Ketoconazole


Curated chemical-gene interactions from CTD
Entrez gene IDGene symbolInteraction typeReference
100020791 ALDH1A4 Increases expression PMID:17966066; PMID:18355885
10005 ACOT8 Increases expression PMID:37077353
10018 BCL2L11 Increases expression PMID:25808816
100506742 CASP12 Increases expression PMID:25808816
100507436 MICA Increases expression PMID:32060585
10084 PQBP1 Decreases expression PMID:36621641
100861531 RN45S Increases expression PMID:36653537
1017 CDK2 Decreases expression PMID:37077353
10193 RNF41 Increases expression PMID:25787151
1021 CDK6 Decreases expression PMID:37077353
10234 LRRC17 Decreases expression PMID:36621641
10240 MRPS31 Increases expression PMID:36621641
1026 CDKN1A Increases expression PMID:16483768; PMID:25808816; PMID:37077353; PMID:25808816
1027 CDKN1B Increases expression PMID:25808816
10276 NET1 Increases expression PMID:36621641
1031 CDKN2C Affects expression PMID:18355885
10361 NPM2 Increases expression PMID:36653537
10367 MICU1 Increases expression PMID:36621641
10368 CACNG3 Increases expression PMID:37077353
10371 SEMA3A Decreases expression PMID:37077353
10395 DLC1 Decreases expression PMID:36653537
10397 NDRG1 Increases expression PMID:37077353
10417 SPON2 Decreases expression PMID:36653537
10435 CDC42EP2 Decreases expression PMID:36653537
10449 ACAA2 Increases expression PMID:37077353
10480 EIF3M Increases expression PMID:36621641
10487 CAP1 Increases expression PMID:36653537
10489 LRRC41 Decreases expression PMID:36621641
1050 CEBPA Increases expression PMID:37077353
10527 IPO7 Increases expression PMID:36621641
10599 SLCO1B1 Decreases expression PMID:16608920
10602 CDC42EP3 Increases expression PMID:28263823
10611 PDLIM5 Increases expression PMID:36621641
10654 PMVK Increases expression PMID:28263823; PMID:37077353
10791 VAMP5 Increases expression PMID:37077353
1081 CGA Decreases expression PMID:25808816
10810 WASF3 Increases expression PMID:36621641
10884 MRPS30 Decreases expression PMID:36621641
10891 PPARGC1A Decreases expression PMID:37077353
10908 PNPLA6 Decreases expression PMID:37077353
10935 PRDX3 Decreases expression PMID:25787151
10941 UGT2A1 Affects expression PMID:18355885
10961 ERP29 Affects expression PMID:18355885
10991 SLC38A3 Decreases expression PMID:37077353
11009 IL24 Increases expression PMID:32816093
11067 DEPP1 Affects expression PMID:15342952; PMID:17175557; PMID:17175557
11069 RAPGEF4 Decreases expression PMID:31099283
11075 STMN2 Decreases expression PMID:36653537
11112 HIBADH Increases expression PMID:36621641
11124 FAF1 Increases expression PMID:25808816
11144 DMC1 Increases expression PMID:16574651
11145 PLAAT3 Increases expression PMID:36621641
11163 NUDT4 Increases expression PMID:36621641
11183 MAP4K5 Decreases expression PMID:36621641
112 ADCY6 Decreases expression PMID:37077353
112399 EGLN3 Increases expression PMID:37077353
112574 SNX18 Increases expression PMID:36621641
11260 XPOT Decreases expression PMID:36621641
112609 MRAP2 Increases expression PMID:36653537
112616 CMTM7 Increases expression PMID:36621641
113419 TEX261 Affects expression PMID:18355885
11343 MGLL Increases expression PMID:37077353
11345 GABARAPL2 Increases expression PMID:37077353
113452 TMEM54 Affects expression PMID:36621641
114548 NLRP3 Increases expression PMID:28138970
114882 OSBPL8 Increases expression PMID:36621641
1149 CIDEA Increases expression PMID:36653537; PMID:37077353
114926 SMIM19 Decreases expression PMID:36621641
115207 KCTD12 Decreases expression PMID:37077353
11522 ADH1 Decreases expression PMID:36653537
115416 MALSU1 Increases expression PMID:36621641
116285 ACSM1 Decreases expression PMID:28263823
116496 NIBAN1 Decreases expression PMID:36653537
116966 WDR17 Increases expression PMID:31099283
1174 AP1S1 Decreases expression PMID:17175557
1191 CLU Decreases expression PMID:17558187; PMID:18289764
11997 AKR1B7 Increases expression PMID:36653537
12 SERPINA3 Increases expression PMID:15342952; PMID:17175557
1203 CLN5 Affects expression PMID:36621641
121536 AEBP2 Decreases expression PMID:36621641
123355 LRRC28 Decreases expression PMID:36653537
12349 CAR2 Increases expression PMID:37077353
1244 ABCC2 Decreases activity PMID:19070657
1269 CNR2 Decreases expression PMID:36653537
127247 ASB17 Increases expression PMID:31099283
1277 COL1A1 Decreases expression PMID:37077353
129685 TAF8 Increases expression PMID:36621641
129787 TMEM18 Decreases expression PMID:36621641
13067 CYCT Increases expression PMID:25787151
13086 CYP2A4 Decreases activity PMID:18420780
13087 CYP2A5 Increases expression PMID:17966066
13088 CYP2B10 Decreases activity PMID:18420780
13088 CYP2B10 Increases expression PMID:17966066
13095 CYP2C29 Decreases activity PMID:18420780
13112 CYP3A11 Decreases activity PMID:18420780
13112 CYP3A11 Increases expression PMID:17966066
13117 CYP4A10 Increases expression PMID:17966066
13121 CYP51 Increases activity PMID:12617470
13121 CYP51 Increases expression PMID:17966066; PMID:28263823; PMID:29337257
133522 PPARGC1B Decreases expression PMID:37077353
134 ADORA1 Increases expression PMID:37077353
134429 STARD4 Increases expression PMID:28263823
134957 STXBP5 Decreases expression PMID:37077353
1370 CPN2 Decreases expression PMID:31099283
137392 CIBAR1 Decreases expression PMID:36621641
1375 CPT1B Decreases expression PMID:37077353
