| GO ID | GO name | Interaction type | Reference |
|---|---|---|---|
| GO:0001694 | Histamine biosynthetic process | Increases phenotype | PMID:30195017 |
| GO:0001774 | Microglial cell activation | Increases phenotype | PMID:22746536; PMID:24991814; PMID:25064079; PMID:37741537; PMID:38629493 |
| GO:0001775 | Cell activation | Increases phenotype | PMID:23562983 |
| GO:0001780 | Neutrophil homeostasis | Decreases phenotype | PMID:34808223 |
| GO:0002260 | Lymphocyte homeostasis | Decreases phenotype | PMID:34808223 |
| GO:0002534 | Cytokine production involved in inflammatory response | Increases phenotype | PMID:37741537 |
| GO:0003990 | Acetylcholinesterase activity | Decreases phenotype | PMID:30529163 |
| GO:0004602 | Glutathione peroxidase activity | Decreases phenotype | PMID:24768735 |
| GO:0004784 | Superoxide dismutase activity | Affects phenotype | PMID:24768735; PMID:38016618; PMID:38016618; PMID:38629493; PMID:38629493 |
| GO:0006749 | Glutathione metabolic process | Increases phenotype | PMID:23943375; PMID:27235848; PMID:36435477 |
| GO:0006750 | Glutathione biosynthetic process | Decreases phenotype | PMID:25053526 |
| GO:0006805 | Xenobiotic metabolic process | Increases phenotype | PMID:19594327 |
| GO:0006809 | Nitric oxide biosynthetic process | Increases phenotype | PMID:24991814 |
| GO:0006915 | Apoptotic process | Increases phenotype | PMID:23201480; PMID:24095822; PMID:24607817; PMID:24607817; PMID:29071302; PMID:32968928; PMID:33368846; PMID:35007524 |
| GO:0006954 | Inflammatory response | Increases phenotype | PMID:37741537; PMID:38629493 |
| GO:0006997 | Nucleus organization | Decreases phenotype | PMID:29071302 |
| GO:0007033 | Vacuole organization | Increases phenotype | PMID:33368846 |
| GO:0007610 | Behavior | Decreases phenotype | PMID:27235848 |
| GO:0007626 | Locomotory behavior | Decreases phenotype | PMID:25406165; PMID:32692843 |
| GO:0008137 | Nadh dehydrogenase (ubiquinone) activity | Decreases phenotype | PMID:10961998; PMID:23562983 |
| GO:0008219 | Cell death | Increases phenotype | PMID:16515773; PMID:18535749; PMID:18535749; PMID:24991814; PMID:22891246; PMID:22891246; PMID:25106480; PMID:25263579; PMID:30195017; PMID:24991814; PMID:25017139; PMID:25106480; PMID:25263579; PMID:27324791; PMID:28978077; PMID:30195017; PMID:8724674 |
| GO:0008283 | Cell population proliferation | Decreases phenotype | PMID:23538867; PMID:23933227; PMID:24995576; PMID:24995576; PMID:25064079; PMID:25064079; PMID:25248837; PMID:30529163 |
| GO:0008344 | Adult locomotory behavior | Affects phenotype | PMID:30195017 |
| GO:0009407 | Toxin catabolic process | Decreases phenotype | PMID:28807673 |
| GO:0009448 | Gamma-aminobutyric acid metabolic process | Affects phenotype | PMID:33368846 |
| GO:0010942 | Positive regulation of cell death | Increases phenotype | PMID:17555897; PMID:1933335; PMID:25693864 |
| GO:0014067 | Negative regulation of phosphatidylinositol 3-kinase signaling | Affects phenotype | PMID:23911879 |
| GO:0014068 | Positive regulation of phosphatidylinositol 3-kinase signaling | Decreases phenotype | PMID:28185818 |
| GO:0015871 | Choline transport | Decreases phenotype | PMID:11406107 |
| GO:0016042 | Lipid catabolic process | Affects phenotype | PMID:28092019; PMID:33368846 |
| GO:0018158 | Protein oxidation | Increases phenotype | PMID:27277809; PMID:27277809; PMID:28092019; PMID:28092019 |
| GO:0019370 | Leukotriene biosynthetic process | Increases phenotype | PMID:30195017 |
