Colchicine
ToxCast endpoints for intended target type: RNA
| Assay Name | Tissue | Organism | Target Gene ID | Target HGNC Symbol | Response | AC50 Value |
|---|
| LTEA_HepaRG_ALPP | Liver | Human | 250 | ALPP | Inhibitory | 0.22 μM |
| LTEA_HepaRG_BCL2L11 | Liver | Human | 10018 | BCL2L11 | Inhibitory | 0.24 μM |
| LTEA_HepaRG_CYP3A4 | Liver | Human | 1576 | CYP3A4 | Inhibitory | 0.21 μM |
| LTEA_HepaRG_GADD45B | Liver | Human | 4616 | GADD45B | Inhibitory | 9.92 μM |
| LTEA_HepaRG_HMGCS2 | Liver | Human | 3158 | HMGCS2 | Activatory | 0.28 μM |
| LTEA_HepaRG_IGFBP1 | Liver | Human | 3484 | IGFBP1 | Activatory | 0.58 μM |
| LTEA_HepaRG_IL6R | Liver | Human | 3570 | IL6R | Activatory | 0.42 μM |
| LTEA_HepaRG_LIPC | Liver | Human | 3990 | LIPC | Inhibitory | 0.3 μM |
| LTEA_HepaRG_MMP10 | Liver | Human | 4319 | MMP10 | Inhibitory | 0.01 μM |
| LTEA_HepaRG_SULT2A1 | Liver | Human | 6822 | SULT2A1 | Inhibitory | 0.18 μM |
| LTEA_HepaRG_UGT1A6 | Liver | Human | 54578 | UGT1A6 | Activatory | 0.24 μM |
| LTEA_HepaRG_XBP1 | Liver | Human | 7494 | XBP1 | Activatory | 0.22 μM |
ToxCast endpoints for intended target type: Protein
| Assay Name | Tissue | Organism | Target Gene ID | Target HGNC Symbol | Response | AC50 Value |
|---|
| NVS_ENZ_hCASP4 | | Human | 837 | CASP4 | Loss | 0.49 μM |
| NVS_ENZ_hMMP13 | | Human | 4322 | MMP13 | Loss | 21.58 μM |
| ATG_E_Box_CIS | Liver | Human | 7391 | USF1 | Inhibitory | 0.54 μM |
| ATG_HIF1a_CIS | Liver | Human | 3091 | HIF1A | Inhibitory | 0.62 μM |
| ATG_NRF1_CIS | Liver | Human | 4899 | NRF1 | Inhibitory | 0.26 μM |
| ATG_p53_CIS | Liver | Human | 7157 | TP53 | Activatory | 0.79 μM |
| ATG_TCF_b_cat_CIS | Liver | Human | 6932|6934|51176|83439 | TCF7|TCF7L2|LEF1|TCF7L1 | Activatory | 0.34 μM |
| BSK_3C_HLADR | Vascular | Human | 3122 | HLA-DRA | Inhibitory | 1.07 μM |
| BSK_3C_VCAM1 | Vascular | Human | 7412 | VCAM1 | Inhibitory | 0.4 μM |
| BSK_4H_Pselectin | Vascular | Human | 6403 | SELP | Inhibitory | 0.29 μM |
| BSK_BE3C_HLADR | Lung | Human | 3122 | HLA-DRA | Inhibitory | 0.47 μM |
| BSK_CASM3C_HLADR | Vascular | Human | 3122 | HLA-DRA | Inhibitory | 0.43 μM |
| BSK_CASM3C_VCAM1 | Vascular | Human | 7412 | VCAM1 | Inhibitory | 0.58 μM |
| BSK_hDFCGF_IP10 | Skin | Human | 3627 | CXCL10 | Inhibitory | 4.08 μM |
| BSK_hDFCGF_MMP1 | Skin | Human | 4312 | MMP1 | Inhibitory | 0.95 μM |
| BSK_hDFCGF_VCAM1 | Skin | Human | 7412 | VCAM1 | Inhibitory | 0.3 μM |
| BSK_KF3CT_MMP9 | Skin | Human | 4318 | MMP9 | Inhibitory | 0.55 μM |
| BSK_LPS_IL1a | Vascular | Human | 3552 | IL1A | Inhibitory | 0.83 μM |
