Perfluorooctanoic acid


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000080 Mitotic g1 phase Affects phenotype PMID:35678645
GO:0000084 Mitotic s phase Increases phenotype PMID:29094436; PMID:29846718; PMID:32700164
GO:0000086 G2/m transition of mitotic cell cycle Affects phenotype PMID:29094436; PMID:32700164
GO:0000278 Mitotic cell cycle Affects phenotype PMID:29094436
GO:0001541 Ovarian follicle development Affects phenotype PMID:36152675
GO:0001545 Primary ovarian follicle growth Decreases phenotype PMID:39141488
GO:0001547 Antral ovarian follicle growth Decreases phenotype PMID:35104888
GO:0001553 Luteinization Decreases phenotype PMID:28219760
GO:0001556 Oocyte maturation Decreases phenotype PMID:36723383
GO:0001780 Neutrophil homeostasis Affects phenotype PMID:31904477
GO:0001821 Histamine secretion Increases phenotype PMID:27682001
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:25586001
GO:0001892 Embryonic placenta development Affects phenotype PMID:32074459
GO:0001967 Suckling behavior Affects phenotype PMID:36105436
GO:0002024 Diet induced thermogenesis Increases phenotype PMID:26001964
GO:0002082 Regulation of oxidative phosphorylation Affects phenotype PMID:36436258
GO:0002250 Adaptive immune response Decreases phenotype PMID:32227269
GO:0002253 Activation of immune response Decreases phenotype PMID:32227269
GO:0002309 T cell proliferation involved in immune response Affects phenotype PMID:31904477
GO:0002316 Follicular b cell differentiation Affects phenotype PMID:37162486
GO:0002381 Immunoglobulin production involved in immunoglobulin-mediated immune response Increases phenotype PMID:27682001
GO:0002437 Inflammatory response to antigenic stimulus Increases phenotype PMID:27682001
GO:0002455 Humoral immune response mediated by circulating immunoglobulin Decreases phenotype PMID:22274686; PMID:26041029
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:23626681; PMID:23626681; PMID:26054880; PMID:35066053; PMID:26054880
GO:0002534 Cytokine production involved in inflammatory response Increases phenotype PMID:27682001
GO:0002553 Histamine secretion by mast cell Increases phenotype PMID:27682001
GO:0002637 Regulation of immunoglobulin production Affects phenotype PMID:37162486
GO:0003006 Developmental process involved in reproduction Decreases phenotype PMID:34171588
GO:0003016 Respiratory system process Decreases phenotype PMID:30737192
GO:0003094 Glomerular filtration Decreases phenotype PMID:23482063; PMID:26590127; PMID:27529882
GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity Decreases phenotype PMID:29156323
GO:0004465 Lipoprotein lipase activity Increases phenotype PMID:30657992
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:26054880; PMID:33422635; PMID:39933620
GO:0004984 Olfactory receptor activity Affects phenotype PMID:38513818
GO:0005243 Gap junction channel activity Decreases phenotype PMID:26023933; PMID:32971237
GO:0005978 Glycogen biosynthetic process Decreases phenotype PMID:28947262
GO:0006006 Glucose metabolic process Affects phenotype PMID:32892005; PMID:33325755; PMID:33993001
GO:0006011 Udp-glucose metabolic process Affects phenotype PMID:33325755
GO:0006089 Lactate metabolic process Affects phenotype PMID:33325755
GO:0006094 Gluconeogenesis Affects phenotype PMID:28947262
GO:0006101 Citrate metabolic process Affects phenotype PMID:33325755
GO:0006108 Malate metabolic process Affects phenotype PMID:33325755
GO:0006110 Regulation of glycolytic process Affects phenotype PMID:37236338
GO:0006111 Regulation of gluconeogenesis Affects phenotype PMID:37236338
GO:0006119 Oxidative phosphorylation Affects phenotype PMID:34311058; PMID:39933620