1376 CPT2 Increases expression PMID:37077353
1380 CR2 Increases expression PMID:37077353
1385 CREB1 Decreases expression PMID:37077353
1390 CREM Decreases expression PMID:18355885; PMID:36653537
1395 CRHR2 Decreases expression PMID:37077353
14 AAMP Increases expression PMID:36621641
140809 SRXN1 Decreases expression PMID:36653537
14187 AKR1B8 Decreases expression PMID:36653537
142 PARP1 Increases expression PMID:36621641
1428 CRYM Decreases expression PMID:36653537
142891 SAMD8 Increases expression PMID:36621641
1432 MAPK14 Decreases expression PMID:36621641
143282 FGFBP3 Increases expression PMID:28263823
144193 AMDHD1 Decreases expression PMID:31099283
144347 RFLNA Increases expression PMID:28263823
144699 FBXL14 Decreases expression PMID:36653537
147199 SCGB1C1 Increases expression PMID:36653537
14867 GSTM6 Decreases expression PMID:36653537
1499 CTNNB1 Decreases expression PMID:37077353
150468 CKAP2L Decreases expression PMID:36621641
15129 HBB-B1 Decreases expression PMID:36653537
1514 CTSL Decreases expression PMID:36621641
1520 CTSS Affects expression PMID:18289764
152217 NCBP2AS2 Increases expression PMID:36621641
152302 CIDECP1 Decreases expression PMID:36621641
152503 SH3D19 Increases expression PMID:36621641
1535 CYBA Increases expression PMID:37077353
154 ADRB2 Increases expression PMID:37077353
1543 CYP1A1 Affects activity PMID:14709627; PMID:17283379; PMID:34181028; PMID:17283379; PMID:18420780; PMID:19070657; PMID:26886340
1543 CYP1A1 Increases expression PMID:17283379; PMID:17283379; PMID:25000292; PMID:26886340; PMID:17283379; PMID:26886340; PMID:25000292; PMID:26886340; PMID:31168027
1544 CYP1A2 Decreases activity PMID:12814958; PMID:15879494; PMID:15618748; PMID:15916432; PMID:18420780
1544 CYP1A2 Increases expression PMID:25000292
1545 CYP1B1 Decreases activity PMID:14709627; PMID:18420780
15496 HSD3B5 Decreases expression PMID:31099283
1551 CYP3A7 Decreases activity PMID:37788138
1555 CYP2B6 Decreases activity PMID:14709627
1557 CYP2C19 Decreases activity PMID:14709627; PMID:15618748
1558 CYP2C8 Decreases activity PMID:14709627; PMID:15601807
1559 CYP2C9 Decreases activity PMID:14709627; PMID:15618748; PMID:18420780
1559 CYP2C9 Decreases expression PMID:16608920
1565 CYP2D6 Decreases activity PMID:15618748; PMID:18420780
1571 CYP2E1 Decreases activity PMID:15618748
1573 CYP2J2 Decreases activity PMID:12851038
157570 ESCO2 Decreases expression PMID:36621641
1576 CYP3A4 Affects expression PMID:17998298; PMID:25343516; PMID:25343516; PMID:31629065; PMID:36893891
1576 CYP3A4 Decreases activity PMID:10997946; PMID:10997946; PMID:15005856; PMID:15135088; PMID:15279827; PMID:15306208; PMID:15328084; PMID:15466163; PMID:15557344; PMID:15560889; PMID:15618748; PMID:15731592; PMID:15784650; PMID:15860655; PMID:15869686; PMID:15896247; PMID:15969931; PMID:16012074; PMID:16204965; PMID:18799805; PMID:19328226; PMID:19593786; PMID:20233841; PMID:20307514; PMID:20507880; PMID:21336516; PMID:21349323; PMID:21915887; PMID:22447115; PMID:23146034; PMID:23274770; PMID:23850985; PMID:23876819; PMID:24799337; PMID:26038696; PMID:27871908; PMID:28119166; PMID:33253783; PMID:33438235; PMID:33775687; PMID:34780725; PMID:18420780; PMID:25343516; PMID:28887089; PMID:31870919
1577 CYP3A5 Decreases activity PMID:15557344; PMID:26302866; PMID:37788138
1580 CYP4B1 Increases expression PMID:37077353
1581 CYP7A1 Increases expression PMID:31099283
1583 CYP11A1 Increases expression PMID:26610754
1584 CYP11B1 Decreases activity PMID:15743198; PMID:31982514
1585 CYP11B2 Decreases activity PMID:15743198; PMID:31982514
1585 CYP11B2 Increases expression PMID:16935330
1586 CYP17A1 Decreases activity PMID:11118046; PMID:15743198; PMID:15771425; PMID:31330226; PMID:31982514; PMID:38795739; PMID:15934942; PMID:25993309
1586 CYP17A1 Decreases expression PMID:16935330; PMID:36653537
1588 CYP19A1 Affects activity PMID:20087668; PMID:31330226; PMID:27159630; PMID:36374910
1588 CYP19A1 Decreases expression PMID:36653537
1589 CYP21A2 Decreases expression PMID:16935330
1589 CYP21A2 Increases activity PMID:17194026
1591 CYP24A1 Decreases activity PMID:16483768; PMID:26485663
1592 CYP26A1 Decreases activity PMID:25492813
1592 CYP26A1 Increases expression PMID:28263823; PMID:37077353
1594 CYP27B1 Decreases activity PMID:16483768
1595 CYP51A1 Decreases activity PMID:16989930
160418 TMTC3 Increases expression PMID:36621641
1606 DGKA Decreases expression PMID:37077353
1642 DDB1 Increases expression PMID:36621641
1647 GADD45A Increases expression PMID:16483768
1649 DDIT3 Increases expression PMID:16330322; PMID:31099283; PMID:36621641
1657 DMXL1 Decreases expression PMID:36621641
1660 DHX9 Increases expression PMID:36621641
16630 KLRA12 Decreases expression PMID:31099283
17110 LYZ1 Decreases expression PMID:31099283
171546 SPTSSA Decreases expression PMID:36621641
1717 DHCR7 Increases expression PMID:28263823; PMID:36653537; PMID:36621641
1728 NQO1 Increases expression PMID:17923278; PMID:21753779; PMID:31168027
1737 DLAT Decreases expression PMID:37077353
1774 DNASE1L1 Decreases expression PMID:36653537
1788 DNMT3A Affects expression PMID:37077353
1789 DNMT3B Decreases expression PMID:37077353
1793 DOCK1 Decreases expression PMID:36653537
18 ABAT Increases expression PMID:37077353
181 AGRP Decreases expression PMID:37077353
1815 DRD4 Decreases expression PMID:19587329
