Colchicine


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000084 Mitotic s phase Decreases phenotype PMID:33684465
GO:0000086 G2/m transition of mitotic cell cycle Increases phenotype PMID:33684465
GO:0000226 Microtubule cytoskeleton organization Decreases phenotype PMID:22044164
GO:0000278 Mitotic cell cycle Decreases phenotype PMID:14342828; PMID:15088997; PMID:19049291; PMID:6319491
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:33894285; PMID:37555854
GO:0004032 Alditol:nadp+ 1-oxidoreductase activity Increases phenotype PMID:38372178
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:38348705
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:38348705
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:37555854; PMID:38348705; PMID:38372178
GO:0004855 Xanthine oxidase activity Increases phenotype PMID:37555854
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:15005753; PMID:15005753; PMID:18255150; PMID:20300959; PMID:7537689; PMID:8135827; PMID:9694399
GO:0006749 Glutathione metabolic process Affects phenotype PMID:38372178
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:37573684
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:34748853
GO:0006909 Phagocytosis Increases phenotype PMID:32712770
GO:0006915 Apoptotic process Affects phenotype PMID:10413674; PMID:10675359; PMID:11151451; PMID:12941380; PMID:12941380; PMID:7537689; PMID:15005753; PMID:15005753; PMID:18255150; PMID:16478524; PMID:17917407; PMID:20300959; PMID:33684465; PMID:7537689; PMID:8135827; PMID:9694399
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:33684465
GO:0006979 Response to oxidative stress Increases phenotype PMID:17652827; PMID:18980205; PMID:21249347
GO:0007019 Microtubule depolymerization Increases phenotype PMID:29679549
GO:0007049 Cell cycle Increases phenotype PMID:10463579; PMID:10754208; PMID:11173539; PMID:15057872; PMID:3119359
GO:0008088 Axo-dendritic transport Decreases phenotype PMID:12676154; PMID:1584340; PMID:16700006; PMID:21310905; PMID:2453250; PMID:2556505; PMID:25614231; PMID:25614231; PMID:6207722; PMID:54262; PMID:6202661; PMID:7714246; PMID:86604; PMID:8837219; PMID:9514555
GO:0008219 Cell death Increases phenotype PMID:21310905; PMID:24519941
GO:0008283 Cell population proliferation Decreases phenotype PMID:19049291; PMID:24759273; PMID:27769712
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:29933105; PMID:32949729; PMID:32949729
GO:0008361 Regulation of cell size Decreases phenotype PMID:6270161
GO:0010765 Positive regulation of sodium ion transport Increases phenotype PMID:1328298
GO:0010918 Positive regulation of mitochondrial membrane potential Decreases phenotype PMID:28942281
GO:0010938 Cytoplasmic microtubule depolymerization Increases phenotype PMID:27769712
GO:0010942 Positive regulation of cell death Increases phenotype PMID:26124276
GO:0015723 Bilirubin transport Increases phenotype PMID:37573684
GO:0015884 Folic acid transport Affects phenotype PMID:18207340
GO:0016042 Lipid catabolic process Affects phenotype PMID:33617922
GO:0016209 Antioxidant activity Decreases phenotype PMID:37573684
GO:0018158 Protein oxidation Increases phenotype PMID:33617922; PMID:38372178
GO:0019722 Calcium-mediated signaling Decreases phenotype PMID:11304499; PMID:1722415; PMID:7537689
GO:0030154 Cell differentiation Increases phenotype PMID:10413674
GO:0030199 Collagen fibril organization Increases phenotype PMID:38348705
GO:0030262 Apoptotic nuclear changes Increases phenotype PMID:26124276
GO:0030595 Leukocyte chemotaxis Decreases phenotype PMID:9848464
GO:0031110 Regulation of microtubule polymerization or depolymerization Decreases phenotype PMID:24028602
GO:0031115 Negative regulation of microtubule polymerization Increases phenotype PMID:28743738
GO:0031987 Locomotion involved in locomotory behavior Decreases phenotype PMID:34453961
GO:0032125 Micronucleus organization Increases phenotype PMID:32512035
GO:0032967 Positive regulation of collagen biosynthetic process Increases phenotype PMID:37573684
GO:0034440 Lipid oxidation Increases phenotype PMID:33002524; PMID:37555854
GO:0034589 Hydroxyproline transport Increases phenotype PMID:37573684
GO:0044237 Cellular metabolic process Decreases phenotype PMID:33617922; PMID:33617922; PMID:34748853; PMID:33684465
GO:0045023 G0 to g1 transition Decreases phenotype PMID:33684465
GO:0045930 Negative regulation of mitotic cell cycle Affects phenotype PMID:33684465
GO:0046034 Atp metabolic process Affects phenotype PMID:32949729
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:38372178
GO:0046323 Glucose import Affects phenotype PMID:32692981
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:17652827; PMID:18980205; PMID:18980205
GO:0048874 Host-mediated regulation of intestinal microbiota composition Increases phenotype PMID:33002524
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:37573684
GO:0050882 Voluntary musculoskeletal movement Decreases phenotype PMID:33002524
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:33684465
GO:0060326 Cell chemotaxis Decreases phenotype PMID:314231
GO:0060729 Intestinal epithelial structure maintenance Decreases phenotype PMID:33002524
GO:0070633 Transepithelial transport Decreases phenotype PMID:33002524
GO:0070994 Detection of oxidative stress Affects phenotype PMID:38348705
GO:0070997 Neuron death Increases phenotype PMID:7870303
GO:0071486 Cellular response to high light intensity Increases phenotype PMID:24519941
GO:0071929 Alpha-tubulin acetylation Decreases phenotype PMID:29679549
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:33617922; PMID:34748853; PMID:37555854; PMID:38372178
GO:0072672 Neutrophil extravasation Increases phenotype PMID:7542281
GO:0090659 Walking behavior Affects phenotype PMID:33894285
GO:0097280 Histamine secretion mediated by immunoglobulin Increases phenotype PMID:1722415; PMID:67049
GO:0110012 Protein localization to p-body Increases phenotype PMID:28743738
GO:0120190 Negative regulation of bile acid secretion Increases phenotype PMID:38311468
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:33002524
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:37573684
GO:1903999 Negative regulation of eating behavior Increases phenotype PMID:33002524
GO:1904252 Negative regulation of bile acid metabolic process Increases phenotype PMID:38311468
GO:1904580 Regulation of intracellular mrna localization Affects phenotype PMID:28743738
GO:2000623 Negative regulation of nuclear-transcribed mrna catabolic process, nonsense-mediated decay Increases phenotype PMID:28743738
GO:2001057 Reactive nitrogen species metabolic process Affects phenotype PMID:33617922
GO:2001170 Negative regulation of atp biosynthetic process Increases phenotype PMID:28942281; PMID:37660997
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.