GO:0006171 Camp biosynthetic process Increases phenotype PMID:28947262
GO:0006306 Dna methylation Increases phenotype PMID:32700164
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:31841032
GO:0006531 Aspartate metabolic process Affects phenotype PMID:33325755
GO:0006536 Glutamate metabolic process Affects phenotype PMID:33325755; PMID:33569802; PMID:34029635
GO:0006544 Glycine metabolic process Affects phenotype PMID:33325755
GO:0006551 Leucine metabolic process Affects phenotype PMID:33325755; PMID:34029635
GO:0006558 L-phenylalanine metabolic process Affects phenotype PMID:34029635
GO:0006560 Proline metabolic process Affects phenotype PMID:33325755
GO:0006568 Tryptophan metabolic process Affects phenotype PMID:33325755; PMID:34029635
GO:0006570 Tyrosine metabolic process Affects phenotype PMID:34029635
GO:0006580 Ethanolamine metabolic process Affects phenotype PMID:33325755
GO:0006600 Creatine metabolic process Affects phenotype PMID:33325755
GO:0006601 Creatine biosynthetic process Decreases phenotype PMID:38123106
GO:0006629 Lipid metabolic process Affects phenotype PMID:32634666; PMID:33113464; PMID:33325755
GO:0006631 Fatty acid metabolic process Affects phenotype PMID:33325755; PMID:34029635; PMID:36436258
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:31931806; PMID:32074459; PMID:32588087; PMID:34464680; PMID:34464680; PMID:38182912; PMID:38117326; PMID:38182912
GO:0006672 Ceramide metabolic process Increases phenotype PMID:34627976
GO:0006684 Sphingomyelin metabolic process Affects phenotype PMID:32634666
GO:0006694 Steroid biosynthetic process Affects phenotype PMID:33991873
GO:0006695 Cholesterol biosynthetic process Affects phenotype PMID:20123614; PMID:25092180; PMID:30508572
GO:0006699 Bile acid biosynthetic process Affects phenotype PMID:32253466; PMID:33991873
GO:0006702 Androgen biosynthetic process Affects phenotype PMID:30508572
GO:0006749 Glutathione metabolic process Affects phenotype PMID:33325755; PMID:33422635; PMID:34029635
GO:0006853 Carnitine shuttle Decreases phenotype PMID:30508572
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:32578922; PMID:35123991
GO:0006915 Apoptotic process Affects phenotype PMID:26054880; PMID:29846718; PMID:32971237; PMID:33422635; PMID:35123991; PMID:35563431; PMID:37044272
GO:0006954 Inflammatory response Decreases phenotype PMID:32916415
GO:0006955 Immune response Affects phenotype PMID:31904477
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:32320774
GO:0006979 Response to oxidative stress Affects phenotype PMID:34029635
GO:0007005 Mitochondrion organization Increases phenotype PMID:34311058
GO:0007049 Cell cycle Affects phenotype PMID:40347494
GO:0007286 Spermatid development Decreases phenotype PMID:31841032
GO:0007346 Regulation of mitotic cell cycle Affects phenotype PMID:38603627
GO:0007595 Lactation Decreases phenotype PMID:27179585
GO:0007610 Behavior Affects phenotype PMID:25567242
GO:0007612 Learning Affects phenotype PMID:32521479
GO:0008121 Ubiquinol-cytochrome-c reductase activity Increases phenotype PMID:25586001
GO:0008137 Nadh dehydrogenase (ubiquinone) activity Increases phenotype PMID:25586001
GO:0008177 Succinate dehydrogenase (ubiquinone) activity Decreases phenotype PMID:25586001
GO:0008202 Steroid metabolic process Affects phenotype PMID:37422089
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:19846564; PMID:32971418; PMID:26942110; PMID:32253466
GO:0008206 Bile acid metabolic process Affects phenotype PMID:36436258
GO:0008216 Spermidine metabolic process Affects phenotype PMID:34029635
GO:0008219 Cell death Affects phenotype PMID:26599974; PMID:27682001; PMID:37738295; PMID:39933616
