| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:32446389 | IVR | 3 - 32 mg/kg/day | 3 - 32 mg/kg/day | Affects implantation | Reproductive endocrine-mediated perturbations |
| IVR | 3 mg/kg/day | 3 mg/kg/day | Oxidative stress in uterus | Reproductive endocrine-mediated perturbations | |
| IVR | 32 mg/kg/day | 32 mg/kg/day | Affects uterine morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 0.3 - 3 mg/kg/day | 0.3 - 3 mg/kg/day | Affects uterine development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVTH | 3 mg/L | 3 mg/L | Cancer phenotype | Endocrine-mediated cancer | |
| IVR | 32 mg/kg/day | 32 mg/kg/day | Changes in ovarian morphology | Reproductive endocrine-mediated perturbations | |
| PMID:33348257 | IVR | 5 mg/kg | 5 mg/kg | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations |
| IVR | 5 mg/kg | 5 mg/kg | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Decreased vas deferens weights | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Alterations in preputial separation | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Oxidative stress in testis | Reproductive endocrine-mediated perturbations | |
| PMID:9009508 | IVR | 1500 mg/kg/day | 1500 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects the biochemical composition of testis | Reproductive endocrine-mediated perturbations | |
| IVR | 1500 mg/kg/day | 1500 mg/kg/day | Affects the biochemical composition of testis | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Increased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1500 mg/kg/day | 1500 mg/kg/day | Uterotrophic effect | Reproductive endocrine-mediated perturbations | |
| IVR | 1500 mg/kg/day | 1500 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 1500 mg/kg/day | 1500 mg/kg/day | Increased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Uterotrophic effect | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Uterotrophic effect | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects the biochemical composition of testis | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Increased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.