| GO:0030263 | Apoptotic chromosome condensation | Increases phenotype | PMID:29071302 |
| GO:0031987 | Locomotion involved in locomotory behavior | Decreases phenotype | PMID:27044752; PMID:27044752; PMID:28978077; PMID:28092019; PMID:28092019; PMID:33368846; PMID:36435477; PMID:38629493; PMID:28978077; PMID:33368846; PMID:36435477; PMID:38629493 |
| GO:0032148 | Activation of protein kinase b activity | Decreases phenotype | PMID:28185818 |
| GO:0032273 | Positive regulation of protein polymerization | Increases phenotype | PMID:34808223 |
| GO:0032981 | Mitochondrial respiratory chain complex i assembly | Decreases phenotype | PMID:29371327 |
| GO:0033058 | Directional locomotion | Decreases phenotype | PMID:24991814 |
| GO:0033278 | Cell proliferation in midbrain | Decreases phenotype | PMID:22511790 |
| GO:0033687 | Osteoblast proliferation | Decreases phenotype | PMID:30529163 |
| GO:0034440 | Lipid oxidation | Increases phenotype | PMID:23943375; PMID:36435477 |
| GO:0034599 | Cellular response to oxidative stress | Affects phenotype | PMID:24095822 |
| GO:0035640 | Exploration behavior | Decreases phenotype | PMID:33472166 |
| GO:0035641 | Locomotory exploration behavior | Decreases phenotype | PMID:37741537 |
| GO:0035684 | Helper t cell extravasation | Increases phenotype | PMID:31351185 |
| GO:0036269 | Swimming behavior | Decreases phenotype | PMID:30195017; PMID:33368846 |
| GO:0040011 | Locomotion | Decreases phenotype | PMID:24140863 |
| GO:0042307 | Positive regulation of protein import into nucleus | Increases phenotype | PMID:27566062 |
| GO:0042416 | Dopamine biosynthetic process | Decreases phenotype | PMID:10318960; PMID:23562983; PMID:27277809; PMID:28377118; PMID:30529163; PMID:23562983; PMID:27044752; PMID:27182044; PMID:27277809 |
| GO:0042417 | Dopamine metabolic process | Increases phenotype | PMID:23943375; PMID:23943375; PMID:30236862; PMID:24103762; PMID:27235848; PMID:28092019; PMID:28092019; PMID:28978077; PMID:32968928; PMID:38016618; PMID:28092019; PMID:33359019; PMID:28807673; PMID:28978077; PMID:28978077; PMID:33368846; PMID:32968928; PMID:33359019; PMID:33368846; PMID:38016618 |
| GO:0042420 | Dopamine catabolic process | Decreases phenotype | PMID:27182044 |
| GO:0042428 | Serotonin metabolic process | Affects phenotype | PMID:28978077 |
| GO:0043065 | Positive regulation of apoptotic process | Increases phenotype | PMID:15621629; PMID:23911879; PMID:25968939; PMID:29371327 |
| GO:0043123 | Positive regulation of i-kappab kinase/nf-kappab signaling | Increases phenotype | PMID:25406165 |
| GO:0043525 | Positive regulation of neuron apoptotic process | Increases phenotype | PMID:20133810; PMID:25406165; PMID:29371327 |
| GO:0043552 | Positive regulation of phosphatidylinositol 3-kinase activity | Decreases phenotype | PMID:28185818 |
| GO:0043954 | Cellular component maintenance | Decreases phenotype | PMID:28807673 |
| GO:0044237 | Cellular metabolic process | Decreases phenotype | PMID:35007524 |
| GO:0045019 | Negative regulation of nitric oxide biosynthetic process | Increases phenotype | PMID:31187328 |
| GO:0045454 | Cell redox homeostasis | Affects phenotype | PMID:27235848 |
| GO:0045793 | Positive regulation of cell size | Increases phenotype | PMID:28807673 |
| GO:0046209 | Nitric oxide metabolic process | Affects phenotype | PMID:35007524 |
| GO:0046466 | Membrane lipid catabolic process | Increases phenotype | PMID:19476553 |
| GO:0048143 | Astrocyte activation | Increases phenotype | PMID:38629493 |
| GO:0050665 | Hydrogen peroxide biosynthetic process | Increases phenotype | PMID:22891246 |
