Mancozeb


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:34830855
GO:0004364 Glutathione transferase activity Increases phenotype PMID:33217513
GO:0004602 Glutathione peroxidase activity Increases phenotype PMID:33217513
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:29283200
GO:0006006 Glucose metabolic process Affects phenotype PMID:37009748
GO:0006117 Acetaldehyde metabolic process Affects phenotype PMID:34830855
GO:0006590 Thyroid hormone generation Affects phenotype PMID:24530807
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:37009748
GO:0006695 Cholesterol biosynthetic process Increases phenotype PMID:24530807
GO:0006749 Glutathione metabolic process Increases phenotype PMID:30037311; PMID:33217513
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:29283200
GO:0006915 Apoptotic process Increases phenotype PMID:35564597
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:19591892; PMID:24764117; PMID:33217513
GO:0007283 Spermatogenesis Decreases phenotype PMID:29283200; PMID:30037311
GO:0007566 Embryo implantation Decreases phenotype PMID:32446389
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:37009748
GO:0008219 Cell death Increases phenotype PMID:23744253
GO:0008283 Cell population proliferation Affects phenotype PMID:23744253; PMID:24764117; PMID:25684042; PMID:34830855; PMID:35564597
GO:0010884 Positive regulation of lipid storage Increases phenotype PMID:27016407
GO:0010942 Positive regulation of cell death Increases phenotype PMID:27016407; PMID:31096615
GO:0016042 Lipid catabolic process Increases phenotype PMID:29283200; PMID:33217513; PMID:35617905
GO:0018158 Protein oxidation Increases phenotype PMID:30037311
GO:0019432 Triglyceride biosynthetic process Increases phenotype PMID:24530807
GO:0033685 Negative regulation of luteinizing hormone secretion Increases phenotype PMID:35617905
GO:0034113 Heterotypic cell-cell adhesion Decreases phenotype PMID:33396126
GO:0034440 Lipid oxidation Increases phenotype PMID:27235710; PMID:30037311
GO:0035176 Social behavior Decreases phenotype PMID:29847083
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:27235710; PMID:30037311; PMID:35617905; PMID:36007320
GO:0044237 Cellular metabolic process Decreases phenotype PMID:33396126; PMID:35564597
GO:0044850 Menstrual cycle Affects phenotype PMID:15583372
GO:0045429 Positive regulation of nitric oxide biosynthetic process Increases phenotype PMID:37236337
GO:0045454 Cell redox homeostasis Decreases phenotype PMID:30037311
GO:0046621 Negative regulation of organ growth Increases phenotype PMID:30037311
GO:0046882 Negative regulation of follicle-stimulating hormone secretion Increases phenotype PMID:35617905
GO:0047045 Testosterone 17-beta-dehydrogenase (nadp+) activity Decreases phenotype PMID:29283200
GO:0051091 Positive regulation of dna-binding transcription factor activity Increases phenotype PMID:28973306
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:35564597
GO:0061370 Testosterone biosynthetic process Decreases phenotype PMID:29283200
GO:0070265 Necrotic cell death Increases phenotype PMID:35564597
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:35564597
GO:0090398 Cellular senescence Increases phenotype PMID:34830855
GO:0097722 Sperm motility Decreases phenotype PMID:29283200
GO:0098598 Learned vocalization behavior or vocal learning Decreases phenotype PMID:27773359
GO:0102727 3beta-hydroxysteroid dehydrogenase activity Decreases phenotype PMID:29283200
GO:1901164 Negative regulation of trophoblast cell migration Increases phenotype PMID:32446389
GO:1901224 Positive regulation of nik/nf-kappab signaling Increases phenotype PMID:27235710
GO:1901318 Negative regulation of flagellated sperm motility Increases phenotype PMID:30037311
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:30037311
GO:1901671 Positive regulation of superoxide dismutase activity Decreases phenotype PMID:27235710
GO:1901992 Positive regulation of mitotic cell cycle phase transition Decreases phenotype PMID:27235710
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:27235710; PMID:36007320
GO:1905643 Positive regulation of dna methylation Increases phenotype PMID:36007320
GO:2000866 Positive regulation of estradiol secretion Increases phenotype PMID:35617905
GO:2000871 Negative regulation of progesterone secretion Increases phenotype PMID:35617905
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.