1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine


Curated chemical-gene interactions from CTD
Entrez gene IDGene symbolInteraction typeReference
100039028 MUP11 Increases expression PMID:29627306
100039054 MUP12 Increases expression PMID:29627306
100039089 MUP13 Increases expression PMID:29627306
100041687 MUP8 Increases expression PMID:29627306
100048884 MUP18 Increases expression PMID:29627306
100124700 HOTAIR Increases expression PMID:32968928
100126297 MIR300 Decreases expression PMID:29071302
10015 PDCD6IP Decreases expression PMID:15329391
10017 BCL2L10 Decreases expression PMID:20230807
100189605 MUP19 Increases expression PMID:29627306
100506658 OCLN Decreases expression PMID:31351185
100506742 CASP12 Increases expression PMID:20230807
100507206 LINC00943 Increases expression PMID:34427876
100526521 MIR3084-1 Decreases expression PMID:29071302
10079 ATP9A Decreases expression PMID:20230807
1009 CDH11 Decreases expression PMID:20230807
10111 RAD50 Increases expression PMID:20230807
10121 ACTR1A Increases expression PMID:20230807
10130 PDIA6 Decreases expression PMID:20230807
10188 TNK2 Increases expression PMID:20230807
10284 SAP18 Increases expression PMID:20230807
1032 CDKN2D Increases expression PMID:15329391
10327 AKR1A1 Increases expression PMID:20230807
10449 ACAA2 Decreases expression PMID:20230807
10519 CIB1 Increases expression PMID:20230807
10536 P3H3 Increases expression PMID:20230807
1070 CETN3 Increases expression PMID:20230807
10745 PHTF1 Decreases expression PMID:20230807
10777 ARPP21 Increases expression PMID:29627306
10891 PPARGC1A Decreases expression PMID:30236862
10935 PRDX3 Affects expression PMID:20230807; PMID:23562983
10963 STIP1 Increases expression PMID:20230807
11193 WBP4 Increases expression PMID:20230807
113 ADCY7 Decreases expression PMID:20230807
11315 PARK7 Increases expression PMID:20230807
1137 CHRNA4 Decreases expression PMID:19594327
114548 NLRP3 Increases expression PMID:32968928; PMID:38016618
114609 TIRAP Increases expression PMID:20230807
114737 IBA1 Increases expression PMID:38629493
120892 LRRK2 Increases expression PMID:32968928
121278 TPH2 Increases expression PMID:20230807
124995 MRPL10 Decreases expression PMID:20230807
1265 CNN2 Increases expression PMID:20230807
1268 CNR1 Decreases expression PMID:28978077
1269 CNR2 Decreases expression PMID:28978077
12716 CKMT1 Increases expression PMID:20230807
1277 COL1A1 Affects expression PMID:20230807; PMID:30529163
1291 COL6A1 Increases expression PMID:20230807
1350 COX7C Decreases expression PMID:20230807
1471 CST3 Decreases expression PMID:20230807
14867 GSTM6 Increases expression PMID:20230807
1508 CTSB Increases expression PMID:20230807
15122 HBA-A1 Decreases expression PMID:20230807
1514 CTSL Increases expression PMID:20230807
151648 SGO1 Decreases expression PMID:29627306
154791 FMC1 Decreases expression PMID:29371327
1583 CYP11A1 Decreases expression PMID:20230807
16190 IL4RA Increases expression PMID:20230807
1649 DDIT3 Increases expression PMID:22940226; PMID:24140863; PMID:28082123
1719 DHFR Decreases expression PMID:31187328
1743 DLST Increases expression PMID:23562983
1749 DLX5 Increases expression PMID:29627306
17750 MT2 Increases expression PMID:20230807
1803 DPP4 Increases expression PMID:20230807
