Mancozeb
ToxCast endpoints for intended target type: RNA
| Assay Name | Tissue | Organism | Target Gene ID | Target HGNC Symbol | Response | AC50 Value |
|---|
| CLD_CYP1A1_6hr | Liver | Human | 1543 | CYP1A1 | Gain | 0.77 μM |
| CLD_CYP1A2_6hr | Liver | Human | 1544 | CYP1A2 | Gain | 0.99 μM |
| CLD_ABCB1_24hr | Liver | Human | 5243 | ABCB1 | Gain | 1.79 μM |
| CLD_ABCB1_48hr | Liver | Human | 5243 | ABCB1 | Gain | 1.15 μM |
| CLD_CYP1A1_48hr | Liver | Human | 1543 | CYP1A1 | Gain | 0.35 μM |
| LTEA_HepaRG_ABCB1 | Liver | Human | 5243 | ABCB1 | Activatory | 0.73 μM |
| LTEA_HepaRG_ABCB11 | Liver | Human | 8647 | ABCB11 | Inhibitory | 0.69 μM |
| LTEA_HepaRG_ABCC2 | Liver | Human | 1244 | ABCC2 | Activatory | 1.44 μM |
| LTEA_HepaRG_ABCC3 | Liver | Human | 8714 | ABCC3 | Activatory | 1.03 μM |
| LTEA_HepaRG_ABCG2 | Liver | Human | 9429 | ABCG2 | Activatory | 0.4 μM |
| LTEA_HepaRG_ACLY | Liver | Human | 47 | ACLY | Activatory | 0.39 μM |
| LTEA_HepaRG_ACOX1 | Liver | Human | 51 | ACOX1 | Activatory | 0.95 μM |
| LTEA_HepaRG_ADK | Liver | Human | 132 | ADK | Activatory | 0.27 μM |
| LTEA_HepaRG_AFP | Liver | Human | 174 | AFP | Activatory | 1.02 μM |
| LTEA_HepaRG_ALPP | Liver | Human | 250 | ALPP | Activatory | 25.0 μM |
| LTEA_HepaRG_BAX | Liver | Human | 581 | BAX | Activatory | 1.62 μM |
| LTEA_HepaRG_BCL2 | Liver | Human | 596 | BCL2 | Activatory | 0.51 μM |
| LTEA_HepaRG_CASP8 | Liver | Human | 841 | CASP8 | Activatory | 1.55 μM |
| LTEA_HepaRG_CAT | Liver | Human | 847 | CAT | Inhibitory | 1.05 μM |
| LTEA_HepaRG_CFLAR | Liver | Human | 8837 | CFLAR | Inhibitory | 1.42 μM |
| LTEA_HepaRG_CYP1A1 | Liver | Human | 1543 | CYP1A1 | Inhibitory | 0.21 μM |
| LTEA_HepaRG_CYP1A2 | Liver | Human | 1544 | CYP1A2 | Activatory | 0.61 μM |
| LTEA_HepaRG_CYP2B6 | Liver | Human | 1555 | CYP2B6 | Inhibitory | 1.15 μM |
| LTEA_HepaRG_CYP2C19 | Liver | Human | 1557 | CYP2C19 | Inhibitory | 1.54 μM |
| LTEA_HepaRG_CYP2C8 | Liver | Human | 1558 | CYP2C8 | Activatory | 1.47 μM |
| LTEA_HepaRG_CYP2C9 | Liver | Human | 1559 | CYP2C9 | Inhibitory | 0.89 μM |
| LTEA_HepaRG_CYP2E1 | Liver | Human | 1571 | CYP2E1 | Activatory | 1.61 μM |
| LTEA_HepaRG_CYP3A4 | Liver | Human | 1576 | CYP3A4 | Inhibitory | 1.02 μM |
| LTEA_HepaRG_CYP3A5 | Liver | Human | 1577 | CYP3A5 | Activatory | 0.7 μM |
| LTEA_HepaRG_CYP3A7 | Liver | Human | 1551 | CYP3A7 | Activatory | 1.41 μM |
| LTEA_HepaRG_CYP4A11 | Liver | Human | 1579 | CYP4A11 | Activatory | 1.36 μM |
| LTEA_HepaRG_CYP4A22 | Liver | Human | 284541 | CYP4A22 | Inhibitory | 1.35 μM |
| LTEA_HepaRG_CYP7A1 | Liver | Human | 1581 | CYP7A1 | Inhibitory | 1.47 μM |
| LTEA_HepaRG_DDIT3 | Liver | Human | 1649 | DDIT3 | Activatory | 1.64 μM |
| LTEA_HepaRG_EGF | Liver | Human | 1950 | EGF | Activatory | 0.67 μM |
| LTEA_HepaRG_FABP1 | Liver | Human | 2168 | FABP1 | Inhibitory | 1.71 μM |
| LTEA_HepaRG_FAS | Liver | Human | 355 | FAS | Activatory | 1.63 μM |
| LTEA_HepaRG_FASN | Liver | Human | 2194 | FASN | Activatory | 1.11 μM |
| LTEA_HepaRG_GSTA2 | Liver | Human | 2939 | GSTA2 | Activatory | 0.99 μM |
| LTEA_HepaRG_HIF1A | Liver | Human | 3091 | HIF1A | Inhibitory | 1.63 μM |