183 AGT Increases expression PMID:37077353
1843 DUSP1 Increases expression PMID:25787151
18617 RHOX5 Decreases expression PMID:19587329
18671 ABCB1A Decreases expression PMID:36653537
19 ABCA1 Decreases expression PMID:37077353
1910 EDNRB Increases expression PMID:36653537
1956 EGFR Decreases expression PMID:37077353
196 AHR Increases activity PMID:17283379; PMID:17283379; PMID:25000292; PMID:25000292
196 AHR Increases expression PMID:31168027
197 AHSG Increases expression PMID:36653537
1975 EIF4B Affects expression PMID:18355885
1978 EIF4EBP1 Increases expression PMID:37077353
2 A2M Decreases expression PMID:18289764
20210 SAA3 Decreases expression PMID:17966066
20249 SCD1 Increases expression PMID:28263823
2034 EPAS1 Increases expression PMID:36621641; PMID:37077353
2052 EPHX1 Increases expression PMID:18355885; PMID:37077353
2054 STX2 Decreases expression PMID:36621641
2069 EREG Increases expression PMID:32816093
207474 KCTD12B Decreases expression PMID:37077353
20944 SVS5 Decreases expression PMID:36653537
2099 ESR1 Decreases expression PMID:37077353
21 ABCA3 Decreases expression PMID:37077353
210045 NLRP4B Decreases expression PMID:31099283
2101 ESRRA Increases expression PMID:37077353
211 ALAS1 Increases expression PMID:36653537
2113 ETS1 Decreases expression PMID:37077353
213 ALB Affects expression PMID:36653537
2145 EZH1 Increases expression PMID:37077353
2146 EZH2 Decreases expression PMID:37077353
2152 F3 Increases expression PMID:25569083
216 ALDH1A1 Affects expression PMID:18355885
2167 FABP4 Increases expression PMID:37077353
2168 FABP1 Increases expression PMID:15342952; PMID:17175557; PMID:17567588; PMID:36653537
2170 FABP3 Increases expression PMID:37077353
2171 FABP5 Increases expression PMID:31099283; PMID:37077353
2182 ACSL4 Decreases expression PMID:37077353
220323 OAF Affects expression PMID:18355885
22061 TRP63 Decreases expression PMID:25808816
2222 FDFT1 Increases expression PMID:28263823
2224 FDPS Increases expression PMID:37077353
2230 FDX1 Decreases expression PMID:36653537
223117 SEMA3D Affects expression PMID:36621641
225 ABCD2 Increases expression PMID:36653537
22808 MRAS Increases expression PMID:36621641
22818 COPZ1 Decreases expression PMID:36621641
22854 NTNG1 Decreases expression PMID:31099283
22933 SIRT2 Decreases expression PMID:37077353
22996 TTC39A Increases expression PMID:31099283
23014 FBXO21 Increases expression PMID:36621641
23022 PALLD Decreases expression PMID:31099283
23085 ERC1 Decreases expression PMID:36621641
23136 EPB41L3 Decreases expression PMID:36653537
23158 TBC1D9 Increases expression PMID:31099283
23160 WDR43 Increases expression PMID:36621641
23179 RGL1 Decreases expression PMID:37077353
23233 EXOC6B Increases expression PMID:36621641
2335 FN1 Decreases expression PMID:37077353
23411 SIRT1 Decreases expression PMID:37077353
23417 MLYCD Increases expression PMID:37077353
23492 CBX7 Increases expression PMID:37077353
23529 CLCF1 Increases expression PMID:31099283
23534 TNPO3 Decreases expression PMID:36653537
23555 TSPAN15 Decreases expression PMID:36621641
23583 SMUG1 Decreases expression PMID:36621641
23621 BACE1 Decreases expression PMID:37077353
23636 NUP62 Decreases expression PMID:36653537
23657 SLC7A11 Increases expression PMID:32816093
23658 LSM5 Increases expression PMID:36621641
23788 MTCH2 Increases expression PMID:36621641
24894 CYP2A1 Decreases activity PMID:15879494
24894 CYP2A1 Increases expression PMID:18355885; PMID:7986207
249 ALPL Increases expression PMID:31099283
2516 NR5A1 Decreases expression PMID:37077353
252969 NEIL2 Increases expression PMID:36621641
2538 G6PC1 Affects expression PMID:18289764
2539 G6PD Increases expression PMID:25399406
2550 GABBR1 Increases expression PMID:37077353
2557 GABRA4 Increases expression PMID:37077353
255738 PCSK9 Increases expression PMID:28263823
2558 GABRA5 Decreases expression PMID:37077353
2563 GABRD Increases expression PMID:37077353
2564 GABRE Decreases expression PMID:37077353
25642 CYP3A23-3A1 Affects expression PMID:18355885
25642 CYP3A23-3A1 Decreases activity PMID:12814958; PMID:15879494
257068 PLCXD2 Increases expression PMID:36653537
2571 GAD1 Decreases expression PMID:31099283
25902 MTHFD1L Decreases expression PMID:36621641
25911 DPCD Increases expression PMID:36621641
259227 VOF16 Increases expression PMID:36653537
25937 WWTR1 Increases expression PMID:36621641
2597 GAPDH Increases expression PMID:37077353
26012 NSMF Increases expression PMID:37077353
26190 FBXW2 Increases expression PMID:31099283
2625 GATA3 Increases expression PMID:37077353
26253 CLEC4E Increases expression PMID:31099283
26284 ERAL1 Decreases expression PMID:36653537
26354 GNL3 Decreases expression PMID:36621641
2645 GCK Decreases expression PMID:37077353
2646 GCKR Affects expression PMID:18355885
26471 NUPR1 Increases expression PMID:15342952; PMID:17175557; PMID:17567588
26515 TIMM10B Affects expression PMID:18355885
26574 AATF Decreases expression PMID:25787151
2665 GDI2 Increases expression PMID:36621641
266682 CYP3A2 Decreases activity PMID:12814958; PMID:12814958; PMID:15879494
26762 HAVCR1 Decreases expression PMID:18289764
268 AMH Increases expression PMID:16684832
2690 GHR Decreases expression PMID:37077353
26985 AP3M1 Decreases expression PMID:36621641
2705 GJB1 Decreases expression PMID:31099283
2706 GJB2 Increases expression PMID:36653537