1808 DPYSL2 Decreases expression PMID:23562983
1811 SLC26A3 Decreases expression PMID:15329391
1893 ECM1 Decreases expression PMID:20230807
1915 EEF1A1 Increases expression PMID:20230807
19349 RAB7 Decreases expression PMID:20230807
1938 EEF2 Increases expression PMID:20230807
1942 EFNA1 Decreases expression PMID:20230807
1949 EFNB3 Increases expression PMID:20230807
1958 EGR1 Decreases expression PMID:20230807; PMID:28801915
1959 EGR2 Decreases expression PMID:28801915
1977 EIF4E Decreases expression PMID:20230807
1983 EIF5 Increases expression PMID:20230807
199 AIF1 Increases expression PMID:28185818; PMID:37741537; PMID:38016618
2011 MARK2 Decreases expression PMID:15329391
2023 ENO1 Affects expression PMID:20230807; PMID:23562983
2026 ENO2 Affects expression PMID:23562983; PMID:30236862
204851 HIPK1 Increases expression PMID:20230807
2081 ERN1 Increases expression PMID:20230807; PMID:24140863
20909 STX4A Increases expression PMID:20230807
2108 ETFA Decreases expression PMID:20230807
216 ALDH1A1 Decreases expression PMID:20230807
2182 ACSL4 Increases expression PMID:36435477
22059 TRP53 Increases expression PMID:23933227
22166 TXN1 Decreases expression PMID:28082123
2247 FGF2 Decreases expression PMID:28801915
226143 CYP2C23 Increases expression PMID:29627306
22821 RASA3 Increases expression PMID:20230807
22823 MTF2 Increases expression PMID:20230807
22859 ADGRL1 Increases expression PMID:20230807
22883 CLSTN1 Decreases expression PMID:20230807
22933 SIRT2 Increases expression PMID:27235848
23071 ERP44 Increases expression PMID:20230807
23095 KIF1B Decreases expression PMID:15329391
23210 JMJD6 Increases expression PMID:20230807
23394 ADNP Decreases expression PMID:20230807
23396 PIP5K1C Increases expression PMID:20230807
23468 CBX5 Increases expression PMID:20230807
23522 KAT6B Decreases expression PMID:20230807
2354 FOSB Increases expression PMID:27566062
23642 SNHG1 Increases expression PMID:29217406; PMID:31907031
23708 GSPT2 Decreases expression PMID:28801915
23787 MTCH1 Increases expression PMID:20230807
2495 FTH1 Decreases expression PMID:36435477
2534 FYN Decreases expression PMID:20230807
2549 GAB1 Increases expression PMID:20230807
2582 GALE Increases expression PMID:20230807
259266 ASPM Decreases expression PMID:20230807
2596 GAP43 Decreases expression PMID:23933227
2597 GAPDH Decreases expression PMID:20230807
26054 SENP6 Increases expression PMID:20230807
2627 GATA6 Increases expression PMID:20230807
2643 GCH1 Decreases expression PMID:31187328
26471 NUPR1 Increases expression PMID:20230807
2668 GDNF Decreases expression PMID:23747572; PMID:23943375; PMID:23747572; PMID:23943375; PMID:31119595
2670 GFAP Increases expression PMID:19199078; PMID:23747572; PMID:24995576; PMID:27182044; PMID:28185818; PMID:33035625; PMID:38629493
27069 GHITM Decreases expression PMID:20230807
27072 VPS41 Increases expression PMID:20230807
2729 GCLC Decreases expression PMID:20230807
2730 GCLM Decreases expression PMID:31187328
2734 GLG1 Decreases expression PMID:15329391
2764 GMFB Increases expression PMID:20230807
2771 GNAI2 Decreases expression PMID:20230807
283131 NEAT1 Increases expression PMID:29575151
2846 LPAR4 Decreases expression PMID:20230807
2878 GPX3 Increases expression PMID:20230807
2879 GPX4 Decreases expression PMID:36435477