| LTEA_HepaRG_HMGCS2 | Liver | Human | 3158 | HMGCS2 | Activatory | 1.9 μM |
| LTEA_HepaRG_IGFBP1 | Liver | Human | 3484 | IGFBP1 | Activatory | 0.17 μM |
| LTEA_HepaRG_IL6R | Liver | Human | 3570 | IL6R | Inhibitory | 1.32 μM |
| LTEA_HepaRG_JUN | Liver | Human | 3725 | JUN | Inhibitory | 1.75 μM |
| LTEA_HepaRG_LIPC | Liver | Human | 3990 | LIPC | Inhibitory | 1.48 μM |
| LTEA_HepaRG_MIR122 | Liver | Human | 406906 | MIR122 | Activatory | 0.82 μM |
| LTEA_HepaRG_MMP10 | Liver | Human | 4319 | MMP10 | Inhibitory | 0.65 μM |
| LTEA_HepaRG_NQO1 | Liver | Human | 1728 | NQO1 | Activatory | 0.9 μM |
| LTEA_HepaRG_PEG10 | Liver | Human | 23089 | PEG10 | Activatory | 0.19 μM |
| LTEA_HepaRG_SDHB | Liver | Human | 6390 | SDHB | Activatory | 0.79 μM |
| LTEA_HepaRG_SLC22A1 | Liver | Human | 6580 | SLC22A1 | Inhibitory | 0.91 μM |
| LTEA_HepaRG_SLCO1B1 | Liver | Human | 10599 | SLCO1B1 | Activatory | 1.54 μM |
| LTEA_HepaRG_STAT3 | Liver | Human | 6774 | STAT3 | Activatory | 0.3 μM |
| LTEA_HepaRG_SULT2A1 | Liver | Human | 6822 | SULT2A1 | Activatory | 1.53 μM |
| LTEA_HepaRG_THRSP | Liver | Human | 7069 | THRSP | Activatory | 0.51 μM |
| LTEA_HepaRG_UGT1A1 | Liver | Human | 54658 | UGT1A1 | Inhibitory | 1.19 μM |
| LTEA_HepaRG_UGT1A6 | Liver | Human | 54578 | UGT1A6 | Activatory | 1.46 μM |
| LTEA_HepaRG_XBP1 | Liver | Human | 7494 | XBP1 | Activatory | 0.95 μM |
| LTEA_HepaRG_ABCB1 | Liver | Human | 5243 | ABCB1 | Activatory | 0.99 μM |
| LTEA_HepaRG_ABCB11 | Liver | Human | 8647 | ABCB11 | Activatory | 0.72 μM |
| LTEA_HepaRG_ABCC2 | Liver | Human | 1244 | ABCC2 | Activatory | 0.99 μM |
| LTEA_HepaRG_ABCC3 | Liver | Human | 8714 | ABCC3 | Inhibitory | 0.9 μM |
| LTEA_HepaRG_ABCG2 | Liver | Human | 9429 | ABCG2 | Inhibitory | 0.27 μM |
| LTEA_HepaRG_ACLY | Liver | Human | 47 | ACLY | Inhibitory | 0.4 μM |
| LTEA_HepaRG_ACOX1 | Liver | Human | 51 | ACOX1 | Activatory | 1.07 μM |
| LTEA_HepaRG_ADK | Liver | Human | 132 | ADK | Inhibitory | 1.08 μM |
| LTEA_HepaRG_AFP | Liver | Human | 174 | AFP | Inhibitory | 1.55 μM |
| LTEA_HepaRG_APOA5 | Liver | Human | 116519 | APOA5 | Activatory | 1.49 μM |
| LTEA_HepaRG_BCL2 | Liver | Human | 596 | BCL2 | Inhibitory | 0.35 μM |
| LTEA_HepaRG_CASP3 | Liver | Human | 836 | CASP3 | Activatory | 0.99 μM |
| LTEA_HepaRG_CAT | Liver | Human | 847 | CAT | Activatory | 1.09 μM |
| LTEA_HepaRG_CFLAR | Liver | Human | 8837 | CFLAR | Inhibitory | 1.18 μM |
| LTEA_HepaRG_CYP1A1 | Liver | Human | 1543 | CYP1A1 | Inhibitory | 0.12 μM |
| LTEA_HepaRG_CYP1A2 | Liver | Human | 1544 | CYP1A2 | Inhibitory | 0.44 μM |
| LTEA_HepaRG_CYP2B6 | Liver | Human | 1555 | CYP2B6 | Activatory | 1.1 μM |
| LTEA_HepaRG_CYP2C19 | Liver | Human | 1557 | CYP2C19 | Inhibitory | 1.4 μM |
| LTEA_HepaRG_CYP2C8 | Liver | Human | 1558 | CYP2C8 | Inhibitory | 1.15 μM |
| LTEA_HepaRG_CYP2C9 | Liver | Human | 1559 | CYP2C9 | Activatory | 0.82 μM |
| LTEA_HepaRG_CYP2E1 | Liver | Human | 1571 | CYP2E1 | Activatory | 1.4 μM |
| LTEA_HepaRG_CYP3A4 | Liver | Human | 1576 | CYP3A4 | Inhibitory | 1.11 μM |
| LTEA_HepaRG_CYP3A5 | Liver | Human | 1577 | CYP3A5 | Inhibitory | 1.32 μM |
| LTEA_HepaRG_CYP3A7 | Liver | Human | 1551 | CYP3A7 | Activatory | 1.22 μM |