27092 CACNG4 Decreases expression PMID:37077353
27097 TAF5L Affects expression PMID:36621641
27165 GLS2 Affects expression PMID:18355885
27246 RNF115 Increases expression PMID:36621641
274 BIN1 Increases expression PMID:37077353
27424 KLRA16 Increases expression PMID:31099283
2770 GNAI1 Increases expression PMID:37077353
2791 GNG11 Decreases expression PMID:36621641
2802 GOLGA3 Decreases expression PMID:36621641
2805 GOT1 Increases expression PMID:31099283
2806 GOT2 Affects expression PMID:18355885
2819 GPD1 Affects expression PMID:19587329; PMID:37077353
28250 SLCO1A4 Affects expression PMID:18355885
283 ANG Increases expression PMID:36621641
2830 GPR6 Decreases expression PMID:31099283
2835 GPR12 Increases expression PMID:37077353
283869 NPW Decreases expression PMID:37077353
2840 GPR17 Affects expression PMID:37077353
285313 IGSF10 Decreases expression PMID:37077353
285489 DOK7 Decreases expression PMID:36621641
285521 COX18 Affects expression PMID:36621641
2861 GPR37 Increases expression PMID:37077353
2875 GPT Increases expression PMID:31099283
2879 GPX4 Increases expression PMID:17679765
2888 GRB14 Affects expression PMID:18355885
2889 RAPGEF1 Decreases expression PMID:37077353
28973 MRPS18B Affects expression PMID:18355885
2898 GRIK2 Decreases expression PMID:37077353
29028 ATAD2 Increases expression PMID:36621641
2907 GRINA Increases expression PMID:36621641
29071 C1GALT1C1 Decreases expression PMID:36621641
29074 MRPL18 Increases expression PMID:36621641
2908 NR3C1 Decreases activity PMID:25000292
29083 GTPBP8 Decreases expression PMID:36621641
29102 DROSHA Decreases expression PMID:36653537
29126 CD274 Decreases expression PMID:37077353
2913 GRM3 Increases expression PMID:37077353
2914 GRM4 Affects expression PMID:37077353
29277 CYP2C11 Decreases activity PMID:15879494
2936 GSR Increases expression PMID:31168027
2938 GSTA1 Decreases expression PMID:16608920
2939 GSTA2 Decreases expression PMID:16608920
293989 CYP2C6 Decreases activity PMID:12814958; PMID:15879494
294228 RT1-S3 Affects expression PMID:18355885
2944 GSTM1 Increases expression PMID:17966066
2946 GSTM2 Affects expression PMID:18289764
30 ACAA1 Increases expression PMID:37077353
30001 ERO1A Decreases expression PMID:37077353
301 ANXA1 Decreases expression PMID:25787151
3030 HADHA Affects expression PMID:36621641; PMID:37077353
3032 HADHB Increases expression PMID:37077353
3034 HAL Affects expression PMID:18355885
3037 HAS2 Increases expression PMID:36621641
3043 HBB Decreases expression PMID:36653537
3096 HIVEP1 Increases expression PMID:36621641
309622 RT1-BB Decreases expression PMID:36653537
3148 HMGB2 Affects expression PMID:18355885
3156 HMGCR Affects activity PMID:12617470; PMID:9199277
3156 HMGCR Affects expression PMID:16935330; PMID:28263823; PMID:37077353
3157 HMGCS1 Increases expression PMID:28263823; PMID:31099283
3158 HMGCS2 Decreases expression PMID:31099283
316 AOX1 Decreases expression PMID:36653537
3162 HMOX1 Increases expression PMID:18289764; PMID:37077353
317 APAF1 Decreases expression PMID:37077353
3170 FOXA2 Increases expression PMID:37077353
3201 HOXA4 Decreases expression PMID:31099283
3249 HPN Increases expression PMID:15342952
326340 ZAR1 Decreases expression PMID:36653537
3265 HRAS Decreases expression PMID:36621641
326625 MMAB Increases expression PMID:36621641
3283 HSD3B1 Decreases expression PMID:17229994
3284 HSD3B2 Decreases expression PMID:16935330
3291 HSD11B2 Decreases activity PMID:10664531
3295 HSD17B4 Increases expression PMID:16935330
33 ACADL Increases expression PMID:37077353
332 BIRC5 Increases expression PMID:37077353
3329 HSPD1 Decreases expression PMID:25787151
335 APOA1 Increases expression PMID:36653537
337 APOA4 Affects expression PMID:18355885
339448 C1ORF174 Increases expression PMID:36621641
34 ACADM Increases expression PMID:37077353
3400 ID4 Increases expression PMID:36621641
340811 AKR1C8 Increases expression PMID:36653537
3422 IDI1 Increases expression PMID:16330322; PMID:28263823
346673 STRA8 Increases expression PMID:16461896
348 APOE Increases expression PMID:37077353
3484 IGFBP1 Increases expression PMID:18289764
3488 IGFBP5 Increases expression PMID:36653537; PMID:37077353
3489 IGFBP6 Increases expression PMID:37077353
3490 IGFBP7 Increases expression PMID:37077353
3491 CCN1 Increases expression PMID:36621641; PMID:36653537
35 ACADS Increases expression PMID:37077353
3514 IGKC Decreases expression PMID:18289764
353116 RILPL1 Decreases expression PMID:36621641
353310 ZFP703 Decreases expression PMID:36653537
3549 IHH Increases expression PMID:37077353
355 FAS Increases expression PMID:25808816
3552 IL1A Increases expression PMID:32816093
3553 IL1B Increases expression PMID:28138970; PMID:28138970; PMID:32816093
3565 IL4 Decreases expression PMID:11886533; PMID:15284827
3567 IL5 Decreases expression PMID:11886533; PMID:15284827
357 SHROOM2 Increases expression PMID:36653537
3576 CXCL8 Increases expression PMID:32816093
3604 TNFRSF9 Decreases expression PMID:36653537
3621 ING1 Decreases expression PMID:36621641
3622 ING2 Decreases expression PMID:36621641
3638 INSIG1 Increases expression PMID:37077353
3640 INSL3 Decreases expression PMID:36653537
3643 INSR Decreases expression PMID:37077353
3646 EIF3E Decreases expression PMID:36621641
3667 IRS1 Decreases expression PMID:37077353
367 AR Affects activity PMID:11118046; PMID:26867867