2895 GRID2 Increases expression PMID:20230807
2902 GRIN1 Increases expression PMID:23538867; PMID:28092019
29108 PYCARD Increases expression PMID:20230807; PMID:32968928; PMID:38016618
2941 GSTA4 Increases expression PMID:20230807; PMID:23933227
2969 GTF2I Decreases expression PMID:15329391
30011 SH3KBP1 Affects expression PMID:18535749
30061 SLC40A1 Decreases expression PMID:19679656
3070 HELLS Increases expression PMID:20230807
3094 HINT1 Increases expression PMID:20230807
3162 HMOX1 Affects expression PMID:19679656; PMID:23933227; PMID:33368846; PMID:38016618; PMID:38629493
3183 HNRNPC Affects expression PMID:20230807
3265 HRAS Decreases expression PMID:20230807
328 APEX1 Increases expression PMID:20230807
3301 DNAJA1 Increases expression PMID:20230807
3309 HSPA5 Increases expression PMID:24140863; PMID:28082123
3320 HSP90AA1 Increases expression PMID:20230807
3336 HSPE1 Increases expression PMID:20230807
3383 ICAM1 Increases expression PMID:30195017
341359 SYT10 Decreases expression PMID:15329391
3419 IDH3A Increases expression PMID:23562983
3479 IGF1 Decreases expression PMID:31351185
3552 IL1A Decreases expression PMID:22940226
3553 IL1B Increases expression PMID:12626429; PMID:24991814; PMID:24995576; PMID:28185818; PMID:30195017; PMID:31351185; PMID:38016618; PMID:38629493; PMID:22940226; PMID:25053526; PMID:32968928; PMID:38016618; PMID:38629493
35577 RAB2 Increases expression PMID:20230807
3558 IL2 Increases expression PMID:30195017
3565 IL4 Increases expression PMID:30195017
3569 IL6 Affects expression PMID:22940226; PMID:24995576; PMID:30195017; PMID:38629493; PMID:32968928; PMID:37741537; PMID:38016618; PMID:38629493
3605 IL17A Increases expression PMID:31351185
3654 IRAK1 Increases expression PMID:20230807
375 ARF1 Decreases expression PMID:20230807
377 ARF3 Decreases expression PMID:20230807
3798 KIF5A Decreases expression PMID:15329391
3815 KIT Increases expression PMID:30195017
3840 KPNA4 Increases expression PMID:34427876
387171 MIR153 Decreases expression PMID:31907031
390205 LRRC10B Increases expression PMID:29627306
3916 LAMP1 Decreases expression PMID:33359019
3925 STMN1 Decreases expression PMID:23562983
406929 MIR138-1 Increases expression PMID:29071302
406934 MIR142 Decreases expression PMID:34427876
406949 MIR15B Decreases expression PMID:29217406
406992 MIR210 Increases expression PMID:29030221
407006 MIR221 Decreases expression PMID:34967706
4086 SMAD1 Increases expression PMID:20230807
4088 SMAD3 Decreases expression PMID:20230807
4128 MAOA Increases expression PMID:20230807
4129 MAOB Increases activity PMID:30195017
4129 MAOB Increases expression PMID:24103762
4133 MAP2 Decreases expression PMID:15329391
4137 MAPT Increases expression PMID:15329391
4158 MC2R Decreases expression PMID:20230807
4189 DNAJB9 Increases expression PMID:20230807
4199 ME1 Decreases expression PMID:20230807
43 ACHE Decreases activity PMID:30529163
43 ACHE Decreases expression PMID:15329391
4316 MMP7 Increases expression PMID:20230807
440823 MIAT Increases expression PMID:34967706
442902 MIR330 Decreases expression PMID:29071302
4504 MT3 Increases expression PMID:23933227
4684 NCAM1 Decreases expression PMID:23933227
4711 NDUFB5 Decreases expression PMID:20230807
4724 NDUFS4 Decreases expression PMID:20230807
