5-Chloro-2-(2,4-dichlorophenoxy)phenol


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0001825 Blastocyst formation Decreases phenotype PMID:36243240
GO:0002377 Immunoglobulin production Increases phenotype PMID:33654271
GO:0003014 Renal system process Decreases phenotype PMID:21147601
GO:0004129 Cytochrome-c oxidase activity Affects phenotype PMID:28478158
GO:0006006 Glucose metabolic process Affects phenotype PMID:38048832
GO:0006304 Dna modification Increases phenotype PMID:26970259
GO:0006590 Thyroid hormone generation Affects phenotype PMID:34460931
GO:0006629 Lipid metabolic process Affects phenotype PMID:38048832
GO:0006631 Fatty acid metabolic process Affects phenotype PMID:38048832
GO:0006805 Xenobiotic metabolic process Increases phenotype PMID:29849464
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:39002938
GO:0006915 Apoptotic process Increases phenotype PMID:25193434
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:19591892; PMID:31714634
GO:0006979 Response to oxidative stress Affects phenotype PMID:34619205
GO:0007283 Spermatogenesis Decreases phenotype PMID:26901211; PMID:29350491
GO:0008121 Ubiquinol-cytochrome-c reductase activity Affects phenotype PMID:28478158
GO:0008152 Metabolic process Affects phenotype PMID:38052405
GO:0008177 Succinate dehydrogenase (ubiquinone) activity Decreases phenotype PMID:28478158
GO:0008217 Regulation of blood pressure Affects phenotype PMID:30503318
GO:0008219 Cell death Increases phenotype PMID:29427707; PMID:31381933
GO:0008283 Cell population proliferation Affects phenotype PMID:24684733; PMID:24684733; PMID:24740835; PMID:24835555; PMID:25193434; PMID:28478158
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:28844962; PMID:29849464
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:29849464; PMID:34160118
GO:0009081 Branched-chain amino acid metabolic process Affects phenotype PMID:38052405
GO:0009410 Response to xenobiotic stimulus Decreases phenotype PMID:29323457
GO:0010424 Dna methylation on cytosine within a cg sequence Affects phenotype PMID:34523531
GO:0010634 Positive regulation of epithelial cell migration Increases phenotype PMID:33171535
GO:0010718 Positive regulation of epithelial to mesenchymal transition Increases phenotype PMID:28844962
GO:0010942 Positive regulation of cell death Increases phenotype PMID:28940058; PMID:40434365
GO:0016049 Cell growth Decreases phenotype PMID:36277366
GO:0016477 Cell migration Increases phenotype PMID:26604029
GO:0030335 Positive regulation of cell migration Increases phenotype PMID:28844962
GO:0031324 Negative regulation of cellular metabolic process Increases phenotype PMID:35413382
GO:0031589 Cell-substrate adhesion Increases phenotype PMID:34801682
GO:0032148 Activation of protein kinase b activity Increases phenotype PMID:34160118
GO:0032731 Positive regulation of interleukin-1 beta production Increases phenotype PMID:32321163
GO:0034440 Lipid oxidation Increases phenotype PMID:29350491; PMID:34160118
GO:0042554 Superoxide anion generation Increases phenotype PMID:28478158
GO:0042593 Glucose homeostasis Affects phenotype PMID:28973666
GO:0042695 Thelarche Increases phenotype PMID:26335517
GO:0042755 Eating behavior Affects phenotype PMID:30321646
GO:0043306 Positive regulation of mast cell degranulation Increases phenotype PMID:31429102
GO:0044237 Cellular metabolic process Decreases phenotype PMID:31381933; PMID:33819548; PMID:34681664; PMID:36277366; PMID:36613676; PMID:39002938; PMID:39778647
GO:0044319 Wound healing, spreading of cells Affects phenotype PMID:31714634
GO:0045333 Cellular respiration Increases phenotype PMID:28478158
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:26604029
GO:0045992 Negative regulation of embryonic development Increases phenotype PMID:36243240
GO:0046034 Atp metabolic process Affects phenotype PMID:39002938