GO:0008283 Cell population proliferation Increases phenotype PMID:23539207; PMID:23978341; PMID:26234195; PMID:29502166; PMID:29502166; PMID:32700164; PMID:35346789; PMID:35678645; PMID:37044272; PMID:37834465
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:25868421; PMID:28511854; PMID:35337807; PMID:36251517
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:30547568; PMID:32353385; PMID:34246126
GO:0008361 Regulation of cell size Affects phenotype PMID:32320774
GO:0008610 Lipid biosynthetic process Increases phenotype PMID:25092180
GO:0008652 Amino acid biosynthetic process Affects phenotype PMID:34029635
GO:0009117 Nucleotide metabolic process Affects phenotype PMID:34029635
GO:0009437 Carnitine metabolic process Affects phenotype PMID:33325755
GO:0009636 Response to toxic substance Affects phenotype PMID:23458897
GO:0010172 Embryonic body morphogenesis Decreases phenotype PMID:34134420
GO:0010424 Dna methylation on cytosine within a cg sequence Affects phenotype PMID:33356526; PMID:35266797; PMID:39862910
GO:0010468 Regulation of gene expression Affects phenotype PMID:26978841; PMID:37738295
GO:0010507 Negative regulation of autophagy Increases phenotype PMID:37806615
GO:0010634 Positive regulation of epithelial cell migration Increases phenotype PMID:36849026
GO:0010729 Positive regulation of hydrogen peroxide biosynthetic process Increases phenotype PMID:28219760
GO:0010867 Positive regulation of triglyceride biosynthetic process Affects phenotype PMID:34252412
GO:0010884 Positive regulation of lipid storage Increases phenotype PMID:32353385
GO:0010890 Positive regulation of sequestering of triglyceride Increases phenotype PMID:28049043
GO:0010907 Positive regulation of glucose metabolic process Increases phenotype PMID:36115532
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:38513818
GO:0010918 Positive regulation of mitochondrial membrane potential Increases phenotype PMID:34311058
GO:0010942 Positive regulation of cell death Increases phenotype PMID:23626681; PMID:25868421; PMID:26879310; PMID:34246126
GO:0014049 Positive regulation of glutamate secretion Increases phenotype PMID:33027616
GO:0015711 Organic anion transport Affects phenotype PMID:28552774
GO:0015808 L-alanine transport Decreases phenotype PMID:33027616
GO:0015825 L-serine transport Increases phenotype PMID:33027616
GO:0015920 Lipopolysaccharide transport Increases phenotype PMID:35066053
GO:0015939 Pantothenate metabolic process Affects phenotype PMID:33325755
GO:0016042 Lipid catabolic process Increases phenotype PMID:26054880; PMID:33422635
GO:0016049 Cell growth Increases phenotype PMID:26234195; PMID:29502166; PMID:29721586; PMID:30144469
GO:0016477 Cell migration Increases phenotype PMID:29502166; PMID:32700164; PMID:29753068; PMID:29753068; PMID:33571556; PMID:33571556; PMID:35346789
GO:0019216 Regulation of lipid metabolic process Affects phenotype PMID:31931806; PMID:37236338; PMID:38513818
GO:0019217 Regulation of fatty acid metabolic process Affects phenotype PMID:37236338
GO:0019369 Arachidonic acid metabolic process Affects phenotype PMID:33991873
GO:0019432 Triglyceride biosynthetic process Affects phenotype PMID:25092180; PMID:29094436
GO:0019530 Taurine metabolic process Affects phenotype PMID:33325755
GO:0019627 Urea metabolic process Affects phenotype PMID:34958885
GO:0019673 Gdp-mannose metabolic process Affects phenotype PMID:33325755
GO:0019674 Nad metabolic process Affects phenotype PMID:33325755
GO:0019752 Carboxylic acid metabolic process Affects phenotype PMID:34029635
GO:0019858 Cytosine metabolic process Affects phenotype PMID:34029635