| LTEA_HepaRG_CYP4A11 | Liver | Human | 1579 | CYP4A11 | Inhibitory | 1.51 μM |
| LTEA_HepaRG_CYP4A22 | Liver | Human | 284541 | CYP4A22 | Inhibitory | 1.38 μM |
| LTEA_HepaRG_CYP7A1 | Liver | Human | 1581 | CYP7A1 | Activatory | 1.44 μM |
| LTEA_HepaRG_DDIT3 | Liver | Human | 1649 | DDIT3 | Activatory | 1.87 μM |
| LTEA_HepaRG_FABP1 | Liver | Human | 2168 | FABP1 | Activatory | 1.26 μM |
| LTEA_HepaRG_FASN | Liver | Human | 2194 | FASN | Inhibitory | 0.71 μM |
| LTEA_HepaRG_FOXO3 | Liver | Human | 2309 | FOXO3 | Inhibitory | 1.21 μM |
| LTEA_HepaRG_GSTA2 | Liver | Human | 2939 | GSTA2 | Inhibitory | 1.14 μM |
| LTEA_HepaRG_HMGCS2 | Liver | Human | 3158 | HMGCS2 | Activatory | 1.36 μM |
| LTEA_HepaRG_HSPA1A | Liver | Human | 3303 | HSPA1A | Activatory | 1.21 μM |
| LTEA_HepaRG_IGF1 | Liver | Human | 3479 | IGF1 | Inhibitory | 1.45 μM |
| LTEA_HepaRG_IGFBP1 | Liver | Human | 3484 | IGFBP1 | Inhibitory | 0.1 μM |
| LTEA_HepaRG_IL6R | Liver | Human | 3570 | IL6R | Inhibitory | 1.5 μM |
| LTEA_HepaRG_KRT19 | Liver | Human | 3880 | KRT19 | Inhibitory | 25.0 μM |
| LTEA_HepaRG_LIPC | Liver | Human | 3990 | LIPC | Inhibitory | 1.2 μM |
| LTEA_HepaRG_LPL | Liver | Human | 4023 | LPL | Inhibitory | 1.17 μM |
| LTEA_HepaRG_MIR122 | Liver | Human | 406906 | MIR122 | Inhibitory | 0.95 μM |
| LTEA_HepaRG_MMP10 | Liver | Human | 4319 | MMP10 | Inhibitory | 0.71 μM |
| LTEA_HepaRG_NFE2L2 | Liver | Human | 4780 | NFE2L2 | Inhibitory | 0.54 μM |
| LTEA_HepaRG_PEG10 | Liver | Human | 23089 | PEG10 | Inhibitory | 0.26 μM |
| LTEA_HepaRG_PPP2R4 | Liver | Human | 5524 | PTPA | Activatory | 0.96 μM |
| LTEA_HepaRG_SDHB | Liver | Human | 6390 | SDHB | Inhibitory | 0.55 μM |
| LTEA_HepaRG_SLC22A1 | Liver | Human | 6580 | SLC22A1 | Activatory | 1.14 μM |
| LTEA_HepaRG_SLCO1B1 | Liver | Human | 10599 | SLCO1B1 | Inhibitory | 1.22 μM |
| LTEA_HepaRG_STAT3 | Liver | Human | 6774 | STAT3 | Activatory | 0.55 μM |
| LTEA_HepaRG_SULT2A1 | Liver | Human | 6822 | SULT2A1 | Inhibitory | 1.29 μM |
| LTEA_HepaRG_THRSP | Liver | Human | 7069 | THRSP | Inhibitory | 0.35 μM |
| LTEA_HepaRG_TP53 | Liver | Human | 7157 | TP53 | Inhibitory | 0.71 μM |
| LTEA_HepaRG_UGT1A1 | Liver | Human | 54658 | UGT1A1 | Activatory | 1.46 μM |
| LTEA_HepaRG_UGT1A6 | Liver | Human | 54578 | UGT1A6 | Inhibitory | 1.74 μM |
| LTEA_HepaRG_XBP1 | Liver | Human | 7494 | XBP1 | Inhibitory | 1.44 μM |
| LTEA_HepaRG_SLC10A1 | Liver | Human | 6554 | SLC10A1 | Inhibitory | 1.74 μM |
| LTEA_HepaRG_ABCB1 | Liver | Human | 5243 | ABCB1 | Inhibitory | 0.88 μM |
| LTEA_HepaRG_ABCB11 | Liver | Human | 8647 | ABCB11 | Activatory | 0.7 μM |
| LTEA_HepaRG_ABCC2 | Liver | Human | 1244 | ABCC2 | Activatory | 1.09 μM |
| LTEA_HepaRG_ABCC3 | Liver | Human | 8714 | ABCC3 | Activatory | 0.72 μM |
| LTEA_HepaRG_ABCG2 | Liver | Human | 9429 | ABCG2 | Activatory | 0.2 μM |
| LTEA_HepaRG_ACLY | Liver | Human | 47 | ACLY | Activatory | 0.2 μM |
| LTEA_HepaRG_ACOX1 | Liver | Human | 51 | ACOX1 | Activatory | 0.8 μM |
| LTEA_HepaRG_ADK | Liver | Human | 132 | ADK | Inhibitory | 0.26 μM |
| LTEA_HepaRG_APOA5 | Liver | Human | 116519 | APOA5 | Activatory | 1.22 μM |
