
MESH:D009410 Nerve Degeneration PMID:23948355
MESH:D009421 Nervous System Malformations PMID:31494276
MESH:D009503 Neutropenia PMID:19540903
MESH:D009845 Oligospermia PMID:19590684
MESH:D010024 Osteoporosis PMID:26058082
MESH:D011041 Poisoning PMID:22465071; PMID:23391484; PMID:27750016; PMID:28728110
MESH:D011297 Prenatal Exposure Delayed Effects PMID:17098816; PMID:17132714; PMID:20637823; PMID:20686339; PMID:21482639; PMID:21501981; PMID:22274686; PMID:25543169; PMID:25567242; PMID:26115335; PMID:27553991; PMID:29800642; PMID:34500360; PMID:34585601
MESH:D012130 Respiratory Hypersensitivity PMID:17369199
MESH:D012893 Sleep Wake Disorders PMID:39512894
MESH:D013158 Splenic Diseases PMID:17369199
MESH:D013959 Thyroid Diseases PMID:20089479
MESH:D015430 Weight Gain PMID:32959518
MESH:D015431 Weight Loss PMID:19240040; PMID:22531602; PMID:30711707; PMID:31904477; PMID:34958885; PMID:38123106
MESH:D016535 Bronchial Hyperreactivity PMID:17369199
MESH:D016649 Primary Ovarian Insufficiency PMID:38830045
MESH:D018248 Adenoma, Liver Cell PMID:21984479
MESH:D018357 Respiratory Syncytial Virus Infections PMID:32717646
MESH:D020964 Embryo Loss PMID:17488742; PMID:28143724; PMID:28219760; PMID:31494276
MESH:D033461 Hyperuricemia PMID:20123605; PMID:22003309; PMID:23552989
MESH:D049188 Prenatal Injuries PMID:22273728
MESH:D050171 Dyslipidemias PMID:32822737
MESH:D056486 Chemical and Drug Induced Liver Injury PMID:20686339; PMID:22289616; PMID:23458897; PMID:26054880; PMID:26879310; PMID:32074459
MESH:D058186 Acute Kidney Injury PMID:38123106
MESH:D058729 Peripheral Arterial Disease PMID:22945282
MESH:D065626 Non-alcoholic Fatty Liver Disease PMID:28049043
MESH:D066087 Perinatal Death PMID:25543169
MESH:D066126 Cardiotoxicity PMID:29800642

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.