| GO:0050729 | Positive regulation of inflammatory response | Increases phenotype | PMID:32692843 |
| GO:0050881 | Musculoskeletal movement | Affects phenotype | PMID:31351185 |
| GO:0051092 | Positive regulation of nf-kappab transcription factor activity | Increases phenotype | PMID:32692843 |
| GO:0051402 | Neuron apoptotic process | Increases phenotype | PMID:32692843; PMID:36435477; PMID:37741537 |
| GO:0051898 | Negative regulation of protein kinase b signaling | Affects phenotype | PMID:23911879 |
| GO:0055072 | Iron ion homeostasis | Affects phenotype | PMID:36435477 |
| GO:0060586 | Multicellular organismal iron ion homeostasis | Decreases phenotype | PMID:25968939 |
| GO:0061430 | Bone trabecula morphogenesis | Decreases phenotype | PMID:30529163 |
| GO:0061744 | Motor behavior | Decreases phenotype | PMID:31119595; PMID:33472166 |
| GO:0061890 | Positive regulation of astrocyte activation | Increases phenotype | PMID:33035625 |
| GO:0061900 | Glial cell activation | Increases phenotype | PMID:32692843 |
| GO:0070265 | Necrotic cell death | Increases phenotype | PMID:33368846 |
| GO:0070662 | Mast cell proliferation | Increases phenotype | PMID:30195017 |
| GO:0070994 | Detection of oxidative stress | Increases phenotype | PMID:25053526; PMID:38016618; PMID:38016618; PMID:38629493; PMID:38629493 |
| GO:0070997 | Neuron death | Increases phenotype | PMID:10318960; PMID:22746536; PMID:27277809; PMID:28377118; PMID:33359019; PMID:28978077; PMID:28978077; PMID:29030221; PMID:37741537; PMID:38629493; PMID:29030221; PMID:33359019; PMID:33472166; PMID:37741537; PMID:37741537; PMID:38629493 |
| GO:0072593 | Reactive oxygen species metabolic process | Affects phenotype | PMID:33359019 |
| GO:0090074 | Negative regulation of protein homodimerization activity | Increases phenotype | PMID:31187328 |
| GO:0090327 | Negative regulation of locomotion involved in locomotory behavior | Increases phenotype | PMID:23943375; PMID:23943375; PMID:34808223; PMID:34808223; PMID:35104500 |
| GO:0120056 | Large intestinal transit | Decreases phenotype | PMID:31187328 |
| GO:0120061 | Negative regulation of gastric emptying | Increases phenotype | PMID:31187328 |
| GO:1901082 | Positive regulation of relaxation of smooth muscle | Increases phenotype | PMID:31187328 |
| GO:1901216 | Positive regulation of neuron death | Increases phenotype | PMID:19594327; PMID:23911879; PMID:23943375; PMID:23943375; PMID:28939911; PMID:31381935; PMID:35104500; PMID:25630971; PMID:28185818; PMID:28185818; PMID:31351185; PMID:28807673; PMID:28939911; PMID:31351185; PMID:31381935; PMID:34808223; PMID:35104500 |
| GO:1901671 | Positive regulation of superoxide dismutase activity | Decreases phenotype | PMID:25968939 |
| GO:1902957 | Negative regulation of mitochondrial electron transport, nadh to ubiquinone | Increases phenotype | PMID:29371327 |
| GO:1903181 | Positive regulation of dopamine biosynthetic process | Decreases phenotype | PMID:19594327 |
| GO:1904124 | Microglial cell migration | Increases phenotype | PMID:30195017 |
| GO:1905319 | Mesenchymal stem cell migration | Increases phenotype | PMID:30195017 |
| GO:1905604 | Negative regulation of blood-brain barrier permeability | Increases phenotype | PMID:31351185 |
| GO:1990535 | Neuron projection maintenance | Decreases phenotype | PMID:24103762; PMID:35104500 |
| GO:2000821 | Regulation of grooming behavior | Decreases phenotype | PMID:31119595 |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.