GO:0019859 Thymine metabolic process Affects phenotype PMID:34029635
GO:0021846 Cell proliferation in forebrain Decreases phenotype PMID:40347494
GO:0021895 Cerebral cortex neuron differentiation Decreases phenotype PMID:40347494
GO:0022008 Neurogenesis Affects phenotype PMID:23948355
GO:0030282 Bone mineralization Affects phenotype PMID:26058082; PMID:34585601; PMID:35750749
GO:0030307 Positive regulation of cell growth Increases phenotype PMID:30711707
GO:0030308 Negative regulation of cell growth Increases phenotype PMID:30711707; PMID:36341878
GO:0030335 Positive regulation of cell migration Increases phenotype PMID:35370244
GO:0030431 Sleep Decreases phenotype PMID:39512894
GO:0030501 Positive regulation of bone mineralization Increases phenotype PMID:33033332
GO:0030879 Mammary gland development Affects phenotype PMID:35163327
GO:0031324 Negative regulation of cellular metabolic process Increases phenotype PMID:36251517
GO:0031325 Positive regulation of cellular metabolic process Increases phenotype PMID:25868421; PMID:36251517
GO:0031331 Positive regulation of cellular catabolic process Increases phenotype PMID:30685356
GO:0031398 Positive regulation of protein ubiquitination Increases phenotype PMID:26879310
GO:0031507 Heterochromatin formation Increases phenotype PMID:26339649
GO:0031987 Locomotion involved in locomotory behavior Affects phenotype PMID:36105436
GO:0032204 Regulation of telomere maintenance Affects phenotype PMID:34454526
GO:0032275 Luteinizing hormone secretion Decreases phenotype PMID:39141488
GO:0032640 Tumor necrosis factor production Increases phenotype PMID:27682001
GO:0032691 Negative regulation of interleukin-1 beta production Increases phenotype PMID:35065522
GO:0032755 Positive regulation of interleukin-6 production Affects phenotype PMID:23458897
GO:0032760 Positive regulation of tumor necrosis factor production Increases phenotype PMID:39141488
GO:0032930 Positive regulation of superoxide anion generation Increases phenotype PMID:28511854
GO:0033023 Mast cell homeostasis Affects phenotype PMID:31904477
GO:0033540 Fatty acid beta-oxidation using acyl-coa oxidase Increases phenotype PMID:30711707
GO:0034109 Homotypic cell-cell adhesion Decreases phenotype PMID:37044272
GO:0034379 Very-low-density lipoprotein particle assembly Decreases phenotype PMID:30657992
GO:0034389 Lipid droplet organization Increases phenotype PMID:23626681
GO:0034440 Lipid oxidation Increases phenotype PMID:25586001; PMID:28219760; PMID:39933620
GO:0035929 Steroid hormone secretion Decreases phenotype PMID:35104888
GO:0035934 Corticosterone secretion Increases phenotype PMID:29721586
GO:0035936 Testosterone secretion Increases phenotype PMID:35104888
GO:0035937 Estrogen secretion Affects phenotype PMID:39933620
GO:0035938 Estradiol secretion Decreases phenotype PMID:35104888
GO:0035942 Dehydroepiandrosterone secretion Decreases phenotype PMID:27219028
GO:0035943 Estrone secretion Decreases phenotype PMID:35104888
GO:0036109 Alpha-linolenic acid metabolic process Affects phenotype PMID:33991873
GO:0036123 Histone h3-k9 dimethylation Decreases phenotype PMID:32700164
GO:0036343 Psychomotor behavior Affects phenotype PMID:32272335
GO:0040029 Epigenetic regulation of gene expression Affects phenotype PMID:39862910
GO:0042098 T cell proliferation Increases phenotype PMID:31904477
GO:0042100 B cell proliferation Decreases phenotype PMID:31904477
GO:0042133 Neurotransmitter metabolic process Affects phenotype PMID:34029635
GO:0042403 Thyroid hormone metabolic process Increases phenotype PMID:25483837; PMID:26517287; PMID:33243245
GO:0042448 Progesterone metabolic process Affects phenotype PMID:30508572