367 AR Decreases expression PMID:19587329
3708 ITPR1 Increases expression PMID:37077353
3712 IVD Increases expression PMID:37077353
373 TRIM23 Affects expression PMID:36621641
3741 KCNA5 Decreases activity PMID:9694927
374383 NCR3LG1 Increases expression PMID:32060585
3756 KCNH1 Decreases expression PMID:36653537
3757 KCNH2 Decreases activity PMID:15272206; PMID:16542653; PMID:24052561; PMID:29143966; PMID:9694927; PMID:17965736
375757 SWI5 Increases expression PMID:36621641
3816 KLK1 Increases expression PMID:31099283
383 ARG1 Increases expression PMID:37077353
3839 KPNA3 Increases expression PMID:36621641
3843 IPO5 Decreases expression PMID:36621641
388 RHOB Increases expression PMID:37077353
388341 LRRC75A Increases expression PMID:28263823
389136 VGLL3 Decreases expression PMID:36621641
389362 PSMG4 Increases expression PMID:36621641
389549 FEZF1 Decreases expression PMID:37077353
3914 LAMB3 Increases expression PMID:37077353
3921 RPSA Increases expression PMID:37077353
3925 STMN1 Affects expression PMID:18355885
392862 GRID2IP Increases expression PMID:37077353
3934 LCN2 Decreases expression PMID:18289764
3973 LHCGR Decreases expression PMID:36653537
3975 LHX1 Increases expression PMID:28263823
4001 LMNB1 Decreases expression PMID:36621641
4015 LOX Affects expression PMID:18355885
401612 SLC25A53 Decreases expression PMID:36621641
4047 LSS Increases expression PMID:15342952; PMID:17175557; PMID:17567588
405 ARNT Increases activity PMID:17283379
4074 M6PR Decreases expression PMID:36621641
4126 MANBA Affects expression PMID:18355885
4154 MBNL1 Decreases expression PMID:37077353
4159 MC3R Decreases expression PMID:37077353
4176 MCM7 Increases expression PMID:37077353
4190 MDH1 Increases expression PMID:37077353
4199 ME1 Increases expression PMID:37077353
4233 MET Increases expression PMID:32816093
4256 MGP Affects expression PMID:18289764
4257 MGST1 Increases expression PMID:37077353
4258 MGST2 Increases expression PMID:36621641
4277 MICB Increases expression PMID:32060585
4288 MKI67 Increases expression PMID:25808816
4323 MMP14 Decreases expression PMID:37077353
4345 CD200 Increases expression PMID:36621641
440 ASNS Increases expression PMID:15342952; PMID:17175557
445 ASS1 Increases expression PMID:36653537
4478 MSN Increases expression PMID:36653537
4489 MT1A Increases expression PMID:18289764
4597 MVD Increases expression PMID:37077353
4615 MYD88 Increases expression PMID:37077353
4625 MYH7 Decreases expression PMID:37077353
4661 MYT1 Increases expression PMID:31099283
4678 NASP Increases expression PMID:36621641
4698 NDUFA5 Increases expression PMID:37077353
4780 NFE2L2 Increases expression PMID:21753779; PMID:31168027; PMID:37077353
4804 NGFR Increases expression PMID:28263823
4814 NINJ1 Increases expression PMID:36621641
4846 NOS3 Decreases expression PMID:37077353
4883 NPR3 Decreases expression PMID:37077353
4887 NPY2R Decreases expression PMID:37077353
4953 ODC1 Increases expression PMID:37077353
501 ALDH7A1 Decreases expression PMID:36621641
5017 OVOL1 Increases expression PMID:26873447
5020 OXT Increases expression PMID:37077353
50486 G0S2 Decreases expression PMID:36621641
50487 PLA2G3 Increases expression PMID:37077353
50511 SYCP3 Increases expression PMID:16574651; PMID:31099283
5071 PRKN Increases expression PMID:25787151
50717 DCAF8 Affects expression PMID:18355885
50814 NSDHL Increases expression PMID:28263823
50865 HEBP1 Increases expression PMID:37077353
5091 PC Increases expression PMID:18355885; PMID:37077353
5092 PCBD1 Increases expression PMID:36621641
5101 PCDH9 Increases expression PMID:36621641
51029 DESI2 Decreases expression PMID:36621641
51082 POLR1D Decreases expression PMID:36621641
5111 PCNA Increases expression PMID:37077353
51122 COMMD2 Decreases expression PMID:36621641
51154 MRTO4 Increases expression PMID:37077353
51166 AADAT Affects expression PMID:18355885
5125 PCSK5 Increases expression PMID:36621641
51280 GOLM1 Decreases expression PMID:36621641
51382 ATP6V1D Increases expression PMID:37077353
51399 TRAPPC4 Decreases expression PMID:36621641
5140 PDE3B Decreases expression PMID:37077353
51478 HSD17B7 Increases expression PMID:28263823
51533 PHF7 Increases expression PMID:36621641
51619 UBE2D4 Increases expression PMID:36621641
5162 PDHB Increases expression PMID:37077353
51667 NUB1 Increases expression PMID:36621641
5169 ENPP3 Decreases expression PMID:31099283
517 ATP5MC2 Increases expression PMID:36621641
51703 ACSL5 Increases expression PMID:37077353
5173 PDYN Decreases expression PMID:37077353
51768 TM7SF3 Decreases expression PMID:36621641
51773 RSF1 Increases expression PMID:36621641
5184 PEPD Increases expression PMID:37077353
5196 PF4 Increases expression PMID:37077353
5228 PGF Increases expression PMID:37077353
5241 PGR Increases expression PMID:35307500
5243 ABCB1 Decreases activity PMID:10350002; PMID:15969931; PMID:19070657; PMID:25844889; PMID:23976943
5243 ABCB1 Decreases expression PMID:17365992; PMID:36893891; PMID:18355885
5244 ABCB4 Decreases activity PMID:28437613
5265 SERPINA1 Increases expression PMID:36653537; PMID:37077353
5292 PIM1 Decreases expression PMID:36621641
5318 PKP2 Increases expression PMID:36621641
5324 PLAG1 Decreases expression PMID:36653537
53373 TPCN1 Increases expression PMID:31099283
5372 PMM1 Increases expression PMID:37077353