4780 NFE2L2 Decreases expression PMID:24991814; PMID:29071302; PMID:31187328; PMID:33368846; PMID:34967706; PMID:38016618; PMID:38629493; PMID:34967706
4792 NFKBIA Decreases expression PMID:37741537
4842 NOS1 Affects expression PMID:17555550; PMID:31187328
4843 NOS2 Increases activity PMID:12626429
4843 NOS2 Increases expression PMID:22940226; PMID:23933227; PMID:24995576; PMID:28185818; PMID:33035625; PMID:33035625; PMID:37741537
4899 NRF1 Decreases expression PMID:21856379
4905 NSF Affects expression PMID:15329391; PMID:20230807
494329 MIR380 Decreases expression PMID:29071302
4982 TNFRSF11B Affects expression PMID:30529163
506 ATP5F1B Increases expression PMID:23562983
50617 ATP6V0A4 Decreases expression PMID:20230807
5062 PAK2 Increases expression PMID:20230807
50640 PNPLA8 Increases expression PMID:20230807
5071 PRKN Affects expression PMID:22342763; PMID:22342763; PMID:27566062; PMID:23643664; PMID:28978077; PMID:28978077
51026 GOLT1B Increases expression PMID:20230807
51160 VPS28 Decreases expression PMID:20230807
51181 DCXR Decreases expression PMID:20230807
5175 PECAM1 Increases expression PMID:30195017
5201 PFDN1 Increases expression PMID:20230807
5209 PFKFB3 Decreases expression PMID:29627306
5245 PHB1 Decreases expression PMID:20230807
526 ATP6V1B2 Decreases expression PMID:20230807
527 ATP6V0C Decreases expression PMID:20230807
5279 PIGC Increases expression PMID:20230807
5300 PIN1 Increases expression PMID:20230807; PMID:23754278; PMID:23754278
54 ACP5 Increases expression PMID:30529163
5413 SEPTIN5 Decreases expression PMID:23562983
54367 ZFP326 Increases expression PMID:29627306
5458 POU4F2 Decreases expression PMID:29627306
547 KIF1A Decreases expression PMID:15329391
54850 FBXL12 Decreases expression PMID:20230807
5495 PPM1B Decreases expression PMID:20230807
55012 PPP2R3C Increases expression PMID:20230807
55052 MRPL20 Decreases expression PMID:20230807
55367 PIDD1 Increases expression PMID:20230807
55512 SMPD3 Increases expression PMID:20230807
55532 SLC30A10 Increases expression PMID:28688763
5564 PRKAB1 Decreases expression PMID:20230807
55890 GPRC5C Increases expression PMID:20230807
5594 MAPK1 Increases expression PMID:20230807
5609 MAP2K7 Increases expression PMID:20230807
56448 CYP2D22 Decreases expression PMID:19594327
56984 PSMG2 Increases expression PMID:20230807
56997 COQ8A Decreases expression PMID:20230807
5701 PSMC2 Decreases expression PMID:20230807
5705 PSMC5 Decreases expression PMID:20230807
57103 TIGAR Increases expression PMID:33359019
572 BAD Increases expression PMID:23911879
5728 PTEN Increases expression PMID:31907031
5743 PTGS2 Increases expression PMID:22940226; PMID:24995576; PMID:33035625; PMID:33035625; PMID:37741537
574506 MIR503 Decreases expression PMID:29071302
581 BAX Increases expression PMID:24095822; PMID:24995576; PMID:25968939; PMID:28185818; PMID:37741537
5810 RAD1 Increases expression PMID:20230807
5813 PURA Decreases expression PMID:15329391
58157 NGB Decreases expression PMID:20230807
5905 RANGAP1 Decreases expression PMID:15329391
5921 RASA1 Decreases expression PMID:15329391
5928 RBBP4 Decreases expression PMID:20230807
5929 RBBP5 Increases expression PMID:20230807
596 BCL2 Decreases expression PMID:23911879; PMID:24095822; PMID:24995576; PMID:25968939; PMID:28185818; PMID:37741537
