DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Ketoconazole

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0001843	Neural tube closure	Decreases phenotype	PMID:28263823
GO:0001938	Positive regulation of endothelial cell proliferation	Increases phenotype	PMID:19464254
GO:0002072	Optic cup morphogenesis involved in camera-type eye development	Decreases phenotype	PMID:28263823
GO:0002523	Leukocyte migration involved in inflammatory response	Increases phenotype	PMID:34627953
GO:0002639	Positive regulation of immunoglobulin production	Increases phenotype	PMID:12230500
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	Increases phenotype	PMID:31168027; PMID:32162908
GO:0006007	Glucose catabolic process	Decreases phenotype	PMID:26616219
GO:0006171	Camp biosynthetic process	Affects phenotype	PMID:11886533
GO:0006595	Polyamine metabolic process	Affects phenotype	PMID:38346634
GO:0006629	Lipid metabolic process	Affects phenotype	PMID:35156134
GO:0006688	Glycosphingolipid biosynthetic process	Decreases phenotype	PMID:14662772
GO:0006701	Progesterone biosynthetic process	Decreases phenotype	PMID:16935330
GO:0006703	Estrogen biosynthetic process	Increases phenotype	PMID:31352099
GO:0006710	Androgen catabolic process	Decreases phenotype	PMID:31102695
GO:0006722	Triterpenoid metabolic process	Decreases phenotype	PMID:32633501
GO:0006749	Glutathione metabolic process	Affects phenotype	PMID:25851819
GO:0006750	Glutathione biosynthetic process	Increases phenotype	PMID:25612170; PMID:29407385; PMID:30426164; PMID:31168027
GO:0006754	Atp biosynthetic process	Decreases phenotype	PMID:23686521; PMID:29407385
GO:0006805	Xenobiotic metabolic process	Increases phenotype	PMID:10874126; PMID:10874126; PMID:11055268; PMID:11824416; PMID:12237780; PMID:19845430; PMID:11055268; PMID:11091129; PMID:11824416; PMID:12237780; PMID:12695342; PMID:12763371; PMID:19845430; PMID:19903449; PMID:22968811; PMID:24021950; PMID:24382416; PMID:24488374; PMID:27769111; PMID:29162470; PMID:30545405; PMID:34875353; PMID:35101544; PMID:39299374
GO:0006855	Xenobiotic transmembrane transport	Decreases phenotype	PMID:17174077; PMID:23976943
GO:0006874	Cellular calcium ion homeostasis	Affects phenotype	PMID:35156134
GO:0006915	Apoptotic process	Increases phenotype	PMID:12244568; PMID:25612170
GO:0007190	Activation of adenylate cyclase activity	Affects phenotype	PMID:11886533; PMID:12164941; PMID:12230500
GO:0007204	Positive regulation of cytosolic calcium ion concentration	Increases phenotype	PMID:23006841
GO:0008202	Steroid metabolic process	Affects phenotype	PMID:36621641
GO:0008206	Bile acid metabolic process	Affects phenotype	PMID:36804361
GO:0008207	C21-steroid hormone metabolic process	Decreases phenotype	PMID:23038793; PMID:26610754
GO:0008209	Androgen metabolic process	Increases phenotype	PMID:19226368; PMID:19903449; PMID:24323034
GO:0008219	Cell death	Increases phenotype	PMID:20345925; PMID:24519941; PMID:30262279
GO:0008283	Cell population proliferation	Decreases phenotype	PMID:12244568; PMID:17432820
GO:0008284	Positive regulation of cell population proliferation	Affects phenotype	PMID:17966066; PMID:18694951; PMID:20206692; PMID:21566342; PMID:25808816
GO:0008610	Lipid biosynthetic process	Affects phenotype	PMID:30426164
GO:0008654	Phospholipid biosynthetic process	Affects phenotype	PMID:30426164
GO:0009060	Aerobic respiration	Decreases phenotype	PMID:38734219
GO:0009636	Response to toxic substance	Increases phenotype	PMID:20803752
GO:0010224	Response to uv-b	Decreases phenotype	PMID:18580964