539 ATP5PO Increases expression PMID:37077353
54108 CHRAC1 Increases expression PMID:36621641
54205 CYCS Affects expression PMID:25787151; PMID:37077353
5443 POMC Decreases expression PMID:25808816
5445 PON2 Increases expression PMID:36621641
5447 POR Increases expression PMID:17966066; PMID:18355885; PMID:36653537
5451 POU2F1 Decreases expression PMID:37077353
54583 EGLN1 Increases expression PMID:37077353
5460 POU5F1 Decreases expression PMID:16574651
54658 UGT1A1 Decreases activity PMID:22447115
54658 UGT1A1 Decreases expression PMID:16608920; PMID:36893891; PMID:18355885
54664 TMEM106B Decreases expression PMID:36621641
5467 PPARD Increases expression PMID:37077353
54675 CRLS1 Increases expression PMID:36653537
54913 RPP25 Increases expression PMID:31099283
54918 CMTM6 Affects expression PMID:18355885
54940 OCIAD1 Increases expression PMID:36621641
55062 WIPI1 Increases expression PMID:15342952; PMID:17175557
551 AVP Increases expression PMID:37077353
55105 GPATCH2 Increases expression PMID:36621641
5516 PPP2CB Decreases expression PMID:25787151
55164 SHQ1 Increases expression PMID:36653537
55186 SLC25A36 Increases expression PMID:31099283
55204 GOLPH3L Decreases expression PMID:36621641
55206 SBNO1 Increases expression PMID:36653537
5521 PPP2R2B Increases expression PMID:37077353
5523 PPP2R3A Decreases expression PMID:36621641
55230 USP40 Decreases expression PMID:36621641
55240 STEAP3 Decreases expression PMID:36621641
55256 ADI1 Decreases expression PMID:36621641
55313 CPPED1 Affects expression PMID:18355885
5546 PRCC Increases expression PMID:36621641
55502 HES6 Decreases expression PMID:36653537
55520 ELAC1 Increases expression PMID:36653537
55604 CARMIL1 Decreases expression PMID:36621641
55662 HIF1AN Increases expression PMID:31099283
55669 MFN1 Increases expression PMID:36621641
55690 PACS1 Decreases expression PMID:37077353
5575 PRKAR1B Decreases expression PMID:36621641
55787 TXLNG Increases expression PMID:36621641
55799 CACNA2D3 Increases expression PMID:37077353
55809 TRERF1 Decreases expression PMID:37077353
55818 KDM3A Increases expression PMID:36653537
55825 PECR Affects expression PMID:18355885
55879 GABRQ Decreases expression PMID:37077353
5593 PRKG2 Increases expression PMID:37077353
5599 MAPK8 Increases expression PMID:25787151
5617 PRL Decreases expression PMID:25808816
56388 CYP3A25 Increases expression PMID:17966066
56448 CYP2D22 Decreases activity PMID:22334051
56448 CYP2D22 Decreases expression PMID:19594327
5653 KLK6 Increases expression PMID:37077353
56675 NRIP3 Increases expression PMID:36653537
56888 KCMF1 Increases expression PMID:36621641
56913 C1GALT1 Decreases expression PMID:36621641
56951 C5ORF15 Increases expression PMID:36621641
5696 PSMB8 Decreases expression PMID:36621641
56975 FAM20C Increases expression PMID:37077353
5701 PSMC2 Decreases expression PMID:36621641
57030 SLC17A7 Increases expression PMID:37077353
57088 PLSCR4 Decreases expression PMID:36621641
57092 PCNP Decreases expression PMID:36621641
5711 PSMD5 Increases expression PMID:36621641
57119 EPPIN Decreases expression PMID:19587329
5719 PSMD13 Decreases expression PMID:36621641
572 BAD Increases expression PMID:25787151
57248 LY6I Increases expression PMID:36653537
5728 PTEN Decreases expression PMID:37077353
5730 PTGDS Affects expression PMID:31099283; PMID:36653537
5733 PTGER3 Increases expression PMID:37077353
57415 CEP15 Increases expression PMID:36621641
5743 PTGS2 Increases expression PMID:32816093
57430 SULT3A1 Increases expression PMID:31099283
57491 AHRR Increases expression PMID:31168027
57572 DOCK6 Increases expression PMID:36653537
57630 SH3RF1 Decreases expression PMID:36621641
57664 PLEKHA4 Increases expression PMID:28263823
57678 GPAM Decreases expression PMID:37077353
5768 QSOX1 Decreases expression PMID:36621641
57688 ZSWIM6 Increases expression PMID:36621641
57817 HAMP Decreases expression PMID:17966066
5784 PTPN14 Increases expression PMID:36621641
5792 PTPRF Decreases expression PMID:37077353
5806 PTX3 Affects expression PMID:36653537
58210 SECTM1B Increases expression PMID:36653537
5836 PYGL Increases expression PMID:37077353
58488 PCTP Increases expression PMID:37077353
58493 INIP Increases expression PMID:36653537
58527 ABRACL Decreases expression PMID:36621641
5865 RAB3B Increases expression PMID:36621641
5915 RARB Affects expression PMID:28263823; PMID:37077353
5919 RARRES2 Increases expression PMID:37077353
59272 ACE2 Increases expression PMID:32808185
5934 RBL2 Affects expression PMID:18355885
5972 REN Decreases expression PMID:2632720
6004 RGS16 Decreases expression PMID:31099283
6038 RNASE4 Decreases expression PMID:36653537
60481 ELOVL5 Decreases expression PMID:36621641
6230 RPS25 Increases expression PMID:36621641
6241 RRM2 Increases expression PMID:36621641
6256 RXRA Decreases expression PMID:37077353
6258 RXRG Decreases expression PMID:37077353
6288 SAA1 Decreases expression PMID:17966066
6289 SAA2 Decreases expression PMID:17966066
629 CFB Increases expression PMID:36653537
629219 SULT2A6 Affects expression PMID:18355885
6307 MSMO1 Increases expression PMID:16330322; PMID:18355885
6309 SC5D Increases expression PMID:28263823
6319 SCD Increases expression PMID:36621641; PMID:37077353
6342 SCP2 Increases expression PMID:37077353
6347 CCL2 Increases expression PMID:37077353
