2,4-Dichlorophenoxyacetic acid


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000226 Microtubule cytoskeleton organization Decreases phenotype PMID:3806697
GO:0000723 Telomere maintenance Affects phenotype PMID:23774483; PMID:25018261
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:36085217
GO:0001776 Leukocyte homeostasis Affects phenotype PMID:33865415
GO:0001780 Neutrophil homeostasis Affects phenotype PMID:33865415
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:39921193
GO:0002260 Lymphocyte homeostasis Affects phenotype PMID:33865415
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:36085217
GO:0005977 Glycogen metabolic process Affects phenotype PMID:29633193
GO:0006006 Glucose metabolic process Affects phenotype PMID:20187939; PMID:29633193
GO:0006695 Cholesterol biosynthetic process Decreases phenotype PMID:26838045
GO:0006749 Glutathione metabolic process Affects phenotype PMID:36085217
GO:0006915 Apoptotic process Increases phenotype PMID:39921193
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:31756860
GO:0007283 Spermatogenesis Decreases phenotype PMID:36214342; PMID:37615203
GO:0008283 Cell population proliferation Decreases phenotype PMID:37567420; PMID:37615203
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:37516258
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:28699141; PMID:34626751; PMID:36214342
GO:0009635 Response to herbicide Decreases phenotype PMID:36214342
GO:0010507 Negative regulation of autophagy Increases phenotype PMID:35099110
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:35099110
GO:0016505 Peptidase activator activity involved in apoptotic process Increases phenotype PMID:28699141
GO:0030262 Apoptotic nuclear changes Increases phenotype PMID:28699141
GO:0030263 Apoptotic chromosome condensation Increases phenotype PMID:34464015
GO:0030335 Positive regulation of cell migration Increases phenotype PMID:35099110
GO:0030850 Prostate gland development Decreases phenotype PMID:26759115
GO:0031122 Cytoplasmic microtubule organization Decreases phenotype PMID:3806697
GO:0034063 Stress granule assembly Increases phenotype PMID:33431410
GO:0034440 Lipid oxidation Increases phenotype PMID:28699141; PMID:34464015; PMID:36214342; PMID:36085217; PMID:36214342
GO:0035356 Cellular triglyceride homeostasis Affects phenotype PMID:20187939
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:28699141; PMID:36214342
GO:0044237 Cellular metabolic process Decreases phenotype PMID:39921193
GO:0045429 Positive regulation of nitric oxide biosynthetic process Increases phenotype PMID:37236337
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:35099110
GO:0046621 Negative regulation of organ growth Increases phenotype PMID:34464015
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:39921193
GO:0061370 Testosterone biosynthetic process Decreases phenotype PMID:26838045; PMID:37615203
GO:0061739 Protein lipidation involved in autophagosome assembly Decreases phenotype PMID:34464015
GO:0070460 Thyroid-stimulating hormone secretion Affects phenotype PMID:20187939
GO:0070668 Positive regulation of mast cell proliferation Increases phenotype PMID:37516258
GO:0071897 Dna biosynthetic process Decreases phenotype PMID:3806697
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:39921193
GO:0160024 Leydig cell proliferation Affects phenotype PMID:37615203
GO:1901142 Insulin metabolic process Affects phenotype PMID:20187939
GO:1901216 Positive regulation of neuron death Increases phenotype PMID:34464015
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:28699141; PMID:34464015; PMID:36214342; PMID:36214342
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:34464015; PMID:36214342; PMID:36214342
GO:1903284 Positive regulation of glutathione peroxidase activity Increases phenotype PMID:28699141
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:35099110; PMID:36214342
GO:1903980 Positive regulation of microglial cell activation Increases phenotype PMID:34464015; PMID:35099110
GO:1905517 Macrophage migration Increases phenotype PMID:37567420
GO:2000134 Negative regulation of g1/s transition of mitotic cell cycle Increases phenotype PMID:28699141
GO:2000516 Positive regulation of cd4-positive, alpha-beta t cell activation Increases phenotype PMID:20728597
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:36214342
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.