| BSK_LPS_MCSF | Vascular | Human | 1435 | CSF1 | Inhibitory | 0.49 μM |
| BSK_LPS_TNFa | Vascular | Human | 7124 | TNF | Inhibitory | 0.87 μM |
| BSK_LPS_VCAM1 | Vascular | Human | 7412 | VCAM1 | Inhibitory | 0.43 μM |
| BSK_SAg_CD40 | Vascular | Human | 958 | CD40 | Inhibitory | 0.22 μM |
| BSK_SAg_CD69 | Vascular | Human | 969 | CD69 | Inhibitory | 0.51 μM |
| TOX21_TR_LUC_GH3_Antagonist | Pituitary gland | Rat | 7067|7068 | THRA|THRB | Loss | 0.55 μM |
| TOX21_CAR_LUC_Antagonist | Liver | Human | 9970 | NR1I3 | Loss | 0.01 μM |
| TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2 | Breast | Human | 2099 | ESR1 | Loss | 0.19 μM |
| TOX21_AR_BLA_Agonist_ratio | Kidney | Human | 367 | AR | Gain | 0.01 μM |
| TOX21_RORg_LUC_CHO_Antagonist | Ovary | Chinese hamster | 6097 | RORC | Loss | 0.73 μM |
| TOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881 | Breast | Human | 367 | AR | Loss | 74.08 μM |
| TOX21_AP1_BLA_Agonist_ratio | Cervix | Human | 2353|3725 | FOS|JUN | Gain | 0.19 μM |
| TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2 | Breast | Human | 2099 | ESR1 | Loss | 9.06 μM |
| TOX21_p450_CYP2C19_Antagonist | | Human | 1557 | CYP2C19 | Loss | 79.04 μM |
| TOX21_p450_CYP1A2_Antagonist | | Human | 1544 | CYP1A2 | Loss | 68.29 μM |
| TOX21_AR_BLA_Antagonist_ratio | Kidney | Human | 367 | AR | Loss | 0.01 μM |
| TOX21_RORg_LUC_CHO_Antagonist | Ovary | Chinese hamster | 6097 | RORC | Loss | 0.71 μM |
| TOX21_AP1_BLA_Agonist_ratio | Cervix | Human | 2353|3725 | FOS|JUN | Gain | 0.25 μM |
| TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2 | Breast | Human | 2099 | ESR1 | Loss | 1.47 μM |
No ToxCast endpoints for intended target type: Molecular messenger
ToxCast endpoints for intended target type: Pathway
| Assay Name | Tissue | Organism | Target Gene ID | Target HGNC Symbol | Response | AC50 Value |
|---|
| OT_NURR1_NURR1RXRa_0480 | Kidney | Human | 4929|6256 | NR4A2|RXRA | Gain | 0.93 μM |
| OT_NURR1_NURR1RXRa_1440 | Kidney | Human | 4929|6256 | NR4A2|RXRA | Gain | 10.58 μM |
| ACEA_AR_antagonist_80hr | Prostate | Human | 367 | AR | Loss | 0.0 μM |
| TOX21_FXR_BLA_Antagonist_ratio | Kidney | Human | 9971 | NR1H4 | Loss | 0.01 μM |
| TOX21_SHH_3T3_GLI3_LUC_Antagonist | Embryo | Mouse | 6469 | SHH | Loss | 0.02 μM |
| TOX21_SHH_3T3_GLI3_LUC_Antagonist | Embryo | Mouse | 6469 | SHH | Loss | 0.01 μM |
No ToxCast endpoints for intended target type: Cellular
No ToxCast endpoints for intended target type: Hormone
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