5970 RELA Increases expression PMID:34808223
5979 RET Decreases expression PMID:17555550
5997 RGS2 Decreases expression PMID:20230807
6125 RPL5 Increases expression PMID:20230807
6154 RPL26 Decreases expression PMID:20230807
627 BDNF Affects expression PMID:15329391; PMID:23747572; PMID:23943375; PMID:23747572; PMID:23943375; PMID:24991814; PMID:29030221
632 BGLAP Decreases expression PMID:30529163
6347 CCL2 Increases expression PMID:22746536; PMID:27277809; PMID:30195017
6421 SFPQ Increases expression PMID:20230807
65005 MRPL9 Increases expression PMID:20230807
65018 PINK1 Decreases expression PMID:28978077
6531 SLC6A3 Affects expression PMID:15329391; PMID:16725203; PMID:20079141; PMID:23643664; PMID:23665943; PMID:23747572; PMID:23911879; PMID:23943375; PMID:28377118; PMID:15329391; PMID:20079141; PMID:23665943; PMID:23747572; PMID:30195017
6531 SLC6A3 Decreases activity PMID:16011487
6571 SLC18A2 Decreases activity PMID:16011487
6571 SLC18A2 Decreases expression PMID:16011487; PMID:23747572; PMID:23943375; PMID:28377118
6622 SNCA Increases expression PMID:19857570; PMID:19857570; PMID:23747572; PMID:24103762; PMID:23747572; PMID:24103762; PMID:32968928; PMID:34808223; PMID:36435477
6623 SNCG Increases expression PMID:20230807
664 BNIP3 Increases expression PMID:20230807
6648 SOD2 Affects expression PMID:19679656; PMID:23562983
6667 SP1 Increases expression PMID:23538867
6670 SP3 Increases expression PMID:29071302
6726 SRP9 Decreases expression PMID:20230807
6733 SRPK2 Decreases expression PMID:15329391
674052 PS-MODR4 Decreases expression PMID:20230807
6774 STAT3 Decreases expression PMID:28801915
6860 SYT4 Affects expression PMID:15329391; PMID:20230807
6886 TAL1 Decreases expression PMID:29627306
7001 PRDX2 Decreases expression PMID:23562983
7019 TFAM Decreases expression PMID:21856379
7037 TFRC Increases expression PMID:20230807
7040 TGFB1 Increases expression PMID:30195017; PMID:34967706; PMID:34967706
7046 TGFBR1 Increases expression PMID:34967706
7052 TGM2 Increases activity PMID:30195017
7052 TGM2 Increases expression PMID:30195017
7054 TH Affects expression PMID:15329391; PMID:20230807; PMID:21605582; PMID:23665943; PMID:23747572; PMID:23933227; PMID:28185818; PMID:30236862; PMID:16725203; PMID:17555550; PMID:18535749; PMID:18573265; PMID:19199078; PMID:19594327; PMID:20230807; PMID:21856379; PMID:23201480; PMID:23643664; PMID:23665943; PMID:23747572; PMID:23754278; PMID:23933227; PMID:23943375; PMID:24140863; PMID:25968939; PMID:27044752; PMID:27182044; PMID:27957685; PMID:28082123; PMID:28092019; PMID:28185818; PMID:28377118; PMID:31119595; PMID:32968928; PMID:34808223; PMID:36435477; PMID:37741537; PMID:38629493; PMID:30195017; PMID:38016618
7078 TIMP3 Decreases expression PMID:20230807
7082 TJP1 Decreases expression PMID:31351185
7099 TLR4 Increases expression PMID:34808223
7124 TNF Increases expression PMID:12626429; PMID:24991814; PMID:24995576; PMID:30195017; PMID:31351185; PMID:34808223; PMID:38629493; PMID:22746536; PMID:27277809; PMID:30236862; PMID:37741537; PMID:38016618; PMID:38629493; PMID:22940226; PMID:25053526
715 C1R Increases expression PMID:20230807
716 C1S Increases expression PMID:20230807
7174 TPP2 Increases expression PMID:20230807
7186 TRAF2 Increases expression PMID:24140863
