2,4-Dichlorophenoxyacetic acid


Curated chemical-gene interactions from CTD
Entrez gene IDGene symbolInteraction typeReference
100136658 PPARB Increases expression PMID:29633193
100506658 OCLN Decreases expression PMID:28699141
1021 CDK6 Increases expression PMID:33865415
10869 USP19 Increases expression PMID:15878651
114548 NLRP3 Increases expression PMID:34464015; PMID:35099110
1195 CLK1 Decreases expression PMID:15878651
1267 CNP Decreases expression PMID:18460445
1384 CRAT Increases activity PMID:1755024
1385 CREB1 Increases expression PMID:29633193
140809 SRXN1 Increases expression PMID:34626751
14103 FASL Increases expression PMID:36214342
1543 CYP1A1 Increases expression PMID:10910964
1544 CYP1A2 Increases expression PMID:10910964
1545 CYP1B1 Increases expression PMID:10910964
1551 CYP3A7 Increases expression PMID:8812189
1586 CYP17A1 Affects expression PMID:26838045
1621 DBH Decreases expression PMID:16931444
1643 DDB2 Increases expression PMID:15878651
1649 DDIT3 Increases expression PMID:34626751
2052 EPHX1 Increases activity PMID:3032197
2053 EPHX2 Increases activity PMID:1755024; PMID:3032197
22059 TRP53 Increases expression PMID:33865415
2308 FOXO1 Increases expression PMID:29633193
2495 FTH1 Increases expression PMID:15878651
2512 FTL Increases expression PMID:15878651
2670 GFAP Increases expression PMID:22954530
2819 GPD1 Decreases activity PMID:11952153
2876 GPX1 Decreases activity PMID:35099110
29108 PYCARD Increases expression PMID:34464015
317 APAF1 Decreases expression PMID:33865415
355 FAS Increases expression PMID:36214342
3553 IL1B Increases expression PMID:34464015; PMID:35099110
356 FASLG Increases expression PMID:36214342
3565 IL4 Increases expression PMID:19467290
3567 IL5 Increases expression PMID:19467290
3569 IL6 Increases expression PMID:19467290; PMID:35099110; PMID:34464015
3606 IL18 Increases expression PMID:34464015; PMID:35099110
3688 ITGB1 Increases expression PMID:33865415
3939 LDHA Decreases expression PMID:23538319
4155 MBP Decreases expression PMID:18460445
4609 MYC Increases expression PMID:17540612
4790 NFKB1 Increases expression PMID:33865415
4953 ODC1 Decreases activity PMID:2017772
5111 PCNA Affects expression PMID:15878651; PMID:37615203
5213 PFKM Decreases expression PMID:23538319
5244 ABCB4 Increases expression PMID:9210621
5733 PTGER3 Decreases expression PMID:15878651
6347 CCL2 Increases expression PMID:19467290
6351 CCL4 Increases expression PMID:19467290
6356 CCL11 Increases expression PMID:19467290
64421 DCLRE1C Increases expression PMID:15878651
6515 SLC2A3 Affects expression PMID:23538319
6647 SOD1 Decreases activity PMID:35099110
7054 TH Increases expression PMID:16931444
7082 TJP1 Decreases expression PMID:28699141
7124 TNF Increases expression PMID:34464015; PMID:35099110
7422 VEGFA Decreases expression PMID:15878651
81631 MAP1LC3B Decreases expression PMID:34464015; PMID:35099110
8313 AXIN2 Increases expression PMID:34463001
836 CASP3 Increases activity PMID:39921193
836 CASP3 Increases expression PMID:36214342
841 CASP8 Increases expression PMID:36214342
8678 BECN1 Decreases expression PMID:34464015; PMID:35099110
8772 FADD Increases expression PMID:36214342
8856 NR1I2 Increases activity PMID:21115097
8878 SQSTM1 Increases expression PMID:34464015; PMID:35099110
90060 CCDC120 Decreases expression PMID:15878651
9076 CLDN1 Decreases expression PMID:28699141
9123 SLC16A3 Affects expression PMID:23538319
9173 IL1RL1 Decreases expression PMID:15878651
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.