GO:0042572 Retinol metabolic process Affects phenotype PMID:33991873
GO:0042593 Glucose homeostasis Affects phenotype PMID:36964247
GO:0042632 Cholesterol homeostasis Decreases phenotype PMID:18000414; PMID:20819969; PMID:23685825; PMID:23441227; PMID:30657992; PMID:32822737; PMID:36174755
GO:0042697 Menopause Increases phenotype PMID:21411548; PMID:39510233; PMID:27529882
GO:0042701 Progesterone secretion Decreases phenotype PMID:34311058; PMID:35104888; PMID:39933620
GO:0042756 Drinking behavior Affects phenotype PMID:26001964
GO:0042866 Pyruvate biosynthetic process Increases phenotype PMID:28947262
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:28219760; PMID:33812015; PMID:34765786
GO:0043303 Mast cell degranulation Increases phenotype PMID:27682001
GO:0043396 Corticotropin-releasing hormone secretion Increases phenotype PMID:33824413
GO:0043651 Linoleic acid metabolic process Affects phenotype PMID:33991873
GO:0044237 Cellular metabolic process Increases phenotype PMID:29094436; PMID:31809754; PMID:32068100; PMID:36336871; PMID:32253466; PMID:32971237; PMID:33422635; PMID:33569802; PMID:34029635; PMID:34311058; PMID:35123991; PMID:35346789; PMID:36326898; PMID:36336871; PMID:36613676; PMID:36864359; PMID:37044272; PMID:38117326; PMID:38549690
GO:0044255 Cellular lipid metabolic process Affects phenotype PMID:34464680
GO:0044319 Wound healing, spreading of cells Increases phenotype PMID:29753068
GO:0044565 Dendritic cell proliferation Increases phenotype PMID:31904477
GO:0045023 G0 to g1 transition Affects phenotype PMID:32700164
GO:0045444 Fat cell differentiation Increases phenotype PMID:34800597; PMID:39111555
GO:0045540 Regulation of cholesterol biosynthetic process Affects phenotype PMID:29156323
GO:0045541 Negative regulation of cholesterol biosynthetic process Increases phenotype PMID:36115532
GO:0045577 Regulation of b cell differentiation Affects phenotype PMID:37162486
GO:0045719 Negative regulation of glycogen biosynthetic process Increases phenotype PMID:35066053; PMID:36115532
GO:0045730 Respiratory burst Increases phenotype PMID:36788734
GO:0045772 Positive regulation of autophagosome size Increases phenotype PMID:26879310
GO:0045793 Positive regulation of cell size Increases phenotype PMID:28049043
GO:0045834 Positive regulation of lipid metabolic process Increases phenotype PMID:34627976
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:26879310
GO:0046031 Adp metabolic process Affects phenotype PMID:33325755
GO:0046033 Amp metabolic process Affects phenotype PMID:33325755
GO:0046034 Atp metabolic process Affects phenotype PMID:25586001; PMID:33325755; PMID:34029635; PMID:34311058; PMID:39933620
GO:0046036 Ctp metabolic process Affects phenotype PMID:33325755
GO:0046039 Gtp metabolic process Affects phenotype PMID:33325755
GO:0046048 Udp metabolic process Affects phenotype PMID:33325755
GO:0046051 Utp metabolic process Affects phenotype PMID:33325755
GO:0046083 Adenine metabolic process Affects phenotype PMID:33325755
GO:0046085 Adenosine metabolic process Affects phenotype PMID:33325755
GO:0046098 Guanine metabolic process Affects phenotype PMID:34029635
GO:0046104 Thymidine metabolic process Affects phenotype PMID:33325755
GO:0046108 Uridine metabolic process Affects phenotype PMID:33325755
GO:0046167 Glycerol-3-phosphate biosynthetic process Affects phenotype PMID:33325755
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:36336871
GO:0046323 Glucose import Decreases phenotype PMID:34311058
GO:0046415 Urate metabolic process Affects phenotype PMID:36174755
GO:0046459 Short-chain fatty acid metabolic process Affects phenotype PMID:30813950