| LTEA_HepaRG_BAD | Liver | Human | 572 | BAD | Activatory | 0.38 μM |
| LTEA_HepaRG_BCL2 | Liver | Human | 596 | BCL2 | Activatory | 0.16 μM |
| LTEA_HepaRG_CASP3 | Liver | Human | 836 | CASP3 | Inhibitory | 0.5 μM |
| LTEA_HepaRG_CASP8 | Liver | Human | 841 | CASP8 | Inhibitory | 1.17 μM |
| LTEA_HepaRG_CAT | Liver | Human | 847 | CAT | Activatory | 0.88 μM |
| LTEA_HepaRG_CCND1 | Liver | Human | 595 | CCND1 | Inhibitory | 0.19 μM |
| LTEA_HepaRG_CDKN1A | Liver | Human | 1026 | CDKN1A | Activatory | 25.0 μM |
| LTEA_HepaRG_CFLAR | Liver | Human | 8837 | CFLAR | Activatory | 1.31 μM |
| LTEA_HepaRG_CYP1A2 | Liver | Human | 1544 | CYP1A2 | Inhibitory | 0.5 μM |
| LTEA_HepaRG_CYP2B6 | Liver | Human | 1555 | CYP2B6 | Inhibitory | 1.05 μM |
| LTEA_HepaRG_CYP2C8 | Liver | Human | 1558 | CYP2C8 | Inhibitory | 1.13 μM |
| LTEA_HepaRG_CYP2C9 | Liver | Human | 1559 | CYP2C9 | Inhibitory | 0.82 μM |
| LTEA_HepaRG_CYP2E1 | Liver | Human | 1571 | CYP2E1 | Activatory | 1.21 μM |
| LTEA_HepaRG_CYP3A4 | Liver | Human | 1576 | CYP3A4 | Activatory | 0.83 μM |
| LTEA_HepaRG_CYP3A5 | Liver | Human | 1577 | CYP3A5 | Activatory | 1.86 μM |
| LTEA_HepaRG_CYP3A7 | Liver | Human | 1551 | CYP3A7 | Activatory | 0.95 μM |
| LTEA_HepaRG_CYP4A11 | Liver | Human | 1579 | CYP4A11 | Activatory | 1.38 μM |
| LTEA_HepaRG_CYP4A22 | Liver | Human | 284541 | CYP4A22 | Inhibitory | 1.15 μM |
| LTEA_HepaRG_CYP7A1 | Liver | Human | 1581 | CYP7A1 | Inhibitory | 1.57 μM |
| LTEA_HepaRG_EGF | Liver | Human | 1950 | EGF | Activatory | 1.85 μM |
| LTEA_HepaRG_FABP1 | Liver | Human | 2168 | FABP1 | Activatory | 1.18 μM |
| LTEA_HepaRG_FASN | Liver | Human | 2194 | FASN | Activatory | 1.02 μM |
| LTEA_HepaRG_FOXO3 | Liver | Human | 2309 | FOXO3 | Inhibitory | 1.62 μM |
| LTEA_HepaRG_GCLM | Liver | Human | 2730 | GCLM | Activatory | 25.0 μM |
| LTEA_HepaRG_GSTA2 | Liver | Human | 2939 | GSTA2 | Activatory | 0.88 μM |
| LTEA_HepaRG_GSTM3 | Liver | Human | 2947 | GSTM3 | Activatory | 0.78 μM |
| LTEA_HepaRG_ICAM1 | Liver | Human | 3383 | ICAM1 | Inhibitory | 1.8 μM |
| LTEA_HepaRG_IGF1 | Liver | Human | 3479 | IGF1 | Inhibitory | 1.35 μM |
| LTEA_HepaRG_IGFBP1 | Liver | Human | 3484 | IGFBP1 | Activatory | 0.06 μM |
| LTEA_HepaRG_IL6 | Liver | Human | 3569 | IL6 | Activatory | 1.73 μM |
| LTEA_HepaRG_IL6R | Liver | Human | 3570 | IL6R | Activatory | 1.55 μM |
| LTEA_HepaRG_JUN | Liver | Human | 3725 | JUN | Inhibitory | 1.36 μM |
| LTEA_HepaRG_LIPC | Liver | Human | 3990 | LIPC | Activatory | 1.21 μM |
| LTEA_HepaRG_LPL | Liver | Human | 4023 | LPL | Inhibitory | 1.11 μM |
| LTEA_HepaRG_MIR122 | Liver | Human | 406906 | MIR122 | Activatory | 0.78 μM |
| LTEA_HepaRG_MMP10 | Liver | Human | 4319 | MMP10 | Inhibitory | 0.85 μM |
| LTEA_HepaRG_NFE2L2 | Liver | Human | 4780 | NFE2L2 | Inhibitory | 0.25 μM |
| LTEA_HepaRG_PEG10 | Liver | Human | 23089 | PEG10 | Activatory | 0.11 μM |
| LTEA_HepaRG_PPP2R4 | Liver | Human | 5524 | PTPA | Activatory | 1.18 μM |
| LTEA_HepaRG_PTEN | Liver | Human | 5728 | PTEN | Activatory | 1.74 μM |
| LTEA_HepaRG_SDHB | Liver | Human | 6390 | SDHB | Inhibitory | 0.6 μM |
| LTEA_HepaRG_SLC22A1 | Liver | Human | 6580 | SLC22A1 | Activatory | 0.98 μM |