7226 TRPM2 Increases expression PMID:27957685
7276 TTR Increases expression PMID:29627306
729230 CCR2 Increases expression PMID:30195017
7295 TXN Decreases expression PMID:24140863
7314 UBB Increases expression PMID:20230807
7316 UBC Decreases expression PMID:20230807
7322 UBE2D2 Decreases expression PMID:20230807
732489 MIR674 Increases expression PMID:29071302
7345 UCHL1 Affects expression PMID:15329391; PMID:20230807; PMID:22342763; PMID:23643664
7390 UROS Decreases expression PMID:20230807
7412 VCAM1 Increases expression PMID:30195017
7430 EZR Decreases expression PMID:20230807
7532 YWHAG Decreases expression PMID:15329391
7786 MAP3K12 Increases expression PMID:20230807
7846 TUBA1A Increases expression PMID:23562983
79191 IRX3 Decreases expression PMID:20230807
801 CALM1 Decreases expression PMID:20230807
80896 NPL Decreases expression PMID:20230807
81669 CCNL2 Increases expression PMID:20230807
8224 SYN3 Decreases expression PMID:15329391
8314 BAP1 Increases expression PMID:20230807
832 CAPZB Decreases expression PMID:15329391
834 CASP1 Increases expression PMID:15329391; PMID:38016618
836 CASP3 Increases activity PMID:20133810; PMID:23911879
836 CASP3 Increases expression PMID:15329391; PMID:23933227
8403 SOX14 Decreases expression PMID:29627306
842 CASP9 Increases activity PMID:23911879
842 CASP9 Increases expression PMID:20230807
8455 ATRN Increases expression PMID:20230807
847 CAT Decreases activity PMID:25053526
847 CAT Decreases expression PMID:33368846
84870 RSPO3 Increases expression PMID:20230807
8539 API5 Decreases expression PMID:20230807
8554 PIAS1 Decreases expression PMID:28801915
860 RUNX2 Decreases expression PMID:30529163
8600 TNFSF11 Affects expression PMID:30529163
8837 CFLAR Increases expression PMID:15329391
8848 TSC22D1 Increases expression PMID:20230807
8851 CDK5R1 Decreases expression PMID:15329391
8890 EIF2B4 Decreases expression PMID:20230807
891 CCNB1 Increases expression PMID:20230807
894 CCND2 Increases expression PMID:20230807
8941 CDK5R2 Increases expression PMID:15329391
8973 CHRNA6 Decreases expression PMID:19594327
899 CCNF Increases expression PMID:20230807
9021 SOCS3 Decreases expression PMID:28801915
90423 ATP6V1E2 Decreases expression PMID:28801915
90990 KIFC2 Decreases expression PMID:15329391
9112 MTA1 Decreases expression PMID:27044752
9143 SYNGR3 Decreases expression PMID:15329391
9144 SYNGR2 Decreases expression PMID:20230807
9145 SYNGR1 Decreases expression PMID:15329391
9167 COX7A2L Decreases expression PMID:20230807
928 CD9 Increases expression PMID:20230807
9314 KLF4 Increases expression PMID:20230807
9371 KIF3B Decreases expression PMID:20230807
9373 PLAA Increases expression PMID:20230807
9377 COX5A Decreases expression PMID:23562983
9429 ABCG2 Decreases expression PMID:19732497
9445 ITM2B Decreases expression PMID:20230807
960 CD44 Increases expression PMID:20230807
9627 SNCAIP Increases expression PMID:15329391
9635 CLCA2 Decreases expression PMID:20230807
968 CD68 Increases expression PMID:22746536; PMID:27277809
977 CD151 Decreases expression PMID:20230807
9817 KEAP1 Affects expression PMID:33368846; PMID:38016618
989 SEPTIN7 Increases expression PMID:20230807
998 CDC42 Increases expression PMID:20230807

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.