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:33812015
GO:0046470 Phosphatidylcholine metabolic process Affects phenotype PMID:32634666
GO:0046483 Heterocycle metabolic process Affects phenotype PMID:34029635
GO:0046622 Positive regulation of organ growth Increases phenotype PMID:30685356; PMID:30711707; PMID:30711707
GO:0046704 Cdp metabolic process Affects phenotype PMID:33325755
GO:0046710 Gdp metabolic process Affects phenotype PMID:33325755
GO:0046890 Regulation of lipid biosynthetic process Affects phenotype PMID:34500360
GO:0046961 Proton-transporting atpase activity, rotational mechanism Decreases phenotype PMID:34029635
GO:0048487 Beta-tubulin binding Decreases phenotype PMID:36181250
GO:0048589 Developmental growth Decreases phenotype PMID:27553991
GO:0050665 Hydrogen peroxide biosynthetic process Increases phenotype PMID:26054880
GO:0050890 Cognition Affects phenotype PMID:32272335
GO:0051462 Regulation of cortisol secretion Affects phenotype PMID:37236338
GO:0051881 Regulation of mitochondrial membrane potential Increases phenotype PMID:25586001; PMID:34029635; PMID:35123991; PMID:37044272; PMID:37834465; PMID:39933620
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:39933620
GO:0051899 Membrane depolarization Increases phenotype PMID:37044272
GO:0055074 Calcium ion homeostasis Affects phenotype PMID:27682001
GO:0055088 Lipid homeostasis Decreases phenotype PMID:32353385
GO:0060208 Proestrus Decreases phenotype PMID:39141488
GO:0060326 Cell chemotaxis Increases phenotype PMID:32700164; PMID:33571556; PMID:35346789
GO:0060612 Adipose tissue development Increases phenotype PMID:27352404
GO:0061028 Establishment of endothelial barrier Decreases phenotype PMID:33571556
GO:0061052 Negative regulation of cell growth involved in cardiac muscle cell development Increases phenotype PMID:34134420
GO:0061516 Monocyte proliferation Increases phenotype PMID:31904477
GO:0070091 Glucagon secretion Affects phenotype PMID:36613676
GO:0070265 Necrotic cell death Increases phenotype PMID:23948355
GO:0070316 Regulation of g0 to g1 transition Affects phenotype PMID:38603627
GO:0070328 Triglyceride homeostasis Decreases phenotype PMID:20819969; PMID:30657992; PMID:30711707
GO:0070858 Negative regulation of bile acid biosynthetic process Increases phenotype PMID:38181850
GO:0070873 Regulation of glycogen metabolic process Affects phenotype PMID:37236338
GO:0071736 Igg immunoglobulin complex, circulating Decreases phenotype PMID:27501995
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:25586001; PMID:34029635; PMID:35123991; PMID:36336871; PMID:39933620
GO:0080182 Histone h3-k4 trimethylation Decreases phenotype PMID:32700164
GO:0090030 Regulation of steroid hormone biosynthetic process Affects phenotype PMID:37236338
GO:0090116 C-5 methylation of cytosine Decreases phenotype PMID:32068100; PMID:32320774
GO:0090181 Regulation of cholesterol metabolic process Affects phenotype PMID:30657992
GO:0090207 Regulation of triglyceride metabolic process Affects phenotype PMID:30657992
GO:0090208 Positive regulation of triglyceride metabolic process Increases phenotype PMID:34627976
GO:0090592 Dna synthesis involved in dna replication Increases phenotype PMID:30711707
GO:0097153 Cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:34029635
GO:0097722 Sperm motility Decreases phenotype PMID:31841032
GO:0098609 Cell-cell adhesion Decreases phenotype PMID:23948355
GO:0110119 Positive regulation of very-low-density lipoprotein particle clearance Increases phenotype PMID:30657992
GO:0120190 Negative regulation of bile acid secretion Increases phenotype PMID:38181850