| LTEA_HepaRG_SLCO1B1 | Liver | Human | 10599 | SLCO1B1 | Activatory | 1.25 μM |
| LTEA_HepaRG_STAT3 | Liver | Human | 6774 | STAT3 | Inhibitory | 0.81 μM |
| LTEA_HepaRG_SULT2A1 | Liver | Human | 6822 | SULT2A1 | Inhibitory | 1.17 μM |
| LTEA_HepaRG_THRSP | Liver | Human | 7069 | THRSP | Activatory | 0.7 μM |
| LTEA_HepaRG_TNFRSF1A | Liver | Human | 7132 | TNFRSF1A | Activatory | 1.18 μM |
| LTEA_HepaRG_UGT1A1 | Liver | Human | 54658 | UGT1A1 | Inhibitory | 1.23 μM |
| LTEA_HepaRG_XBP1 | Liver | Human | 7494 | XBP1 | Activatory | 0.91 μM |
ToxCast endpoints for intended target type: Protein
| Assay Name | Tissue | Organism | Target Gene ID | Target HGNC Symbol | Response | AC50 Value |
|---|
| NVS_ENZ_hAKT1 | | Human | 207 | AKT1 | Loss | 1.36 μM |
| NVS_ENZ_hAKT2 | | Human | 208 | AKT2 | Loss | 1.69 μM |
| NVS_ENZ_hCDK2 | | Human | 1017 | CDK2 | Loss | 0.88 μM |
| NVS_ENZ_hCK1D | | Human | 1453 | CSNK1D | Loss | 33.57 μM |
| NVS_ENZ_hDUSP3 | | Human | 1845 | DUSP3 | Loss | 0.01 μM |
| NVS_ENZ_hEGFR | | Human | 1956 | EGFR | Loss | 21.45 μM |
| NVS_ENZ_hEphA1 | | Human | 2041 | EPHA1 | Loss | 43.52 μM |
| NVS_ENZ_hFGFR3 | | Human | 2261 | FGFR3 | Loss | 38.22 μM |
| NVS_ENZ_hGSK3b | | Human | 2932 | GSK3B | Loss | 0.68 μM |
| NVS_ENZ_hHDAC3 | | Human | 8841 | HDAC3 | Loss | 0.44 μM |
| NVS_ENZ_hHDAC6 | | Human | 10013 | HDAC6 | Loss | 0.82 μM |
| NVS_ENZ_hJak2 | | Human | 3717 | JAK2 | Loss | 40.19 μM |
| NVS_ENZ_hMAPK1 | | Human | 5594 | MAPK1 | Loss | 1.15 μM |
| NVS_ENZ_hMAPK3 | | Human | 5595 | MAPK3 | Loss | 25.0 μM |
| NVS_ENZ_hMAPKAPK2 | | Human | 9261 | MAPKAPK2 | Loss | 0.4 μM |
| NVS_ENZ_hMARK1 | | Human | 4139 | MARK1 | Loss | 1.37 μM |
| NVS_ENZ_hPAK4 | | Human | 10298 | PAK4 | Loss | 0.26 μM |
| NVS_ENZ_hPTEN | | Human | 5728 | PTEN | Loss | 0.27 μM |
| NVS_ENZ_hPTPN1 | | Human | 5770 | PTPN1 | Loss | 1.81 μM |
| NVS_ENZ_hPTPN11 | | Human | 5781 | PTPN11 | Loss | 0.6 μM |
| NVS_ENZ_hPTPN12 | | Human | 5782 | PTPN12 | Loss | 1.34 μM |
| NVS_ENZ_hPTPN14 | | Human | 5784 | PTPN14 | Loss | 25.0 μM |
| NVS_ENZ_hPTPN2 | | Human | 5771 | PTPN2 | Loss | 0.51 μM |
| NVS_ENZ_hPTPN4 | | Human | 5775 | PTPN4 | Loss | 0.04 μM |
| NVS_ENZ_hPTPN6 | | Human | 5777 | PTPN6 | Loss | 28.34 μM |
| NVS_ENZ_hPTPN9 | | Human | 5780 | PTPN9 | Loss | 0.03 μM |
| NVS_ENZ_hSIRT3 | | Human | 23410 | SIRT3 | Loss | 25.0 μM |
| NVS_ENZ_hVEGFR3 | | Human | 2324 | FLT4 | Loss | 1.3 μM |
| NVS_ENZ_hDYRK1a | | Human | 1859 | DYRK1A | Loss | 1.39 μM |
| NVS_GPCR_g5HT4 | Brain | Guinea pig | 100135548 | Htr4 | Loss | 31.14 μM |
| NVS_GPCR_gBK2 | Intestinal | Guinea pig | 100135486 | Bdkrb2 | Loss | 26.61 μM |
| NVS_GPCR_rCRF | Brain | Rat | 58959 | Crhr1 | Loss | 25.0 μM |
| NVS_GPCR_rNK3 | Brain | Rat | 24808 | Tacr3 | Loss | 25.0 μM |
| NVS_LGIC_rGluNMDA_MK801_Agonist | Brain | Rat | 24408 | Grin1 | Gain | 25.0 μM |
| NVS_NR_hFXR_Antagonist | | Human | 9971 | NR1H4 | Loss | 41.08 μM |
| NVS_NR_hPXR | | Human | 8856 | NR1I2 | Loss | 1.52 μM |
| BSK_hDFCGF_MCSF | Skin | Human | 1435 | CSF1 | Inhibitory | 1.41 μM |
| NVS_ENZ_hCASP4 | | Human | 837 | CASP4 | Loss | 0.18 μM |
| NVS_ENZ_hCASP5 | | Human | 838 | CASP5 | Loss | 1.47 μM |