GO:0010731	Protein glutathionylation	Increases phenotype	PMID:39793773
GO:0010739	Positive regulation of protein kinase a signaling	Increases phenotype	PMID:17680988
GO:0010942	Positive regulation of cell death	Increases phenotype	PMID:14662772; PMID:16330322; PMID:20233841; PMID:22524704; PMID:25512232; PMID:25656284; PMID:25808816; PMID:27836570
GO:0016042	Lipid catabolic process	Affects phenotype	PMID:34627953; PMID:35358606
GO:0016049	Cell growth	Decreases phenotype	PMID:25612170; PMID:29407385; PMID:30426164
GO:0016125	Sterol metabolic process	Decreases phenotype	PMID:12617470; PMID:23125191
GO:0030501	Positive regulation of bone mineralization	Increases phenotype	PMID:12016462
GO:0030573	Bile acid catabolic process	Decreases phenotype	PMID:31102695
GO:0030595	Leukocyte chemotaxis	Decreases phenotype	PMID:2177039
GO:0031394	Positive regulation of prostaglandin biosynthetic process	Increases phenotype	PMID:12164941
GO:0032308	Positive regulation of prostaglandin secretion	Increases phenotype	PMID:23688403; PMID:23688403; PMID:24471457; PMID:24471457
GO:0032793	Positive regulation of creb transcription factor activity	Increases phenotype	PMID:12164941; PMID:17680988
GO:0034199	Activation of protein kinase a activity	Affects phenotype	PMID:11886533; PMID:12164941; PMID:12230500
GO:0035635	Entry of bacterium into host cell	Affects phenotype	PMID:12183525
GO:0036378	Calcitriol biosynthetic process from calciol	Decreases phenotype	PMID:18580964
GO:0042267	Natural killer cell mediated cytotoxicity	Increases phenotype	PMID:32060585
GO:0042554	Superoxide anion generation	Affects phenotype	PMID:30426164
GO:0043065	Positive regulation of apoptotic process	Increases phenotype	PMID:14512701; PMID:15703382; PMID:19587329; PMID:23125191; PMID:24752500; PMID:25787151
GO:0044237	Cellular metabolic process	Decreases phenotype	PMID:31066974; PMID:35156134; PMID:31103741; PMID:32659470; PMID:34655687; PMID:34762139; PMID:34780725; PMID:36621641
GO:0045333	Cellular respiration	Decreases phenotype	PMID:23686521
GO:0045669	Positive regulation of osteoblast differentiation	Increases phenotype	PMID:21542014
GO:0046326	Positive regulation of glucose import	Decreases phenotype	PMID:26616219
GO:0046466	Membrane lipid catabolic process	Decreases phenotype	PMID:1884432
GO:0046618	Xenobiotic export from cell	Decreases phenotype	PMID:26301745
GO:0046649	Lymphocyte activation	Increases phenotype	PMID:2177039
GO:0048266	Behavioral response to pain	Decreases phenotype	PMID:17720801
GO:0048295	Positive regulation of isotype switching to ige isotypes	Increases phenotype	PMID:12230500
GO:0050810	Regulation of steroid biosynthetic process	Affects phenotype	PMID:26781511
GO:0050965	Detection of temperature stimulus involved in sensory perception of pain	Decreases phenotype	PMID:17720801
GO:0050966	Detection of mechanical stimulus involved in sensory perception of pain	Decreases phenotype	PMID:17720801
GO:0051092	Positive regulation of nf-kappab transcription factor activity	Increases phenotype	PMID:12230500; PMID:16784723; PMID:23688403
GO:0051350	Negative regulation of lyase activity	Increases phenotype	PMID:31330226
GO:0051354	Negative regulation of oxidoreductase activity	Increases phenotype	PMID:31330226
GO:0051464	Positive regulation of cortisol secretion	Decreases phenotype	PMID:20529775
GO:0051881	Regulation of mitochondrial membrane potential	Affects phenotype	PMID:30426164; PMID:35156134
GO:0052697	Xenobiotic glucuronidation	Decreases phenotype	PMID:25070100
GO:0055007	Cardiac muscle cell differentiation	Decreases phenotype	PMID:29337257