GO:0140042 Lipid droplet formation Increases phenotype PMID:29094436; PMID:32320774; PMID:38182912; PMID:32353385; PMID:34464680; PMID:36251517; PMID:39778647
GO:1900103 Positive regulation of endoplasmic reticulum unfolded protein response Increases phenotype PMID:36251517
GO:1900533 Palmitic acid metabolic process Affects phenotype PMID:33325755
GO:1901098 Positive regulation of autophagosome maturation Decreases phenotype PMID:26879310
GO:1901164 Negative regulation of trophoblast cell migration Increases phenotype PMID:32219433; PMID:35548680
GO:1901216 Positive regulation of neuron death Increases phenotype PMID:33027616
GO:1901334 Lactone metabolic process Affects phenotype PMID:34029635
GO:1901671 Positive regulation of superoxide dismutase activity Decreases phenotype PMID:28219760
GO:1901713 Negative regulation of urea catabolic process Increases phenotype PMID:38123106
GO:1902807 Negative regulation of cell cycle g1/s phase transition Increases phenotype PMID:38513818
GO:1902884 Positive regulation of response to oxidative stress Increases phenotype PMID:36849026
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:32700164; PMID:35678645
GO:1903052 Positive regulation of proteolysis involved in protein catabolic process Decreases phenotype PMID:26879310
GO:1903180 Negative regulation of dopamine biosynthetic process Increases phenotype PMID:34371090
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:33812015
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:28511854; PMID:34765786; PMID:36075290; PMID:36251517; PMID:38513818
GO:1903851 Negative regulation of cristae formation Increases phenotype PMID:33812015
GO:1903998 Regulation of eating behavior Affects phenotype PMID:26001964
GO:1904177 Regulation of adipose tissue development Affects phenotype PMID:36436258
GO:1904178 Negative regulation of adipose tissue development Increases phenotype PMID:30711707; PMID:36115532
GO:1904197 Positive regulation of granulosa cell proliferation Increases phenotype PMID:38603627
GO:1904253 Positive regulation of bile acid metabolic process Increases phenotype PMID:34627976
GO:1904358 Positive regulation of telomere maintenance via telomere lengthening Increases phenotype PMID:34193151
GO:1990182 Exosomal secretion Increases phenotype PMID:37851381
GO:1990402 Embryonic liver development Affects phenotype PMID:36436258
GO:1990403 Embryonic brain development Decreases phenotype PMID:40347494
GO:1990428 Mirna transport Increases phenotype PMID:37851381
GO:1990959 Eosinophil homeostasis Affects phenotype PMID:31904477
GO:2000045 Regulation of g1/s transition of mitotic cell cycle Affects phenotype PMID:29502166
GO:2000064 Regulation of cortisol biosynthetic process Affects phenotype PMID:37236338
GO:2000180 Negative regulation of androgen biosynthetic process Increases phenotype PMID:38050817
GO:2000609 Regulation of thyroid hormone generation Affects phenotype PMID:29488882; PMID:32311629
GO:2000614 Positive regulation of thyroid-stimulating hormone secretion Increases phenotype PMID:26517287
GO:2000726 Negative regulation of cardiac muscle cell differentiation Increases phenotype PMID:34134420
GO:2000786 Positive regulation of autophagosome assembly Increases phenotype PMID:26879310; PMID:38513818
GO:2000865 Negative regulation of estradiol secretion Increases phenotype PMID:38603627
GO:2000872 Positive regulation of progesterone secretion Affects phenotype PMID:28219760; PMID:38603627
GO:2001057 Reactive nitrogen species metabolic process Affects phenotype PMID:36336871
GO:2001170 Negative regulation of atp biosynthetic process Increases phenotype PMID:38513818
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.