635 BHMT Affects expression PMID:18355885
6352 CCL5 Increases expression PMID:37077353
637 BID Increases expression PMID:25808816
6382 SDC1 Increases expression PMID:36621641; PMID:37077353
6385 SDC4 Increases expression PMID:36653537
639 PRDM1 Decreases expression PMID:37077353
64062 RBM26 Decreases expression PMID:36621641
64065 PERP Decreases expression PMID:36621641
64077 LHPP Increases expression PMID:37077353
64131 XYLT1 Decreases expression PMID:37077353
64135 IFIH1 Increases expression PMID:36653537
64282 TENT4B Increases expression PMID:36653537
643155 SMIM15 Increases expression PMID:36621641
64326 COP1 Decreases expression PMID:36621641
6434 TRA2B Decreases expression PMID:36621641
64412 GZF1 Increases expression PMID:36653537
6446 SGK1 Increases expression PMID:36653537; PMID:37077353
64499 TPSB2 Increases expression PMID:36653537
6457 SH3GL3 Affects expression PMID:18355885
646 BNC1 Decreases expression PMID:36653537
64838 FNDC4 Increases expression PMID:15342952; PMID:17175557; PMID:17567588
64855 NIBAN2 Decreases expression PMID:36621641
64895 PAPOLG Increases expression PMID:36621641
64983 MRPL32 Increases expression PMID:36621641
65003 MRPL11 Decreases expression PMID:36621641
6513 SLC2A1 Increases expression PMID:37077353
6515 SLC2A3 Decreases expression PMID:15342952; PMID:17567588
652 BMP4 Decreases expression PMID:36653537
6533 SLC6A6 Affects expression PMID:18355885
653361 NCF1 Affects expression PMID:25787151; PMID:37077353
654 BMP6 Increases expression PMID:32816093
6576 SLC25A1 Increases expression PMID:37077353
6590 SLPI Affects expression PMID:32816093; PMID:36653537
6599 SMARCC1 Decreases expression PMID:36621641
66002 CYP4F12 Decreases activity PMID:14709627
66008 TRAK2 Increases expression PMID:37077353
662 BNIP1 Increases expression PMID:25808816
6623 SNCG Increases expression PMID:37077353
6624 FSCN1 Decreases expression PMID:36621641
663 BNIP2 Increases expression PMID:25808816
664 BNIP3 Increases expression PMID:25808816
6642 SNX1 Increases expression PMID:37077353
6647 SOD1 Increases expression PMID:37077353
665 BNIP3L Decreases expression PMID:36621641
6662 SOX9 Increases expression PMID:36653537
6667 SP1 Decreases expression PMID:37077353
668 FOXL2 Increases expression PMID:36621641
6696 SPP1 Increases expression PMID:37077353
6709 SPTAN1 Increases expression PMID:36621641
6713 SQLE Increases expression PMID:28263823
6721 SREBF2 Increases expression PMID:28263823
6729 SRP54 Increases expression PMID:36621641
6767 ST13 Affects expression PMID:18355885
6770 STAR Increases expression PMID:10960482
6772 STAT1 Increases expression PMID:25787151
6774 STAT3 Decreases expression PMID:37077353
6777 STAT5B Decreases expression PMID:37077353
6781 STC1 Affects expression PMID:36653537
6783 SULT1E1 Increases expression PMID:31099283
6786 STIM1 Decreases expression PMID:37077353
685222 CYP2B15 Affects expression PMID:18355885
6876 TAGLN Affects expression PMID:17175557; PMID:37077353
6898 TAT Decreases expression PMID:16608920; PMID:25000292
6903 TBCC Affects expression PMID:36621641; PMID:37077353
690419 ZFP709L1 Decreases expression PMID:36653537
6916 TBXAS1 Increases expression PMID:37077353
6925 TCF4 Decreases expression PMID:37077353
6945 MLX Affects expression PMID:18355885
7025 NR2F1 Increases expression PMID:36621641
7029 TFDP2 Decreases expression PMID:36621641
7031 TFF1 Increases expression PMID:35307500
7043 TGFB3 Decreases expression PMID:36653537
7046 TGFBR1 Decreases expression PMID:37077353
7048 TGFBR2 Decreases expression PMID:37077353
7076 TIMP1 Decreases expression PMID:18289764
7079 TIMP4 Increases expression PMID:37077353
7082 TJP1 Decreases expression PMID:37077353
7086 TKT Increases expression PMID:37077353
7103 TSPAN8 Decreases expression PMID:31099283
7114 TMSB4X Decreases expression PMID:31099283
7124 TNF Increases expression PMID:25808816
7132 TNFRSF1A Increases expression PMID:25808816; PMID:36621641
7133 TNFRSF1B Increases expression PMID:25808816
7161 TP73 Decreases expression PMID:25808816
7169 TPM2 Increases expression PMID:37077353
7172 TPMT Decreases expression PMID:36621641
71724 AOX3 Decreases expression PMID:31099283
71773 UGT2B1 Affects expression PMID:18355885
718 C3 Increases expression PMID:37077353
7189 TRAF6 Decreases expression PMID:37077353
7253 TSHR Decreases expression PMID:37077353
7264 GFUS Increases expression PMID:36621641
729359 PLIN4 Increases expression PMID:37077353
7311 UBA52 Affects expression PMID:18355885
7376 NR1H2 Increases expression PMID:37077353
7422 VEGFA Decreases expression PMID:37077353
7423 VEGFB Increases expression PMID:36653537
7431 VIM Affects expression PMID:18289764
7436 VLDLR Decreases expression PMID:37077353
7456 WIPF1 Decreases expression PMID:37077353
7531 YWHAE Increases expression PMID:37077353
760 CA2 Increases expression PMID:37077353
76279 CYP2D26 Decreases activity PMID:15879494
7681 MKRN3 Decreases expression PMID:37077353
782 CACNB1 Decreases expression PMID:37077353
788 SLC25A20 Increases expression PMID:37077353
79048 SECISBP2 Decreases expression PMID:36621641
79071 ELOVL6 Decreases expression PMID:37077353
79134 TMEM185B Increases expression PMID:36653537
79153 GDPD3 Increases expression PMID:15342952; PMID:17175557
79176 FBXL15 Decreases expression PMID:36621641
793 CALB1 Decreases expression PMID:31099283
794 CALB2 Decreases expression PMID:36653537