| NVS_ENZ_hElastase | | Human | 1991 | ELANE | Loss | 1.52 μM |
| NVS_ENZ_hPTPRC | | Human | 5788 | PTPRC | Loss | 1.82 μM |
| NVS_GPCR_hNK2 | | Human | 6865 | TACR2 | Loss | 0.17 μM |
| NVS_NR_hGR | | Human | 2908 | NR3C1 | Loss | 1.36 μM |
| NVS_ADME_hCYP2C19 | | Human | 1557 | CYP2C19 | Loss | 1.85 μM |
| NVS_ADME_hCYP2C9 | | Human | 1559 | CYP2C9 | Loss | 1.63 μM |
| NVS_ENZ_hPTPRC | | Human | 5788 | PTPRC | Loss | 0.24 μM |
| NVS_ENZ_hTrkA | | Human | 4914 | NTRK1 | Loss | 22.06 μM |
| NVS_GPCR_hNK2 | | Human | 6865 | TACR2 | Loss | 0.13 μM |
| NVS_NR_hGR | | Human | 2908 | NR3C1 | Loss | 1.07 μM |
| NVS_NR_rAR | Prostate | Rat | 24208 | Ar | Loss | 1.52 μM |
| NVS_ADME_hCYP2C9 | | Human | 1559 | CYP2C9 | Loss | 1.2 μM |
| NVS_ENZ_hAMPKa1 | | Human | 5562 | PRKAA1 | Loss | 1.32 μM |
| NVS_ENZ_hCASP5 | | Human | 838 | CASP5 | Loss | 0.88 μM |
| NVS_ENZ_hCSF1R | | Human | 1436 | CSF1R | Loss | 0.31 μM |
| NVS_ENZ_hFGFR1 | | Human | 2260 | FGFR1 | Loss | 0.93 μM |
| NVS_ENZ_hGSK3b | | Human | 2932 | GSK3B | Loss | 1.08 μM |
| NVS_ENZ_hPTEN | | Human | 5728 | PTEN | Loss | 0.08 μM |
| NVS_ENZ_hPTPRC | | Human | 5788 | PTPRC | Loss | 0.25 μM |
| NVS_ENZ_hPTPRM | | Human | 5797 | PTPRM | Loss | 0.79 μM |
| NVS_GPCR_hNK2 | | Human | 6865 | TACR2 | Loss | 0.12 μM |
| BSK_BE3C_MMP1 | Lung | Human | 4312 | MMP1 | Inhibitory | 0.61 μM |
| BSK_BE3C_uPA | Lung | Human | 5328 | PLAU | Inhibitory | 1.08 μM |
| BSK_BE3C_uPA | Lung | Human | 5328 | PLAU | Inhibitory | 0.21 μM |
| NVS_GPCR_hORL1 | | Human | 4987 | OPRL1 | Loss | 0.62 μM |
| NVS_NR_rAR | Prostate | Rat | 24208 | Ar | Loss | 1.82 μM |
| NVS_TR_hNET | | Human | 6530 | SLC6A2 | Loss | 0.27 μM |
| NVS_ENZ_hAKT1 | | Human | 207 | AKT1 | Loss | 0.61 μM |
| NVS_ENZ_hAMPKa1 | | Human | 5562 | PRKAA1 | Loss | 1.45 μM |
| NVS_ENZ_hCSF1R | | Human | 1436 | CSF1R | Loss | 0.93 μM |
| NVS_ENZ_hMsk1 | | Human | 9252 | RPS6KA5 | Loss | 1.22 μM |
| NVS_ENZ_hPTPN11 | | Human | 5781 | PTPN11 | Loss | 0.45 μM |
| NVS_ENZ_hPTPRC | | Human | 5788 | PTPRC | Loss | 1.27 μM |
| NVS_GPCR_rSST | Brain | Rat | 25033 | Sstr1 | Loss | 1.36 μM |
| NVS_ADME_hCYP2C19 | | Human | 1557 | CYP2C19 | Loss | 0.99 μM |
| NVS_ENZ_hDUSP3 | | Human | 1845 | DUSP3 | Loss | 1.3 μM |
| NVS_ENZ_hPTPRC | | Human | 5788 | PTPRC | Loss | 0.77 μM |
| NVS_GPCR_hOpiate_mu | | Human | 4988 | OPRM1 | Loss | 0.05 μM |
| NVS_GPCR_hORL1 | | Human | 4987 | OPRL1 | Loss | 0.16 μM |
| ATG_E_Box_CIS | Liver | Human | 7391 | USF1 | Activatory | 0.49 μM |
| ATG_HIF1a_CIS | Liver | Human | 3091 | HIF1A | Activatory | 0.96 μM |
| ATG_Oct_MLP_CIS | Liver | Human | 5451 | POU2F1 | Inhibitory | 0.58 μM |
| ATG_Xbp1_CIS | Liver | Human | 7494 | XBP1 | Inhibitory | 0.98 μM |
| ATG_Ahr_CIS | Liver | Human | 196 | AHR | Activatory | 22.84 μM |
| ATG_AP_1_CIS | Liver | Human | 2353|3725 | FOS|JUN | Inhibitory | 29.38 μM |
| ATG_DR4_LXR_CIS | Liver | Human | 7376|10062 | NR1H2|NR1H3 | Inhibitory | 50.0 μM |
| ATG_E_Box_CIS | Liver | Human | 7391 | USF1 | Inhibitory | 0.71 μM |
| ATG_MRE_CIS | Liver | Human | 4520 | MTF1 | Activatory | 28.72 μM |
| ATG_Oct_MLP_CIS | Liver | Human | 5451 | POU2F1 | Activatory | 1.81 μM |