GO:0055074	Calcium ion homeostasis	Affects phenotype	PMID:30426164
GO:0060013	Righting reflex	Decreases phenotype	PMID:16819505
GO:0060037	Pharyngeal system development	Decreases phenotype	PMID:28263823
GO:0060081	Membrane hyperpolarization	Affects phenotype	PMID:35156134
GO:0061154	Endothelial tube morphogenesis	Increases phenotype	PMID:19464254
GO:0061366	Behavioral response to chemical pain	Increases phenotype	PMID:23006841
GO:0061370	Testosterone biosynthetic process	Affects phenotype	PMID:16935330; PMID:31352099
GO:0061436	Establishment of skin barrier	Decreases phenotype	PMID:18580964
GO:0070265	Necrotic cell death	Increases phenotype	PMID:23686521; PMID:31629065
GO:0070633	Transepithelial transport	Decreases phenotype	PMID:18063342
GO:0070640	Vitamin d3 metabolic process	Decreases phenotype	PMID:12016462; PMID:16824767; PMID:26704532
GO:0070989	Oxidative demethylation	Affects phenotype	PMID:11055268; PMID:16595712
GO:0070994	Detection of oxidative stress	Increases phenotype	PMID:24486436
GO:0071466	Cellular response to xenobiotic stimulus	Decreases phenotype	PMID:23125191
GO:0071486	Cellular response to high light intensity	Increases phenotype	PMID:24519941
GO:0071493	Cellular response to uv-b	Affects phenotype	PMID:16365879; PMID:16824767
GO:0071717	Thromboxane transport	Affects phenotype	PMID:23688403; PMID:24471457
GO:0072593	Reactive oxygen species metabolic process	Affects phenotype	PMID:35156134
GO:0090030	Regulation of steroid hormone biosynthetic process	Affects phenotype	PMID:31330226
GO:0097153	Cysteine-type endopeptidase activity involved in apoptotic process	Increases phenotype	PMID:31629065
GO:0098662	Inorganic cation transmembrane transport	Decreases phenotype	PMID:12582005
GO:0098739	Import across plasma membrane	Increases phenotype	PMID:25844889
GO:1901113	Erythromycin metabolic process	Affects phenotype	PMID:16673044; PMID:16844145
GO:1901216	Positive regulation of neuron death	Increases phenotype	PMID:19594327
GO:1901661	Quinone metabolic process	Affects phenotype	PMID:38346634
GO:1901687	Glutathione derivative biosynthetic process	Affects phenotype	PMID:31168027; PMID:32484342
GO:1902260	Negative regulation of delayed rectifier potassium channel activity	Increases phenotype	PMID:22975497
GO:1902512	Positive regulation of apoptotic dna fragmentation	Increases phenotype	PMID:17936189
GO:1903181	Positive regulation of dopamine biosynthetic process	Decreases phenotype	PMID:19594327
GO:1903409	Reactive oxygen species biosynthetic process	Affects phenotype	PMID:30426164
GO:1903428	Positive regulation of reactive oxygen species biosynthetic process	Increases phenotype	PMID:25787151
GO:1903451	Negative regulation of g1 to g0 transition	Increases phenotype	PMID:20206692
GO:1903609	Negative regulation of inward rectifier potassium channel activity	Increases phenotype	PMID:22975497
GO:1903761	Negative regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	Increases phenotype	PMID:25822712
GO:1903817	Negative regulation of voltage-gated potassium channel activity	Increases phenotype	PMID:16542653
GO:1904078	Positive regulation of estrogen biosynthetic process	Decreases phenotype	PMID:16935330
GO:1904878	Negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	Increases phenotype	PMID:22975497
GO:2000833	Positive regulation of steroid hormone secretion	Decreases phenotype	PMID:11572034
GO:2000845	Positive regulation of testosterone secretion	Decreases phenotype	PMID:16684832; PMID:19587329

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.