GO:0046470 Phosphatidylcholine metabolic process Affects phenotype PMID:38048832
GO:0048874 Host-mediated regulation of intestinal microbiota composition Affects phenotype PMID:34515797
GO:0051017 Actin filament bundle assembly Affects phenotype PMID:31714634
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:28478158
GO:0055007 Cardiac muscle cell differentiation Increases phenotype PMID:30510588
GO:0060047 Heart contraction Increases phenotype PMID:30510588
GO:0060180 Female mating behavior Affects phenotype PMID:30321646
GO:0060322 Head development Decreases phenotype PMID:25061923; PMID:26908126
GO:0060914 Heart formation Increases phenotype PMID:30510588
GO:0061436 Establishment of skin barrier Affects phenotype PMID:34515797
GO:0070091 Glucagon secretion Affects phenotype PMID:36613676
GO:0070373 Negative regulation of erk1 and erk2 cascade Increases phenotype PMID:35413382
GO:0070460 Thyroid-stimulating hormone secretion Decreases phenotype PMID:35964788
GO:0070584 Mitochondrion morphogenesis Decreases phenotype PMID:32321163
GO:0071466 Cellular response to xenobiotic stimulus Increases phenotype PMID:26921727
GO:0071743 Ige immunoglobulin complex, circulating Increases phenotype PMID:33654271
GO:0071897 Dna biosynthetic process Increases phenotype PMID:25193434; PMID:30238133
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:39002938
GO:0086003 Cardiac muscle cell contraction Increases phenotype PMID:28940058
GO:0097327 Response to antineoplastic agent Decreases phenotype PMID:29849464
GO:0097722 Sperm motility Decreases phenotype PMID:26901211
GO:0140042 Lipid droplet formation Increases phenotype PMID:31714634; PMID:39778647
GO:1900017 Positive regulation of cytokine production involved in inflammatory response Increases phenotype PMID:32321163
GO:1900020 Positive regulation of protein kinase c activity Increases phenotype PMID:31429102
GO:1901318 Negative regulation of flagellated sperm motility Increases phenotype PMID:29350491
GO:1901522 Positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus Increases phenotype PMID:26921727
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:29350491
GO:1901671 Positive regulation of superoxide dismutase activity Increases phenotype PMID:29350491; PMID:34160118
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:34160118
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:31381933
GO:1903426 Regulation of reactive oxygen species biosynthetic process Affects phenotype PMID:32321163
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:34160118; PMID:39653182
GO:1903753 Negative regulation of p38mapk cascade Increases phenotype PMID:35413382
GO:1904007 Positive regulation of phospholipase d activity Increases phenotype PMID:31429102
GO:1904078 Positive regulation of estrogen biosynthetic process Increases phenotype PMID:29501854
GO:1904202 Negative regulation of iodide transport Increases phenotype PMID:39069214
GO:1904214 Positive regulation of iodide transmembrane transport Decreases phenotype PMID:26827900
GO:1990349 Gap junction-mediated intercellular transport Decreases phenotype PMID:35413382
GO:2000224 Regulation of testosterone biosynthetic process Affects phenotype PMID:22461451
GO:2000354 Regulation of ovarian follicle development Affects phenotype PMID:29323457
GO:2000569 Regulation of t-helper 2 cell activation Affects phenotype PMID:26048654
GO:2000609 Regulation of thyroid hormone generation Affects phenotype PMID:39069214
GO:2000610 Negative regulation of thyroid hormone generation Increases phenotype PMID:29323457; PMID:29323457; PMID:29501854; PMID:29501854
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:29350491
GO:2000866 Positive regulation of estradiol secretion Increases phenotype PMID:29323457; PMID:29350491; PMID:29350491; PMID:30940137
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.