| ATG_Sox_CIS | Liver | Human | 6656 | SOX1 | Inhibitory | 22.28 μM |
| ATG_TCF_b_cat_CIS | Liver | Human | 6932|6934|51176|83439 | TCF7|TCF7L2|LEF1|TCF7L1 | Activatory | 26.93 μM |
| ATG_Ahr_CIS | Liver | Human | 196 | AHR | Inhibitory | 25.99 μM |
| ATG_DR4_LXR_CIS | Liver | Human | 7376|10062 | NR1H2|NR1H3 | Inhibitory | 67.74 μM |
| ATG_E_Box_CIS | Liver | Human | 7391 | USF1 | Activatory | 1.46 μM |
| ATG_HIF1a_CIS | Liver | Human | 3091 | HIF1A | Activatory | 21.53 μM |
| ATG_ISRE_CIS | Liver | Human | 3659 | IRF1 | Activatory | 50.0 μM |
| ATG_MRE_CIS | Liver | Human | 4520 | MTF1 | Activatory | 22.4 μM |
| ATG_NRF2_ARE_CIS | Liver | Human | 4780 | NFE2L2 | Activatory | 1.43 μM |
| ATG_Oct_MLP_CIS | Liver | Human | 5451 | POU2F1 | Activatory | 1.13 μM |
| ATG_TCF_b_cat_CIS | Liver | Human | 6932|6934|51176|83439 | TCF7|TCF7L2|LEF1|TCF7L1 | Activatory | 27.8 μM |
| ATG_Xbp1_CIS | Liver | Human | 7494 | XBP1 | Inhibitory | 1.66 μM |
| ATG_PPARg_TRANS | Liver | Human | 5468 | PPARG | Gain | 50.0 μM |
| NVS_ENZ_hAKT2 | | Human | 208 | AKT2 | Loss | 1.62 μM |
| NVS_ENZ_hHDAC6 | | Human | 10013 | HDAC6 | Loss | 0.23 μM |
| NVS_ENZ_hMAPKAPK2 | | Human | 9261 | MAPKAPK2 | Loss | 0.39 μM |
| NVS_ENZ_hPTPN1 | | Human | 5770 | PTPN1 | Loss | 0.83 μM |
| NVS_ENZ_hPTPN12 | | Human | 5782 | PTPN12 | Loss | 0.49 μM |
| NVS_ENZ_hPTPN2 | | Human | 5771 | PTPN2 | Loss | 0.82 μM |
| NVS_ENZ_hPTPN4 | | Human | 5775 | PTPN4 | Loss | 0.18 μM |
| NVS_ENZ_hPTPN9 | | Human | 5780 | PTPN9 | Loss | 0.42 μM |
| NVS_ENZ_hPTPRB | | Human | 5787 | PTPRB | Loss | 0.02 μM |
| NVS_ENZ_hPTPRF | | Human | 5792 | PTPRF | Loss | 1.38 μM |
| NVS_ENZ_hSRC | | Human | 6714 | SRC | Loss | 1.45 μM |
| NVS_GPCR_hORL1 | | Human | 4987 | OPRL1 | Loss | 0.46 μM |
| ATG_MRE_CIS | Liver | Human | 4520 | MTF1 | Inhibitory | 50.0 μM |
| ATG_Sox_CIS | Liver | Human | 6656 | SOX1 | Inhibitory | 22.97 μM |
| ATG_VDRE_CIS | Liver | Human | 7421 | VDR | Activatory | 30.31 μM |
| ATG_Xbp1_CIS | Liver | Human | 7494 | XBP1 | Inhibitory | 1.77 μM |
| ATG_Oct_MLP_CIS | Liver | Human | 5451 | POU2F1 | Activatory | 0.41 μM |
| ATG_Xbp1_CIS | Liver | Human | 7494 | XBP1 | Activatory | 0.45 μM |
| CCTE_Simmons_AUR_rTPO | Thyroid gland | Rat | 54314 | Tpo | Loss | 21.88 μM |
| CCTE_Simmons_AUR_rTPO | Thyroid gland | Rat | 54314 | Tpo | Loss | 23.83 μM |
| CCTE_GLTED_hDIO1 | | Human | 1733 | DIO1 | Loss | 50.0 μM |
| CCTE_GLTED_hDIO1 | | Human | 1733 | DIO1 | Loss | 29.5 μM |
| CCTE_GLTED_hDIO2 | | Human | 1734 | DIO2 | Loss | 50.0 μM |
| CCTE_GLTED_hDIO3 | | Human | 1735 | DIO3 | Loss | 36.38 μM |
| TOX21_TR_LUC_GH3_Antagonist | Pituitary gland | Rat | 7067|7068 | THRA|THRB | Loss | 44.4 μM |
| TOX21_ERR_LUC_Antagonist | Kidney | Human | 2101 | ESRRA | Loss | 39.81 μM |
| TOX21_ERb_BLA_Antagonist_ratio | Kidney | Human | 2100 | ESR2 | Loss | 36.04 μM |
| TOX21_PR_BLA_Antagonist_ratio | Kidney | Human | 5241 | PGR | Loss | 21.81 μM |
| TOX21_AChE_Colorimetric_Antagonist | Bone | Human | 43 | ACHE | Loss | 30.04 μM |
No ToxCast endpoints for intended target type: Molecular messenger
ToxCast endpoints for intended target type: Pathway
| Assay Name | Tissue | Organism | Target Gene ID | Target HGNC Symbol | Response | AC50 Value |