7941 PLA2G7 Decreases expression PMID:36653537
79443 FYCO1 Affects expression PMID:36621641; PMID:36653537
79602 ADIPOR2 Increases expression PMID:37077353
79609 VCPKMT Increases expression PMID:36621641
79670 TUT7 Increases expression PMID:36621641
79682 CENPU Decreases expression PMID:36621641
79784 MYH14 Increases expression PMID:37077353
79877 DCAKD Increases expression PMID:36653537
80114 BICC1 Decreases expression PMID:31099283
80178 TEDC2 Increases expression PMID:36653537
8021 NUP214 Decreases expression PMID:36653537
80232 WDR26 Increases expression PMID:36621641
80308 FLAD1 Decreases expression PMID:36621641
8061 FOSL1 Affects expression PMID:25787151; PMID:31099283
80765 STARD5 Decreases expression PMID:36653537
80856 LNPK Increases expression PMID:36621641
8089 YEATS4 Increases expression PMID:36621641
8091 HMGA2 Increases expression PMID:31099283
81832 NETO1 Decreases expression PMID:37077353
836 CASP3 Increases activity PMID:19631732
83604 TMEM47 Increases expression PMID:36621641
8365 H4C8 Decreases expression PMID:36653537
83695 RHNO1 Increases expression PMID:36621641
83729 INHBE Increases expression PMID:15342952; PMID:17175557; PMID:17567588
839 CASP6 Affects expression PMID:25787151; PMID:25808816
8394 PIP5K1A Increases expression PMID:36621641
83955 NACA4P Decreases expression PMID:36621641
83987 CCDC8 Increases expression PMID:36653537
840 CASP7 Increases expression PMID:25808816
84072 HORMAD1 Increases expression PMID:36653537
842 CASP9 Increases expression PMID:25808816
84258 SYT3 Decreases expression PMID:31099283
84262 PSMG3 Increases expression PMID:36621641
84266 ALKBH7 Decreases expression PMID:36653537
84285 EIF1AD Increases expression PMID:36621641
84295 PHF6 Increases expression PMID:36621641
8431 NR0B2 Increases expression PMID:15342952; PMID:17175557
8458 TTF2 Affects expression PMID:36621641
8462 KLF11 Decreases expression PMID:37077353
84668 HYCC1 Decreases expression PMID:36621641
84678 KDM2B Affects expression PMID:36621641
847 CAT Decreases expression PMID:25787151
8482 SEMA7A Increases expression PMID:37077353
84897 TBRG1 Increases expression PMID:36621641
84984 CEP19 Increases expression PMID:36621641
8505 PARG Increases expression PMID:36621641
8529 CYP4F2 Affects expression PMID:18355885
8529 CYP4F2 Decreases activity PMID:14709627
8540 AGPS Increases expression PMID:36621641
85460 ZNF518B Increases expression PMID:36621641
857 CAV1 Increases expression PMID:36621641
860 RUNX2 Decreases expression PMID:37077353
8614 STC2 Decreases expression PMID:36621641
8647 ABCB11 Decreases activity PMID:20147439; PMID:20829430; PMID:23956101; PMID:24014644; PMID:28437613
8673 VAMP8 Increases expression PMID:37077353
8678 BECN1 Increases expression PMID:37077353
8682 PEA15 Increases expression PMID:37077353
8692 HYAL2 Increases expression PMID:36621641
8754 ADAM9 Affects expression PMID:25787151
8788 DLK1 Decreases expression PMID:37077353
8824 CES2 Affects expression PMID:18355885
885 CCK Increases expression PMID:37077353
8856 NR1I2 Affects activity PMID:17998298; PMID:23525103; PMID:25343516; PMID:25680588
8856 NR1I2 Decreases expression PMID:16608920; PMID:16608920; PMID:17998298; PMID:36893891
8863 PER3 Decreases expression PMID:37077353
8877 SPHK1 Increases expression PMID:25787151
8898 MTMR2 Decreases expression PMID:36621641
8911 CACNA1I Decreases expression PMID:37077353
8912 CACNA1H Decreases expression PMID:37077353
8935 SKAP2 Increases expression PMID:36621641
8987 STBD1 Affects expression PMID:18355885
900 CCNG1 Increases expression PMID:18289764
9019 MPZL1 Decreases expression PMID:36621641
9025 RNF8 Decreases expression PMID:36621641
9055 PRC1 Decreases expression PMID:37077353
90865 IL33 Increases expression PMID:18355885; PMID:37077353
91404 SESTD1 Increases expression PMID:36621641
9168 TMSB10 Decreases expression PMID:18289764
91869 RFT1 Decreases expression PMID:36621641
9209 LRRFIP2 Decreases expression PMID:36621641
9249 DHRS3 Increases expression PMID:37077353
9315 NREP Affects expression PMID:18355885
9353 SLIT2 Increases expression PMID:36621641
93589 CACNA2D4 Increases expression PMID:37077353
9367 RAB9A Increases expression PMID:36621641
9370 ADIPOQ Increases expression PMID:36653537
93986 FOXP2 Increases expression PMID:36653537
9429 ABCG2 Increases expression PMID:37077353
949 SCARB1 Affects expression PMID:36621641; PMID:37077353
950 SCARB2 Decreases expression PMID:36621641
9547 CXCL14 Increases expression PMID:37077353
9555 MACROH2A1 Affects expression PMID:18355885
9563 H6PD Affects expression PMID:36621641; PMID:37077353
9568 GABBR2 Increases expression PMID:37077353
9572 NR1D1 Increases expression PMID:37077353
9590 AKAP12 Decreases expression PMID:36621641
961 CD47 Increases expression PMID:36621641
9686 VGLL4 Decreases expression PMID:36621641
9687 GREB1 Increases expression PMID:35307500
9723 SEMA3E Increases expression PMID:31099283
9741 LAPTM4A Increases expression PMID:37077353
9817 KEAP1 Increases expression PMID:37077353
98403 ZFP451 Increases expression PMID:31099283
9970 NR1I3 Decreases activity PMID:16608920; PMID:16819505; PMID:16819505; PMID:20869355
9970 NR1I3 Decreases expression PMID:16608920
9992 KCNE2 Increases expression PMID:36653537
9994 CASP8AP2 Affects expression PMID:36621641

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.