|---|
| APR_HepG2_MitoticArrest_24hr | Liver | Human | 3020 | H3-3A | Activatory | 106.52 μM |
| APR_HepG2_P-H2AX_24hr | Liver | Human | 3014 | H2AX | Activatory | 100.0 μM |
| APR_HepG2_p53Act_24hr | Liver | Human | 7157 | TP53 | Activatory | 113.59 μM |
| APR_HepG2_StressKinase_24hr | Liver | Human | 3725 | JUN | Inhibitory | 82.87 μM |
| OT_NURR1_NURR1RXRa_1440 | Kidney | Human | 4929|6256 | NR4A2|RXRA | Gain | 40.28 μM |
| OT_NURR1_NURR1RXRa_1440 | Kidney | Human | 4929|6256 | NR4A2|RXRA | Gain | 40.19 μM |
| OT_NURR1_NURR1RXRa_1440 | Kidney | Human | 4929|6256 | NR4A2|RXRA | Gain | 38.2 μM |
| APR_HepG2_P-H2AX_24hr | Liver | Human | 3014 | H2AX | Activatory | 41.2 μM |
| APR_HepG2_MitoticArrest_72hr | Liver | Human | 3020 | H3-3A | Inhibitory | 51.36 μM |
| APR_HepG2_P-H2AX_72hr | Liver | Human | 3014 | H2AX | Inhibitory | 44.68 μM |
| APR_HepG2_P-H2AX_24hr | Liver | Human | 3014 | H2AX | Activatory | 45.2 μM |
| APR_HepG2_MitoticArrest_72hr | Liver | Human | 3020 | H3-3A | Activatory | 51.09 μM |
| APR_HepG2_P-H2AX_72hr | Liver | Human | 3014 | H2AX | Activatory | 43.66 μM |
| APR_HepG2_P-H2AX_24hr | Liver | Human | 3014 | H2AX | Inhibitory | 49.68 μM |
| APR_HepG2_MitoticArrest_72hr | Liver | Human | 3020 | H3-3A | Inhibitory | 50.71 μM |
| APR_HepG2_P-H2AX_72hr | Liver | Human | 3014 | H2AX | Activatory | 50.0 μM |
| ACEA_ER_80hr | Breast | Human | 2099 | ESR1 | Gain | 0.9 μM |
| APR_HepG2_P-H2AX_24hr | Liver | Human | 3014 | H2AX | Activatory | 50.0 μM |
| APR_HepG2_p53Act_24hr | Liver | Human | 7157 | TP53 | Inhibitory | 48.98 μM |
| APR_HepG2_MitoticArrest_72hr | Liver | Human | 3020 | H3-3A | Inhibitory | 36.93 μM |
| APR_HepG2_p53Act_72hr | Liver | Human | 7157 | TP53 | Inhibitory | 26.89 μM |
| APR_HepG2_StressKinase_72hr | Liver | Human | 3725 | JUN | Activatory | 39.76 μM |
| APR_HepG2_MitoticArrest_24hr | Liver | Human | 3020 | H3-3A | Inhibitory | 55.23 μM |
| APR_HepG2_P-H2AX_24hr | Liver | Human | 3014 | H2AX | Activatory | 41.28 μM |
| APR_HepG2_p53Act_24hr | Liver | Human | 7157 | TP53 | Inhibitory | 38.54 μM |
| APR_HepG2_StressKinase_24hr | Liver | Human | 3725 | JUN | Activatory | 39.09 μM |
| APR_HepG2_MitoticArrest_72hr | Liver | Human | 3020 | H3-3A | Activatory | 48.64 μM |
| APR_HepG2_P-H2AX_72hr | Liver | Human | 3014 | H2AX | Activatory | 48.72 μM |
| APR_HepG2_p53Act_72hr | Liver | Human | 7157 | TP53 | Activatory | 45.47 μM |
| APR_HepG2_P-H2AX_24hr | Liver | Human | 3014 | H2AX | Activatory | 53.83 μM |
| APR_HepG2_P-H2AX_72hr | Liver | Human | 3014 | H2AX | Activatory | 40.33 μM |
| OT_AR_ARSRC1_0480 | Kidney | Human | 367|6714 | AR|SRC | Gain | 40.01 μM |
| OT_AR_ARSRC1_0960 | Kidney | Human | 367|6714 | AR|SRC | Gain | 38.26 μM |
| OT_NURR1_NURR1RXRa_1440 | Kidney | Human | 4929|6256 | NR4A2|RXRA | Gain | 27.92 μM |
| ACEA_AR_agonist_80hr | Prostate | Human | 367 | AR | Gain | 0.49 μM |
| TOX21_ARE_BLA_Agonist_ratio | Liver | Human | 4780 | NFE2L2 | Gain | 1.28 μM |
No ToxCast endpoints for intended target type: Cellular
No ToxCast endpoints for intended target type: Hormone
DISCLAIMER
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.